Bioaccumulation potential of air contaminants: Combining biological allometry, chemical equilibrium and mass-balances to predict accumulation of air pollutants in various mammals

Toxicology and Applied Pharmacology

Volumn 238, Issue 1, 2009, Pages 47-55

  Veltman, Karin ^a   McKone, Thomas E ^b   Huijbregts, Mark A J ^a   Hendriks, A Jan ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bioaccumulation; Human; Mammals; Mechanistic model; Volatile organic compounds

Indexed keywords

OCTANOL; WATER;

AIR CONDITIONING; AIR POLLUTION; ALLOMETRY; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; HEART OUTPUT; HUMAN; HUMAN TISSUE; LIPID ANALYSIS; MAMMAL; MASS BALANCE; MOUSE; NONHUMAN; PARTITION COEFFICIENT; PREDICTION; RAT; RISK ASSESSMENT; STEADY STATE;

AIR POLLUTANTS; ANIMALS; BIOTRANSFORMATION; BLOOD PROTEINS; CARDIAC OUTPUT; EXHALATION; HUMANS; INHALATION; INHALATION EXPOSURE; LIPIDS; MICE; MODELS, BIOLOGICAL; RATS; RISK ASSESSMENT; SPECIES SPECIFICITY; TISSUE DISTRIBUTION; VOLATILE ORGANIC COMPOUNDS;

MAMMALIA; MUS; RATTUS;

EID: 67349139115     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.04.012     Document Type: Article

References (92)

