Combined QM/MM mechanistic study of the acylation process in furin complexed with the H5N1 avian influenza virus hemagglutinin's cleavage site

Proteins: Structure, Function and Bioinformatics

Volumn 76, Issue 1, 2009, Pages 62-71

  Rungrotmongkol, Thanyada ^a   Decha, Panita ^a   Sompornpisut, Pornthep ^a   Malaisree, Maturos ^a   Intharathep, Pathumwadee ^a   Nunthaboot, Nadtanet ^b   Udommaneethanakit, Thanyarat ^a   Aruksakunwong, Ornjira ^c   Hannongbua, Supot ^a  

^a CHULALONGKORN UNIVERSITY   (Thailand)

^b MAHASARAKHAM UNIVERSITY   (Thailand)

^c RANGSIT UNIVERSITY   (Thailand)

Author keywords

Cleavage mechanism; Highly pathogenic avian influenza virus; Michaelis enzyme substrate complex; Nucleophilic attack; Proton transfer

Indexed keywords

AMIDE; ASPARAGINE; CARBON; CARBONYL CARBON; CHEMICAL COMPOUND; FURIN; HISTIDINE; NUCLEOPHILE; OXYANION; OXYGEN; SERINE; SERINE PROTEINASE; UNCLASSIFIED DRUG; VIRUS HEMAGGLUTININ;

ACYLATION; ARTICLE; BINDING SITE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONCERTED REACTION; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; INFLUENZA VIRUS A H5N1; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTON TRANSPORT; QUANTUM MECHANICS; REACTION ANALYSIS;

ACYLATION; ANIMALS; BIRDS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; FURIN; HEMAGGLUTININS; HUMANS; HYDROGEN BONDING; INFLUENZA A VIRUS, H5N1 SUBTYPE; MODELS, MOLECULAR; QUANTUM THEORY; STATIC ELECTRICITY; SUBSTRATE SPECIFICITY;

AVIAN INFLUENZA VIRUS;

EID: 66249123584     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.22318     Document Type: Article

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