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Volumn 27, Issue 2-3, 2003, Pages 149-159

Regulation, counter-regulation, and immunotherapy of autoimmune responses to immunologically privileged retinal antigens

Author keywords

Autoimmune disease; T Cells; Th1 Th2; Tolerance; Uveitis

Indexed keywords

DNA VACCINE; IMMUNOSUPPRESSIVE AGENT; IMMUNOTOXIN; INTERLEUKIN 10; INTERLEUKIN 4; MONOCLONAL ANTIBODY; RETINA ANTIGEN;

EID: 0043022039     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/IR:27:2-3:149     Document Type: Review
Times cited : (20)

References (42)
  • 2
    • 0002407688 scopus 로고
    • Experimental autoimmune uveoretinitis - Rat and mouse
    • Cohen IR, Miller A, (eds). Academic Press, San Diego
    • Caspi RR: Experimental autoimmune uveoretinitis - rat and mouse; in Cohen IR, Miller A, (eds). Animal Models for Autoimmune Diseases: A Guidebook. Academic Press, San Diego. 1994; pp. 57-81.
    • (1994) Animal Models for Autoimmune Diseases: A Guidebook , pp. 57-81
    • Caspi, R.R.1
  • 3
    • 0022873282 scopus 로고
    • Retinal specific antigens and immunopathogenic processes they provoke
    • Gery I, Mochizuki M, Nussenblatt RB: Retinal specific antigens and immunopathogenic processes they provoke. Prog Retinal Res 1986;5:75-109.
    • (1986) Prog Retinal Res , vol.5 , pp. 75-109
    • Gery, I.1    Mochizuki, M.2    Nussenblatt, R.B.3
  • 4
    • 0032827979 scopus 로고    scopus 로고
    • Regional immunity and ocular immune privilege
    • Streilein JW: Regional immunity and ocular immune privilege. Chem Immunol 1999;73:11-38.
    • (1999) Chem Immunol , vol.73 , pp. 11-38
    • Streilein, J.W.1
  • 6
    • 0025201339 scopus 로고
    • Dual effect of ciliary body cells on T lymphocyte proliferation
    • Helbig H, Gurley RC, Palestine AG, et al.: Dual effect of ciliary body cells on T lymphocyte proliferation. Eur J Immunol 1990;20:2457-2463.
    • (1990) Eur J Immunol , vol.20 , pp. 2457-2463
    • Helbig, H.1    Gurley, R.C.2    Palestine, A.G.3
  • 7
    • 0023213620 scopus 로고
    • Organ-resident, nonlymphoid cells suppress proliferation of autoimmune T-helper lymphocytes
    • Caspi RR, Roberge FG, Nussenblatt RB: Organ-resident, nonlymphoid cells suppress proliferation of autoimmune T-helper lymphocytes. Science 1987;237:1029-1032.
    • (1987) Science , vol.237 , pp. 1029-1032
    • Caspi, R.R.1    Roberge, F.G.2    Nussenblatt, R.B.3
  • 8
    • 0033987174 scopus 로고    scopus 로고
    • Transgenic expression of an immunologically privileged retinal antigen extraocularly enhances self tolerance and abrogates susceptibility to autoimmune uveitis
    • Xu H, Wawrousek EF, Redmond TM, et al.: Transgenic expression of an immunologically privileged retinal antigen extraocularly enhances self tolerance and abrogates susceptibility to autoimmune uveitis. Eur J Immunol 2000;30:272-278.
    • (2000) Eur J Immunol , vol.30 , pp. 272-278
    • Xu, H.1    Wawrousek, E.F.2    Redmond, T.M.3
  • 9
    • 0031255108 scopus 로고    scopus 로고
    • Thymic expression of autoantigens correlates with resistance to autoimmune disease
    • Egwuagu CE, Charukamnoetkanok P, Gery I: Thymic expression of autoantigens correlates with resistance to autoimmune disease. J Immunol 1997;159:3109-3112.
