-
1
-
-
85031366728
-
-
National Cancer Institute. National Cancer Institute, Bethesda, MD. Available at:
-
National Cancer Institute. Ovarian Cancer (Invasive) Survival Rates, By Race, Diagnosis year, Stage and Age. SEER Cancer Statistics Review 1975-2005. National Cancer Institute, Bethesda, MD. Available at: http://seer.cancer.gov/ csr/1975-2005/.
-
Ovarian Cancer (Invasive) Survival Rates, by Race, Diagnosis Year, Stage and Age. SEER Cancer Statistics Review 1975-2005
-
-
-
2
-
-
18844432114
-
Treatment goals in ovarian cancer
-
DOI 10.1111/j.1525-1438.2005.15351.x
-
Ozols RF (2005). Treatment goals in ovarian cancer. Int J Gynecol Cancer 15 (Suppl 1), 3-11. (Pubitemid 40696471)
-
(2005)
International Journal of Gynecological Cancer
, vol.15
, Issue.SUPPL. 1
, pp. 3-11
-
-
Ozols, R.F.1
-
3
-
-
0343596536
-
Differentiation in erythroleukemic cells and their somatic hybrids
-
Orkin SH, Harosi FI, and Leder P (1975). Differentiation in erythroleukemic cells and their somatic hybrids. Proc Natl Acad Sci USA 72, 98-102.
-
(1975)
Proc Natl Acad Sci USA
, vol.72
, pp. 98-102
-
-
Orkin, S.H.1
Harosi, F.I.2
Leder, P.3
-
4
-
-
0032539890
-
A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases
-
DOI 10.1073/pnas.95.6.3003
-
Richon VM, Emiliani S, Verdin E, Webb Y, Breslow R, Rifkind RA, and Marks PA (1998). A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci USA 95, 3003-3007. (Pubitemid 28135844)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.6
, pp. 3003-3007
-
-
Richon, V.M.1
Emiliani, S.2
Verdin, E.3
Webb, Y.4
Breslow, R.5
Rifkind, R.A.6
Marks, P.A.7
-
5
-
-
33748451151
-
Anticancer activities of histone deacetylase inhibitors
-
DOI 10.1038/nrd2133, PII NRD2133
-
Bolden JE, Peart MJ, and Johnstone RW (2006). Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov 5, 769-784. (Pubitemid 44348499)
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, Issue.9
, pp. 769-784
-
-
Bolden, J.E.1
Peart, M.J.2
Johnstone, R.W.3
-
6
-
-
30344477367
-
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
-
DOI 10.1038/nrc1779
-
Minucci S and Pelicci PG (2006). Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer 6, 38-51. (Pubitemid 43054973)
-
(2006)
Nature Reviews Cancer
, vol.6
, Issue.1
, pp. 38-51
-
-
Minucci, S.1
Pelicci, P.G.2
-
7
-
-
33846122993
-
Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug
-
DOI 10.1038/nbt1272, PII NBT1272
-
Marks PA and Breslow R (2007). Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug. Nat Biotechnol 25, 84-90. (Pubitemid 46087907)
-
(2007)
Nature Biotechnology
, vol.25
, Issue.1
, pp. 84-90
-
-
Marks, P.A.1
Breslow, R.2
-
8
-
-
33846142183
-
HDAC inhibitors overcome first hurdle
-
DOI 10.1038/nbt0107-17, PII NBT010717
-
Garber K (2007). HDAC inhibitors overcome first hurdle. Nat Biotechnol 25, 17-19. (Pubitemid 46087886)
-
(2007)
Nature Biotechnology
, vol.25
, Issue.1
, pp. 17-19
-
-
Garber, K.1
-
9
-
-
55749101363
-
Histone deacetylase inhibitors in cancer therapy
-
Lee MJ, Kim YS, Kummar S, Giaccone G, and Trepel JB (2008). Histone deacetylase inhibitors in cancer therapy. Curr Opin Oncol 20, 639-649.
-
(2008)
Curr Opin Oncol
, vol.20
, pp. 639-649
-
-
Lee, M.J.1
Kim, Y.S.2
Kummar, S.3
Giaccone, G.4
Trepel, J.B.5
-
10
-
-
49249116407
-
A work in progress: The clinical development of histone deacetylase inhibitors
-
Marsoni S, Damia G, and Camboni G (2008). A work in progress: the clinical development of histone deacetylase inhibitors. Epigenetics 3, 164-171.
-
(2008)
Epigenetics
, vol.3
, pp. 164-171
-
-
Marsoni, S.1
Damia, G.2
Camboni, G.3
-
11
-
-
43049091153
-
A phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: A Gynecologic Oncology Group study
-
Modesitt SC, Sill M, Hoffman JS, and Bender DP (2008). A phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 109, 182-186.
