PBPK modeling of the metabolic interactions of carbon tetrachloride and tetrachloroethylene in B6C3F1 mice

Environmental Toxicology and Pharmacology

Volumn 16, Issue 1-2, 2004, Pages 93-105

  Fisher, J ^a   Lumpkin, M ^a   Boyd, J ^a   Mahle, D ^b   Bruckner, J V ^a   El Masri, H A ^c  

^a UNIVERSITY OF GEORGIA   (United States)

^b AIR FORCE RESEARCH LABORATORY   (United States)

^c AGENCY FOR TOXIC SUBSTANCES AND DISEASE REGISTRY   (United States)

Author keywords

Carbon tetrachloride; Metabolic inhibition; Metabolism; Mice; PBPK model; Tetrachloroethylene

Indexed keywords

CARBON TETRACHLORIDE; CYTOCHROME P450; TETRACHLOROETHYLENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; MALE; MICHAELIS CONSTANT; MODEL; MOUSE; NONHUMAN; PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL; PRIORITY JOURNAL; TOXICOKINETICS;

EID: 1542286118     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2003.10.006     Document Type: Article

References (37)

1. Abbas R., Fisher J.W. A physiologically based pharmacokinetic model for trichloroethylene and its metabolites, chloral hydrate, trichloroacetate, dichloroacetate, trichloroethanol, and trichloroethanol glucuronide in B6C3F1 mice. Toxicol. Appl. Pharmacol. 127:1998;15-30.
2. Ashley D.L., Bonin M.A., Cardinali F.L., McCraw J.M., Wooten J.W. Blood concentrations of volatile organic compounds in a nonoccupationally exposed US population and in groups with suspected exposure. Clin. Chem. 40:1994;1401-1404.
3. Barton H.A., Creech J.R., Godin C.S., Randall G.M., Seckel C.S. Chloroethylene mixtures: pharmacokinetic modeling and in vitro metabolism of vinyl chloride, trichloroethylene, and trans-1,2-dichloroethylene in rat. Toxicol. Appl. Pharmacol. 130:1995;237-247.
4. Brown R.P., Delp M.D., Lindstedt S.L., Rhomberg L.R., Belilas R.P. Physiological parameter values for physiologically based pharmacokinetic models. Toxicol. Ind. Health. 13:1997;407-484.
5. Comporti M. Three models of free radical-induced cell injury. Chem.-Biol. Interact. 72:1989;1-56.
6. Corongiu F., Lai M., Milia A. Carbon tetrachloride, bromotrichloromethane and ethanol acute intoxication. New chemical evidence for lipid peroxidation in rat tissue microsomes. Biochem. J. 212:1983;625-631.
7. Delp M.D., Manning R.O., Bruckner J.V., Armstrong R.B. Distribution of cardiac output during diurnal changes of activity in rats. Am. J. Physiol. 261:1991;H1487-H1493.
8. Delrat P., Dupin S., Galtier P., Alvinerie M., Voigt J.J., Tufenkji A.E., Saivin S., Houin G. Assessment of hepatic insufficiency model in rabbits using carbon tetrachloride intoxication. J. Pharmacol. Sci. 83:1994;1637-1642.
9. Diaz-Garcia J.M., Oliver-Botana J., Fos-Galve D. Pharmacokinetics of diazepam in the rat: influence of a carbon tetrachloride-induced hepatic injury. J. Pharmacol. Sci. 81:1992;768-772.
10. Dobrev I.D., Andersen M.E., Yang R.S.H. Assessing interaction thresholds for trichloroethylene in combination with tetrachloroethylene and 1,1,1-trichloroethane using gas uptake studies and PBPK modeling. Arch. Toxicol. 75:2001;134-144.
11. Dupin S., Delrat P., Le Quellec A., Voigt J.J., Houin G. Indocyanine green pharmacokinetics in rats with progressive carbon tetrachloride-induced hepatocellular insufficiency. Drug Res. 44:1994;367-370.
12. El-Masri H.A., Tessari J.D., Yang R.S.H. Exploration of an interaction threshold for the joint toxicity of trichloroethylene and 1,1-dichloroethylene: utilization of a PBPK model. Arch. Toxicol. 70:1996;527-539.
13. El-Masri H.A., Thomas R.S., Sabados G.R., Phillips J.K., Andersen M.E., Mehendale H.M., Yang R.S.H. Physiologically based pharmacokinetic/ pharmacodynamic modeling of the toxicologic interaction between kepone and carbon tetrachloride. Arch. Toxicol. 70:1996;704-713.
14. Fay R.M., Mumtaz M.M. Development of a priority list of chemical mixtures occurring at 1188 hazardous waste sites, using the HazDat database. Food Chem. Toxicol. 34:1996;1163-1165.
15. Fisher J.W., Gargas M.L., Allen B.C., Andersen M.E. Physiologically based pharmacokinetic modeling with trichloroethylene and its metabolite, trichloroacetic acid in the rat and mouse. Toxicol. Appl. Pharmacol. 109:1991;183-195.
16. Gargas M.L., Andersen M.E., Clewell H.J. A physiologically based simulation approach for determining metabolic constants from gas uptake data. Toxicol. Appl. Pharmacol. 86:1986;341-352.
