Development and progression of alopecia in the vitamin D receptor null mouse

Journal of Cellular Physiology

Volumn 207, Issue 2, 2006, Pages 340-353

  Bikle, Daniel D ^a,c   Elalieh, Hashem ^a   Chang, Sandra ^a   Xie, Zhongjian ^a   Sundberg, John P ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b JACKSON LABORATORY   (United States)

^c SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VITAMIN D RECEPTOR;

ALOPECIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL CELL; CONTROLLED STUDY; DETERIORATION; EXTRACELLULAR MATRIX; GENE; GENE EXPRESSION REGULATION; GENE MUTATION; HAIR FOLLICLE; HR GENE; MORPHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; VDR GENE;

ALKALINE PHOSPHATASE; ALOPECIA; ANIMALS; COLLAGEN TYPE I; DISEASE PROGRESSION; EPIDERMIS; FIBROBLASTS; GENE EXPRESSION; HAIR FOLLICLE; HYPERPLASIA; KERATIN-5; KERATINOCYTES; KERATINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, SCANNING; PROLIFERATING CELL NUCLEAR ANTIGEN; RECEPTORS, CALCITRIOL; SKIN; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 33645671653     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20578     Document Type: Article

References (44)

1. Ahmad W, Faiyaz ul Haque M, Brancolini V, Tsou HC, ul Haque S, Lam H, Aita VM, Owen J, deBlaquiere M, Frank J, et al. 1998. Alopecia universalis associated with a mutation in the human hairless gene. Science 279(5351):720-724.
2. Bikle DD, Chang S, Crumrine D, Elalieh H, Man MQ, Choi EH, Dardenne O, Xie Z, Arnaud RS, Feingold K, Elias PM. 2004. 25 Hydroxyvitamin D1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis. J Invest Dermatol 122(4): p 984-992.
3. Chen CH, Sakai Y, Demay MB. 2001. Targeting expression of the human vitamin D receptor to the keratinocytes of vitamin D receptor null mice prevents alopecia. Endocrinology 142(12):5386-5389.
4. Cotsarelis G, Sun TT, Lavker RM. 1990. Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 61:1329-1337.
5. Dardenne O, Prud'homme J, Arabian A, Glorieux FH, St-Arnaud R. 2001. Targeted inactivation of the 25-hydroxyvitamin D(3)-1(alpha)- hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D- deficiency rickets. Endocrinology 142(7):3135-3141.
6. DasGupta R, Rhee H, Fuchs E. 2002. A developmental conundrum: A stabilized form of beta-catenin lacking the transcriptional activation domain triggers features of hair cell fate in epidermal cells and epidermal cell fate in hair follicle cells. J Cell Biol 158(2):331-344.
7. Djabali K, Aita VM, Christiano AM. 2001. Hairless is translocated to the nucleus via a novel bipartite nuclear localization signal and is associated with the nuclear matrix. J Cell Sci 114(Pt 2):367-376.
8. Engelhard A, Christiano AM. 2004. The hairless promoter is differentially regulated by thyroid hormone in keratinocytes and neuroblastoma cells. Exp Dermatol 13(4):257-264.
9. Fuchs E, Merrill BJ, Jamora C, DasGupta R. 2001. At the roots of a never-ending cycle. Dev Cell 1(1):13-25.
10. Hochberg Z, Gilhar A, Haim S, Friedman-Birnbaum R, Levy J, Benderly A. 1985. Calcitriol-resistant rickets with alopecia. Arch Dermatol 121(5):646-647.
11. Hsieh JC, Sisk JM, Jurutka PW, Haussler CA, Slater SA, Haussler MR, Thompson CC. 2003. Physical and functional interaction between the vitamin D receptor and hair less corepressor, two proteins required for hair cycling. J Biol Chem 278(40): p 38665-38674.
12. Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W. 2001. beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 105(4):533-545.
13. Kong J, Li XJ, Gavin D, Jiang Y, Li YC. 2002. Targeted expression of human vitamin d receptor in the skin promotes the initiation of the postnatal hair follicle cycle and rescues the alopecia in vitamin D receptor null mice. J Invest Dermatol 118(4):631-638.
14. Li YC, Pirro AE, Amling M, Delling G, Baron R, Bronson R, Demay MB. 1997. Targeted ablation of the vitamin D receptor: An animal model of vitamin D-dependent rickets type II with alopecia. Proc Natl Acad Sci USA 94(18):9831-9835.
15. Li YC, Amling M, Pirro AE, Priemel M, Meuse J, Baron R, Delling G, Demay MB. 1998. Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice. Endocrinology 139(10):4391-4396.
16. Li M, Indra AK, Warot X, Brocard J, Messaddeq N, Kato S, Metzger D, Chambon P. 2000. Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis. Nature 407(6804):633-636.
17. Link RE, Paus R, Stenn KS, Kuklinska E, Moellmann G. 1990. Epithelial growth by rat vibrissae follicles in vitro requires mesenchymal contact via native extracellular matrix. J Invest Dermatol 95(2):202-207.
18. Marx SJ, Bliziotes MM, Nanes M. 1986. Analysis of the relation between alopecia and resistance to 1,25-dihydroxyvitamin D. Clin Endocrinol (Oxf) 25(4):373-381.
