A general acid-base mechanism for the stabilization of a tetrahedral adduct in a serine carboxyl peptidase: A computational study

Journal of the American Chemical Society

Volumn 127, Issue 45, 2005, Pages 15662-15663

  Guo, Haobo ^a   Wlodawer, Alexander ^b   Guo, Hong ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAL; ACID; ALDEHYDE; BASE; HYDROGEN; PEPTIDASE; SEDOLISIN; SERINE CARBOXYPEPTIDASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; HYDROGEN BOND; MOLECULAR DYNAMICS; PH; PROTON TRANSPORT; QUANTUM MECHANICS; SIMULATION; X RAY CRYSTALLOGRAPHY;

ACIDS; ALKALIES; BINDING SITES; CARBOXYPEPTIDASES; COMPUTATIONAL BIOLOGY; ENZYME STABILITY; MODELS, CHEMICAL; MOLECULAR STRUCTURE; MUTATION; SERINE; THERMODYNAMICS;

EID: 27844499177     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0520565     Document Type: Article

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