-
(2008)
Gynecol Oncol
, vol.109
, pp. 182-186
-
-
Modesitt, S.C.1
Sill, M.2
Hoffman, J.S.3
Bender, D.P.4
-
12
-
-
27444435580
-
Toward selective histone deacetylase inhibitor design: Homology modeling, docking studies, and molecular dynamics simulations of human class I histone deacetylases
-
DOI 10.1021/jm0505011
-
Wang DF, Helquist P, Wiech NL, and Wiest O (2005). Toward selective histone deacetylase inhibitor design: homology modeling, docking studies, and molecular dynamics simulations of human class I histone deacetylases. J Med Chem 48, 6936-6947. (Pubitemid 41533115)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.22
, pp. 6936-6947
-
-
Wang, D.-F.1
Helquist, P.2
Wiech, N.L.3
Wiest, O.4
-
13
-
-
0033539092
-
Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors
-
DOI 10.1038/43710
-
Finnin MS, Donigian JR, Cohen A, Richon VM, Rifkind RA, Marks PA, Breslow R, and Pavletich NP (1999). Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature 401, 188-193. (Pubitemid 29436325)
-
(1999)
Nature
, vol.401
, Issue.6749
, pp. 188-193
-
-
Finnin, M.S.1
Donigian, J.R.2
Cohen, A.3
Richon, V.M.4
Rifkind, R.A.5
Marks, P.A.6
Breslow, R.7
Pavletich, N.P.8
-
14
-
-
1542588471
-
Second generation hybrid polar compounds are potent inducers of transformed cell differentiation
-
DOI 10.1073/pnas.93.12.5705
-
Richon VM, Webb Y, Merger R, Sheppard T, Jursic B, Ngo L, Civoli F, Breslow R, Rifkind RA, and Marks PA (1996). Second generation hybrid polar compounds are potent inducers of transformed cell differentiation. Proc Natl Acad Sci USA 93, 5705-5708. (Pubitemid 26191313)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.12
, pp. 5705-5708
-
-
Richon, V.M.1
Webb, Y.2
Merger, R.3
Sheppard, T.4
Jursic, B.5
Ngo, L.6
Civoli, F.7
Breslow, R.8
Rifkind, R.A.9
Marks, P.A.10
-
15
-
-
0033523895
-
Amide analogues of trichostatin a as inhibitors of histone deacetylase and inducers of terminal cell differentiation
-
DOI 10.1021/jm991091h
-
Jung M, Brosch G, Kolle D, Scherf H, Gerhauser C, and Loidl P (1999). Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. J Med Chem 42, 4669-4679. (Pubitemid 29530020)
-
(1999)
Journal of Medicinal Chemistry
, vol.42
, Issue.22
, pp. 4669-4679
-
-
Jung, M.1
Brosch, G.2
Kolle, D.3
Scherf, H.4
Gerhauser, C.5
Loidl, P.6
-
16
-
-
33847258674
-
Discovery and development of SAHA as an anticancer agent
-
DOI 10.1038/sj.onc.1210204, PII 1210204
-
Marks PA (2007). Discovery and development of SAHA as an anticancer agent. Oncogene 26, 1351-1356. (Pubitemid 46328465)
-
(2007)
Oncogene
, vol.26
, Issue.9
, pp. 1351-1356
-
-
Marks, P.A.1
-
17
-
-
0028267278
-
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice
-
Ueda H, Manda T, Matsumoto S, Mukumoto S, Nishigaki F, Kawamura I, and Shimomura K (1994). FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice. J Antibiot (Tokyo) 47, 315-323.
-
(1994)
J Antibiot (Tokyo)
, vol.47
, pp. 315-323
-
-
Ueda, H.1
Manda, T.2
Matsumoto, S.3
Mukumoto, S.4
Nishigaki, F.5
Kawamura, I.6
Shimomura, K.7
-
18
-
-
23944487678
-
Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors
-
DOI 10.1021/jm0503749
-
Lu Q, Wang DS, Chen CS, Hu YD, and Chen CS (2005). Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem 48, 5530-5535. (Pubitemid 41209250)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.17
, pp. 5530-5535
-
-
Lu, Q.1
Wang, D.-S.2
Chen, C.-S.3
Hu, Y.-D.4
Chen, C.-S.5
-
19
-
-
33749029926
-
Antitumor effects of a novel phenylbutyrate-based histone deacetylase inhibitor, (S)-HDAC-42, in prostate cancer
-
DOI 10.1158/1078-0432.CCR-06-0429
-
Kulp SK, Chen CS, Wang DS, Chen CY, and Chen CS (2006). Antitumor effects of a novel phenylbutyrate-based histone deacetylase inhibitor, (S )-HDAC-42, in prostate cancer. Clin Cancer Res 12, 5199-5206. (Pubitemid 44453349)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.17
, pp. 5199-5206
-
-
Kulp, S.K.1
Chen, C.-S.2
Wang, D.-S.3
Chen, C.-Y.4
Chen, C.-S.5
-
20
-
-
45549091261
-
OSU-HDAC42, a histone deacetylase inhibitor, blocks prostate tumor progression in the transgenic adenocarcinoma of the mouse prostate model
-
Sargeant AM, Rengel RC, Kulp SK, Klein RD, Clinton SK, Wang YC, and Chen CS (2008). OSU-HDAC42, a histone deacetylase inhibitor, blocks prostate tumor progression in the transgenic adenocarcinoma of the mouse prostate model. Cancer Res 68, 3999-4009.