19. Millar SE. 2002. Molecular mechanisms regulating hair follicle development. J Invest Dermatol 118:216-225.
20. Miller J, Djabali K, Chen T, Liu Y, Ioffreda M, Lyle S, Christiano AM, Holick M, Cotsarelis G. 2001. Atrichia caused by mutations in the vitamin D receptor gene is a phenocopy of generalized atrichia caused by mutations in the hairless gene. J Invest Dermatol 117(3):612-617.
21. Panda DK, Miao D, Tremblay ML, Sirois J, Farookhi R, Hendy GN, Goltzman D. 2001. Targeted ablation of the 25-hydroxyvitamin D1 alpha-hydroxylase enzyme: Evidence for skeletal, reproductive, and immune dysfunction. Proc Natl Acad Sci USA 98(13):7498-7503.
22. Panteleyev AA, Paus R, Ahmad W, Sundberg JP, Christiano AM. 1998. Molecular and functional aspects of the hairless (hr) gene in laboratory rodents and humans. Exp Dermatol 7:249-267.
23. Panteleyev AA, Botchkareva NV, Sundberg JP, Christiano AM, Paus R. 1999. The role of the hairless (hr) gene in the regulation of hair follicle catagen transformation. Am J Pathol 155(1):159-171.
24. Panteleyev AA, Paus R, Christiano AM. 2000a. Patterns of hairless (hr) gene expression in mouse hair follicle morphogenesis and cycling. Am J Pathol 157(4):1071-1079.
25. Panteleyev AA, Christiano AM, O'Brien TG, Sundberg JP. 2000b. Ornithine decarboxylase transgenic mice as a model for human atrichia with papular lesions. Exp Dermatol 9:146-151.
26. Paus R, Müller-Röver S, van der Veen C, Maurer M, Eichmuller S, Ling G, Hofmann U, Foitzik K, Mecklenburg L, Handjiski B. 1999. A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogenesis. J Invest Dermatol 113:523-532.
27. Pietila M, Parkkinen JJ, Alhonen L, Janne J. 2001. Relation of skin polyamines to the hairless phenotype in transgenic mice overexpressing spermidine/spermine N-acetyltransferase. J Invest Dermatol 116(5):801-805.
28. Prufer K, Barsony J. 2002. Retinoid X receptor dominates the nuclear import and export of the unliganded vitamin D receptor. Mol Endocrinol 16(8):1738-1751.
29. Reichrath J, Schilli M, Kerber A, Bahmer FA, Czarnetzki BM, Paus R. 1994. Hair follicle expression of 1,25-dihydroxyvitamin D3 receptors during the murine hair cycle. Br J Dermatol 131(4):477-482.
30. Sakai Y, Demay MB. 2000. Evaluation of keratinocyte proliferation and differentiation in vitamin D receptor knockout mice. Endocrinology 141(6):2043-2049.
31. Sakai Y, Kishimoto J, Demay MB. 2001. Metabolic and cellular analysis of alopecia in vitamin D receptor knockout mice. J Clin Invest 107(8):961-966.
32. Skorija K, Cox M, Sisk JM, Dowd DR, Macdonald PN, Thompson CC, Demay MB. 2005. Ligand-independent actions of the vitamin D receptor maintain hair follicle homeostasis. Mol Endocrinol 19:855-862.
33. Soler AP, Gilliard G, Megosh LC, O'Brien TG. 1996. Modulation of murine hair follicle function by alterations in ornithine decarboxylase activity. J Invest Dermatol 106(5):1108-1113.
34. Sone T, Kerner S, Pike JW. 1991. Vitamin D receptor interaction with specific DNA Association as a 1,25- dihydroxyvitamin D3-modulated heterodimer. J Biol Chem 266(34):23296-23305.
35. Stenn KS, Paus R. 2001. Controls of hair follicle cycling. Physiol Rev 81(1):449-494.
36. Sundberg JP, Dunstan RW, Compton JF. 1989. Hairless mouse, HRS/J hr/hr. In: Jones TC, Mohr U, Hunt RD, editors. Integument and mammary glands. Monographs on pathology of laboratory animals. Heidelberg: Springer-Verlag. pp 192-197.
37. Sundberg JP, Roop DR, Dunstan R, Lavker R, Sun TT. 1991. Interaction between dermal papilla and bulge: The rhino mouse mutation as a model system. Ann NY Acad Sci 642:496-499.
38. Sundberg JP, Price VH, King LE Jr. 1999. The "hairless" gene in mouse and man. Arch Dermatol 135:718-720.
39. Thompson CC. 1996. Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog. J Neurosci 16(24):7832-7840.
40. Thompson CC, Bottcher MC. 1997. The product of a thyroid hormone-responsive gene interacts with thyroid hormone receptors. Proc Natl Acad Sci USA 94(16):8527-8532.
41. Xie Z, Komuves L, Yu QC, Elalieh H, Ng DC, Leary C, Chang S, Crumrine D, Yoshizawa T, Kato S, et al. 2002. Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth. J Invest Dermatol 118(1):11-16.
42. Xie Z, Chang S, Oda Y, Bikle DD. 2005. Hairless suppresses vitamin D receptor transactivation in human keratinocytes. Endocrinology [Epub ahead of print].
43. Yoshizawa T, Handa Y, Uematsu Y, Takeda S, Sekine K, Yoshihara Y, Kawakami T, Arioka K, Sato H, Uchiyama Y, et al. 1997. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet 16(4):391-396.
44. Zarach JM, Beaudoin GM III, Coulombe PA, Thompson CC. 2004. The corepressor hairless has a role in epithelial cell differentiation in the skin. Development 131(17): p 4189-4200.