Parathyroid hormone and ionized calcium levels are related to the severity of illness and survival in critically ill patients

European Journal of Clinical Investigation

Volumn 28, Issue 11, 1998, Pages 898-903

  Carlstedt, F ^a   Lind, L ^a   Rastad, J ^a   Stjernstrom H ^a   Wide, L ^a   Ljunghall, S ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

APACHE II; Critically ill; Intensive care unit; Ionized calcium; Mortality; Parathyroid hormone

Indexed keywords

CALCIUM ION; PARATHYROID HORMONE;

ARTICLE; CALCIUM BLOOD LEVEL; CRITICAL ILLNESS; DISEASE SEVERITY; HUMAN; HYPOCALCEMIA; INTENSIVE CARE; MAJOR CLINICAL STUDY; MAJOR SURGERY; PARATHYROID HORMONE BLOOD LEVEL; PRIORITY JOURNAL; SEPSIS; SURVIVAL;

AGED; APACHE; CALCIUM; CRITICAL ILLNESS; FEMALE; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; PARATHYROID HORMONE;

EID: 0031774164     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.1998.00391.x     Document Type: Article

References (36)

1. Desai TK, Carlson RW, Geheb MA. Prevalence and clinical implications of hypocalcemia in acutely ill patients in a medical intensive care setting. Am J Med 1988; 84: 209-14.
2. Zaloga GP. Hypocalcemia in critically ill patients. Crit Care Med 1992; 20 (2): 251-62.
3. Burchard KW, Gann DS, Colliton J, Forster J. Ionized calcium, parathormone, and mortality in critically ill surgical patients. Ann Surg 1990; 212: 543-9.
4. Forman DT, Lorenzo L. Ionized calcium: its significance and clinical usefulness. Ann Clin Lab Sci 1991; 21 (5): 297-304.
5. Henderson SA, Graham HK, Mollan RA. Serum and other calcium fractions in patients after severe musculoskeletal trauma. Clin Orthop 1992; 275: 306-11.
6. McKay C, Beastall GH, Imrie CW, Baxter JN. Circulating intact parathyroid hormone levels in acute pancreatitis. Br J Surs 1994; 81 (3): 357-60.
7. Carlstedt F, Lind L, Wide L, et al. Serum levels of parathyroid hormone are related to the mortality and severity of illness in patients in the emergency department [see comments]. Eur J Clin Invest 1997; 27: 977-81.
8. Zaloga GP, Chernow B. The multifactorial basis for hypocalcemia during sepsis. Studies of the parathyroid hormone-vitamin D axis. Ann Intern Med 1987; 107 (1): 36-41.
9. Dettelbach MA, Deftos LJ, Stewart AF. Intraperitoneal free fatty acids induce severe hypocalcemia in rats: a model for the hypocalcemia of pancreatitis. J Bone Miner Res 1990; 5: 1249-55.
10. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine [see comments]. Chest 1992; 101: 1644-55.
11. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med 1985; 13: 818-29.
12. Nussbaum SR, Zahradnik RJ, Lavigne JR, et al. Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia. Clin Chem 1987; 33: 1364-7.
13. Robertson WG, Marshall RW. Ionized calcium in body fluids. CRC Rev Clin Lab Sci 1981; 15: 85-125.
14. Prielipp RC, Zaloga GP. Life-threatening hypocalcemia after abdominal aortic aneurysm repair in patients with renal insufficiency. Anesth Analg 1991; 73: 638-41.
15. Ljunghall S. Influence of magnesium on parathyroid hormone secretion and action. Rev Magnesium Bull 1986; 8: 237-43.
16. Brown EM. Extracellular Ca2+ sensing, regulation of parathyroid cell function, and role of Ca2+ and other ions as extracellular (first) messengers. Phys Rev 1991; 71: 371-411.
17. de Werra I, Jaccard C, Corradin SB, et al. Cytokines, nitrite/ nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations: comparisons in patients with septic shock, cardiogenic shock, and bacterial pneumonia. Crit Care Med 1997; 25: 607-13.