1. Abbas R., and Fisher J.W. A physiologically based pharmacokinetic model for trichloroethylene and its metabolites, chloral hydrate, trichloroacetate, dichloroacetate, trichloroethanol, and trichloroethanol glucuronide in B6C3F1 mice. Toxicol. Appl. Pharmacol. 147 (1997) 15-30
2. Altman, P.L. 1961. Blood and other body fluids. Federation of American Societies for Experimental Biology. Washington D.C. p. 19, pp. 80-81
3. Andersen M.E. A physiologically based toxicokinetic description of the metabolism of inhaled gases and vapors: analysis at steady-state. Toxicol. Appl. Pharmacol. 60 (1981) 509-526
4. Andersen M.E. Toxicokinetic modeling and its applications in chemical risk assessment. Toxicol. Lett. 138 (2003) 9-27
5. Andersen M.E., Gargas M.L., Jones R.A., and Jenkins L.J. Determination of the kinetic constants for metabolism of inhaled toxicants in vivo using gas uptake measurements. Toxicol. Appl. Pharmacol. 54 (1980) 100-116
6. Andersen M.E., Gargas M.L., and Ramsey J.C. Inhalation pharmacokinetics: evaluating systemic extraction, total in vivo metabolism, and the time course of enzyme induction for inhaled styrene in rats based on arterial blood:inhalation air concentration ratios. Toxicol. Appl. Pharmacol. 73 (1984) 176-187
7. Archbold J.A., Hull R.N., and Diamond M. Potential importance of inhalation exposures for wildlife using screening-level ecological risk assessment. Human. Ecol. Risk. Assessment 13 (2007) 870-883
8. Armitage J.M., and Gobas F.A.P.C. A terrestrial food-chain bioaccumulation model for POPs. Environ. Sci. Technol. 41 (2007) 4019-4025
9. Arms A.D., and Travis C.C. Reference physiological parameters in pharmacokinetic modeling (1988), US Environmental Protection Agency, Washington, DC Report No. EPA/600/6-88/004
10. Ashley D.L., Bonin M.A., Frederick L.C., McGraw J.M., and Wooten J.V. Measurement of volatile organic compounds in human blood. Environ. Health. Perspect 104 (1996) 871-877
11. Barton H.A., Creech J.R., Godin C.S., Randall G.M., and Seckel C.S. Chloroethylene mixtures: pharmacokinetic modelling and in vitro metabolism of vinyl chloride, trichloroethylene, and trans-1,2-dichloroethylene in rat. Toxicol. Appl. Pharmacol. 130 (1994) 237-247
12. Batterman S., Zhang L., Wang S., and Franzblau A. Partition coefficients for the trihalomethanes among blood, urine, water, milk and air. Sci. Total. Environ. 284 (2002) 237-247
13. Béliveau M., Charest-Tardif G., and Krishnan K. Blood-air partition coefficients of individual and mixtures of trihalomethanes. Chemosphere 44 (2001) 377-381
14. Beyer A., Wania F., Gouin T., MacKay D., and Matthies M. Selecting internally consistent physico-chemical properties of organic compounds. Environ. Toxicol. Chem. 21 (2002) 941-953
15. Bolt H.M., Filser J.G., and Buchter A. Inhalation pharmacokinetics based on gas uptake studies. III. A pharmacokinetic assessment in man of "peak concentrations" of vinyl chloride. Arch. Toxicol. 48 (1981) 213-228
16. Bolt H.M., Filser J.G., and Störmer F. Inhalation pharmacokinetics based on gas uptake studies V. Comparative pharmacokinetics of ethylene and 1,3-butadiene in rats. Arch. Toxicol. 55 (1984) 213-218
17. Bradbury S.P., Feijtel T.C.J., and Van Leeuwen C.J. Meeting the scientific needs of ecological risk assessment in a regulatory context. Environ. Sci. Technol (2004) 463A-470A
18. Bridges J. Human health and environmental risk assessment: the need for a more harmonized and integrated approach. Chemosphere 52 (2003) 1347-1351
19. Cahill T.M., Cousins I., and Mackay D. Development and application of a generalized physiologically based pharmacokinetic model for multiple environmental contaminants. Environ. Toxicol. Chem. 22 (2003) 26-34
20. Chiu W.A., and White P. Steady-state solutions to PBPK models and their applications to risk assessment I: Route-to-route extrapolation of volatile chemicals. Risk Anal. 26 (2006) 769-780
21. Clewell H.J. The application of physiologically based pharmacokinetic modeling in human health risk assessment of hazardous substances. Toxicol. Lett. 79 (1995) 207-217
22. Czub G., and McLachlan M.S. Bioaccumulation potential of persistent organic chemicals in humans. Environ. Sci. Technol. 38 (2004) 2406-2412
