Brief, repeated exposure to substrates down-regulates dopamine transporter function in Xenopus oocytes in vitro and rat dorsal striatum in vivo

Journal of Neurochemistry

Volumn 83, Issue 2, 2002, Pages 400-411

  Gulley, Joshua M ^a   Doolen, Suzanne ^a   Zahniser, Nancy R ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Dopamine clearance; Dopamine transporter; Regulation; Trafficking; Transport mediated currents; Voltammetry

Indexed keywords

3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; AMPHETAMINE DERIVATIVE; ASCORBIC ACID; DEXAMPHETAMINE; DOPAMINE; DOPAMINE TRANSPORTER; META TYRAMINE; PROTEIN KINASE C INHIBITOR;

AMPEROMETRY; ANIMAL CELL; ARTICLE; CELL SURFACE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC TRANSMISSION; DOWN REGULATION; ELECTROCHEMISTRY; ELECTROPHYSIOLOGY; LIGAND BINDING; MEMBRANE CURRENT; MOLECULAR MODEL; NONHUMAN; NUCLEUS ACCUMBENS; OOCYTE; POTENTIOMETRY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; VOLTAGE CLAMP; XENOPUS LAEVIS;

AMPHETAMINE; ANIMALS; CORPUS STRIATUM; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOWN-REGULATION; ENZYME INHIBITORS; FEMALE; INDOLES; MALE; MALEIMIDES; MEMBRANE GLYCOPROTEINS; MEMBRANE POTENTIALS; MEMBRANE TRANSPORT PROTEINS; MICROINJECTIONS; NERVE TISSUE PROTEINS; NUCLEUS ACCUMBENS; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; RNA, COMPLEMENTARY; TIME FACTORS; TYRAMINE; XENOPUS;

ANIMALIA; XENOPUS LAEVIS;

EID: 0036796804     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.01133.x     Document Type: Article

References (64)