-
(2008)
Cancer Res
, vol.68
, pp. 3999-4009
-
-
Sargeant, A.M.1
Rengel, R.C.2
Kulp, S.K.3
Klein, R.D.4
Clinton, S.K.5
Wang, Y.C.6
Chen, C.S.7
-
21
-
-
36348996655
-
Efficacy of a novel histone deacetylase inhibitor in murine models of hepatocellular carcinoma
-
DOI 10.1002/hep.21804
-
Lu YS, Kashida Y, Kulp SK, Wang YC, Wang D, Hung JH, Tang M, Lin ZZ, Chen TJ, Cheng AL, et al. (2007). Efficacy of a novel histone deacetylase inhibitor in murine models of hepatocellular carcinoma. Hepatology 46, 1119-1130. (Pubitemid 350144776)
-
(2007)
Hepatology
, vol.46
, Issue.4
, pp. 1119-1130
-
-
Lu, Y.-S.1
Kashida, Y.2
Kulp, S.K.3
Wang, Y.-C.4
Wang, D.5
Hung, J.-H.6
Tang, M.7
Lin, Z.-Z.8
Chen, T.-J.9
Cheng, A.-L.10
Chen, C.-S.11
-
22
-
-
33644663872
-
Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes
-
DOI 10.1074/jbc.M505733200
-
Chen CS, Weng SC, Tseng PH, and Lin HP (2005). Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes. J Biol Chem 280, 38879-38887. (Pubitemid 43853791)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.46
, pp. 38879-38887
-
-
Chen, C.-S.1
Weng, S.-C.2
Tseng, P.-H.3
Lin, H.-P.4
Chen, C.-S.5
-
23
-
-
34347206854
-
Histone deacetylase inhibitors sensitize prostate cancer cells to agents that produce DNA double-strand breaks by targeting Ku70 acetylation
-
DOI 10.1158/0008-5472.CAN-06-3996
-
Chen CS, Wang YC, Yang HC, Huang PH, Kulp SK, Yang CC, Lu YS, Matsuyama S, Chen CY, and Chen CS (2007). Histone deacetylase inhibitors sensitize prostate cancer cells to agents that produce DNA double-strand breaks by targeting Ku70 acetylation. Cancer Res 67, 5318-5327. (Pubitemid 46997271)
-
(2007)
Cancer Research
, vol.67
, Issue.11
, pp. 5318-5327
-
-
Chen, C.-S.1
Wang, Y.-C.2
Yang, H.-C.3
Huang, P.-H.4
Kulp, S.K.5
Yang, C.-C.6
Lu, Y.-S.7
Matsuyama, S.8
Chen, C.-Y.9
Chen, C.-S.10
-
24
-
-
0142258488
-
Efficacy of a glutathione S-transferase pi-activated prodrug in platinum-resistant ovarian cancer cells
-
Townsend DM, Shen H, Staros AL, Gate L, and Tew KD (2002). Efficacy of a glutathione S-transferase pi-activated prodrug in platinum-resistant ovarian cancer cells. Mol Cancer Ther 1, 1089-1095.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 1089-1095
-
-
Townsend, D.M.1
Shen, H.2
Staros, A.L.3
Gate, L.4
Tew, K.D.5
-
25
-
-
46949099039
-
Activities of DNA-PK and Ku86, but not Ku70, may predict sensitivity to cisplatin in human gliomas
-
Shao CJ, Fu J, Shi HL, Mu YG, and Chen ZP (2008). Activities of DNA-PK and Ku86, but not Ku70, may predict sensitivity to cisplatin in human gliomas. J Neurooncol 89, 27-35.
-
(2008)
J Neurooncol
, vol.89
, pp. 27-35
-
-
Shao, C.J.1
Fu, J.2
Shi, H.L.3
Mu, Y.G.4
Chen, Z.P.5
-
26
-
-
19744368302
-
Cancer of the ovary
-
Cannistra SA (2004). Cancer of the ovary. N Engl J Med 351, 2519-2529.
-
(2004)
N Engl J Med
, vol.351
, pp. 2519-2529
-
-
Cannistra, S.A.1
-
27
-
-
50849154478
-
Aberrant transforming growth factor beta1 signaling and SMAD4 nuclear translocation confer epigenetic repression of ADAM19 in ovarian cancer
-
Chan MW, Huang YW, Hartman-Frey C, Kuo CT, Deatherage D, Qin H, Cheng AS, Yan PS, Davuluri RV, Huang TH, et al. (2008). Aberrant transforming growth factor beta1 signaling and SMAD4 nuclear translocation confer epigenetic repression of ADAM19 in ovarian cancer. Neoplasia 10, 908-919.
