-
1
-
-
0033082394
-
RNA surveillance: Unforesen consequences for gene expression, inherited genetic disorders and cancer
-
PII S0168952598016588
-
Culbertson MR. RNA surveillance. Unforeseen consequences for gene expression, inherited genetic disorders and cancer. Trends Genet. 15(2), 74-80 (1999). (Pubitemid 129749886)
-
(1999)
Trends in Genetics
, vol.15
, Issue.2
, pp. 74-81
-
-
Culbertson, M.R.1
-
2
-
-
0029908912
-
A splicing-dependent regulatory mechanism that detects translation signals
-
Carter MS, Li S, Wilkinson MF. A splicing-dependent regulatory mechanism that detects translation signals. EMBO J. 15(21), 5965-5975 (1996). (Pubitemid 26375518)
-
(1996)
EMBO Journal
, vol.15
, Issue.21
, pp. 5965-5975
-
-
Carter, M.S.1
Li, S.2
Wilkinson, M.F.3
-
3
-
-
0035028094
-
Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay
-
DOI 10.1017/S1355838201002229
-
Maquat LE, Li X. Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay. RNA 7(3), 445-456 (2001). (Pubitemid 32381918)
-
(2001)
RNA
, vol.7
, Issue.3
, pp. 445-456
-
-
Maquat, L.E.1
Li, X.2
-
4
-
-
0034672093
-
The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions
-
DOI 10.1093/emboj/19.24.6860
-
Le Hir H, Izaurralde E, Maquat LE, Moore MJ. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. EMBO J. 19(24), 6860-6869 (2000). (Pubitemid 32011679)
-
(2000)
EMBO Journal
, vol.19
, Issue.24
, pp. 6860-6869
-
-
Le Hir, H.1
Izaurralde, E.2
Maquat, L.E.3
Moore, M.J.4
-
5
-
-
33744994837
-
EJC-independent degradation of nonsense immunoglobulin-μ mRNA depends on 3′ UTR length
-
DOI 10.1038/nsmb1081, PII N1081
-
Buhler M, Steiner S, Mohn F, Paillusson A, Mühlemann O. EJC-independent degradation of nonsense immunoglobulin-μ mRNA depends on 3′ UTR length. Nat. Struct. Mol. Biol. 13(5), 462-464 (2006). (Pubitemid 43881589)
-
(2006)
Nature Structural and Molecular Biology
, vol.13
, Issue.5
, pp. 462-464
-
-
Buhler, M.1
Steiner, S.2
Mohn, F.3
Paillusson, A.4
Muhlemann, O.5
-
6
-
-
0034928832
-
Nonsense-mediated decay of human HEXA mRNA
-
DOI 10.1128/MCB.21.16.5512-5519.2001
-
Rajavel KS, Neufeld EF. Nonsense-mediated decay of human HEXA mRNA. Mol. Cell Biol. 21(16), 5512-5519 (2001). (Pubitemid 32702455)
-
(2001)
Molecular and Cellular Biology
, vol.21
, Issue.16
, pp. 5512-5519
-
-
Rajavel, K.S.1
Neufeld, E.F.2
-
7
-
-
2342644903
-
Unspliced Rous Sarcoma Virus Genomic RNAs Are Translated and Subjected to Nonsense-Mediated mRNA Decay before Packaging
-
DOI 10.1128/JVI.78.10.5139-5146.2004
-
LeBlanc JJ, Beemon KL. Unspliced Rous sarcoma virus genomic RNAs are translated and subjected to nonsense-mediated mRNA decay before packaging. J. Virol. 78(10), 5139-5146 (2004). (Pubitemid 38581466)
-
(2004)
Journal of Virology
, vol.78
, Issue.10
, pp. 5139-5146
-
-
Leblanc, J.J.1
Beemon, K.L.2
-
8
-
-
43249084802
-
A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay
-
Singh G, Rebbapragada I, Lykke-Andersen J. A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay. PLoS Biol. 6(4), e111 (2008).
-
(2008)
PLoS Biol.
, vol.6
, Issue.4
-
-
Singh, G.1
Rebbapragada, I.2
Lykke-Andersen, J.3
-
9
-
-
59649124310
-
Nonsense-mediated mRNA decay (NMD) mechanisms
-
Brogna S, Wen J. Nonsense-mediated mRNA decay (NMD) mechanisms. Nat. Struct. Mol. Biol. 16(2), 107-113 (2009).
