The hepatic vagal reception of intraportal GLP-1 is via receptor different from the pancreatic GLP-1 receptor

Journal of the Autonomic Nervous System

Volumn 80, Issue 1-2, 2000, Pages 14-21

  Nishizawa, Makoto ^a   Nakabayashi, Hajime ^b   Kawai, Koichi ^c   Ito, Tomohiko ^a   Kawakami, Satoshi ^a   Nakagawa, Atsushi ^a   Niijima, Akira ^d   Uchida, Kenzo ^a  

^a KANAZAWA MEDICAL UNIVERSITY   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d NIIGATA UNIVERSITY   (Japan)

Author keywords

Afferent vagal nerve; Exendin (9 39)amide; Exendin 4; GLP 1 receptor; Rat

Indexed keywords

EXENDIN 4; EXENDIN[9-39] AMIDE; GLUCAGON LIKE PEPTIDE 1 [7-36] AMIDE; HORMONE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MECHANISM; LIVER; MALE; NERVE CONDUCTION; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; RAT; SENSORY NERVE; VAGUS NERVE;

ANIMALS; ELECTROPHYSIOLOGY; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCAGON-LIKE PEPTIDES; INJECTIONS, INTRAVENOUS; LIVER; MALE; NEURONS, AFFERENT; PANCREAS; PEPTIDE FRAGMENTS; PEPTIDES; PORTAL VEIN; RATS; RATS, WISTAR; RECEPTORS, GLUCAGON; VAGUS NERVE; VENOMS;

EID: 0034639946     PISSN: 01651838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1838(99)00086-7     Document Type: Article

References (46)