-
(2008)
Neoplasia
, vol.10
, pp. 908-919
-
-
Chan, M.W.1
Huang, Y.W.2
Hartman-Frey, C.3
Kuo, C.T.4
Deatherage, D.5
Qin, H.6
Cheng, A.S.7
Yan, P.S.8
Davuluri, R.V.9
Huang, T.H.10
-
28
-
-
50949104573
-
Expression of class I histone deacetylases indicates poor prognosis in endometrioid subtypes of ovarian and endometrial carcinomas
-
Weichert W, Denkert C, Noske A, Darb-Esfahani S, Dietel M, Kalloger SE, Huntsman DG, and Kobel M (2008). Expression of class I histone deacetylases indicates poor prognosis in endometrioid subtypes of ovarian and endometrial carcinomas. Neoplasia 10, 1021-1027.
-
(2008)
Neoplasia
, vol.10
, pp. 1021-1027
-
-
Weichert, W.1
Denkert, C.2
Noske, A.3
Darb-Esfahani, S.4
Dietel, M.5
Kalloger, S.E.6
Huntsman, D.G.7
Kobel, M.8
-
29
-
-
2942532642
-
Trichostatin a - Like hydroxamate histone deacetylase inhibitors as therapeutic agents: Toxicological point of view
-
Vanhaecke T, Papeleu P, Elaut G, and Rogiers V (2004). Trichostatin A-like hydroxamate histone deacetylase inhibitors as therapeutic agents: toxicological point of view. Curr Med Chem 11, 1629-1643. (Pubitemid 38735799)
-
(2004)
Current Medicinal Chemistry
, vol.11
, Issue.12
, pp. 1629-1643
-
-
Vanhaecke, T.1
Papeleu, P.2
Elaut, G.3
Rogiers, V.4
-
30
-
-
0034904625
-
DNA methylation and ovarian cancer. I. Analysis of CpG island hypermethylation in human ovarian cancer using differential methylation hybridization
-
Ahluwalia A, Yan P, Hurteau JA, Bigsby RM, Jung SH, Huang TH, and Nephew KP (2001). DNA methylation and ovarian cancer. I. Analysis of CpG island hypermethylation in human ovarian cancer using differential methylation hybridization. Gynecol Oncol 82, 261-268.
-
(2001)
Gynecol Oncol
, vol.82
, pp. 261-268
-
-
Ahluwalia, A.1
Yan, P.2
Hurteau, J.A.3
Bigsby, R.M.4
Jung, S.H.5
Huang, T.H.6
Nephew, K.P.7
-
32
-
-
0017076160
-
Derivation and properties of Michaelis-Menten type and Hill type equations for reference ligands
-
Chou TC (1976). Derivation and properties of Michaelis-Menten type and Hill type equations for reference ligands. J Theor Biol 59, 253-276.
-
(1976)
J Theor Biol
, vol.59
, pp. 253-276
-
-
Chou, T.C.1
-
33
-
-
0035710746
-
-ΔΔCT method
-
DOI 10.1006/meth.2001.1262
-
Livak KJ and Schmittgen TD (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25, 402-408. (Pubitemid 34164012)
-
(2001)
Methods
, vol.25
, Issue.4
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
34
-
-
0025733535
-
Comparison of commercially available cytokeratin antibodies in normal and neoplastic adult epithelial and non-epithelial tissues
-
Goddard MJ, Wilson B, and Grant JW (1991). Comparison of commercially available cytokeratin antibodies in normal and neoplastic adult epithelial and non-epithelial tissues. J Clin Pathol 44, 660-663.
-
(1991)
J Clin Pathol
, vol.44
, pp. 660-663
-
-
Goddard, M.J.1
Wilson, B.2
Grant, J.W.3
-
35
-
-
0034665124
-
Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo
-
Butler LM, Agus DB, Scher HI, Higgins B, Rose A, Cordon-Cardo C, Thaler HT, Rifkind RA, Marks PA, and Richon VM (2000). Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo. Cancer Res 60, 5165-5170.
