Hydrogen peroxide scavenging is not a virulence determinant in the pathogenesis of Haemophilus influenzae type b strain Eagan

BMC Microbiology

Volumn 6, Issue , 2006, Pages

  Vergauwen, Bjorn ^a   Herbert, Mark ^b   Van Beeumen, Jozef J ^a  

^a GHENT UNIVERSITY   (Belgium)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CATALASE; GLUTAREDOXIN; GLUTATHIONE; HYDROGEN PEROXIDE; OXIDOREDUCTASE; PEROXIDASE; PEROXIREDOXIN; SCAVENGER; HKTE PROTEIN, HAEMOPHILUS INFLUENZAE; PGDX PROTEIN, HAEMOPHILUS INFLUENZAE;

ANIMAL CELL; ARTICLE; BACTEREMIA; BACTERIAL GROWTH; BACTERIAL INFECTION; BACTERIAL STRAIN; CATALASE DEFICIENCY; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME SUBSTRATE; GENE SEQUENCE; HAEMOPHILUS INFLUENZAE TYPE B; HUMAN; KINETICS; MENINGITIS; NONHUMAN; PATHOGENESIS; PEROXIDATION; PHENOTYPE; RAT; VIRULENCE; VITAMIN SUPPLEMENTATION; ENZYMOLOGY; GENE DELETION; GENETICS; METABOLISM; MUTATION; OXIDATIVE STRESS; PATHOGENICITY;

ANIMALIA; BACTERIA (MICROORGANISMS); HAEMOPHILUS INFLUENZAE RD KW20; HAEMOPHILUS INFLUENZAE SEROTYPE B; PROKARYOTA;

CATALASE; FREE RADICAL SCAVENGERS; GENE DELETION; HAEMOPHILUS INFLUENZAE TYPE B; HYDROGEN PEROXIDE; MUTATION; OXIDATIVE STRESS; PEROXIDASES; VIRULENCE;

EID: 32344438072     PISSN: 14712180     EISSN: 14712180     Source Type: Journal    
DOI: 10.1186/1471-2180-6-3     Document Type: Article

References (42)

