EMD273316 & EMD95833, type 4 phosphodiesterase inhibitors, stimulate fibroblastic-colony formation by bone marrow cells via direct inhibition of PDE4 and the induction of endogenous prostaglandin synthesis

BMC Pharmacology

Volumn 4, Issue , 2004, Pages

  Scutt, Andrew ^a   Beier, Norbert ^b   Fittschen, Claus ^b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b MERCK KGAA   (Germany)

Author keywords

Bone; CFU f; Osteoblast; Phosphodiesterase inhibitor; Prostaglandin E2

Indexed keywords

ALKALINE PHOSPHATASE; CALCIUM; CYCLIC AMP; EMD 219906; EMD 249615; EMD 273316; EMD 95833; ENZYME INHIBITOR; INDOMETACIN; ISOBUTYLMETHYLXANTHINE; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; PROSTAGLANDIN; PROSTAGLANDIN E2; PROSTANOID; ROLIPRAM; UNCLASSIFIED DRUG; PHOSPHODIESTERASE INHIBITOR;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL PROLIFERATION; CELL STIMULATION; COLONY FORMING CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; ENZYME INHIBITION; FIBROBLAST; IC 50; INCUBATION TIME; MALE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PHENOTYPE; PROSTAGLANDIN SYNTHESIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; STATISTICAL ANALYSIS; STEM CELL; ANIMAL; BONE DEVELOPMENT; DRUG EFFECT; METABOLISM; PHYSIOLOGY; WISTAR RAT;

ANIMALS; BONE MARROW CELLS; CALCIUM; DINOPROSTONE; FIBROBLASTS; MALE; OSTEOGENESIS; PHOSPHODIESTERASE INHIBITORS; PROSTAGLANDINS; RATS; RATS, WISTAR;

EID: 12944250749     PISSN: 14712210     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2210-4-10     Document Type: Article

References (26)

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