17. Gargas, M.L., Andersen, M.E., 1988. Physiologically based approaches of examining the pharmacokinetics of inhaled vapors. In: Gardner, D.E., Crapo, J.D., Massaro, E.J. (Eds.), Toxicology of the Lung. Raven Press, New York.
18. Gargas M.L., Burgess R.J., Voisard D.E., Cason G.H., Andersen M.E. Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues. Toxicol. Appl. Pharmacol. 98:1989;87-99.
19. Gearhart J.M., Mahle D.A., Greene R.J., Seckel C.S., Flemming C.D., Fisher J.W., Clewell H.J. III Variability of physiologically based pharmacokinetic (PBPK) model parameters and their effects on PBPK model predictions in a risk assessment for perchloroethylene (PCE). Toxicol. Lett. 68:1993;131-144.
20. Hanioka N., Jinno H., Toyo'oka T., Nishimura T., Ando M. Induction of rat liver drug-metabolizing enzymes by tetrachloroethylene. Arch. Environ. Con. Tox. 282:1995;273-280.
21. Lilly P.D., Thorton-Manning J.R., Gargas M.L., Clewell H.J., Andersen M.E. Kinetic characterization of CYP2E1 inhibition in vivo and in vitro by the chloroethylenes. Arch. Toxicol. 72:1998;609-621.
22. Lowrey K., Glende E.A. Jr., Recknagel R.O. Rapid depression of rat liver microsomal calcium pump activity after administration of carbon tetrachloride or bromotrichloromethane and lack of effect after ethanol. Toxicol. Appl. Pharmacol. 59:1981;389-394.
23. Nikula K., Bensen J., Barr E., Springer D. Comparative interspecies metabolism of carbon tetrachloride, cytolethality, and regenerative cell proliferation. Toxicol. Sci. 42:1998;368.
24. Osawa Y., Davila J.C., Nakatsuka M., Meyer C.A., Darbyshire J.F. Inhibition of P450 cytochromes by reactive intermediates. Drug. Metab. Rev. 27:1995;61-72.
25. Ramsey J.C., Andersen M.E. A physiologically based description of the inhalation pharmacokinetics of styrene monomer in rats and humans. Toxicol. Appl. Pharmacol. 73:1984;159-175.
26. Rao K.S., Recknagel R.O. Early onset of lipoperoxidation in rat liver after carbon tetrachloride administration. Exper. Mol. Pathol. 9:1968;271-278.
27. Rao K.S., Recknagel R.O. Early incorporation of carbon-labeled carbon tetrachloride into rat liver particulate lipids and proteins. Exper. Mol. Pathol. 10:1969;219-228.
28. 4 hepatotoxicity: a novel dose-response. Toxicology. 118:1997;181-193.
29. Sanzgiri U.Y., Kim H.J., Muralidhara S., Dallas C.E., Bruckner J.V. Effect of route and pattern of exposure on the pharmacokinetics and acute hepatotoxicity of carbon tetrachloride hepatotoxicity. Toxicol. Appl. Pharmacol. 134:1995;148-154.
30. Sanzgiri U.Y., Srivatsan V., Muralidhara S., Dallas C.A., Bruckner J.V. Uptake, distribution, and elimination of carbon tetrachloride in rat tissues following inhalation and ingestion exposure. Toxicol. Appl. Pharmacol. 143:1997;120-129.
31. Staats D.A., Fisher J.W., Conolly R.B. Gastrointestinal absorption of xenobiotics in physiologically based pharmacokinetic models: a two-compartment description. Drug Metab. Dispos. 19:1991;144-148.
32. Thrall K.D., Vucelick M.E., Gies R.A., Zangar R.C., Weitz K.K., Poet T.S., Springer D.L., Grant D.M., Bensen J.M. Comparative metabolism of carbon tetrachloride in rats, mice and hamsters using gas uptake and PBPK modeling. J. Toxicol. Environ. Health. 60:2000;531-548.
33. Wang P.-Y., Kaneko T., Tsukada H., Nakano M., Nakajima T., Sato A. Time course of hepatic injuries induced by chloroform and by carbon tetrachloride: comparison of biochemical and histological changes. Arch. Toxicol. 71:1997;638-645.
34. White I.N.H., Razvi N., Gibbs A.H., Davies A.M., Manno M., Zaccaro C., Matteis F.D., Pahler A., Dekant W. Neoantigen formation and clastogenic action of HCFC-123 and perchloroethylene in human MCL-5 cells. Toxicol. Lett. 124:2001;129-138.
35. Wong F.W., Chan W.Y., Lee S.S. Resistance to carbon tetrachloride- induced hepatotoxicity in mice which lack CYP2E1 expression. Toxicol. Appl. Pharmacol. 153:1998;109-118.
36. Yoshioka T., Krauser J.A., Guengerich F.P. Tetrachloroethylene oxide: hydrolytic products and reactions with phosphate and lysine. Chem. Res. Toxicol. 15:2002;1096-1105.
37. Zangar R.C., Bensom J.M., Burnett V.L., Springer D.L. Cytochrome P450 2E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes. Chem.-Biol. Interact. 125:2000;233-243.