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, Issue.2
, pp. 107-113
-
-
Brogna, S.1
Wen, J.2
-
10
-
-
1842577707
-
EIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay
-
DOI 10.1038/nsmb750
-
Shibuya T, Tange TØ, Sonenberg N, Moore MJ. eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay. Nat. Struct. Mol. Biol. 11(4), 346-351 (2004). (Pubitemid 38436799)
-
(2004)
Nature Structural and Molecular Biology
, vol.11
, Issue.4
, pp. 346-351
-
-
Shibuya, T.1
Tange, T.O.2
Sonenberg, N.3
Moore, M.J.4
-
11
-
-
2342540912
-
The ever-increasing complexities of the exon junction complex
-
DOI 10.1016/j.ceb.2004.03.012, PII S095506740400050X
-
Tange TO, Nott A, Moore MJ. The ever-increasing complexities of the exon junction complex. Curr. Opin. Cell Biol. 16(3), 279-284 (2004). (Pubitemid 38610408)
-
(2004)
Current Opinion in Cell Biology
, vol.16
, Issue.3
, pp. 279-284
-
-
Tange, T.O.1
Nott, A.2
Moore, M.J.3
-
12
-
-
0029791449
-
Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 protein
-
Weng Y, Czaplinski K, Peltz SW. Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 protein. Mol. Cell Biol. 16(10), 5477-5490 (1996). (Pubitemid 26315068)
-
(1996)
Molecular and Cellular Biology
, vol.16
, Issue.10
, pp. 5477-5490
-
-
Weng, Y.1
Czaplinski, K.2
Peltz, S.W.3
-
13
-
-
0033835231
-
Characterization of the biochemical properties of the human UPF1 gene product that is involved in nonsense-mediated mRNA decay
-
Bhattacharya A, Czaplinski K, Trifillis P, He F, Jacobson A, Peltz SW. Characterization of the biochemical properties of the human UPF1 gene product that is involved in nonsense-mediated mRNA decay. RNA 6(9), 1226-1235 (2000).
-
(2000)
RNA
, vol.6
, Issue.9
, pp. 1226-1235
-
-
Bhattacharya, A.1
Czaplinski, K.2
Trifillis, P.3
He, F.4
Jacobson, A.5
Peltz, S.W.6
-
14
-
-
12944327374
-
Mammalian Staufen1 recruits Upf1 to specific mRNA 3′UTRs so as to elicit mRNA decay
-
DOI 10.1016/j.cell.2004.11.050, PII S0092867404011572
-
Kim YK, Furic L, Desgroseillers L, Maquat LE. Mammalian Staufen1 recruits Upf1 to specific mRNA 3′UTRs so as to elicit mRNA decay. Cell 120(2), 195-208 (2005). (Pubitemid 40174763)
-
(2005)
Cell
, vol.120
, Issue.2
, pp. 195-208
-
-
Kim, Y.K.1
Furic, L.2
Desgroseillers, L.3
Maquat, L.E.4
-
15
-
-
26944503146
-
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
-
DOI 10.1038/nsmb972, PII NSMB972
-
Kaygun H, Marzluff WF. Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1. Nat. Struct. Mol. Biol. 12(9), 794-800 (2005). (Pubitemid 43086254)
-
(2005)
Nature Structural and Molecular Biology
, vol.12
, Issue.9
, pp. 794-800
-
-
Kaygun, H.1
Marzluff, W.F.2
-
16
-
-
0035862813
-
Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability
-
Medghalchi SM, Frischmeyer PA, Mendell JT, Kelly AG, Lawler AM, Dietz HC. Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability. Hum. Mol. Genet. 10(2), 99-105 (2001). (Pubitemid 32098119)
-
(2001)
Human Molecular Genetics
, vol.10
, Issue.2
, pp. 99-105
-
-
Medghalchi, S.M.1
Frischmeyer, P.A.2
Mendell, J.T.3
Kelly, A.G.4
Lawler, A.M.5
Dietz, H.C.6
-
17
-
-
32944458421
-
The human RNA surveillance factor UPF1 is required for S phase progression and genome stability
-
DOI 10.1016/j.cub.2006.01.018, PII S0960982206000959
-
Azzalin CM, Lingner J. The human RNA surveillance factor UPF1 is required for S phase progression and genome stability. Curr. Biol. 16(4), 433-439 (2006). (Pubitemid 43259356)
-
(2006)
Current Biology
, vol.16
, Issue.4
, pp. 433-439
-
-
Azzalin, C.M.1
Lingner, J.2
-
18
-
-
0034751160
-
Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)
-
Serin G, Gersappe A, Black JD, Aronoff R, Maquat LE. Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). Mol. Cell Biol. 21(1), 209-223 (2001).