-
(2000)
Cancer Res
, vol.60
, pp. 5165-5170
-
-
Butler, L.M.1
Agus, D.B.2
Scher, H.I.3
Higgins, B.4
Rose, A.5
Cordon-Cardo, C.6
Thaler, H.T.7
Rifkind, R.A.8
Marks, P.A.9
Richon, V.M.10
-
36
-
-
7944236864
-
Characterisation of molecular events following cisplatin treatment of two curable ovarian cancer models: Contrasting role for p53 induction and apoptosis in vivo
-
DOI 10.1038/sj.bjc.6602167
-
Clarke PA, Pestell KE, Di Stefano F, Workman P, and Walton MI (2004). Characterisation of molecular events following cisplatin treatment of two curable ovarian cancer models: contrasting role for p53 induction and apoptosis in vivo. Br J Cancer 91, 1614-1623. (Pubitemid 39486371)
-
(2004)
British Journal of Cancer
, vol.91
, Issue.8
, pp. 1614-1623
-
-
Clarke, P.A.1
Pestell, K.E.2
Di Stefano, F.3
Workman, P.4
Walton, M.I.5
-
37
-
-
3042561471
-
Tumor hypoxia correlates with metastatic tumor growth of pancreatic cancer in an orthotopic murine model
-
DOI 10.1016/j.jss.2004.02.014, PII S0022480404000599
-
Buchler P, Reber HA, Lavey RS, Tomlinson J, Buchler MW, Friess H, and Hines OJ (2004). Tumor hypoxia correlates with metastatic tumor growth of pancreatic cancer in an orthotopic murine model. J Surg Res 120, 295-303. (Pubitemid 38834199)
-
(2004)
Journal of Surgical Research
, vol.120
, Issue.2
, pp. 295-303
-
-
Buchler, P.1
Reber, H.A.2
Lavey, R.S.3
Tomlinson, J.4
Buchler, M.W.5
Friess, H.6
Hines, O.J.7
-
38
-
-
0023111825
-
Characterization of a cis-diamminedichloroplatinum(II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues
-
Behrens BC, Hamilton TC, Masuda H, Grotzinger KR, Whang-Peng J, Louie KG, Knutsen T, McKoy WM, Young RC, and Ozols RF (1987). Characterization of a cis-diamminedichloroplatinum(II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues. Cancer Res 47, 414-418. (Pubitemid 17009602)
-
(1987)
Cancer Research
, vol.47
, Issue.2
, pp. 414-418
-
-
Behrens, B.C.1
Hamilton, T.C.2
Masuda, H.3
-
39
-
-
0031020450
-
Increased platinum-DNA damage tolerance is associated with cisplatin resistance and cross-resistance to various chemotherapeutic agents in unrelated human ovarian cancer cell lines
-
Johnson SW, Laub PB, Beesley JS, Ozols RF, and Hamilton TC (1997). Increased platinum-DNA damage tolerance is associated with cisplatin resistance and cross-resistance to various chemotherapeutic agents in unrelated human ovarian cancer cell lines. Cancer Res 57, 850-856. (Pubitemid 27098008)
-
(1997)
Cancer Research
, vol.57
, Issue.5
, pp. 850-856
-
-
Johnson, S.W.1
Laub, P.B.2
Beesley, J.S.3
Ozols, R.F.4
Hamilton, T.C.5
-
40
-
-
17444362227
-
Identification of genes associated with platinum drug sensitivity and resistance in human ovarian cancer cells
-
DOI 10.1038/sj.bjc.6602447
-
Roberts D, Schick J, Conway S, Biade S, Laub PB, Stevenson JP, Hamilton TC, O'Dwyer PJ, and Johnson SW (2005). Identification of genes associated with platinum drug sensitivity and resistance in human ovarian cancer cells. Br J Cancer 92, 1149-1158. (Pubitemid 40546683)
-
(2005)
British Journal of Cancer
, vol.92
, Issue.6
, pp. 1149-1158
-
-
Roberts, D.1
Schick, J.2
Conway, S.3
Biade, S.4
Laub, P.B.5
Stevenson, J.P.6
Hamilton, T.C.7
O'Dwyer, P.J.8
Johnson, S.W.9
-
41
-
-
0642286495
-
Cyclin B1 and CDK1: Nuclear localization and upstream regulators
-
Porter LA and Donoghue DJ (2003). Cyclin B1 and CDK1: nuclear localization and upstream regulators. Prog Cell Cycle Res 5, 335-347.
-
(2003)
Prog Cell Cycle Res
, vol.5
, pp. 335-347
-
-
Porter, L.A.1
Donoghue, D.J.2
-
42
-
-
18144416611
-
The transcriptional targets of p53 in apoptosis control
-
DOI 10.1016/j.bbrc.2005.03.189, Apoptosis Control
-
Yu J and Zhang L (2005). The transcriptional targets of p53 in apoptosis control. Biochem Biophys Res Commun 331, 851-858. (Pubitemid 40615516)
-
(2005)
Biochemical and Biophysical Research Communications
, vol.331
, Issue.3
, pp. 851-858
-
-
Yu, J.1
Zhang, L.2
-
43
-
-
0034654011
-
Acetylation: A regulatory modification to rival phosphorylation?
-
Kouzarides T (2000). Acetylation: a regulatory modification to rival phosphorylation? EMBO J 19, 1176-1179.
-
(2000)
EMBO J
, vol.19
, pp. 1176-1179
-
-
Kouzarides, T.1
-
44
-
-
0036731055
-
Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity
-
Blagosklonny MV, Robey R, Sackett DL, Du L, Traganos F, Darzynkiewicz Z, Fojo T, and Bates SE (2002). Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity. Mol Cancer Ther 1, 937-941.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 937-941
-
-
Blagosklonny, M.V.1
Robey, R.2
Sackett, D.L.3
Du, L.4
Traganos, F.5
Darzynkiewicz, Z.6
Fojo, T.7
Bates, S.E.8
-
45
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski CA, Lombardo F, Dominy BW, and Feeney PJ (2001). Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 46, 3-26.