1. Aubrey R, Tang C: The pathogenesis of disease due to type b Haemophilus influenzae. Methods Mol Med 2003, 71:29-50.
2. Foxwell AR, Kyd JM, Cripps AW: Nontypeable Haemophilus influenzae: pathogenesis and prevention. Microbiol Mol Biol Rev 1998, 62:294-308.
3. Martin-Du Pan RC, Benoit R, Girardier L: The role of body position and gravity in the symptoms and treatment of various medical diseases. Swiss Med Wkly 2004, 134:543-551.
4. D'Mello RA, Langford PR, Kroll JS: Role of bacterial Mn-cofactored superoxide dismutase in oxidative stress responses, nasopharyngeal colonization, and sustained bacteremia caused by Haemophilus influenzae type b. Infect Immun 1997, 65:2700-2706.
5. Wang G, Maier RJ: An NADPH quinone reductase of Helicobacter pylori plays an important role in oxidative stress resistance and host colonization. Infect Immun 2004, 72:1391-1396.
6. Buchmeier N, Bossie S, Chen CY, Fang FC, Guiney DG, Libby SJ: SlyA, a transcriptional regulator of Salmonella typhimurium, is required for resistance to oxidative stress and is expressed in the intracellular environment of macrophages. Infect Immun 1997, 65:3725-3730.
7. Buchmeier NA, Lipps CJ, So MY, Heffron F: Recombination-deficient mutants of Salmonella typhimurium are avirulent and sensitive to the oxidative burst of macrophages. Mol Microbiol 1993, 7:933-936.
8. Seaver LC, Imlay JA: Are respiratory enzymes the primary sources of intracellular hydrogen peroxide? J Biol Chem 2004, 279:48742-48750.
9. Pericone CD, Overweg K, Hermans PW, Weiser JN: Inhibitory and bactericidal effects of hydrogen peroxide production by Streptococcus pneumoniae on other inhabitants of the upper respiratory tract. Infect Immun 2000, 68:3990-3997.
10. Carlioz A, Touati D: Isolation of superoxide dismutase mutants in Escherichia coli: is superoxide dismutase necessary for aerobic life? Embo J 1986, 5:623-630.
11. Seaver LC, Imlay JA: Alkyl hydroperoxide reductase is the primary scavenger of endogenous hydrogen peroxide in Escherichia coli. J Bacteriol 2001, 183:7173-7181.
12. Storz G, Jacobson FS, Tartaglia LA, Morgan RW, Silveira LA, Ames BN: An alkyl hydroperoxide reductase induced by oxidative stress in Salmonella typhimurium and Escherichia coli: genetic characterization and cloning of ahp. J Bacteriol 1989, 171:2049-2055.
13. Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, McKenney K, Sutton G, Fitzhugh W, Fields C, Gocayne JD, Scott J, Shirley R, Liu LI, Glodek A, Kelley JM, Weidman JF, Phillips CA, Spriggs T, Hedblom E, Cotton MD, Utterback TR, Hanna MC, Nguyen DT, Saudek DM, Brandon RC, Fine LD, Fritchman JL, Fuhrmann JL, Geoghagen NSM, Gnehm CL, McDonald LA, Small KV, Fraser CM, Smith HO, Venter JC: Whole-Genome Random Sequencing and Assembly of Haemophilus-Influenzae Rd. Science 1995, 269:496-512.
14. Bishai WR, Howard NS, Winkelstein JA, Smith HO: Characterization and virulence analysis of catalase mutants of Haemophilus influenzae. Infect Immun 1994, 62:4855-4860.
15. Pauwels F, Vergauwen B, Vanrobaeys F, Devreese B, Van Beeumen JJ: Purification and characterization of a chimeric enzyme from Haemophilus influenzae Rd that exhibits glutathione-dependent peroxidase activity. J Biol Chem 2003, 278:16658-16666.
16. Vergauwen B, Pauwels F, Vaneechoutte M, Van Beeumen JJ: Exogenous glutathione completes the defense against oxidative stress in Haemophilus influenzae. J Bacteriol 2003, 185:1572-1581.
17. Murphy TF, Kirkham C, Sethi S, Lesse AJ: Expression of a peroxiredoxin-glutaredoxin by Haemophilus influenzae in biofilms and during human respiratory tract infection. FEMS Immunol Med Microbiol 2005, 44:81-89.
18. Pauwels F, Vergauwen B, Van Beeumen JJ: Physiological characterization of Haemophilus influenzae Rd deficient in its glutathione-dependent peroxidase PGdx. J Biol Chem 2004, 279:12163-12170.
19. Vergauwen B, Pauwels F, Van Beeumen JJ: Glutathione and catalase provide overlapping defenses for protection against respiration-generated hydrogen peroxide in Haemophilus influenzae. J Bacteriol 2003, 185:5555-5562.
20. Varma SD, Morris SM: Peroxide damage to the eye lens in vitro prevention by pyruvate. Free Radic Res Commun 1988, 4:283-290.
21. Boehm DE, Vincent K, Brown OR: Oxygen and toxicity inhibition of amino acid biosynthesis. Nature 1976, 262:418-420.
22. Repine JE, Fox RB, Berger EM: Hydrogen peroxide kills Staphylococcus aureus by reacting with staphylococcal iron to form hydroxyl radical. J Biol Chem 1981, 256:7094-7096.
23. McCord JM, Fridovich I: The biology and pathology of oxygen radicals. Ann Intern Med 1978, 89:122-127.
24. Herbert M, Kraiss A, Hilpert AK, Schlor S, Reidl J: Aerobic growth deficient Haemophilus influenzae mutants are non-virulent: implications on metabolism. Int J Med Microbiol 2003, 293:145-152.
25. Buchmeier NA, Libby SJ, Xu Y, Loewen PC, Switala J, Guiney DG, Fang FC: DNA repair is more important than catalase for Salmonella virulence in mice. J Clin Invest 1995, 95:1047-1053.
26. Taylor PD, Inchley CJ, Gallagher MP: The Salmonella typhimurium AhpC polypeptide is not essential for virulence in BALB/c mice but is recognized as an antigen during infection. Infect Immun 1998, 66:3208-3217.
27. Christman MF, Morgan RW, Jacobson FS, Ames BN: Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium. Cell 1985, 41:753-762.
28. Niimura Y, Poole LB, Massey V: Amphibacillus xylanus NADH oxidase and Salmonella typhimurium alkyl-hydroperoxide reductase flavoprotein components show extremely high scavenging activity for both alkyl hydroperoxide and hydrogen peroxide in the presence of S. typhimurium alkylhydroperoxide reductase 22-kDa protein component. J Biol Chem 1995, 270:25645-25650.
29. Yoon SH, Han MJ, Lee SY, Jeong KJ, Yoo JS: Combined transcriptome and proteome analysis of Escherichia coli during high cell density culture. Biotechnol Bioeng 2003, 81:753-767.
30. Johnson NA, Liu Y, Fletcher HM: Alkyl hydroperoxide peroxidase subunit C (ahpC) protects against organic peroxides but does not affect the virulence of Porphyromonas gingivalis W83. Oral Microbiol Immunol 2004, 19:233-239.
31. O'Toole PW, Logan SM, Kostrzynska M, Wadstrom T, Trust TJ: Isolation and biochemical and molecular analyses of a speciesspecific protein antigen from the gastric pathogen Helicobacter pylori. J Bacteriol 1991, 173:505-513.
32. Blander SJ, Szeto L, Shuman HA, Horwitz MA: An immunoprotective molecule, the major secretory protein of Legionella pneumophila, is not a virulence factor in a guinea pig model of Legionnaires' disease. J Clin Invest 1990, 86:817-824.
33. Hwang YS, Chae HZ, Kim K: Characterization of Haemophilus influenzae Peroxiredoxins. J Biochem Mol Biol 2000, 33:514-518.
34. Coves J, Eschenbrenner M, Fontecave M: NAD(P)H oxidation by hydrogen peroxide in Escherichia coli. Biochem Biophys Res Commun 1991, 178:54-59.
35. Chang CL, Marra G, Chauhan DP, Ha HT, Chang DK, Ricciardiello L, Randolph A, Carethers JM, Boland CR: Oxidative stress inactivates the human DNA mismatch repair system. Am J Physiol Cell Physiol 2002, 283:C148-54.
36. Gonzalez-Flecha B, Demple B: Homeostatic regulation of intracellular hydrogen peroxide concentration in aerobically growing Escherichia coli. J Bacteriol 1997, 179:382-388.
37. Seaver LC, Imlay JA: Hydrogen peroxide fluxes and compartmentalization inside growing Escherichia coli. J Bacteriol 2001, 183:7182-7189.
38. Birnboim HC, Doly J: A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res 1979, 7:1513-1523.
39. Herriott RM, Meyer EY, Vogt M, Modan M: Defined medium for growth of Haemophilus influenzae. J Bacteriol 1970, 101:513-516.
40. Herriott RM, Meyer EM, Vogt M: Defined nongrowth media for stage II development of competence in Haemophilus influenzae. J Bacteriol 1970, 101:517-524.
41. Greenwald RA: Therapeutic benefits of oxygen radical scavenger treatments remain unproven. J Free Radic Biol Med 1985, 1:173-177.
42. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254.