1. Barish M. E. (1983) A transient calcium-dependent chloride current in the immature Xenopus oocyte. J. Physiol. 342, 309-325.
2. Beckman M. L. and Quick M. W. (1998) Neurotransmitter transporters: regulators of function and functional regulation. J. Membr Biol. 164, 1-10.
3. Berman S. B., Zigmond M. J. and Hastings T. G. (1996) Modification of dopamine transporter function: effect of reactive oxygen species and dopamine. J. Neurochem. 67, 593-600.
4. Bernstein E. M. and Quick M. W. (1999) Regulation of γ-aminobutyric acid (GABA) transporters by extracellular GABA. J. Biol. Chem. 274, 889-895.
5. Blakely R. D. and Bauman A. L. (2000) Biogenic amine transporters: regulation in flux. Curr. Opin. Neurobiol. 10, 328-336.
6. Cass W. A., Gerhardt G. A., Mayfield R. D., Curella P. and Zahniser N. R. (1992) Differences in dopamine clearance and diffusion in rat striatum and nucleus accumbens following systemic cocaine administration. J. Neurochem. 59, 259-266.
7. Cass W. A., Gerhardt G. A., Gillespie K., Curella P., Mayfield R. D. and Zahniser N. R. (1993a) Reduced clearance of exogenous dopamine in rat nucleus accumbens, but not in dorsal striatum, following cocaine challenge in rats withdrawn from repeated cocaine administration. J. Neurochem. 61, 273-283.
8. Cass W. A., Zahniser N. R., Flach K. A. and Gerhardt G. A. (1993b) Clearance of exogenous dopamine in rat dorsal striatum and nucleus accumbens: role of metabolism and effects of locally applied uptake inhibitors. J. Neurochem. 61, 2269-2278.
9. Cass W. A. and Gerhardt G. A. (1994) Direct in vivo evidence that D2 dopamine receptors can modulate dopamine uptake. Neurosci. Lett. 176, 259-263.
10. Chang M. Y., Lee S. H., Kim J. H., Lee K. H., Kim Y. S., Son H. and Lee Y. S. (2001) Protein kinase C-mediated functional regulation of dopamine transporter is not achieved by direct phosphorylation of the dopamine transporter protein. J. Neurochem. 77, 754-761.
11. Copeland B. J., Vogelsberg V., Neff N. H. and Hadjiconstantinou M. (1996) Protein kinase C activators decrease dopamine uptake into striatal synaptosomes. J. Pharmacol. Exp. Ther 277, 1527-1532.
12. Daniels G. M. and Amara S. G. (1999) Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters. J. Biol. Chem. 274, 35794-35801.
13. David D. J., Zahniser N. R., Hoffer B. J. and Gerhardt G. A. (1998) In vivo electrochemical studies of dopamine clearance in subregions of rat nucleus accumbens: differential properties of the core and shell. Exp. Neurol. 153, 277-286.
14. Daws L. C., Callaghan P. D., Morón J. A., Kahlig K. M., Shippenberg T. S., Javitch J. A. and Galli A. (2002) Cocaine increases dopamine uptake and cell surface expression of dopamine transporters. Biochem. Biophys. Res. Commun. 290, 1545-1550.
15. Dickinson S. D., Sabeti J., Larson G. A., Giardina K., Rubinstein M., Kelly M. A., Grandy D. K., Low M. J., Gerhardt G. A. and Zahniser N. R. (1999) Dopamine D2 receptor-deficient mice exhibit decreased dopamine transporter function but no changes in dopamine release in dorsal striatum. J. Neurochem. 72, 148-156.
16. Doolen S. and Zahniser N. R. (2001) Protein tyrosine kinase inhibitors alter human dopamine transporter activity in Xenopus oocytes. J. Pharmacol. Exp. Ther. 296, 931-938.
17. Friedemann M. N. and Gerhardt G. A. (1992) Regional effects of aging on dopaminergic function in the Fischer-344 rat. Neurobiol. Aging 13, 325-332.
18. Garris P. A. and Wightman R. M. (1994) Different kinetics govern dopaminergic transmission in the amygdala, prefrontal cortex, and striatum: an in vivo voltammetric study. J. Neurosci. 14, 442-450.
19. Garris P. A. and Wightman R. M. (1995) Distinct pharmacological regulation of evoked dopamine efflux in the amygdala and striatum of the rat in vivo. Synapse 20, 269-279.
20. Gerhardt G. A. and Hoffman A. F. (2001) Effects of recording media composition on the responses of Nafion-coated carbon fiber microelectrodes measured using high-speed chronoamperometry. J. Neurosci. Methods 109, 13-21.