-
(2001)
Mol. Cell Biol.
, vol.21
, Issue.1
, pp. 209-223
-
-
Serin, G.1
Gersappe, A.2
Black, J.D.3
Aronoff, R.4
Maquat, L.E.5
-
19
-
-
33749239197
-
Crystal structure of the UPF2-interacting domain of nonsense-mediated mRNA decay factor UPF1
-
DOI 10.1261/rna.177606
-
Kadlec J, Guilligay D, Ravelli RB, Cusack S. Crystal structure of the UPF2-interacting domain of nonsense-mediated mRNA decay factor UPF1. RNA 12(10), 1817-1824 (2006). (Pubitemid 44484255)
-
(2006)
RNA
, vol.12
, Issue.10
, pp. 1817-1824
-
-
Kadlec, J.1
Guilligay, D.2
Ravelli, R.B.3
Cusack, S.4
-
20
-
-
1842473091
-
The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3
-
DOI 10.1038/nsmb741
-
Kadlec J, Izaurralde E, Cusack S. The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. Nat. Struct. Mol. Biol. 11(4), 330-337 (2004). (Pubitemid 38436797)
-
(2004)
Nature Structural and Molecular Biology
, vol.11
, Issue.4
, pp. 330-337
-
-
Kadlec, J.1
Izaurralde, E.2
Cusack, S.3
-
21
-
-
25844512736
-
Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements
-
DOI 10.1016/j.molcel.2005.08.012, PII S1097276505015546
-
Gehring NH, Kunz JB, Neu-Yilik G et al. Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. Mol. Cell 20(1), 65-75 (2005). (Pubitemid 41396563)
-
(2005)
Molecular Cell
, vol.20
, Issue.1
, pp. 65-75
-
-
Gehring, N.H.1
Kunz, J.B.2
Neu-Yilik, G.3
Breit, S.4
Viegas, M.H.5
Hentze, M.W.6
Kulozik, A.E.7
-
22
-
-
0345708148
-
The cycle of nonsense
-
DOI 10.1016/S1097-2765(03)00448-9
-
Wilkinson MF. The cycle of nonsense. Mol. Cell 12(5), 1059-1061 (2003). (Pubitemid 37487914)
-
(2003)
Molecular Cell
, vol.12
, Issue.5
, pp. 1059-1061
-
-
Wilkinson, M.F.1
-
23
-
-
2942572923
-
The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells
-
DOI 10.1016/j.molcel.2004.05.005, PII S1097276504002722
-
Brumbaugh KM, Otterness DM, Geisen C et al. The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. Mol. Cell 14(5), 585-598 (2004). (Pubitemid 38739082)
-
(2004)
Molecular Cell
, vol.14
, Issue.5
, pp. 585-598
-
-
Brumbaugh, K.M.1
Otterness, D.M.2
Geisen, C.3
Oliveira, V.4
Brognard, J.5
Li, X.6
Lejeune, F.7
Tibbetts, R.S.8
Maquat, L.E.9
Abraham, R.T.10
-
24
-
-
59649089120
-
The telomeric transcriptome and SMG proteins at the crossroads
-
Chawla R, Azzalin CM. The telomeric transcriptome and SMG proteins at the crossroads. Cytogenet. Genome Res. 122(3-4), 194-201 (2008).
-
(2008)
Cytogenet. Genome Res.
