Cyclosporine A protects against arachidonic acid toxicity in rat hepatocytes: Role of CYP2E1 and mitochondria

Hepatology

Volumn 35, Issue 6, 2002, Pages 1420-1430

  Wu, Defeng ^a   Cederbaum, Arthur I ^a  

^a NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLYL SULFIDE; ARACHIDONIC ACID; CASPASE 3; CATALASE; CYCLOSPORIN A; CYTOCHROME C; CYTOCHROME P450 2E1; POLYUNSATURATED FATTY ACID; PYRAZOLE DERIVATIVE; REACTIVE OXYGEN METABOLITE; SALICYLIC ACID; TROLOX C;

ALCOHOL LIVER CIRRHOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL COMPARTMENTALIZATION; CELL DAMAGE; CELL MEMBRANE PERMEABILITY; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DIETARY INTAKE; ENZYME ACTIVATION; LIPID PEROXIDATION; LIVER CELL; MALE; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0036614377     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2002.33639     Document Type: Article

References (52)

1. Implication of free radical mechanisms in ethanol-induced cellular injury
2. Current concepts in the pathogenesis of alcoholic liver injury
3. Introduction-serial review: Alcohol, oxidative stress and cell injury
4. 4 and iron-dependent microsomal lipid peroxidation
5. Fish oil, alcohol and liver pathology: Role of cytochrome P4502E1
6. Characterization of cytochrome P4502E1 induction in a rat hepatoma FGC-4 cell model by ethanol
7. Markedly enhanced cytochrome P4502E1 induction and lipid peroxidation is associated with severe liver injury in fish oil-ethanol-fed rat
8. CYP2E1 is not involved in early alcohol-induced liver injury
9. Cytotoxicity and apoptosis produced by arachidonic acid in HepG2 cells overexpressing human cytochrome P4502E1
10. Ethanol and arachidonic acid produce toxicity in hepatocytes from pyrazole-treated rats with high levels of CYP2E1
11. Inhibition of prostaglandin biosynthesis
12. The mode of action of anti-inflammatory drugs
13. Analgesic-antipyretic and anti-inflammatory agents and drugs employed in the treatment of gout
14. Salicylate is a transcriptional inhibitor of the inducible nitric oxide synthase in cultured cardiac fibroblasts
15. The anti-inflammatory drug sodium salicylate inhibits nitric oxide formation induced by interleukin-1β at a translational step, but not a transcriptional step, in hepatocytes
16. Salicylic acid and aspirin inhibit the activity of RSK2 kinase and depress RSK2-dependent transcription of cyclic AMP response element binding protein and NF-kappa B-responsive genes
17. Inhibition of tumor necrosis factor-induced P42, P44 mitogen-activated protein kinases activation by sodium salicylate
18. Sodium salicylate induces apoptosis via P38 mitogen-activated protein kinases but inhibits tumor necrosis factor induced C-jun N-terminal kinases/stress-activated protein kinase activation
19. Salicylate-enhanced activation of transcription factors induced by interferon-Y
20. The alterations in the energy-linked properties induced in rat liver mitochondria by acetylsalicylate are prevented by cyclosporin A or Mg
21. Role of the mitochondrial permeability transition in salicylate toxicity to cultured rat hepatocytes
22. Involvement of cytochromes P4502E1 and 3A4 in the 5-hydroxylation of salicylate in humans
23. Induction of hepatic cytochrome P4502E1 in rats by acetylsalicylic acid or sodium salicylate
24. Sodium salicyate increase CYP2E1 levels and enhances arachidonic acid toxicity in HepG2 cells and cultured rat hepatocytes
25. The identification of 2, 3-dihydroxybenzoic acid as a potentially useful iron-chelating agent
26. Prevention of reoxygenation injury by sodium salicylate in isolated perfused rat liver
27. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death
28. Mitochondria as regulators of apoptosis: Doubt no more
29. Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat
30. Acute and chronic ethanol increases reactive oxygen species generation and decreases viability in fresh, isolated rat hepatocytes
31. Ethanol stimulates the production of reactive oxygen species at mitochondrial complexes I and III
32. Mitochondrial energy metabolism in chronic alcoholism
33. Oxidative stress on mitochondria and cell membrane of cultured rat hepatocytes and perfused liver exposed to ethanol
34. The mitochondrial permeability transition contributes to acute ethanol-induced apoptosis in rat hepatocytes
35. Oxidative stress and cytotoxicity induced by ferric-nitrilotriacetate in HepG2 cells that express cytochrome P4502E1
36. Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against cytochrome P4502E1-dependent toxicity in HepG2 cells
37. Rapid decrease of cytochrome P450IIE1 in primary hepatocyte culture and its maintenance by added 4-methylpyrazole
38. Overexpression of catalase in cytosolic or mitochondrial compartment protects HepG2 cells against oxidative injury
39. Mitochondrial targeted cytochrome P4502E1 (P450MT5) contains an intact N terminus and requires mitochondrial specific electron transfer proteins for activity
40. A soluble NH (2)-terminally truncated catalytically active form of rat cytochrome P4502E1 targeted to liver mitochondria (1)
41. The effect of chronic ethanol consumption on hepatic mitochondrial energy metabolism
42. Molecular injury to mitochondria produced by ethanol and acetaldehyde
43. Potentiation by chronic ethanol treatment of the mitochondrial permeability transition
44. Ethanol potentiates TNFα cytotoxicity in hepatoma cells and primary rat hepatocytes by promoting induction of the mitochondrial permeability transition
45. Complimentary DNA and protein sequences of ethanol-inducible rat and human cytochrome P450s: Transcriptional and posttranscriptional regulation of the rat enzyme
46. Multiple mechanisms in the regulation of ethanol-inducible cytochrome P450IIE1
47. Ligand-dependent maintenance of ethanol-inducible cytochrome P450 in primary hepatocyte cell cultures
48. Inhibition of NF-kB by sodium salicylate and aspirin
49. Inhibition of I-kB kinase activity by sodium salicylate inhibitor does not reflect its inhibitory mechanism in intact cells
50. Salicylate-enhanced activation of transcription factors induced by interferon-Y
51. Sodium salicylate induced apoptosis of human peripheral blood eosinophils is independent of the activation of c-jun N-terminal kinase and P38 mitogen-activated protein kinase
52. Sodium salicylate activates caspases and induces apoptosis of myeloid leukemia cell lines