Current chemotherapy of human African trypanosomiasis

Parasitology Research

Volumn 90, Issue SUPPL.1, 2003, Pages

  Docampo, Roberto ^a   Moreno, Silvia N J ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPROTOZOAL AGENT; DIHYDROFOLATE REDUCTASE; EFLORNITHINE; GLYCOLYTIC ENZYME; MELARSOPROL; ORNITHINE DECARBOXYLASE; PENTACARINATE; PENTAMIDINE; PREDNISOLONE; SURAMIN; THYMIDINE KINASE;

ABDOMINAL PAIN; ACQUIRED IMMUNE DEFICIENCY SYNDROME; AFRICAN TRYPANOSOMIASIS; ANEMIA; ANTIBIOTIC RESISTANCE; ANTIPROTOZOAL ACTIVITY; AUTOIMMUNE DISEASE; BONE MARROW SUPPRESSION; BRAIN DISEASE; CELL LEVEL; CELLULITIS; CLINICAL TRIAL; CONVULSION; DIARRHEA; DRUG ABSORPTION; DRUG ACTIVITY; DRUG COST; DRUG DISTRIBUTION; DRUG EFFECT; DRUG EFFICACY; DRUG ELIMINATION; DRUG EXCRETION; DRUG FEVER; DRUG HALF LIFE; DRUG INDICATION; DRUG INHIBITION; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG SAFETY; DRUG SELECTIVITY; EXFOLIATIVE DERMATITIS; GENOTOXICITY; HUMAN; HYPOCALCEMIA; HYPOGLYCEMIA; LEISHMANIASIS; MONOTHERAPY; NAUSEA; NEPHROTOXICITY; NEUROLOGIC DISEASE; PHARMACOPHORE; POLYNEUROPATHY; PRIORITY JOURNAL; PRURITUS; RASH; RECURRENT DISEASE; REVIEW; SIDE EFFECT; STRUCTURE ACTIVITY RELATION; TACHYCARDIA; THORAX PAIN; TRYPANOSOMA; VOMITING;

TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA BRUCEI GAMBIENSE; TRYPANOSOMA BRUCEI RHODESIENSE;

EID: 0037625351     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-002-0752-y     Document Type: Review

References (16)

1. Barrett SV, Barrett MP (2000) Anti-sleeping sickness drugs and cancer chemotherapy. Parasitol Today 16:7-9
2. 2+-pump in plasma membrane vesicles from Trypanosoma brucei. Selective inhibition by pentamidine. Biochem J 296:759-763
3. Blum J, Burri C (2002) Treatment of late stage sleeping sickness caused by T. b. gambiense: a new approach to the use of an old drug. Swiss Med Wkly 132:51-56
4. Damper D, Patton, CL (1976) Pentamidine transport and sensitivity in brucei group trypanosomes. J Protozool 23:349-356
5. De Koning HP (2001) Transporters in African trypanosomes: role in drug action and resistance. Int J Parasitol 31:512-522
6. Denise H, Barrett, MP (2001) Uptake and mode of action of drugs against sleeping sickness. Biochem Pharmacol 61:1-5
7. Fairlamb AH, Carter NS, Cunningham M, Smith K (1992) Characterization of melarsen-resistant Trypanosoma brucei brucei with respect to cross-resistance to other drugs and trypanothione metabolism. Mol Biochem Parasitol 5:213-222
8. Friedheim EAH (1949) Mel B in the treatment of human trypanosomiasis. Am J Trop Med Hyg 29:173-192
9. Kaminsky R, Mässer P (2000) Drug resistance in African trypanosomes. Curr Opin Anti-infect Invest Drugs 2:76-82
10. Legros D, Ollivier G, Gastellu-Etchegorry M, Paquet, C, Burri, C, Jannin J, Büscher P (2002) Treatment of human African trypanosomiasis - present situation and needs for research and development. Lancet Infect Dis 2:437-440
11. Moreno SNJ (1996) Pentamidine is an uncoupler of oxidative phosphorylation in rat liver mitochondria. Arch Biochem Biophys 326:15-20
12. Pal A, Hall BS, Field MC (2000) Evidence for a non-LDL-mediated entry route for the trypanocidal drug suramin in Trypanosoma brucei. Mol Biochem Parasitol 122:217-221
13. Pépin J, Milord F (1994) The treatment of human African trypanosomiasis. Adv Parasitol 33:1-47
14. Vansterkenburg ELM, Coppens I, Wilting J, Bos OJM, Fischer MJE, Janssen LHM, Opperdoes FR (1993) The uptake of the trypanocidal drug suramin in combination with low-density lipoproteins by Trypanosoma brucei and its possible mode of action. Acta Trop 54:237-250
15. 2+, pentamidine and WR-6026 on mitochondrial membrane potential in situ. Biochem J 284:463-467
16. Wang CC (1995) Molecular mechanisms and therapeutic approaches to the treatment of African trypanosomiasis. Annu Rev Pharmacol Ther 35:93-127