Calcium regulating hormones and serum calcium and magnesium concentrations in septic and critically ill foals and their association with survival

Journal of Veterinary Internal Medicine

Volumn 23, Issue 2, 2009, Pages 335-343

  Hurcombe, S D A ^a   Toribio, R E ^a   Slovis, N M ^b   Saville, W J ^a   Mudge, M C ^a   MacGillivray, K ^b   Frazer, M L ^b  

^a OHIO STATE UNIVERSITY   (United States)

^b HAGYARD EQUINE MEDICAL INSTITUTE   (United States)

Author keywords

Endocrine; Equine; Mortality; Neonate; Sepsis

Indexed keywords

ANIMALIA; EQUIDAE;

CALCITONIN; CALCIUM; MAGNESIUM; PARATHYROID HORMONE; PARATHYROID HORMONE RELATED PROTEIN; PEPTIDE HORMONE;

ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; FEMALE; HORSE; HORSE DISEASE; MALE; NEWBORN; PROSPECTIVE STUDY; SEPSIS; SURVIVAL;

ANIMALS; ANIMALS, NEWBORN; CALCITONIN; CALCIUM; FEMALE; HORSE DISEASES; HORSES; MAGNESIUM; MALE; PARATHYROID HORMONE; PARATHYROID HORMONE-RELATED PROTEIN; PEPTIDE HORMONES; PROSPECTIVE STUDIES; SEPSIS; SURVIVAL ANALYSIS;

EID: 66149107516     PISSN: 08916640     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1939-1676.2009.0275.x     Document Type: Article

References (55)