21. Gerhardt G. A., Oke A. F., Nagy G., Moghaddam B. and Adams R. N. (1984) Nafion-coated electrodes with high selectivity for CNS electrochemistry. Brain Res. 290, 390-395.
22. Giros B., Jaber M., Jones S. R., Wightman R. M. and Caron M. G. (1996) Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379, 606-612.
23. Hoffman A. F. and Gerhardt G. A. (1998) In vivo electrochemical studies of dopamine clearance in the rat substantia nigra: effects of locally applied uptake inhibitors and unilateral 6-hydroxydopamine lesions. J. Neurochem. 70, 179-189.
24. max. J. Neurochem. 68, 225-232.
25. Jones S. R., Garris P. A. and Wightman R. M. (1995) Different effects of cocaine and nomifensine on dopamine uptake in the caudate-putamen and nucleus accumbens. J. Pharmacol. Exp. Ther. 274, 396-403.
26. Kim S., Westphalen R., Callahan B., Hatzidimitriou G., Yuan J. and Ricaurte G. A. (2000) Toward development of an in vitro model of methamphetamine-induced dopamine nerve terminal toxicity. J. Pharmacol. Exp. Ther. 293, 625-633.
27. Kitayama S., Dohi T. and Uhl G. R. (1994) Phorbol esters alter functions of the expressed dopamine transporter. Eur. J. Pharmacol. 268, 115-119.
28. Kiyatkin E. A., Kiyatkin D. E. and Rebec G. V. (2000) Phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. Neuroscience 98, 729-741.
29. Kokoshka J. M., Vaughan R. A., Hanson G. R. and Fleckenstein A. E. (1998) Nature of methamphetamine-induced rapid and reversible changes in dopamine transporters. Eur. J. Pharmacol. 361,269-275.
30. Little K. Y., Elmer L. W., Zhong H. I., Scheys J. O. and Zhang L. (2002) Cocaine induction of dopamine transporter trafficking to the plasma membrane. Mol. Pharmacol. 61, 436-445.
31. Marshall J. F., O'Dell S. J., Navarrete R. and Rosenstein A. J. (1990) Dopamine high-affinity transport site topography in rat brain: major differences between dorsal and ventral striatum. Neuroscience 37, 11-21.
32. May L. J. and Wightman R. M. (1989) Heterogeneity of stimulated dopamine overflow within rat striatum as observed with in vivo voltammetry. Brain Res. 487, 311-320.
33. May L. J., Kuhr W. G. and Wightman R. M. (1988) Differentiation of dopamine overflow and uptake processes in the extracellular fluid of the rat caudate nucleus with fast-scan in vivo voltammetry. J. Neurochem. 51, 1060-1069.
34. McElvain J. S. and Schenk J. O. (1992) A multisubstrate mechanism of striatal dopamine uptake and its inhibition by cocaine. Biochem. Pharmacol. 43, 2189-2199.
35. Meiergerd S. M., Patterson T. A. and Schenk J. O. (1993) D2 receptors may modulate the function of the striatal transporter for dopamine: kinetic evidence from studies in vitro and in vivo. J. Neurochem. 61, 764-767.
36. Melikian H. E. and Buckley K. M. (1999) Membrane trafficking regulates the activity of the human dopamine transporter. J. Neurosci. 19, 7699-7710.
37. 3H-GBR 12935. J. Neural Transm General Sect 87, 1-14.
38. Metzger R. R., Haughey H. M., Wilkins D. G., Gibb J. W., Hanson G. R. and Fleckenstein A. E. (2000) Methamphetamine-induced rapid decrease in dopamine transporter function: role of dopamine and hyperthermia. J. Pharmacol. Exp. Ther. 295, 1077-1085.
39. Ng J. P., Menacherry S. D., Liem B. J., Anderson D., Singer M. and Justice J. B. Jr (1992) Anomalous effect of mazindol on dopamine uptake as measured by in vivo voltammetry and microdialysis. Neurosci. Lett. 134, 229-232.
40. Nicholson C. (1995) Interaction between diffusion and MichaelisMenten uptake of dopamine after iontophoresis in striatum. Biophys. J. 68, 1699-1715.
41. Paxinos G. and Watson C. (1998) The Rat Brain in Stereotaxic Coordinates. Academic Press, New York.
42. Prasad B. M. and Amara S. G. (2001) The dopamine transporter in mesencephalic cultures is refractory to physiological changes in membrane voltage. J. Neurosci. 21, 7561-7567.
43. Pristupa Z. B., McConkey F., Liu F., Man H. Y., Lee F. J., Wang Y. T. and Niznik H. B. (1998) Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter. Synapse 30, 79-87.