23. Dallas C.E., Chen X.M., Muralidhara S., Varkonyi P., Tackett R.L., and Bruckner J.V. Use of tissue disposition data from rats and dogs to determine species differences in input parameters for a physiological model for perchloroethylene. Environ. Res. 67 (1994) 54-67
24. Davies B., and Morris T. Physiological parameters in laboratory animals and humans. Pharm. Res. 10 (1993) 1093-1095
25. DeBruyn A.M.H., and Gobas F.A.P.C. The sorptive capacity of animal protein. Environ. Toxicol. Chem. 26 (2007) 1803-1808
26. Dills R.L., Ackerlund W.S., Kalman D.A., and Morgan M.S. Blood-air partition coefficient determinations: automation and improvement of the equilibrium partitioning in closed systems method. J. Expo. Anal. Environ. Epidemiol. 4 (1993) 471-489
27. EPA. Reference Physiological Parameters in Pharmacokinetic Modeling (1988), Office of Health and Environmental Assessment, Washington DC, US EPA report no. EPA/600/6-88/004
28. Fang Z., Ionescu P., Chortkoff B.S., Kandell L., Sonner J., Laster M.J., and Eger E. Anesthetic potencies of n-alkanols: results of additivity and solubility studies suggest a mechanism of action similar to that for conventional inhaled anesthetics. Anesth. Analg. 84 (1997) 1042-1048
29. Filser J.G., and Bolt H.M. Pharmacokinetics of halogenated ethylenes in rats. Arch. Toxicol. 42 (1979) 123-136
30. Filser J.G., Peter H., Bolt H.M., and Fedtke N. Pharmacokinetics of neurotoxin n-hexane in rat and man. Arch. Toxicol. 60 (1987) 77-80
31. Filser J.G., Schwegler U., Csanády G.A., Greim H., Kreuzer P.E., and Kessler W. Species-specific pharmacokinetics of styrene in rat and mouse. Arch. Toxicol. 67 (1993) 517-530
32. Filser J.G., Schmidbauer R., Rampf F., Baur C.M., Putz C., and Csanady G.A. Toxicokinetics of inhaled propylene in mouse, rat and human. Toxicol. Appl. Pharmacol. 169 (2000) 40-51
33. Fiserova-Bergerova V., and Diaz M.L. Determination and prediction of tissue-gas partition coefficients. Int. Arch. Occup. Environ. Health. 58 (1986) 75-87
34. Fisher J.W., Gargas M.L., Allen B.C., and Andersen M.E. Physiologically based pharmacokinetic modelling with trichloroethylene and its metabolite, trichloroacetic acid, in the rat and mouse. Toxicol. Appl. Pharmacol. 109 (1991) 183-195
35. Fisher J.W., Lumpkin M., Boyd J., Mahle D., Bruckner J.V., and El-Masri H.A. PBPK modelling of the metabolic interactions of carbon tetrachloride and tetrachloroethylene in B6C3F1 mice. Environ. Toxicol. Pharmacol. 16 (2004) 93-105
36. Gargas M.L., Burgess R.J., Voisard D.E., Cason G.H., and Andersen M.E. Partition-coefficients of low-molecular weight volatile chemicals in various liquids and tissues. Toxicol. Appl. Pharmacol. 98 (1989) 87-99
37. Gearhart J.M., Mahle D.A., Greene R.J., Seckel C.S., Fleming C.D., Fisher J.W., and Clewell H.J. Variability of physiologically based pharmacokinetic (PBPK) model parameters and their effects on PBPK model predictions in a risk assessment for perchloroethylene (PCE). Toxicol. Lett. 68 (1993) 131-144
38. Gearhart J.M., Seckel C., and Vinegar A. In vivo metabolism of chloroform in B6C2F1 mice determined by the method of gas uptake: the effects of body temperature on tissue partition coefficients and metabolism. Toxicol. Appl. Pharmacol. 119 (1993) 258-266
39. Haddad S., Poulin P., and Krishnan K. Relative lipid content as the sole mechanistic determinant of the adipose tissue:blood partition coefficients of highly lipophilic organic chemicals. Chemosphere 40 (2000) 839-843
40. Hendriks A.J. The power of size: a meta-analysis reveals consistency of allometric regressions. Ecol. Model. 205 (2007) 196-208
41. Hendriks A.J., van der Linde A., Cornelissen G., and Sijm D.T.H.M. The power of size I. Rate constants and equilibrium ratios for accumulation of organic substances related to octanol-water partition ratio and species-weight. Environ. Toxicol. Chem. 20 (2001) 1399-1420
42. Hendriks A.J., Traas T.P., and Huijbregts M.A.J. Critical body residues linked to octanol-water partitioning, organism composition, and LC50 QSARs: meta-analysis and Model. Environ. Sci. Technol. 39 (2005) 3226-3236
43. Hendriks A.J., Smítková H., and Huijbregts M.A.J. A new twist on an old regression: transfer of chemicals to beef and milk in human and ecological risk assessment. Chemosphere 70 (2007) 46-56
