Alterations in serum parathyroid hormone and electrolyte concentrations and urinary excretion of electrolytes in horses with induced endotoxemia

Journal of Veterinary Internal Medicine

Volumn 19, Issue 2, 2005, Pages 223-231

  Toribio, Ramiro E ^a   Kohn, Catherine W ^a   Hardy, Joanne ^a,b   Rosol, Thomas J ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Equine; Hypocalcemia; Hypokalemia; Hypomagnesemia; Hypophosphatemia; Insulin; Lipopolysaccharide

Indexed keywords

CALCIUM ION; CHLORIDE ION; ELECTROLYTE; ENDOTOXIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INSULIN; MAGNESIUM ION; PARATHYROID HORMONE; PHOSPHATE; POTASSIUM ION; SODIUM ION; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BODY TEMPERATURE; BREATHING RATE; CONTROLLED STUDY; ENDOTOXEMIA; ESCHERICHIA COLI; FEMALE; HEART RATE; HORSE; HYPOCALCEMIA; HYPOMAGNESEMIA; LEUKOCYTE COUNT; NONHUMAN; PARATHYROID HORMONE BLOOD LEVEL; STATISTICAL SIGNIFICANCE; URINARY EXCRETION;

ANIMALS; ELECTROLYTES; ENDOTOXEMIA; ESCHERICHIA COLI; FEMALE; HORSE DISEASES; HORSES; LIPOPOLYSACCHARIDES; PARATHYROID HORMONE; TIME FACTORS;

EQUIDAE; ESCHERICHIA COLI;

EID: 16244421362     PISSN: 08916640     EISSN: None     Source Type: Journal    
DOI: 10.1892/0891-6640(2005)19<223:AISPHA>2.0.CO;2     Document Type: Article

References (46)