-
(2001)
Adv Drug Deliv Rev
, vol.46
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
46
-
-
0041532109
-
Cell cycle blockade and differentiation of ovarian cancer cells by the histone deacetylase inhibitor trichostatin a are associated with changes in p21, Rb, and Id proteins
-
Strait KA, Dabbas B, Hammond EH, Warnick CT, Iistrup SJ, and Ford CD (2002). Cell cycle blockade and differentiation of ovarian cancer cells by the histone deacetylase inhibitor trichostatin A are associated with changes in p21, Rb, and Id proteins. Mol Cancer Ther 1, 1181-1190.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 1181-1190
-
-
Strait, K.A.1
Dabbas, B.2
Hammond, E.H.3
Warnick, C.T.4
Iistrup, S.J.5
Ford, C.D.6
-
47
-
-
18044366441
-
2-checkpoint arrest and apoptosis in cisplatinum-resistant ovarian cancer cells associated with overexpression of the Bcl-2-related protein Bad
-
DOI 10.1158/1535-7163.MCT-04-0107
-
Strait KA, Warnick CT, Ford CD, Dabbas B, Hammond EH, and Ilstrup SJ (2005). Histone deacetylase inhibitors induce G2-checkpoint arrest and apoptosis in cisplatinum-resistant ovarian cancer cells associated with overexpression of the Bcl-2-related protein Bad. Mol Cancer Ther 4, 603-611. (Pubitemid 40601842)
-
(2005)
Molecular Cancer Therapeutics
, vol.4
, Issue.4
, pp. 603-611
-
-
Strait, K.A.1
Warnick, C.T.2
Ford, C.D.3
Dabbas, B.4
Hammond, E.H.5
Ilstrup, S.J.6
-
48
-
-
34547100275
-
The resurgence of platinum-based cancer chemotherapy
-
Kelland L (2007). The resurgence of platinum-based cancer chemotherapy. Nat Rev Cancer 7, 573-584.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 573-584
-
-
Kelland, L.1
-
49
-
-
16844368698
-
Tumour stem cells and drug resistance
-
DOI 10.1038/nrc1590
-
Dean M, Fojo T, and Bates S (2005). Tumour stem cells and drug resistance. Nat Rev Cancer 5, 275-284. (Pubitemid 40488633)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.4
, pp. 275-284
-
-
Dean, M.1
Fojo, T.2
Bates, S.3
-
50
-
-
0029043888
-
A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V
-
Vermes I, Haanen C, Steffens-Nakken H, and Reutelingsperger C (1995). A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V. J Immunol Methods 184, 39-51.
-
(1995)
J Immunol Methods
, vol.184
, pp. 39-51
-
-
Vermes, I.1
Haanen, C.2
Steffens-Nakken, H.3
Reutelingsperger, C.4
-
51
-
-
10044225745
-
Human ovarian carcinoma cells: Histone deacetylase inhibitors exhibit antiproliferative activity and potently induce apoptosis
-
DOI 10.1002/cncr.20709
-
Takai N, Kawamata N, Gui D, Said JW, Miyakawa I, and Koeffler HP (2004). Human ovarian carcinoma cells: histone deacetylase inhibitors exhibit antiproliferative activity and potently induce apoptosis. Cancer 101, 2760-2770. (Pubitemid 39603184)
-
(2004)
Cancer
, vol.101
, Issue.12
, pp. 2760-2770
-
-
Takai, N.1
Kawamata, N.2
Gui, D.3
Said, J.W.4
Miyakawa, I.5
Koeffler, H.P.6
-
52
-
-
34548176264
-
Valproic acid for the treatment of myeloid malignancies
-
DOI 10.1002/cncr.22891
-
Kuendgen A and Gattermann N (2007). Valproic acid for the treatment of myeloid malignancies. Cancer 110, 943-954. (Pubitemid 47312858)
-
(2007)
Cancer
, vol.110
, Issue.5
, pp. 943-954
-
-
Kuendgen, A.1
Gattermann, N.2
-
53
-
-
1642453460
-
Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101
-
Plumb JA, Finn PW, Williams RJ, Bandara MJ, Romero MR, Watkins CJ, La Thangue NB, and Brown R (2003). Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101. Mol Cancer Ther 2, 721-728.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 721-728
-
-
Plumb, J.A.1
Finn, P.W.2
Williams, R.J.3
Bandara, M.J.4
Romero, M.R.5
Watkins, C.J.6
La Thangue, N.B.7
Brown, R.8
-
54
-
-
33748353002
-
Activity of PXD101, a histone deacetylase inhibitor, in preclinical ovarian cancer studies
-
DOI 10.1158/1535-7163.MCT-06-0111
-
Qian X, LaRochelle WJ, Ara G, Wu F, Petersen KD, Thougaard A, Sehested M, Lichenstein HS, and Jeffers M (2006). Activity of PXD101, a histone deacetylase inhibitor, in preclinical ovarian cancer studies. Mol Cancer Ther 5, 2086-2095. (Pubitemid 44336581)
-
(2006)
Molecular Cancer Therapeutics
, vol.5
, Issue.8
, pp. 2086-2095
-
-
Qian, X.1
Larochelle, W.J.2
Ara, G.3
Wu, F.4
Petersen, K.D.5
Thougaard, A.6
Sehested, M.7
Lichenstein, H.S.8
Jeffers, M.9
-
55
-
-
43549123821
-
Valproic acid resensitizes cisplatin-resistant ovarian cancer cells
-
Lin CT, Lai HC, Lee HY, Lin WH, Chang CC, Chu TY, Lin YW, Lee KD, and Yu MH (2008). Valproic acid resensitizes cisplatin-resistant ovarian cancer cells. Cancer Sci 99, 1218-1226.