1. Benito E., Blazquez E., Bosch M.A. Glucagon-like peptide-1-(7-36)amide increases pulmonary surfactant secretion through a cyclic adenosine 3′, 5′-monophosphate-dependent protein kinase mechanism in rat type II pneumocytes. Endocrinology. 139:1998;2363-2368.
2. Berthoud H.R., Kressel M., Neuhuber W.L. An anterograde tracing study of the vagal innervation of rat liver, portal vein and biliary system. Anat. Embryol. 186:1992;431-442.
3. Bullock B.P., Heller R.S., Habener J.F. Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology. 137:1996;2968-2978.
4. Campos R.V., Lee Y.C., Drucker D.J. Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse. Endocrinology. 134:1994;2156-2164.
5. Delgado E., Luque M.A., Alcántara A., Trapote M.A., Clemente F., Galera C., Valverde I., Villanueva-Peñacarrillo M.L. Glucagon-like peptide-1 binding to rat skeletal muscle. Peptides. 16:1995;225-229.
6. Drucker D.J. Glucagon-like peptides. Diabetes. 47:1998;159-169.
7. Edwards C.M.B., Todd J.F., Mahmoudi M., Wang Z., Wang R.M., Ghatei M.A. Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans. Studies with the antagonist exendin 9-39. Diabetes. 48:1999;86-93.
8. Eng J., Kleinman W.A., Singh L., Singh G., Raufman J.-P. Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas. J. Biol. Chem. 267:1992;7402-7405.
9. Fehmann H.-C., Göke R., Göke B. Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide. Endocr. Rev. 16:1995;390-410.
10. Fung L.C., Chisholm C., Greenberg G.R. Glucagon-like peptide-1-(7-36)amide and peptide YY mediate intraduodenal fat-induced inhibition of acid secretion in dogs. Endocrinology. 139:1998;189-194.
11. Galera C., Clemente F., Alcántara A., Trapote M.A., Perea A., Lopez-Delgado M.I., Villanueva-Peñacarrillo M.L., Valverde I. Inositolphosphoglycans and diacyglycerol are possible mediators in the glycogenic effect of GLP-1(7-36)amide in BC3H-1 myocytes. Cell Biochem. Funct. 14:1996;43-48.
12. Giralt M., Vergara P. Sympathetic pathways mediate GLP-1 actions in the gastrointestinal tract of the rat. Regul. Pept. 24:1998;19-25.
13. Greig N.H., Holloway H.W., De Ore K.A., Jani D., Wang Y., Zhou J., Garant M.J., Egan J.M. Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations. Diabetologia. 42:1999;45-50.
14. Göke R., Fehmann H.-C., Linn T., Schmidt H., Krause M., Eng J., Göke B. Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin- secreting β-cells. J. Biol. Chem. 268:1993;19650-19655.
15. Holst J.J., Ørskov C., Nielsen O.V., Schwartz T.W. Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut. FEBS Lett. 211:1987;169-174.
16. Imeryüz N., Yegen B.C., Bozkurt A., Coskun T., Villanueva-Penacarrillo M.L., Ulusoy N.B. Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms. Am. J. Physiol. 273:1997;G920-G927. Gastrointest. Liver Physiol. 36.
17. Kawai K., Suzuki S., Ohashi S., Mukai H., Ohmori H., Murayama Y., Yamashita K. Comparison of the effects of glucagon-like peptide-1-(1-37) and -(7-37) and glucagon on islet hormone release from isolated perfused canine and rat pancreases. Endocrinology. 124:1989;1768-1773.
18. Kolligs F., Fehmann H.-C., Göke R., Göke B. Reduction of the incretin effect in rats by the glucagon-like peptide 1 receptor antagonist exendin (9-39)amide. Diabetes. 44:1995;16-19.
19. Kreymann B., Williams G., Ghatei M.A., Bloom S.R. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet. 2:1987;1300-1304.
20. Lee H.B., Blaufox M.D. Blood volume in the rat. J. Nucl. Med. 26:1985;72-76.
21. Mansbach C.M. II, Dowell R.F., Pritchett D. Portal transport of absorbed lipids in rats. Am. J. Physiol. 261:1991;G530-G538. Gastrointest. Liver Physiol. 14.
22. Mojsov S., Weir G.C., Habener J.F. Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J. Clin. Invest. 79:1987;616-619.
23. Montrose-Rafizadeh C., Yang H., Wang Y., Roth J., Montrose M.H., Adams L.G. Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes. J. Cell. Physiol. 172:1997;275-283.
24. Nakabayashi H. Neural monitoring system for circulating somatostatin in the hepatoportal area. Nutrition. 13:1997;225-229.
25. Nakabayashi H., Kobayashi K., Nakabayashi I.O., Kurata Y. Somatostatin receptor on the afferent nerve terminals in the rat hepatoportal area. Neurosci. Lett. 183:1995;46-49.
26. Nakabayashi H., Niijima A., Kurata Y., Usukura N., Takeda R. Somatostatin-sensitive neural system in the liver. Neurosci. Lett. 67:1986;78-81.
27. Nakabayashi H., Niijima A., Nishizawa M., Nakabayashi I.O., Takeda R. A unique receptor-mediated mechanism in vagal chemoreception of somatostatin in the hepatoportal area. J. Auton. Nerv. Syst. 50:1994;45-50.
28. Nakabayashi H., Nishizawa M., Nakagawa A., Takeda R., Niijima A. Vagal hepatopancreatic reflex effect evoked by intraportal appearance of tGLP-1. Am. J. Physiol. 271:1996;E808-E813. Endocrinol. Metab. 34.
29. Nakabayashi I.O., Nakabayashi H. Monoclonal antibodies to somatostatin receptor of rat brain. Hybridoma. 11:1992;789-794.
30. Navarro M., Rodriquez de Fronseca F., Alvarez E., Chowen J.A., Zueco J.A., Gomez R., Eng J., Blazquez E. Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake. J. Neurochem. 67:1996;1982-1991.
31. Niijima A. Afferent impulse discharges from glucoreceptors in the liver of the guinea pig. Ann. N. Y. Acad. Sci. 157:1969;690-700.
32. Nishizawa M., Nakabayashi H., Uchida K., Nakagawa A., Niijima A. The hepatic vagal nerve is receptive to incretin hormone glucagon-like peptide-1, but not to glucose-dependent insulinotropic polypeptide, in the portal vein. J. Auton. Nerv. Syst. 61:1996;149-154.
33. Orskov C. Glucagon-like peptide-1, a new hormone of the entero-insular axis. Diabetologia. 35:1992;701-711.
34. Raufman J.-P., Singh L., Singh G., Eng J. Truncated glucagon-like peptide-1 interacts with exendin receptors on dispersed acini from guinea pig pancreas: Identification of a mammalian analogue of the reptilian peptide exendin-4. J. Biol. Chem. 267:1992;21432-21437.
35. 2. Eur. J. Pharmacol. 269:1994;183-191.
36. Tang-Christensen M., Larsen P.J., Göke R., Fink-Jensen A., Jessop D.S., Møller M., Sheikh S.P. Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats. Am. J. Physiol. 271:1996;R848-R856.
37. Thorens B. Expression cloning of the pancreatic β cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proc. Natl. Acad. Sci. U.S.A. 89:1992;8641-8645.
38. Thorens B., Porret A., Buhler L., Deng S.P., Morel P., Widmann C. Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes. 42:1993;1678-1682.
39. Valverde I., Morales M., Clemente F., López-Delgado M.I., Delgado E., Perea A., Villanueva-Peñacarrillo M.L. Glucagon-like peptide 1: a potent glycogenic hormone. FEBS Lett. 349:1994;313-316.
40. Villanueva-Peñacarrillo M.L., Alcántara A.I., Clemente F., Delgado E., Valverde I. Potent glycogenic effect of GLP-1(7-36)amide in rat skeletal muscle. Diabetologia. 37:1994;1163-1166.
41. Wang Z., Wang R.M., Owji A.A., Smith D.M., Ghatei M.A., Bloom S.R. Glucagon-like peptide-1 is a physiological incretin in rat. J. Clin. Invest. 95:1995;417-421.
42. Wettergren A., Petersen H., Ørskov C., Christiansen J., Sheikh S.P., Holst J.J. Glucagon-like peptide-1 7-36 amide and peptide YY from the L-cell of the ileal mucosa are potent inhibitors of vagally induced gastric acid secretion in man. Scand. J. Gastroenterol. 29:1994;501-505.
43. Wettergren A., Wøjdemann M., Holst J.J. Glucagon-like peptide-1 inhibits gastropancreatic function by inhibiting central parasympathetic outflow. Am. J. Physiol. 275:1998;G984-G992. Gastrointest. Liver Physiol. 38.
44. Wettergren A., Wøjdemann M., Meisner S., Stadil F., Holst J.J. The inhibitory effect of glucagon-like peptide-1 (GLP-1) 7-36 amide on gastric acid secretion in humans depends on an intact vagal innervation. Gut. 40:1997;597-601.
45. Wheeler M.B., Lu M., Dillon J.S., Leng X.-H., Chen C., Boyd III A.E. Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C. Endocrinology. 133:1993;57-62.
46. Yang H., Egan J.M., Wang Y., Moyes C.D., Roth J., Montrose M.H., Montrose-Rafizadeh C. GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor. Am. J. Physiol. 275:1998;C675-C683. Cell Physiol. 44.