1. Carlstedt F, Lind L, Rastad J, et al. Parathyroid hormone and ionized calcium levels are related to the severity of illness and survival in critically ill patients. Eur J Clin Invest 1998;28:898-903.
2. Dart AJ, Snyder JR, Spier SJ, et al. Ionized calcium concentration in horses with surgically managed gastrointestinal disease: 147 cases (1988-1990). J Am Vet Med Assoc 1992;201:1244-1248.
3. Garcia-Lopez JM, Provost PJ, Rush JE, et al. Prevalence and prognostic importance of hypomagnesemia and hypocalcemia in horses that have colic surgery. Am J Vet Res 2001;62:7-12.
4. Toribio RE, Kohn CW, Chew DJ, et al. Comparison of serum parathyroid hormone and ionized calcium and magnesium concentrations and fractional urinary clearance of calcium and phosphorus in healthy horses and horses with enterocolitis. Am J Vet Res 2001;62:938-947.
5. Lind L, Carlstedt F, Rastad J, et al. Hypocalcemia and parathyroid hormone secretion in critically ill patients. Crit Care Med 2000;28:93-99.
6. Soliman HM, Mercan D, Lobo SS, et al. Development of ionized hypomagnesemia is associated with higher mortality rates. Crit Care Med 2003;31:1082-1087.
7. Johansson AM, Gardner SY, Jones SL, et al. Hypomagnesemia in hospitalized horses. J Vet Intern Med 2003;17:860-867.
8. King JN, Gerring EL. Detection of endotoxin in cases of equine colic. Vet Rec 1988;123:269-271.
9. Bueno AC, Seahorn TL, Cornick-Seahorn J, et al. Plasma and urine nitric oxide concentrations in horses given below a low dose of endotoxin. Am J Vet Res 1999;60:969-976.
10. Seethanathan P, Bottoms GD, Schafer K. Characterization of release of tumor necrosis factor, interleukin-1, and superoxide anion from equine white blood cells in response to endotoxin. Am J Vet Res 1990;51:1221-1225.
11. Winchell WW, Hardy J, Levine DM, et al. Effect of administration of a phospholipid emulsion on the initial response of horses administered endotoxin. Am J Vet Res 2002;63:1370-1378.
12. Morris DD, Crowe N, Moore JN. Correlation of clinical and laboratory data with serum tumor necrosis factor activity in horses with experimentally induced endotoxemia. Am J Vet Res 1990;51:1935-1940.
13. Carlstedt E, Ridefelt P, Lind L, et al. Interleukin-6 induced suppression of bovine parathyroid hormone secretion. Biosci Rep 1999;19:35-42.
14. Nielsen PK, Rasmussen AK, Butters R, et al. Inhibition of PTH secretion by interleukin-1 beta in bovine parathyroid glands in vitro is associated with an up-regulation of the calcium-sensing receptor mRNA. Biochem Biophys Res Commun 1997;238:880-885.
15. Toribio RE, Kohn CW, Capen CC, et al. Parathyroid hormone (PTH) secretion, PTH mRNA and calcium-sensing receptor mRNA expression in equine parathyroid cells, and effects of interleukin (IL)-1, IL-6, and tumor necrosis factor-alpha on equine parathyroid cell function. J Mol Endocrinol 2003;31:609-620.
16. Giraudet A, Hinchcliff KW, Kohn CW, et al. Early insulin response to an intravenous glucose tolerance test in horses. Am J Vet Res 1994;55:379-381.
17. Van Belle G, Fisher L, Heagerty P, Lumley T. Biostatistics: A Methodology for the Health Sciences, 2nd ed. Hoboken, NJ: John Wiley & Sons Inc; 2004:253-290.
18. Carlstedt F, Eriksson M, Kiiski R, et al. Hypocalcemia during porcine endotoxemic shock: Effects of calcium administration. Crit Care Med 2000;28:2909-2914.
19. Nakamura T, Mimura Y, Uno K, et al. Parathyroid hormone activity increases during endotoxemia in conscious rats. Horm Metab Res 1998;30:88-92.
20. Waldron MR, Nonnecke BJ, Nishida T, et al. Effect of lipopolysaccharide infusion on serum macromineral and vitamin D concentrations in dairy cows. J Dairy Sci 2003;86:3440-3446.
21. Zaloga GP. Ionized hypocalcemia during sepsis. Crit Care Med 2000;28:266-268.
22. Crouser ED, Dorinsky PM. Metabolic consequences of sepsis. Correlation with altered intracellular calcium homeostasis. Clin Chest Med 1996;17:249-261.
23. Assicot M, Gendrel D, Carsin H, et al. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 1993;341:515-518.
24. Fatemi S, Ryzen E, Flores J, et al. Effect of experimental human magnesium depletion on parathyroid hormone secretion and 1,25-dihydroxyvitamin D metabolism. J Clin Endocrinol Metab 1991;73:1067-1072.
25. Toribio RE. Disorders of the endocrine system. In: Reed SM, Bayly WM, Sellon DC, eds. Equine Internal Medicine. St Louis, MO: WB Saunders; 2004:1295-1379.
26. Alexander SL, Irvine CH. The effect of endotoxin administration on the secretory dynamics of oxytocin in follicular phase mares: Relationship to stress axis hormones. J Neuroendocrinol 2002;14:540-548.
27. 2+ regulation in the liver in endotoxic shock. Am J Physiol 1986;250:R884-R891.
28. Romani A, Marfella C, Scarpa A. Hormonal stimulation of Mg2+ uptake in hepatocytes. Regulation by plasma membrane and intracellular organelles. J Biol Chem 1993;268:15489-15495.
29. Fessier JF, Bottoms GD, Roesel OF, et al. Endotoxin-induced change in hemograms, plasma enzymes, and blood chemical values in anesthetized ponies: Effects of flunixin meglumine. Am J Vet Res 1982;43:140-144.
30. Barbagallo M, Dominguez LJ, Galioto A, et al. Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. Mol Aspects Med 2003;24:39-52.
31. Brown EM, Hurwitz S, Aurbach GD. Beta-adrenergic stimulation of cyclic AMP content and parathyroid hormone release from isolated bovine parathyroid cells. Endocrinology 1977;100:1696-1702.
32. van Bockel EA, Tulleken JE, Muller Kobold AC, et al. Cardiac troponin I release and cytokine response during experimental human endotoxaemia. Intensive Care Med 2003;29:1598-1600.
33. Angeletti RH, D'Amico T, Ashok S, et al. The chemokine interleukin-8 regulates parathyroid secretion. J Bone Miner Res 1998;13:1232-1237.
34. Carlstedt F, Lind L. Hypocalcemic syndromes. Crit Care Clin 2001;17:139-153.
35. Seeliger S, Hausberg M, Eue I, et al. The parathyroid hormone-2 receptor is expressed on human leukocytes and down-regulated in hyperparathyroidism. Clin Nephrol 2003;59:429-435.
36. Salem M, Kasinski N, Munoz R, et al. Progressive magnesium deficiency increases mortality from endotoxin challenge: Protective effects of acute magnesium replacement therapy. Crit Care Med 1995;23:108-118.
37. Barak V, Schwartz A, Kalickman I, et al. Prevalence of hypophosphatemia in sepsis and infection: The role of cytokines. Am J Med 1998;104:40-47.
38. Mimura Y, Uno K, Nakamura T. Renal regulation of phosphate excretion in endotoxaemic rats. Clin Exp Pharmacol Physiol 1997;24:353-358.
39. Funk JL, Moser AH, Strewler GJ, et al. Parathyroid hormone-related protein is induced during lethal endotoxemia and contributes to endotoxin-induced mortality in rodents. Mol Med 1996;2:204-210.
40. Aiura K, Ueda M, Endo M, et al. Circulating concentrations and physiologic role of atrial natriuretic peptide during endotoxic shock in the rat. Crit Care Med 1995;23:1898-1906.
41. Shiber JR, Mattu A. Serum phosphate abnormalities in the emergency department. J Emerg Med 2002;23:395-400.
42. +-ATPase and raises blood lactate under aerobic conditions in humans. Am J Physiol Heart Circ Physiol 2003;284:H1028-H1034.
43. Agwunobi AO, Reid C, Maycock P, et al. Insulin resistance and substrate utilization in human endotoxemia. J Clin Endocrinol Metab 2000;85:3770-3778.
44. + pump*. Clin Sci (Lond) 1998;95:3-17.
45. Brown EM. Physiology and pathophysiology of the extracellular calcium-sensing receptor. Am J Med 1999;106:238-253.
46. Zhang Y, Norian JM, Magyar CE, et al. In vivo PTH provokes apical NHE3 and NaPi2 redistribution and Na-K-ATPase inhibition. Am J Physiol 1999;276:F711-F719.