-
(2008)
Cancer Sci
, vol.99
, pp. 1218-1226
-
-
Lin, C.T.1
Lai, H.C.2
Lee, H.Y.3
Lin, W.H.4
Chang, C.C.5
Chu, T.Y.6
Lin, Y.W.7
Lee, K.D.8
Yu, M.H.9
-
56
-
-
33644559077
-
M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells
-
DOI 10.1016/j.ygyno.2005.09.044, PII S0090825805008425
-
Takai N, Ueda T, Nishida M, Nasu K, and Narahara H (2006). M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells. Gynecol Oncol 101, 108-113. (Pubitemid 43303568)
-
(2006)
Gynecologic Oncology
, vol.101
, Issue.1
, pp. 108-113
-
-
Takai, N.1
Ueda, T.2
Nishida, M.3
Nasu, K.4
Narahara, H.5
-
57
-
-
33845950849
-
Inhibition of EGFR/PI3K/AKT cell survival pathway promotes TSA's effect on cell death and migration in human ovarian cancer cells
-
Zhou C, Qiu L, Sun Y, Healey S, Wanebo H, Kouttab N, Di W, Yan B, and Wan Y (2006). Inhibition of EGFR/PI3K/AKT cell survival pathway promotes TSA's effect on cell death and migration in human ovarian cancer cells. Int J Oncol 29, 269-278.
-
(2006)
Int J Oncol
, vol.29
, pp. 269-278
-
-
Zhou, C.1
Qiu, L.2
Sun, Y.3
Healey, S.4
Wanebo, H.5
Kouttab, N.6
Di, W.7
Yan, B.8
Wan, Y.9
-
58
-
-
38949146354
-
Histone deacetylase inhibitors enhance the chemosensitivity of tumor cells with cross-resistance to a wide range of DNA-damaging drugs
-
Ozaki K, Kishikawa F, Tanaka M, Sakamoto T, Tanimura S, and Kohno M (2008). Histone deacetylase inhibitors enhance the chemosensitivity of tumor cells with cross-resistance to a wide range of DNA-damaging drugs. Cancer Sci 99, 376-384.
-
(2008)
Cancer Sci
, vol.99
, pp. 376-384
-
-
Ozaki, K.1
Kishikawa, F.2
Tanaka, M.3
Sakamoto, T.4
Tanimura, S.5
Kohno, M.6
-
59
-
-
0034086168
-
Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells
-
Qiu L, Burgess A, Fairlie DP, Leonard H, Parsons PG, and Gabrielli BG (2000). Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells. Mol Biol Cell 11, 2069-2083. (Pubitemid 30408065)
-
(2000)
Molecular Biology of the Cell
, vol.11
, Issue.6
, pp. 2069-2083
-
-
Qiu, L.1
Burgess, A.2
Fairlie, D.P.3
Leonard, H.4
Parsons, P.G.5
Gabrielli, B.G.6
-
60
-
-
25444472340
-
1 gene expression via a p21/WAF-1-dependent mechanism in human colon cancer cells
-
DOI 10.1152/ajpgi.00575.2004
-
Archer SY, Johnson J, Kim HJ, Ma Q, Mou H, Daesety V, Meng S, and Hodin RA (2005). The histone deacetylase inhibitor butyrate downregulates cyclin B1 gene expression via a p21/WAF-1-dependent mechanism in human colon cancer cells. Am J Physiol Gastrointest Liver Physiol 289, G696-G703. (Pubitemid 41377176)
-
(2005)
American Journal of Physiology - Gastrointestinal and Liver Physiology
, vol.289
, Issue.4
-
-
Archer, S.Y.1
Johnson, J.2
Kim, H.-J.3
Ma, Q.4
Mou, H.5
Daesety, V.6
Meng, S.7
Hodin, R.A.8
-
61
-
-
23844472871
-
Depletion of mutant p53 and cytotoxicity of histone deacetylase inhibitors
-
DOI 10.1158/0008-5472.CAN-04-3433
-
Blagosklonny MV, Trostel S, Kayastha G, Demidenko ZN, Vassilev LT, Romanova LY, Bates S, and Fojo T (2005). Depletion of mutant p53 and cytotoxicity of histone deacetylase inhibitors. Cancer Res 65, 7386-7392. (Pubitemid 41161272)
-
(2005)
Cancer Research
, vol.65
, Issue.16
, pp. 7386-7392
-
-
Blagosklonny, M.V.1
Trostel, S.2
Kayastha, G.3
Demidenko, Z.N.4
Vassilev, L.T.5
Romanova, L.Y.6
Bates, S.7
Fojo, T.8
-
62
-
-
0033570026
-
P53 negatively regulates cdc2 transcription via the CCAAT-binding NF-Y transcription factor
-
DOI 10.1074/jbc.274.42.29677
-