44. Hughes G.M. Scaling of respiratory areas in relation to oxygen consumption of vertebrates. Experientia 40 (1984) 519-562
45. Jarnberg J., and Johanson G. Liquid/air partition coefficients of trimethylbenzenes. Toxicol. Ind. Health. 11 (1995) 81-88
46. Johanson G., and Filser J.G. Experimental data from closed chamber gas uptake studies in rodents suggest lower uptake of chemical than calculated from literature values on alveolar ventilation. Arch. Toxicol. 66 (1992) 291-295
47. Johanson G., and Filser J.G. A physiologically based pharmacokinetic model for butadiene and its metabolite butadiene monoxide in rat and mouse and its significance for risk extrapolation. Arch. Toxicol. 67 (1993) 151-163
48. Kaneko T., Wang P.-Y., and Sato A. Relationship between blood-air partition coefficients of lipophilic organic solvents and blood triglyceride levels. Toxicology 143 (2000) 203-208
49. Kelly B.C., and Gobas F.A.P.C. An Arctic terrestrial food-chain bioaccumulation model for persistent organic pollutants. Environ. Sci. Technol. 37 (2003) 2966-2974
50. Kelly B.C., Ikonomou M.G., Blair J.D., Morin A.E., and Gobas F.A.P.C. Food-web specific biomagnification of persistent organic pollutants. Science 317 (2007) 236-238
51. Kim Y.M., Harrad S., and Harrison R.M. Concentrations and sources of VOCs in urban domestic and public microenvironments. Environ. Sci. Technol. 35 (2001) 997-1004
52. Kleiber M. Body size and metabolism. Hilgardia 6 (1932) 315-353
53. Lam C.-W., Galen T.J., Boyd J.F., and Pierson D.L. Mechanism of transport and distribution of organic solvents in blood. Toxicol. Appl. Pharmacol. 104 (1990) 117-129
54. Lin J.H. Applications and limitations of interspecies scaling and in vitro extrapolation in pharmacokinetics. Drug. Metab. Dispos. 26 (1998) 1202-1212
55. Lin Y.-S., Smith T.J., Kelsey K.T., and Wypij D. Human physiological factors in respiratory uptake of 1,3-butadiene. Environ. Health. Perspect. 109 (2001) 921-926
56. Lin Y.-S., Smith T.J., Wypij D., Kelsey K.T., and Sacks F.M. Association of the blood/air partition coefficient of 1,3-butadiene with blood lipids and albumin. Environ. Health Perspect. 110 (2002) 165-168
57. Lindstedt S.L. Pulmonary transit time and diffusing capacity in mammals. Am. J. Physiol. 246 (1984) R384-R388
58. Lindstedt S.L., and Schaeffer P.J. Use of allometry in predicting anatomical and physiological parameters of mammals. Lab. Anim. 36 (2002) 1-19
59. Liu J., Laster M.J., Taheri S., Eger E.I., Chortkoff B., and Halsey M.J. Effect of n-alkane kinetics in rats on potency estimations and the Meyer-Overton hypothesis. Anesth. Analg. 79 (1994) 1049-1055
60. MacKay D., Shiu W.Y., Ma K.-C., and Lee S.C. Physical-Chemical Properties and Environmental Fate for Organic Chemicals. Second Edition. Vol. I. Hydrocarbons, Vol II. Halogenated hydrocarbons (2006), CRC press
61. Mania J.N. Structure, function and evolution of the gas exchangers: comparative perspectives. J. Anat. 201 (2002) 281-304
62. Mania J.N., and West J.B. Thin and strong! The bioengineering dilemma in the structural and functional design of the blood-gas barrier. Physiol. Rev. 85 (2005) 811-844
63. MacLeod M., Scheringer M., and Hungerbühler K. Estimating enthalpy of vaporization from vapor pressure using Trouton's rule. Environ. Sci. Technol. 41 (2007) 2827-2832
64. McKone T.E., Castorina R., Kuwabara Y., Harnly M.E., Eskenazi B., and Bradman A. Merging models and biomonitoring data to characterize sources and pathways of human exposure to organophosphorous pesticides in the Salinas Valley of California. Environ. Sci. Technol 41 (2007) 3233-3240
65. Nelson G.J. The phospholipids composition of plasma in various mammalian species. Lipids 2 (1967) 323-328
66. Nelson G.J. Lipid composition and metabolism of erythrocytes. In: Nelson G.J. (Ed). Blood Lipids and Lipoproteins: Quantification, Composition and Metabolism (1972), Wiley, New York 317-386
67. Nihlén A., Lof A., and Johanson G. Liquid-air partition coefficients of methyl and t-butyl ethers, t-amyl ether and t-butyl alcohol. J. Exp. Anal. Environ. Epidemiol. 5 (1995) 573-582
68. Pastino G.M., Yap W.Y., and Carroquino M. Human variability and susceptibility to trichloroethylene. Environ. Health Perspect. 108 (2000) 210-214
