Human physiologic factors in respiratory uptake of 1,3-Butadiene

Environmental Health Perspectives

Volumn 109, Issue 9, 2001, Pages 921-926

  Lin, Yu Sheng ^a   Smith, Thomas J ^a   Kelsey, Karl T ^a   Wypij, David ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

1,3 butadiene; Alveolar ventilation; Blood:air partition coefficient; Human; Physiologic; Respiratory uptake; Sex

Indexed keywords

1,3 BUTADIENE; CARCINOGEN; PLASTIC; RUBBER;

ABSORPTION; ADULT; AGE; AIR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; BODY WEIGHT; CIGARETTE SMOKING; CLINICAL PROTOCOL; CLINICAL RESEARCH; CLINICAL STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE ASSOCIATION; EPIDEMIOLOGY; EXHALATION; EXPOSURE; FEMALE; HUMAN; HUMAN EXPERIMENT; INDUSTRY; INHALATION; KINETICS; LUNG GAS EXCHANGE; LUNG VENTILATION; MALE; MODEL; NONHUMAN; NORMAL HUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PURIFICATION; REGRESSION ANALYSIS; RESPIRATORY SYSTEM; SEX DIFFERENCE; SIMULATION; UNITED STATES; VOLUNTEER;

ANIMALIA;

EID: 0034775251     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.01109921     Document Type: Article

References (49)

1. In-use barrier integrity of gloves: Latex and nitrile superior to vinyl
2. Occupational exposure of workers to 1,3-butadiene
3. 1,3-Butadiene: Toxicity and carcinogenicity in laboratory animals and in humans
4. Toxicology and epidemiology of 1,3-butadiene
5. Cancer mortality among workers at a butadiene production facility
6. Carcinogenicity of 1,3-butadiene
7. Exposure to butadiene and lymphatic and hematopoietic cancer
8. Mortality study of workers in 1,3-butadiene production units identified from a chemical workers cohort
9. Molecular epidemiology: Principles and practices
10. Assessment of human exposure to gaseous pollutants
11. PBPK model for butadiene metabolism to epoxides: Quantitative species differences in metabolism
12. A physiologically based simulation approach for determining metabolic constants from gas uptake data
13. Toxicokinetics of inhaled 1,3-butadiene in monkeys: Comparison to toxicokinetics in rats and mice
14. A physiological toxicokinetic model for 1,3-butadiene in rodents and man: Blood concentrations of 1,3-butadiene, its metabolically formed epoxides, and of haemoglobin adducts-relevance of glutathione depletion
15. Species differences in the metabolism and disposition of inhaled 1,3-butadiene and isoprene
16. Epidemiological and mechanistic data suggest that 1,3-butadiene will not be carcinogenic to humans at exposures likely to be encountered in the environment or workplace
17. Physiologically based pharmacokinetic modeling of 1,3-butadiene, 1,2-epoxy-3-butene, and 1,2:3,4-diepoxybutane toxicokinetics in mice and rats
18. Optimal design for a study of butadiene toxicokinetics in humans
19. Bayesian compartmental model for evaluation of 1,3-butadiene biomarkers
20. Increase in anesthetic uptake, excretion, and blood solubility in man after eating
21. Respiratory uptake and elimination of ethylene glycol monoethyl ether after experimental human exposure
22. Species differences in the production and clearance of 1,3-butadiene metabolites: A mechanistic model indicates predominantly physiological, not biochemical, control
23. Revised standards for normal resting dead-space volume and venous admixture in men and women
24. Introduction to mathematical model
25. Respiratory input in inhalation experiments
26. Percutaneous absorption of 2-butoxyethanol vapour in human subjects
27. Controlled ethyl tert-butyl ether (ETBE) exposure of male volunteers. I. Toxicokinetics
28. Effects of biosolubility on pulmonary uptake and disposition of gases and vapors of lipophilic chemicals
29. The relevance of fat content in toxicity of lipophilic chemicals to terrestrial animals with special reference to dieldrin and 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD)
30. Sex and age specific prediction formulas for estimating body composition from bioelectrical impedance: A cross-validation study
31. A simulation study of physiological factors affecting pharmacokinetic behaviour of organic solvent vapours
32. Issues relating to normalization of body fat content in men and women
33. Cigarette smoke-sensitive asthma: Challenge studies
34. Acute effect of passive smoking on lung function and airway responsiveness in asthmatic children
35. Anethesia at a constant alveolar ventilation
36. Simulation of inhalational anaesthetic uptake using a lung model with charcoal
37. Absorption, distribution, and excretion of toxicants
38. Solubility of I-653, sevoflurane, isoflurane, and halothane in human tissues
39. A physiological model for simulation of benzene metabolism by rats and mice
40. The expanding role of quantitative structure-activity relationships (QSAR) in toxicology