Hypercalcomia hypercalcemia and high serum parathyroid hormone-related protein concentration in a horse with multiple myeloma

Journal of the American Veterinary Medical Association

Volumn 225, Issue 3, 2004, Pages 409-413+376

  Barton, Michelle Henry ^a   Sharma, Prachi ^a   LeRoy, Bruce E ^a   Howerth, Elizabeth W ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; PARATHYROID HORMONE; PARATHYROID HORMONE RELATED PROTEIN;

ANIMAL TISSUE; ARTICLE; AUTOPSY; DIFFERENTIAL DIAGNOSIS; DISEASE COURSE; HISTOPATHOLOGY; HORSE DISEASE; HYPERCALCEMIA; IMMUNODIFFUSION; LABORATORY TEST; MULTIPLE MYELOMA; NONHUMAN; PARACENTESIS; PARATHYROID HORMONE BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN ELECTROPHORESIS; QUANTITATIVE ANALYSIS; ANIMAL; ANIMAL DISEASE; BLOOD; CASE REPORT; FATALITY; HORSE; IMMUNOHISTOCHEMISTRY; MALE;

ANIMALIA; EQUUS CABALLUS;

ANIMALS; DIAGNOSIS, DIFFERENTIAL; FATAL OUTCOME; HORSE DISEASES; HORSES; HYPERCALCEMIA; IMMUNOHISTOCHEMISTRY; MALE; MULTIPLE MYELOMA; PARATHYROID HORMONE; PARATHYROID HORMONE-RELATED PROTEIN;

EID: 4644243839     PISSN: 00031488     EISSN: None     Source Type: Journal    
DOI: 10.2460/javma.2004.225.409     Document Type: Article

References (24)

1. Schott H. Examination of the urinary system. In: Reed S, Bayly W, eds. Equine internal medicine. Philadelphia: WB Saunders Co, 1998;836.
2. Roussel AJ, Lin YC, Striat JR, et al. Radioimmunoassay for parathyroid hormone in equids. Am J Vet Res 1987;48:586-589.
3. Morris DD, Crowe N, Moore JN. Correlation of clinical and laboratory data with serum tumor necrosis factor activity in horses with experimentally induced endotoxemia. Am J Vet Res 1990;51:1935-1940.
4. Edwards D, Parker J, Wilkinson J, et al. Plasma cell myeloma in the horse. J Vet Intern Med 1993;7:169-176.
5. Frank N, Hawkins JF, Couetil LL, et al. Primary hyperparathyroidism with osteodystrophia fibrosa of the facial bones in a pony. J Am Vet Med Assoc 1998;212:84-86.
6. David J, Cohen N, Nachreiner R. Equine nutritional secondary hyperparathyroidism. Compend Contin Educ Pract Vet 1997;19:1380-1387.
7. Krook L, Wasserman R, Shively J, et al. Hypercalcemia and calcinosis in Florida horses: implications of the shrub, Cestrum diurnum, as the causative agent. Cornell Vet 1975;65:26-56.
8. Fenger CK, Bertone JJ, Biller D, et al. Generalized medullary infarction in the long bones of a horse. J Am Vet Med Assoc 1993;202:621-623.
9. Peauroi JR, Fisher DJ, Mohr FC, et al. Primary hyperparathyroidism caused by a functional parathyroid adenoma in a horse. J Am Vet Med Assoc 1998;212:1915-1918.
10. Meuten D, Price S, Seiler R, et al. Gastric carcinoma with pseudohyperparathyroidism in a horse. Cornell Vet 1978;68:179-195.
11. Fix A, Miller L. Equine adrenocortical carcinoma with hypercalcemia. Vet Pathol 1987;24:190-192.
12. Mair T, Yeo S, Lucke V. Hypercalcemia and soft tissue mineralization associated with lymphosarcoma in two horses. Vet Rec 1990;126:99-101.
13. Karcher L, LeNet J, Turner B, et al. Pseudohyperparathyroidism in a mare associated with squamous cell carcinoma of the vulva. Cornell Vet 1990;80:153-162.
14. Marr C, Love S, Pirie H. Clinical, ultrasonographic, and pathological findings in a horse with splenic lymphosarcoma and pseudoparathyroidism. Equine Vet J 1989;21:221-226.
15. Vasilopulos RJ, Mackin A. Humoral hypercalcemia of malignancy: diagnosis and treatment. Compend Contin Educ Pract Vet 2003;25:129-136.
16. Wysolmerski J, Stewart A. The physiology of parathyroid hormone-related protein: an emerging role as a developmental factor. Annu Rev Physiol 1998;60:431-460.
17. Care A, Abbas S, Ousey J, et al. The relationship between the concentration of ionised calcium and parathyroid hormone-related protein (PTHrP 1-34) in milk of mares. Equine Vet J 1997;29:186-189.
18. Vasilopulos RJ, Mackin A. Humoral hypercalcemia of malignancy: pathophysiology and clinical signs. Compend Contin Educ Pract Vet 2003;25:122-128.
19. Mundy G. Incidence and pathophysiology of hypercalcemia. Calcif Tissue Int 1990;46:S3-S10.
20. Fradkin J, Braniecki A, Craig T, et al. Elevated parathyroid hormone-related protein and hypercalcemia in two dogs with schistosomias. J Am Anim Hosp Assoc 2001;37:349-355.
21. Rankin W, Grill V, Martin T. Parathyroid hormone-related protein and hypercalcemia. Cancer 1997;80:1564-1571.
22. Gelberg HB. Alimentary system. In: McGavin MD, Carlton WW, Zachary JF, eds. Thompson's special veterinary pathology. 3rd ed. Philadelphia: Mosby Year Book Inc, 2001;1-79.
23. Delaporte C, Varet B, Fardeau M, et al. In vitro myotrophic effect of serum kappa chain immunoglobulins from a patient with kappa light chain myeloma and muscular hypertrophy. J Clin Invest 1986;78:922-927.
24. De Miguel F, Fiaschi-Taeshh N, Lopez-Talavera J, et al. The C-terminal region of PTHrP, in addition to the nuclear localization signal, is essential for the intracrine stimulation of proliferation in vascular smooth muscle cells. Endocrinology 2001;142:4096-4105.