S-adenosylmethionine regulates thiopurine methyltransferase activity and decreases 6-mercaptopurine cytotoxicity in MOLT lymphoblasts

Biochemical Pharmacology

Volumn 77, Issue 12, 2009, Pages 1845-1853

  Milek, Miha ^a   Kuzelicki, Natasa Karas ^a   Smid, Alenka ^a   Mlinaric Rascan, Irena ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

6 Mercaptopurine; Cytotoxicity; Lymphoblasts; S adenosylmethionine; Thiopurine methyltransferase

Indexed keywords

ADENOSINE TRIPHOSPHATE; MERCAPTOPURINE; MESSENGER RNA; METHYLTHIOINOSINE MONOPHOSPHATE; PHOSPHATE; PURINE; S ADENOSYLMETHIONINE; THIOGUANOSINE; THIOPURINE METHYLTRANSFERASE; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHOBLAST; PRIORITY JOURNAL;

6-MERCAPTOPURINE; CELL LINE, TUMOR; DRUG ANTAGONISM; HUMANS; LYMPHOCYTES; METHYLTRANSFERASES; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RNA, MESSENGER; S-ADENOSYLMETHIONINE;

EID: 67349108946     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.03.006     Document Type: Article

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