Structural basis of allele variation of human thiopurine-S- methyltransferase

Proteins: Structure, Function and Genetics

Volumn 67, Issue 1, 2007, Pages 198-208

  Wu, Hong ^a   Horton, John R ^b   Battaile, Kevin ^c   Allali Hassani, Abdellah ^a   Martin, Fernando ^a   Zeng, Hong ^a   Loppnau, Peter ^a   Vedadi, Masoud ^a   Bochkarev, Alexey ^a,d,e   Plotnikov, Alexander N ^a,d   Cheng, Xiaodong ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ARGONNE NATIONAL LABORATORY   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Crystallography; Pharmacogenetics; Polymorphisms; S methylation; Structural genomics; Thiopurine drugs

Indexed keywords

AZATHIOPRINE; MERCAPTOPURINE; THIOPURINE METHYLTRANSFERASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; AUTOIMMUNE DISEASE; CRYSTAL STRUCTURE; ENTERITIS; ENZYME STRUCTURE; GRAFT REJECTION; HUMAN; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN STRUCTURE; STRUCTURAL GENOMICS; STRUCTURE ACTIVITY RELATION; THERMOSTABILITY; X RAY CRYSTALLOGRAPHY;

ALLELES; AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DNA MUTATIONAL ANALYSIS; HUMANS; METHYLTRANSFERASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POINT MUTATION; POLYMORPHISM, GENETIC; S-ADENOSYLHOMOCYSTEINE;

EID: 33847360477     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21272     Document Type: Article

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