PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major

Current Genetics

Volumn 55, Issue 3, 2009, Pages 287-299

  Nare, Bakela ^b,c   Garraway, Levi A ^b,d   Vickers, Tim J ^a   Beverley, Stephen M ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c SCYNEXIS Inc   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Folates; Forward genetics; Hydrogen peroxide; Nitric oxide; Pteridines; Trypanothione

Indexed keywords

BIOPTERIN; DIHYDROFOLATE REDUCTASE; FOLIC ACID; FOLIC ACID ANTAGONIST; HYDROGEN PEROXIDE; NITRIC OXIDE; OXIDIZING AGENT; OXIDOREDUCTASE; PTERIDINE REDUCTASE 1; TETRAHYDROBIOPTERIN; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

CELL MUTANT; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME SYNTHESIS; GENE LOCUS; GENE OVEREXPRESSION; GENETIC SCREENING; LEISHMANIA MAJOR; NONHUMAN; OXIDATIVE STRESS; PARASITE SURVIVAL; PARASITE VIRULENCE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REVIEW; SCAVENGING SYSTEM; TRYPANOSOMA;

ANIMALS; BIOPTERIN; DRUG RESISTANCE; FOLIC ACID; HYDROGEN PEROXIDE; LEISHMANIA MAJOR; METHYLNITRONITROSOGUANIDINE; MOLSIDOMINE; MULTIENZYME COMPLEXES; MUTATION; NITRIC OXIDE DONORS; NITROSO COMPOUNDS; OXIDANTS; OXIDOREDUCTASES; PROTOZOAN PROTEINS; PTERIDINES; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE;

EUKARYOTA; LEISHMANIA MAJOR; PROTOZOA; TRYPANOSOMATIDAE;

EID: 67349132416     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00294-009-0244-z     Document Type: Review

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