Yun J, Chae HD, Choy HE, Chung J, Yoo HS, Han MH, and Shin DY (1999). p53 negatively regulates cdc2 transcription via the CCAAT-binding NF-Y transcription factor. J Biol Chem 274, 29677-29682. (Pubitemid 29483335)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.42
, pp. 29677-29682
-
-
Yun, J.1
Chae, H.-D.2
Choy, H.E.3
Chung, J.4
Yoo, H.-S.5
Han, M.-H.6
Shin, D.Y.7
-
63
-
-
0031574205
-
CDF-1, a novel E2F-unrelated factor, interacts with cell cycle-regulated repressor elements in multiple promoters
-
DOI 10.1093/nar/25.24.4915
-
Liu N, Lucibello FC, Korner K, Wolfraim LA, Zwicker J, and Muller R (1997). CDF-1, a novel E2F-unrelated factor, interacts with cell cycle-regulated repressor elements in multiple promoters. Nucleic Acids Res 25, 4915-4920. (Pubitemid 28022250)
-
(1997)
Nucleic Acids Research
, vol.25
, Issue.24
, pp. 4915-4920
-
-
Liu, N.1
Lucibello, F.C.2
Korner, K.3
Wolfraim, L.A.4
Zwicker, J.5
Muller, R.6
-
64
-
-
23744495968
-
Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor α, in response to deacetylase inhibition by valproic acid and trichostatin a
-
DOI 10.1038/sj.onc.1208662
-
Reid G, Metivier R, Lin CY, Denger S, Ibberson D, Ivacevic T, Brand H, Benes V, Liu ET, and Gannon F (2005). Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A. Oncogene 24, 4894-4907. (Pubitemid 41129094)
-
(2005)
Oncogene
, vol.24
, Issue.31
, pp. 4894-4907
-
-
Reid, G.1
Metivier, R.2
Lin, C.-Y.3
Denger, S.4
Ibberson, D.5
Ivacevic, T.6
Brand, H.7
Benes, V.8
Liu, E.T.9
Gannon, F.10
-
65
-
-
0030974869
-
The intrinsic radiosensitivity of some human tumor cells throughout their cell cycles
-
DOI 10.2307/3579497
-
Biade S, Stobbe CC, and Chapman JD (1997). The intrinsic radiosensitivity of some human tumor cells throughout their cell cycles. Radiat Res 147, 416-421. (Pubitemid 27150371)
-
(1997)
Radiation Research
, vol.147
, Issue.4
, pp. 416-421
-
-
Biade, S.1
Stobbe, C.C.2
Chapman, J.D.3
-
66
-
-
49849092584
-
Trichostatin a up-regulates p73 and induces Bax-dependent apoptosis in cisplatin-resistant ovarian cancer cells
-
Muscolini M, Cianfrocca R, Sajeva A, Mozzetti S, Ferrandina G, Costanzo A, and Tuosto L (2008). Trichostatin A up-regulates p73 and induces Bax-dependent apoptosis in cisplatin-resistant ovarian cancer cells. Mol Cancer Ther 7, 1410-1419.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1410-1419
-
-
Muscolini, M.1
Cianfrocca, R.2
Sajeva, A.3
Mozzetti, S.4
Ferrandina, G.5
Costanzo, A.6
Tuosto, L.7
-
67
-
-
0344640906
-
Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation
-
DOI 10.1073/pnas.0430973100
-
Haggarty SJ, Koeller KM, Wong JC, Grozinger CM, and Schreiber SL (2003). Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc Natl Acad Sci USA 100, 4389-4394. (Pubitemid 36457739)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.8
, pp. 4389-4394
-
-
Haggarty, S.J.1
Koeller, K.M.2
Wong, J.C.3
Grozinger, C.M.4
Schreiber, S.L.5
-
68
-
-
54749101159
-
The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis
-
Lee YS, Lim KH, Guo X, Kawaguchi Y, Gao Y, Barrientos T, Ordentlich P, Wang XF, Counter CM, and Yao TP (2008). The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis. Cancer Res 68, 7561-7569.
-
(2008)
Cancer Res
, vol.68
, pp. 7561-7569
-
-
Lee, Y.S.1
Lim, K.H.2
Guo, X.3
Kawaguchi, Y.4
Gao, Y.5
Barrientos, T.6
Ordentlich, P.7
Wang, X.F.8
Counter, C.M.9
Yao, T.P.10
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