44. Rabinovic A. D., Lewis D. A. and Hastings T. G. (2000) Role of oxidative changes in the degeneration of dopamine terminals after injections of neurotoxic levels of dopamine. Neuroscience 101, 67-76.
45. 3H]tropane to the dopamine uptake carrier. J. Neurochem. 61, 167-177.
46. Rice M. E. and Nicholson C. (1989) Measurement of nanomolar dopamine diffusion using low-noise perfluorinated ionomer coated carbon fiber microelectrodes and high-speed cyclic voltammetry. Anal Chem 61, 1805-1810.
47. 3H]GBR 12935: binding characteristics. Brain Res. 540, 1-13.
48. Robinson M. B. (2002) Regulated trafficking of neurotransmitter transporters: common notes but different melodies. J. Neurochem. 80, 1-11.
49. Sandoval V., Riddle E. L., Ugarte Y. V., Hanson G. R. and Fleckenstein A. E. (2001) Methamphetamine-induced rapid and reversible changes in dopamine transporter function: an in vitro model. J. Neurosci. 21, 1413-1419.
50. Saunders C., Ferrer J. V., Shi L., Chen J., Merrill G., Lamb M. E., Leeb-Lundberg L. M., Carvelli L., Javitch J. A. and Galli A. (2000) Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism. Proc. Natl Acad. Sci. U S A 97, 6850-6855.
51. Schmitz Y., Lee C. J., Schmauss C., Gonon F. and Sulzer D. (2001) Amphetamine distorts stimulation-dependent dopamine overflow: effects on D2 autoreceptors, transporters, and synaptic vesicle stores. J. Neurosci. 21, 5916-5924.
52. Sonders M. S., Zhu S. J., Zahniser N. R., Kavanaugh M. P. and Amara S. G. (1997) Multiple ionic conductances of the human dopamine transporter: the actions of dopamine and psychostimulants. J. Neurosci. 17, 960-974.
53. Stamford J. A., Kruk Z. L., Millar J. and Wightman R. M. (1984) Striatal dopamine uptake in the rat: in vivo analysis by fast cyclic voltammetry. Neurosci. Lett. 51, 133-138.
54. Suaud-Chagny M. F., Dugast C., Chergui K., Msghina M. and Gonon F. (1995) Uptake of dopamine released by impulse flow in the rat mesolimbic and striatal systems in vivo. J. Neurochem. 65, 2603-2611.
55. Vaughan R. A., Huff R. A., Uhl G. R. and Kuhar M. J. (1997) Protein kinase C-mediated phosphorylation and functional regulation of dopamine transporters in striatal synaptosomes. J. Biol. Chem. 272, 15541-15546.
56. Whitehead R. E., Ferrer J. V., Javitch J. A. and Justice J. B. (2001) Reaction of oxidized dopamine with endogenous cysteine residues in the human dopamine transporter. J. Neurochem. 76, 1242-1251.
57. Wightman R. M. and Zimmerman J. B. (1990) Control of dopamine extracellular concentration in rat striatum by impulse flow and uptake. Brain Res. Brain Res. Rev. 15, 135-144.
58. Wightman R. M., Amatore C., Engstrom R. C., Hale P. D., Kristensen E. W., Kuhr W. G. and May L. J. (1988) Real-time characterization of dopamine overflow and uptake in the rat striatum. Neuroscience 25, 513-523.
59. Wu Q., Reith M. E., Wightman R. M., Kawagoe K. T. and Garris P. A. (2001) Determination of release and uptake parameters from electrically evoked dopamine dynamics measured by real-time voltammetry. J. Neurosci. Methods 112, 119-133.
60. Zahniser N. R. and Doolen S. (2001) Chronic and acute regulation of Na(+)/Cl(-)-dependent neurotransmitter transporters: drugs, substrates, presynaptic receptors, and signaling systems. Pharmacol. Ther. 92, 21-55.
61. Zahniser N. R., Dickinson S. D. and Gerhardt G. A. (1998) High-speed chronoamperometric electrochemical measurements of dopamine clearance. Methods Enzymol. 296, 708-719.
62. Zahniser N. R., Larson G. A. and Gerhardt G. A. (1999) In vivo dopamine clearance rate in rat striatum: regulation by extracellular dopamine concentration and dopamine transporter inhibitors. J. Pharmacol. Exp. Ther. 289, 266-277.
63. Zhang L., Coffey L. L. and Reith M. E. (1997) Regulation of the fimctional activity of the human dopamine transporter by protein kinase C. Biochem. Pharmacol. 53, 677-688 .
64. Zhu S. J., Kavanaugh M. P., Sonders M. S., Amara S. G. and Zahniser N. R. (1997) Activation of protein kinase C inhibits uptake, currents and binding associated with the human dopamine transporter expressed in Xenopus oocytes. J. Pharmacol. Exp. Ther 282, 1358-1365.