    • (1997) J Immunol , vol.159 , pp. 3109-3112
    • Egwuagu, C.E.1    Charukamnoetkanok, P.2    Gery, I.3
  • 10
    • 0035171545 scopus 로고    scopus 로고
    • Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
    • Derbinski J, Schulte A, Kyewski B, Klein L: Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat Immunol 2001;2:1032-1039.
    • (2001) Nat Immunol , vol.2 , pp. 1032-1039
    • Derbinski, J.1    Schulte, A.2    Kyewski, B.3    Klein, L.4
  • 11
    • 0032526453 scopus 로고    scopus 로고
    • Early onset photoreceptor abnormalities induced by targeted disruption of the interphotoreceptor retinoid-binding protein gene
    • Liou GI, Fei Y, Peachey NS, et al.: Early onset photoreceptor abnormalities induced by targeted disruption of the interphotoreceptor retinoid-binding protein gene. J Neurosci 1998;18:4511-4520.
    • (1998) J Neurosci , vol.18 , pp. 4511-4520
    • Liou, G.I.1    Fei, Y.2    Peachey, N.S.3
  • 12
    • 0041638002 scopus 로고    scopus 로고
    • Immunologically privileged expression of a sequestered ocular antigen results in tolerance
    • Caspi RR, Avichezer D, Chan C-C, et al. Immunologically privileged expression of a sequestered ocular antigen results in tolerance. FASEB J 2002;16:A 1066.
    • (2002) FASEB J , vol.16
    • Caspi, R.R.1    Avichezer, D.2    Chan, C.-C.3
  • 13
    • 0031570957 scopus 로고    scopus 로고
    • Genetic susceptibility to experimental autoimmune uveitis involves more than a predisposition to generate a T helper-1-like or a T helper-2-like response
    • Sun B, Rizzo LV, Sun SH, et al.: Genetic susceptibility to experimental autoimmune uveitis involves more than a predisposition to generate a T helper-1-like or a T helper-2-like response. J Immunol 1997;159:1004-1011.
    • (1997) J Immunol , vol.159 , pp. 1004-1011
    • Sun, B.1    Rizzo, L.V.2    Sun, S.H.3
  • 14
    • 0030587090 scopus 로고    scopus 로고
    • Genetic susceptibility to experimental autoimmune uveoretinitis in the rat is associated with an elevated Th1 response
    • Caspi RR, Silver PB, Chan CC, et al.: Genetic susceptibility to experimental autoimmune uveoretinitis in the rat is associated with an elevated Th1 response. J Immunol 1996;157:2668-2675.
    • (1996) J Immunol , vol.157 , pp. 2668-2675
    • Caspi, R.R.1    Silver, P.B.2    Chan, C.C.3
  • 15
    • 0032754609 scopus 로고    scopus 로고
    • The requirement for pertussis to induce EAU is strain-dependent: B10.RIII, but not B10.A mice, develop EAU and Th1 responses to IRBP without pertussis treatment
    • Silver PB, Chan CC, Wiggert B, Caspi RR: The requirement for pertussis to induce EAU is strain-dependent: B10.RIII, but not B10.A mice, develop EAU and Th1 responses to IRBP without pertussis treatment. Invest Ophthalmol Vis Sci 1999;40:2898-2905.
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 2898-2905
    • Silver, P.B.1    Chan, C.C.2    Wiggert, B.3    Caspi, R.R.4
  • 16
    • 0032877699 scopus 로고    scopus 로고
    • Immunopathogenic mechanisms in intraocular inflammation
    • Forrester JV, McMenamin PG: Immunopathogenic mechanisms in intraocular inflammation. Chem Immunol 1999;73:159-185.
    • (1999) Chem Immunol , vol.73 , pp. 159-185
    • Forrester, J.V.1    McMenamin, P.G.2
  • 17
    • 0031965903 scopus 로고    scopus 로고
    • T cell traffic and the inflammatory response in experimental autoimmune uveoretinitis
    • Prendergast RA, Iliff CE, Coskuncan NM, et al.: T cell traffic and the inflammatory response in experimental autoimmune uveoretinitis. Invest Ophthalmol Vis Sci 1998;39:754-762.