, vol.122
, Issue.3-4
, pp. 194-201
-
-
Chawla, R.1
Azzalin, C.M.2
-
25
-
-
0037415691
-
SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A
-
DOI 10.1093/emboj/cdg056
-
Anders KR, Grimson A, Anderson P. SMG-5, required for C. elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A. EMBO J. 22(3), 641-650 (2003). (Pubitemid 36193608)
-
(2003)
EMBO Journal
, vol.22
, Issue.3
, pp. 641-650
-
-
Anders, K.R.1
Grimson, A.2
Anderson, P.3
-
26
-
-
8844245615
-
SMG7 acts as a molecular link between mRNA surveillance and mRNA decay
-
DOI 10.1016/j.molcel.2004.10.013, PII S1097276504006392
-
Unterholzner L, Izaurralde E. SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. Mol. Cell 16(4), 587-596 (2004). (Pubitemid 39531881)
-
(2004)
Molecular Cell
, vol.16
, Issue.4
, pp. 587-596
-
-
Unterholzner, L.1
Izaurralde, E.2
-
27
-
-
57049126216
-
SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan
-
Huntzinger E, Kashima I, Fauser M, Saulière J, Izaurralde E. SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan. RNA 14(12), 2609-2617 (2008).
-
(2008)
RNA
, vol.14
, Issue.12
, pp. 2609-2617
-
-
Huntzinger, E.1
Kashima, I.2
Fauser, M.3
Saulière, J.4
Izaurralde, E.5
-
28
-
-
58149291462
-
Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex
-
Cho H, Kim KM, Kim YK. Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex. Mol. Cell 33(1), 75-86 (2009).
-
(2009)
Mol. Cell
, vol.33
, Issue.1
, pp. 75-86
-
-
Cho, H.1
Kim, K.M.2
Kim, Y.K.3
-
29
-
-
0028344092
-
Nonsense codon mutations in the terminal exon of the β-globin gene are not associated with a reduction in β-mRNA accumulation: A mechanism for the phenotype of dominant β-thalassemia
-
Hall GW, Thein S. Nonsense codon mutations in the terminal exon of the β-globin gene are not associated with a reduction in β-mRNA accumulation: a mechanism for the phenotype of dominant β-thalassemia. Blood 83(8), 2031-2037 (1994). (Pubitemid 24112712)
-
(1994)
Blood
, vol.83
, Issue.8
, pp. 2031-2037
-
-
Hall, G.W.1
Thein, S.2
-
30
-
-
0036193436
-
Myotonia caused by mutations in the muscle chloride channel gene CLCN1
-
DOI 10.1002/humu.10063
-
Pusch M. Myotonia caused by mutations in the muscle chloride channel gene CLCN1. Hum. Mutat. 19(4), 423-434 (2002). (Pubitemid 34252324)
-
(2002)
Human Mutation
, vol.19
, Issue.4
, pp. 423-434
-
-
Pusch, M.1
-
31
-
-
38149054906
-
Does the nonsense-mediated mRNA decay mechanism prevent the synthesis of truncated BRCA1, CHK2, and p53 proteins?
-
Anczukow O, Ware MD, Buisson M et al. Does the nonsense-mediated mRNA decay mechanism prevent the synthesis of truncated BRCA1, CHK2, and p53 proteins? Hum. Mutat. 29(1), 65-73 (2008).
-
(2008)
Hum. Mutat.
, vol.29
, Issue.1
, pp. 65-73
-
-
Anczukow, O.1
Ware, M.D.2
Buisson, M.3
-
32
-
-
0027261517
-
Four novel FBN1 mutations: Significance for mutant transcript level and EGF-like domain calcium binding in the pathogenesis of Marfan syndrome
-
DOI 10.1006/geno.1993.1349
-
Dietz HC, Mcintosh I, Sakai LY et al. Four novel FBN1 mutations: significance for mutant transcript level and EGF-like domain calcium binding in the pathogenesis of Marfan syndrome. Genomics 17(2), 468-475 (1993). (Pubitemid 23231307)
-
(1993)
Genomics
, vol.17
, Issue.2
, pp. 468-475
-
-
Dietz, H.C.1
McIntosh, I.2
Sakai, L.Y.3
Corson, G.M.4
Chalberg, S.C.5
Pyeritz, R.E.6
Francomano, C.A.7
-
33
-
-
60549102070
-
Studies on nonsense mediated decay reveal novel therapeutic options for genetic diseases
-
Bashyam MD. Studies on nonsense mediated decay reveal novel therapeutic options for genetic diseases. Recent Pat. DNA Gene Seq. 3(1), 7-15 (2009).