18. Dinarello CA. Cytokines as mediators in the pathogenesis of septic shock. Curr Top Microbiol Immunol 1996; 216: 133-65.
19. Dofferhoff AS, de Bom VJ, VHH, et al. Patterns of cytokines, plasma endotoxin, plasminogen activator inhibitor, and acute-phase proteins during the treatment of severe sepsis in humans. Crit Care Med 1992; 20: 185-92.
20. Moldawer LL. Biology of proinflammatory cytokines and their antagonists. Crit Care Med 1994; 22: 53-7.
21. Hoch RC, Rodriguez R, Manning T, et al. Effects of accidental trauma on cytokine and endotoxin production [see comments]. Crit Care Med 1993; 21: 839-45.
22. Roumen RM, Hendriks T, van der Meer JW, et al. Cytokine patterns in patients after major vascular surgery, hemorrhagic shock, and severe blunt trauma. Relation with subsequent adult respiratory distress syndrome and multiple organ failure. Ann Surg 1993; 218: 769-76.
23. Hotchkiss RS, Karl IE. Calcium: a regulator of the inflammatory response in endotoxemia and sepsis. New Horiz 1996; 4: 58-71.
24. Hotchkiss RS, Karl IE. Ca2+, a regulator of the inflammatory response - the good, the bad, and the possibilities [editorial; comment]. Shock 1997; 7 (4): 308-10.
25. Katz MS, Gutierrez GE, Mundy GR, Hymer TK, Caulfield MP, McKee RL. Tumor necrosis factor and interleukin 1 inhibit parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by down-regulating parathyroid hormone receptors. J Cell Physiol 1992; 153: 206-13.
26. Greenfield EM, Shaw SM, Gornik SA, Banks MA. Adenyl cyclase and interleukin 6 are downstream effectors of parathyroid hormone resulting in stimulation of bone resorption. J Clin Invest 1995; 96: 1238-44.
27. Weryha G, Leclère J. Paracrine regulation of bone remodeling. Horm Ref 1995; 43: 69-75.
28. Jiang Y, Yoshida A, Ishioka C, Kimata H, Mikawa H. Parathyroid hormone inhibits immunoglobulin production without affecting cell growth in human B cells. Clin Immunol Immunopathol 1992; 65: 286-93.
29. Klinger M, Alexiewicz JM, Linker IM et al. Effect of parathyroid hormone on human T cell activation. Kidney Int 1990; 37: 1543-51.
30. af Ekenstam E, Benson L, Hallgren R, Wide L, Ljunghall S. Impaired secretion of parathyroid hormone in patients with rheumatoid arthritis: relationship to inflammatory activity. Clin Endocrinol Oxf 1990; 32: 323-8.
31. Song SK, Karl IE, Ackerman JJ, Hotchkiss RS. Increased intracellular Ca2+: a critical link in the pathophysiology of sepsis? Proc Natl Acad Sci USA 1993; 90: 3933-7.
32. Joborn H, Hjemdahl P, Larsson PT et al. Effects of prolonged adrenaline infusion and of mental stress on plasma minerals and parathyroid hormone [published erratum appears in Clin Physiol 1990; 10: 403]. Clin Physiol 1990; 10: 37-53.
33. Brown EM, Hurwitz S, Woodard CJ, Aurbach GD. Direct identification of beta-adrenergic receptors on isolated bovine parathyroid cells. Endocrinology 1977; 100: 1703-9.
34. Wuster C. Parathyroid hormone - a new prognostic marker of mortality? [Comment]. Eur J Clin Invest 1997; 27: 982-3.
35. Vincent JL, Bredas P, Jankowski S, Kahn RJ. Correction of hypocalcaemia in the critically ill: what is the haemodynamic benefit? Intensive Care Med 1995; 21: 838-41.
36. Zaloga GP, Sager A, Black KW, Prielipp R. Low dose calcium administration increases mortality during septic peritonitis in rats. Circ Shock 1992; 37: 226-9.