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 754-762
    • Prendergast, R.A.1    Iliff, C.E.2    Coskuncan, N.M.3
  • 18
    • 0027483929 scopus 로고
    • Recruitment of antigen-nonspecific cells plays a pivotal role in the pathogenesis of a T cell-mediated organ-specific autoimmune disease, experimental autoimmune uveoretinitis
    • Caspi RR, Chan CC, Fujino Y, et al.: Recruitment of antigen-nonspecific cells plays a pivotal role in the pathogenesis of a T cell-mediated organ-specific autoimmune disease, experimental autoimmune uveoretinitis. J Neuroimmunol 1993;47:177-188.
    • (1993) J Neuroimmunol , vol.47 , pp. 177-188
    • Caspi, R.R.1    Chan, C.C.2    Fujino, Y.3
  • 19
    • 0035399951 scopus 로고    scopus 로고
    • Pertussis toxin inhibits induction of tissue-specific autoimmune disease by disrupting G protein-coupled signals
    • Su SB, Silver PB, Zhang M, et al.: Pertussis toxin inhibits induction of tissue-specific autoimmune disease by disrupting G protein-coupled signals. J Immunol 2001;167:250-256.
    • (2001) J Immunol , vol.167 , pp. 250-256
    • Su, S.B.1    Silver, P.B.2    Zhang, M.3
  • 20
  • 21
    • 0031586024 scopus 로고    scopus 로고
    • Uveitogenicity is associated with a Th1-like lymphokine profile: Cytokine-dependent modulation of early and committed effector T cells in experimental autoimmune uveitis
    • Xu H, Rizzo LV, Silver PB, Caspi RR: Uveitogenicity is associated with a Th1-like lymphokine profile: cytokine-dependent modulation of early and committed effector T cells in experimental autoimmune uveitis. Cell Immunol 1997;178:69-78.
    • (1997) Cell Immunol , vol.178 , pp. 69-78
    • Xu, H.1    Rizzo, L.V.2    Silver, P.B.3    Caspi, R.R.4
  • 22
    • 0031813361 scopus 로고    scopus 로고
    • IL-10 has a protective role in experimental autoimmune uveoretinitis
    • Rizzo LV, Xu H, Chan CC, et al.: IL-10 has a protective role in experimental autoimmune uveoretinitis. Int Immunol 1998;10:807-814.
    • (1998) Int Immunol , vol.10 , pp. 807-814
    • Rizzo, L.V.1    Xu, H.2    Chan, C.C.3
  • 23
    • 0033836979 scopus 로고    scopus 로고
    • Evaluation of in vivo cytokine expression in EAU-susceptible and resistant rats: A role for IL-10 in resistance?
    • Sun B, Sun SH, Chan CC, Caspi RR: Evaluation of in vivo cytokine expression in EAU-susceptible and resistant rats: a role for IL-10 in resistance? Exp Eye Res 2000;70:493-502.
    • (2000) Exp Eye Res , vol.70 , pp. 493-502
    • Sun, B.1    Sun, S.H.2    Chan, C.C.3    Caspi, R.R.4
  • 24
    • 0028181363 scopus 로고
    • Endogenous systemic IFN-gamma has a protective role against ocular autoimmunity in mice
    • Caspi RR, Chan CC, Grubbs BG, et al.: Endogenous systemic IFN-gamma has a protective role against ocular autoimmunity in mice. J Immunol 1994;152:890-899.
    • (1994) J Immunol , vol.152 , pp. 890-899
    • Caspi, R.R.1    Chan, C.C.2    Grubbs, B.G.3
  • 25
    • 0034601012 scopus 로고    scopus 로고
    • Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis
    • Chu CQ, Wittmer S, Dalton DK: Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis. J Exp Med 2000;192:123-128.