-
(2009)
Recent Pat. DNA Gene Seq.
, vol.3
, Issue.1
, pp. 7-15
-
-
Bashyam, M.D.1
-
34
-
-
0035168526
-
Long mutant dystrophins and variable phenotypes: Evasion of nonsense-mediated decay?
-
DOI 10.1007/s004390100598
-
Kerr TP, Sewry CA, Robb SA, Roberts RG. Long mutant dystrophins and variable phenotypes: evasion of nonsense-mediated decay? Hum. Genet. 109(4), 402-407 (2001). (Pubitemid 33064519)
-
(2001)
Human Genetics
, vol.109
, Issue.4
, pp. 402-407
-
-
Kerr, T.P.1
Sewry, C.A.2
Robb, S.A.3
Roberts, R.G.4
-
35
-
-
33746928462
-
Exploring the Frontiers of Therapeutic Exon Skipping for Duchenne Muscular Dystrophy by Double Targeting within One or Multiple Exons
-
DOI 10.1016/j.ymthe.2006.02.022, PII S1525001606001298
-
Aartsma-Rus A, De Winter CL, Janson AA et al. Exploring the frontiers of therapeutic exon skipping for Duchenne muscular dystrophy by double targeting within one or multiple exons. Mol. Ther. 14(3), 401-407 (2006). (Pubitemid 44184959)
-
(2006)
Molecular Therapy
, vol.14
, Issue.3
, pp. 401-407
-
-
Aartsma-Rus, A.1
Kaman, W.E.2
Weij, R.3
Den Dunnen, J.T.4
Van Ommen, G.-J.B.5
Van Deutekom, J.C.T.6
-
37
-
-
7444230353
-
Pharmacologic therapy for stop mutations: How much CFTR activity is enough?
-
Kerem E. Pharmacologic therapy for stop mutations: how much CFTR activity is enough? Curr. Opin. Pulm. Med. 10(6), 547-552 (2004). (Pubitemid 39441452)
-
(2004)
Current Opinion in Pulmonary Medicine
, vol.10
, Issue.6
, pp. 547-552
-
-
Kerem, E.1
-
38
-
-
0141863491
-
Gentamicin-induced correction of CFTR, function in patients with cystic fibrosis and CFTR stop mutations
-
DOI 10.1056/NEJMoa022170
-
Wilschanski M, Yahav Y, Yaacov Y et al. Gentamicin-induced correction of CFTR function in patients with cystic fibrosis and CFTR stop mutations. N. Engl. J. Med. 349(15), 1433-1441 (2003). (Pubitemid 37211058)
-
(2003)
New England Journal of Medicine
, vol.349
, Issue.15
, pp. 1433-1441
-
-
Wilschanski, M.1
Yahav, Y.2
Yaacov, Y.3
Blau, H.4
Bentur, L.5
Rivlin, J.6
Aviram, M.7
Bdolah-Abram, T.8
Bebok, Z.9
Shushi, L.10
Kerem, B.11
Kerem, E.12
-
39
-
-
50149098401
-
Effectiveness of PTC124 treatment of cystic fibrosis caused by nonsense mutations: A prospective Phase II trial
-
Kerem E, Hirawat S, Armoni S et al. Effectiveness of PTC124 treatment of cystic fibrosis caused by nonsense mutations: a prospective Phase II trial. Lancet 372(9640), 719-727 (2008).
-
(2008)
Lancet
, vol.372
, Issue.9640
, pp. 719-727
-
-
Kerem, E.1
Hirawat, S.2
Armoni, S.3
-
40
-
-
36049007065
-
A novel therapeutic approach for genetic diseases by introduction of suppressor tRNA
-
Sako Y, Usuki F, Suga H. A novel therapeutic approach for genetic diseases by introduction of suppressor tRNA. Nucleic Acids Symp. Ser. (Oxf.) 50, 239-240 (2006).
-
(2006)
Nucleic Acids Symp. Ser. (Oxf.)
, vol.50
, pp. 239-240
-
-
Sako, Y.1
Usuki, F.2
Suga, H.3
|