1. Carlstedt F, Lind L, Rastad J, et al. Parathyroid hormone and ionized calcium levels are related to the severity of illness and survival in critically ill patients. Eur J Clin Invest 1998;28:898-903.
2. Toribio RE, Kohn CW, Chew DJ, et al. Comparison of serum parathyroid hormone and ionized calcium and magnesium concentrations and fractional urinary clearance of calcium and phosphorus in healthy horses and horses with enterocolitis. Am J Vet Res 2001;62:938-947.
3. Toribio RE, Kohn CW, Hardy J, et al. Alterations in serum parathyroid hormone and electrolyte concentrations and urinary excretion of electrolytes in horses with induced endotoxemia. J Vet Intern Med 2005;19:223-231.
4. Johansson AM, Gardner SY, Jones SL, et al. Hypomagnesemia in hospitalized horses. J Vet Intern Med 2003;17:860-867.
5. Gayle JM, Cohen ND, Chaffin MK. Factors associated with survival in septicemic foals: 65 cases (1988-1995). J Vet Intern Med 1998;12:140-146.
6. Furr MO, Tinker MK, Edens L. Prognosis for neonatal foals in an intensive care unit. J Vet Intern Med 1997;11:183-188.
7. Cohen ND. Causes of and farm management factors associated with disease and death in foals. J Am Vet Med Assoc 1994;204:1644-1651.
8. Hurcombe SDA, Toribio RE, Slovis N, et al. Blood arginine vasopressin, adrenocorticotropin hormone and cortisol concentrations at admission in septic and critically ill foals and their association with survival. J Vet Intern Med 2008;22:639-647.
9. Slack JA, McGuirk S, Erb HN, et al. Biochemical markers of cardiac injury in normal, surviving septic, or non-surviving septic foals. J Vet Intern Med 2005;19:577-580.
10. Peek SF, Semrad S, McGuirk SM, et al. Prognostic value of clinicopathologic variables obtained at admission and effect of antiendotoxin plasma on survival in septic and critically ill foals. J Vet Intern Med 2006;20:569-574.
11. Rohrbach BW, Buchanan BR, Drake JM, et al. Use of a multivariable model to estimate the probability of discharge in hospitalized foals that are 7 days of age or less. J Am Vet Med Assoc 2006;228:1748-1755.
12. Corley KTT, Donaldson LL, Furr MO. Arterial lactate concentration, hospital survival, sepsis and SIRS in critically ill neonatal foals. Equine Vet J 2005;37:53-59.
13. Brewer BD, Koterba AM. Development of a scoring system for the early diagnosis of equine neonatal sepsis. Equine Vet J 1988; 20:18-22.
14. Gold JR, Divers TJ, Barton MH, et al. Plasma adrenocorticotropin, cortisol, and adrenocorticotropin/cortisol ratios in septic and normal-term foals. J Vet Intern Med 2007;21:791-796.
15. Berlin D, Aroch I. Concentrations of ionized and total magnesium and calcium in healthy horses: Effects of age, pregnancy, lactation, pH and sample type. Vet J 2008, available online.
16. Hintz HF, Schryver HH. Magnesium metabolism in the horse. J Anim Sci 1972;35:755-759.
17. Care AD. Fetal calcium homeostasis. Equine Vet J 1997; 24(Suppl):59-61.
18. Rosol TJ, Nagode LA, Robertson JT, et al. Humoral hypercalcemia of malignancy associated with ameloblastoma in a horse. J Am Vet Med Assoc 1994;204:1930-1933.
19. Barton MH, Sharma P, LeRoy BE, et al. Hypercalcemia and high serum parathyroid hormone-related protein concentration in a horse with multiple myeloma. J Am Vet Med Assoc 2004;225: 409-413.
20. Lind L, Carlstedt F, Rastad J, et al. Hypocalcemia and parathyroid hormone secretion in critically ill patients. Crit Care Med 2000;28:93-99.
21. Dacey MJ. Hypomagnesemic disorders. Crit Care Clin 2001;17:155-173.
22. Estepa JC, Aguilera-Tejero E, Mayer-Valor R, et al. Measurement of parathyroid hormone in horses. Equine Vet J 1998; 30:476-481.
23. Burchard KW, Gann DS, Colliton J, et al. Ionized calcium, parathormone, and mortality in critically ill surgical patients. Ann Surg 1990;212:543-550.
24. Nakamura T, Mimura Y, Uno K, et al. Parathyroid hormone activity increases during endotoxemia in conscious rats. Horm Metab Res 1988;30:88-92.
25. 2+ and other ions as extracellular (first) messengers. Phys Rev 1991;71:371-411.
26. Joborn H, Hjemdahl P, Larsson PT, et al. Effects of prolonged adrenaline infusion and of mental stress on plasma minerals and parathyroid hormone. Clin Physiol 1990;10:37-53.
27. Lopez I, Aguilera-Tejero E, Felsenfeld AJ, et al. Direct effect of acute metabolic and respiratory acidosis on parathyroid hormone secretion in the dog. J Bone Miner Res 2002;17:1691-1700.
28. Carlstedt F, Lind L. Hypocalcemic syndromes. Crit Care Clin 2001;17:139-153.