    • (2000) J Exp Med , vol.192 , pp. 123-128
    • Chu, C.Q.1    Wittmer, S.2    Dalton, D.K.3
  • 26
    • 0026547871 scopus 로고
    • Genetic control of susceptibility to experimental autoimmune uveoretinitis in the mouse model. Concomitant regulation by MHC and non-MHC genes
    • Caspi RR, Grubbs BG, Chan CC, et al.: Genetic control of susceptibility to experimental autoimmune uveoretinitis in the mouse model. Concomitant regulation by MHC and non-MHC genes. J Immunol 1992;148:2384-2389.
    • (1992) J Immunol , vol.148 , pp. 2384-2389
    • Caspi, R.R.1    Grubbs, B.G.2    Chan, C.C.3
  • 27
    • 0025831088 scopus 로고
    • Regulation of experimental autoimmune uveitis in rats - Separation of MHC and non-MHC gene effects
    • Hirose S, Ogasawara K, Natori T, et al.: Regulation of experimental autoimmune uveitis in rats - separation of MHC and non-MHC gene effects. Clin Exp Immunol 1991;86:419-425.
    • (1991) Clin Exp Immunol , vol.86 , pp. 419-425
    • Hirose, S.1    Ogasawara, K.2    Natori, T.3
  • 28
    • 0032902739 scopus 로고    scopus 로고
    • Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats
    • Sun SH, Silver PB, Caspi RR, et al.: Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats. Int Immunol 1999;11:529-534.
    • (1999) Int Immunol , vol.11 , pp. 529-534
    • Sun, S.H.1    Silver, P.B.2    Caspi, R.R.3
  • 29
    • 0032544004 scopus 로고    scopus 로고
    • Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases
    • Becker KG, Simon RM, Bailey-Wilson JE, et al.: Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases. Proc Natl Acad Sci USA 1998;95:9979-9984.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9979-9984
    • Becker, K.G.1    Simon, R.M.2    Bailey-Wilson, J.E.3
  • 30
    • 0034327175 scopus 로고    scopus 로고
    • Blockade of costimulation through B7/CD28 inhibits experimental autoimmune uveoretinitis, but does not induce long-term tolerance
    • Silver PB, Hathcock KS, Chan CC, et al.: Blockade of costimulation through B7/CD28 inhibits experimental autoimmune uveoretinitis, but does not induce long-term tolerance. J Immunol 2000;165:5041-5047.
    • (2000) J Immunol , vol.165 , pp. 5041-5047
    • Silver, P.B.1    Hathcock, K.S.2    Chan, C.C.3
  • 31
    • 0031570381 scopus 로고    scopus 로고
    • IFN-gamma-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response
    • Jones LS, Rizzo LV, Agarwal RK, et al.: IFN-gamma-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response. J Immunol 1997;158:5997-6005.
    • (1997) J Immunol , vol.158 , pp. 5997-6005
    • Jones, L.S.1    Rizzo, L.V.2    Agarwal, R.K.3
  • 32
    • 0030739650 scopus 로고    scopus 로고
    • Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease
    • Lafaille JJ, Keere FV, Hsu AL, et al.: Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease. J Exp Med 1997;186:307-312.
    • (1997) J Exp Med , vol.186 , pp. 307-312
    • Lafaille, J.J.1    Keere, F.V.2    Hsu, A.L.3
  • 33
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
    • Bielekova B, Goodwin B, Richert N, et al.: Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat Med 2000;6:1167-1175.
    • (2000) Nat Med , vol.6 , pp. 1167-1175
    • Bielekova, B.1    Goodwin, B.2    Richert, N.3
  • 34
    • 0033791462 scopus 로고    scopus 로고
    • Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial
    • The Altered Peptide Ligand in Relapsing MS Study Group
    • Kappos L, Comi G, Panitch H, et al.: Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. The Altered Peptide Ligand in Relapsing MS Study Group. Nat Med 2000;6:1176-1182.
    • (2000) Nat Med , vol.6 , pp. 1176-1182
    • Kappos, L.1    Comi, G.2    Panitch, H.3
  • 35
    • 0025347507 scopus 로고
    • Inhibition of S-antigen induced experimental autoimmune uveoretinitis by oral induction of tolerance with S-antigen
    • Nussenblatt RB, Caspi RR, Mahdi R, et al.: Inhibition of S-antigen induced experimental autoimmune uveoretinitis by oral induction of tolerance with S-antigen. J Immunol 1990;144:1689-1695.