69. Peters R.H. The Ecological Implications of Body Size (1983), Cambridge University Press, New York, NY, USA
70. Pierce C.H., Dills R.L., Sivley G.W., and Kalman D.A. Partition coefficients between human blood or adipose tissue and air for aromatic solvents. Scand. J. Work. Environ. Health 22 (1996) 112-118
71. Ramsey J.C., and Andersen M.E. A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol. Appl. Pharmacol. 73 (1984) 159-175
72. Reitz R.Z., Gargas M.L., Mendrala A.L., and Schuman A.M. In vivo and in vitro studies of perchloroethylene metabolism for physiologically based pharmacokinetic modelling in rats, mice and humans. Toxicol. Appl. Pharmacol. 136 (1996) 289-306
73. Robinson, P.J. 2000. Pharmacokinetic Modelling of JP-8 fuel components I. Nonane and C9-C12 aliphatic components. United States Air Force Research Laboratory, Technical Report. AFRL-HE-WP-TR-2000-0046
74. Sato A., and Nakajima T. Partition coefficients of some aromatic hydrocarbons and ketones in water, blood and oil. Brit. J. Ind. Med. 36 (1979) 231-234
75. Sato A., Nakajima T., Fujiwara Y., and Hirosawa K. Pharmacokinetics of benzene and toluene. Int. Arch. Arbeitsmed. 33 (1974) 169-182
76. Sato A., Nakajima T., and Fujiwara Y. Determination of benzene and toluene in blood by means of a syringe-equilibration method using a small amount of blood. Brit. J. Ind. Med. 32 (1975) 210-214
77. Schaafsma G., Kroese E.D., Tielemans E.L.J.P., Van de Sandt J.J.M., and Van Leeuwen C.J. REACH, non-testing approaches and the urgent need for a change in mind set. Regul. Toxicol. Pharmacol. 53 (2009) 70-80
78. Schwarzenbach R.P., Gschwend P.M., and Imboden D.M. Environmental organic chemistry (1993), New York 1993. 681 p.
79. Sexton K., Adgate J.L., Mongin S.J., Pratt G.C., Ramachandran G., Stock T.H., and Morandi M.T. Evaluating differences between measured personal exposures to volatile organic compounds and concentrations in outdoor and indoor air. Environ. Sci. Technol. 38 (2004) 2593-2602
80. Sexton K., Adgate J.L., Ramachandran G., Pratt G.C., Mongin S.J., Stock T.H., and Morandi M.T. Comparison of personal, indoor and outdoor exposures to hazardous air pollutants in three urban communities. Environ. Sci. Technol. 38 (2004) 423-430
81. Smith A., Campbell J., Keys D., and Fisher J. Rat tissue and blood partition coefficients of n-alkanes (C8 to C12). Intern. J. Toxicol. 24 (2005) 35-41
82. Suter G. Bottom-up and top-down integration of human and ecological risk assessment. J. Toxicol. Environ. Health. Part A. 67 (2004) 779-790
83. Suter G.W., Vermeire T., Munns W.R., and Sekizawa J. An integrated framework for health and ecological risk assessment. Toxicol. Appl. Pharmacol. (2005) S611-S616
84. Tardif R., Charest-Tardif G., Brodeur J., and Krishnan K. Physiologically based pharmacokinetic modeling of a ternary mixture of alkylbenzenes in rats and humans. Toxicol. Appl. Pharmacol. 144 (1997) 120-134
85. Thrall K.D., Woodstock A.D., and Kania M.R. Development of a physiologically based pharmacokinetic model for chlorobenzene in F-344 rats. J. Toxicol. Environ. Health Part. A 67 (2004) 525-536
86. Vermeire T.G., MacPhail R., and Waters M. Integrated human and ecological risk assessment: a case study of organophosphorous pesticides in the environment. Hum. Ecol. Risk. Assess. 9 (2003) 343-357
87. Wallace L.A. Human exposure to volatile organic pollutants: implications for indoor air studies. Annual. Rev. Energy. Environ. 26 (2001) 269-301
88. Weibel E.R. Oxygen demand and the size of respiratory structures in mammals. In: Wood S.C., and Lenfant C. (Eds). Evolution of Respiratory Processes. A Comparative Approach (1979)
89. Weschler C.J., and Nazaroff W.W. Semi-volatile organic compounds in indoor environments. Atmos. Environ. 42 (2008) 9018-9040
90. West G.B., Brown J.H., and Enquist B.J. A general model for the origin of allometric scaling laws in biology. Science 276 (1997) 122-126
91. Wiester M.J., Winsett D.W., Richards J.H., Doerfler D.L., and Costa D.L. Partitioning of benzene in blood: influence of hemoglobin type in humans and animals. Environ. Health Perspect. 110 (2002) 161-255
92. Yoshida T., Andoh K., and Fukuhara M. Estimation of absorption of environmental contaminants in low-level exposure by pharmacokinetic analysis. J. Toxicol. Environ. Health Part A 54 (1998) 145-158