29. Zaloga GP, Malcolm D, Chernow B, et al. Endotoxin-induced hypocalcemia results in defective calcium mobilization in rats. Circ Shock 1988;24:143-148.
30. Katz MS, Gutierrez GE, Mundy GR, et al. Tumor necrosis factor and interleukin 1 inhibit parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by down-regulating parathyroid hormone receptors. J Cell Physiol 1992;153:206-213.
31. Angeletti RH, D'Amico T, Ashok S, et al. The chemokine interleukin-8 regulates parathyroid secretion. J Bone Miner Res 1988;13:1232-1237.
32. Carlstedt F, Ridefelt P, Lind L, et al. Interleukin-6 induced suppression of bovine parathyroid hormone secretion. Biosci Rep 1999;19:35-42.
33. Toribio RE, Kohn CW, Capen CC, et al. Parathyroid hormone (PTH) secretion, PTH mRNA and calcium sensing receptor mRNA expression in equine parathyroid cells, and effects of interleukin (IL)-1, IL-6, and tumor necrosis factor-alpha on equine parathyroid cell function. J Mol Endocrinol 2003;31:609-620.
34. Pusterla N, Magdesian KG, Mapes S, et al. Expression of molecular markers in blood of neonatal foals with sepsis. Am J Vet Res 2006;67:1045-1049.
35. Nagata S, Takeda F, Kurosawa M, et al. Plasma adrenocorticotropin, cortisol and catecholamine responses to various exercises. Equine Vet J 1999;30:570-574.
36. Vervuert I, Stanik K, Coenen M. Effects of different levels of calcium and phosphorus intake on calcium homeostasis in exercising horses. Equine Vet J 2006;36(Suppl):659-663.
37. Vervuert I, Coenen M, Wedemeyer U, et al. Calcium homeostasis and intact plasma parathyroid hormone during exercise and training in young Standardbred horses. Equine Vet J 2002; 34:713-718.
38. Aguilera-Tejero E, Estepa JC, Lopez I, et al. Plasma ionized calcium and parathyroid hormone concentrations in horses after endurance rides. J Am Vet Med Assoc 2001;219:488-490.
39. Muller B, Becker KL, Kranzlin M, et al. Disordered calcium homeostasis of sepsis: Association with calcitonin precursors. Eur J Clin Invest 2000;30:823-831.
40. Gallardo J, Fardella P, Pumarino H, et al. Plasma calcium levels in critical patients with and without sepsis. Rev Med Chil 1991;119:262-266.
41. Beyer MJ, Freestone JF, Reimer JM, et al. Idiopathic hypocalcemia in foals. J Vet Intern Med 1997;11:356-360.
42. Garcia-Lopez JM, Provost PJ, Rush JE, et al. Prevalence and prognostic importance of hypomagnesemia and hypocalcemia in horses that have colic surgery. Am J Vet Res 2001;62:7-12.
43. Pantaleon LG, Furr MO, McKenzie HC, et al. Effects of small- and large-volume resuscitation on coagulation and electrolytes during experimental endotoxemia in anesthetized horses. J Vet Intern Med 2007;21:1374-1379.
44. Delesalle C, Dewulf J, Lefebvre RA, et al. Use of plasma ionized calcium and Ca21 substitution response patterns as prognostic parameters for ileus and survival in colic horses. Vet Q 2005;27:157-172.
45. Carlstedt F, Erickson M, Kiiski R, et al. Hypocalcemia during porcine endotoxemic shock: Effects of calcium administration. Crit Care Med 2000;28:2909-2914.
46. Zaloga GP. Ionized hypocalcemia during sepsis. Crit Care Med 2000;28:266-268.
47. Suh SM, Tashjian AH, Matsuo N, et al. Pathogenesis of hypocalcemia in primary hypomagnesemia: Normal end-organ responsiveness to parathyroid hormone, impaired parathyroid gland function. J Clin Invest 1973;52:153-160.
48. Alexander SL, Irvine CHG. The effect of endotoxin administration on the secretory dynamics of oxytocin in follicular phase mares: Relationship to stress axis hormones. J Neuroendocrinol 2002;14:540-548.
49. Fatemi S, Ryzen E, Flores J, et al. Effect of experimental human magnesium depletion on parathyroid hormone secretion and 1,25-dihydroxyvitamin D metabolism. J Clin Endocrinol Metab 1991;73:1067-1072.
50. Whang KT, Steinwald PM, White JC, et al. Serum calcitonin precursors in sepsis and systemic inflammation. J Clin Endocrinol Metab 1998;83:3296-3301.
51. Assicot M, Gendrel D, Carsin H, et al. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 1993;341:515-518.
52. Uzzan B, Cohen R, Nicolas P, et al. Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: A systematic review and meta-analysis. Crit Care Med 2006;34:1996-2003.
53. Tang BM, Eslick GD, Craig JC, et al. Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: Systematic review and meta-analysis. Lancet Infect Dis 2007;7:210-217.
54. Harrington DD. Influence of magnesium deficiency on horse foal tissue concentration of Mg, calcium and phosphorus. Br J Nutr 1975;34:45-57.
55. Holowaychuk MK, Martin LG. Review of hypocalcemia in septic patients. J Vet Emerg Crit Care 2007;17:348-358.