    • (1990) J Immunol , vol.144 , pp. 1689-1695
    • Nussenblatt, R.B.1    Caspi, R.R.2    Mahdi, R.3
  • 36
    • 0028041556 scopus 로고
    • Interleukin-2 treatment potentiates induction of oral tolerance in a murine model of autoimmunity
    • Rizzo LV, Miller-Rivero NE, Chan CC, et al.: Interleukin-2 treatment potentiates induction of oral tolerance in a murine model of autoimmunity. J Clin Invest 1994;94:1668-1672.
    • (1994) J Clin Invest , vol.94 , pp. 1668-1672
    • Rizzo, L.V.1    Miller-Rivero, N.E.2    Chan, C.C.3
  • 37
    • 0032146847 scopus 로고    scopus 로고
    • Heterologous epitopes of IRBP protect against autoimmune uveitis induced by the autologous epitope
    • Silver PB, Rizzo LV, Sun B, et al.: Heterologous epitopes of IRBP protect against autoimmune uveitis induced by the autologous epitope. J Neuroimmunol 1998;88:128-136.
    • (1998) J Neuroimmunol , vol.88 , pp. 128-136
    • Silver, P.B.1    Rizzo, L.V.2    Sun, B.3
  • 38
    • 0030757911 scopus 로고    scopus 로고
    • Oral tolerance in a murine model of relapsing experimental autoimmune uveoretinitis (EAU): Induction of protective tolerance in primed animals
    • Thurau SR, Chan CC, Nussenblatt RB, Caspi RR: Oral tolerance in a murine model of relapsing experimental autoimmune uveoretinitis (EAU): induction of protective tolerance in primed animals. Clin Exp Immunol 1997;109:370-376.
    • (1997) Clin Exp Immunol , vol.109 , pp. 370-376
    • Thurau, S.R.1    Chan, C.C.2    Nussenblatt, R.B.3    Caspi, R.R.4
  • 39
    • 0030946927 scopus 로고    scopus 로고
    • Treatment of uveitis by oral administration of retinal antigens: Results of a phase I/II randomized masked trial
    • Nussenblatt RB, Gery I, Weiner HL, et al.: Treatment of uveitis by oral administration of retinal antigens: results of a phase I/II randomized masked trial. Am J Ophthalmol 1997;123:583-592.
    • (1997) Am J Ophthalmol , vol.123 , pp. 583-592
    • Nussenblatt, R.B.1    Gery, I.2    Weiner, H.L.3
  • 40
    • 0033106370 scopus 로고    scopus 로고
    • IL-4 and IL-10 are both required for the induction of oral tolerance
    • Rizzo LV, Morawetz RA, Miller-Rivero NE, et al.: IL-4 and IL-10 are both required for the induction of oral tolerance. J Immunol 1999;162:2613-2622.
    • (1999) J Immunol , vol.162 , pp. 2613-2622
    • Rizzo, L.V.1    Morawetz, R.A.2    Miller-Rivero, N.E.3
  • 41
    • 0033927572 scopus 로고    scopus 로고
    • Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis
    • Agarwal RK, Kang Y, Zambidis E, et al.: Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis. J Clin Invest 2000;106:245-252.
    • (2000) J Clin Invest , vol.106 , pp. 245-252
    • Agarwal, R.K.1    Kang, Y.2    Zambidis, E.3
  • 42
    • 4243334659 scopus 로고    scopus 로고
    • Vaccination with a plasmid encoding retinal interphotoreceptor retinoid-binding protein (IRBP) protects mice against experimental autoimmune uveitis (EAU)
    • Agarwal R, Silver P, Su S-B, et al.: Vaccination with a plasmid encoding retinal interphotoreceptor retinoid-binding protein (IRBP) protects mice against experimental autoimmune uveitis (EAU). FASEB J 2002;16:A1066.
    • (2002) FASEB J , vol.16
    • Agarwal, R.1    Silver, P.2    Su, S.-B.3


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