Induction by low Na+ or Cl- of cocaine sensitive carrier-mediated efflux of amines from cells transfected with the cloned human catecholamine transporters

British Journal of Pharmacology

Volumn 121, Issue 2, 1997, Pages 205-212

  Pifl, Christian ^a   Agneter, Ernst ^a   Drobny, Helmut ^a   Reither, Harald ^a   Singer, Ernst A ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Carrier mediated release; Cocaine; Desipramine; Dopamine; Dopamine transporter; Ion dependence; Mazindol; Noradrenaline; Noradrenaline transporter; Transfected cells

Indexed keywords

AMINE; CATECHOLAMINE TRANSPORTER; CHLORIDE ION; COCAINE; DESIPRAMINE; DOPAMINE TRANSPORTER; MAZINDOL; NORADRENALINE TRANSPORTER; PROTON; SODIUM ION; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL TRANSPORT; CONTROLLED STUDY; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT; SODIUM CELL LEVEL; SODIUM TRANSPORT;

EID: 0030948154     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701137     Document Type: Article

References (21)

1. 2+-independent release of neurotransmitters. J. Neurochem., 58, 395-405.
2. AMARA, S.G. & KUHAR, M.J. (1993). Neurotransmitter transporters: Recent progress. Annu. Rev. Neurosci., 16, 73-93.
3. ATTWELL, D., BARBOUR, B. & SZATKOWSKI, M. (1993). Non-vesicular release of neurotransmitter. Neuron. 11, 401-407.
4. CULLEN, B.R. (1987). Use of eukaryotic expression technology in the functional analysis of cloned genes. Methods Enzymol., 152, 684-704.
5. DILIBERTO, P.A., JEFFS, R.A. & CUBEDDU, L.X. (1989). Effects of low extracellular chloride on dopamine release and the dopamine transporter. J. Pharmacol. Exp. Ther., 248, 644-651.
6. GALLI, A., DEFELICE, L.J., DUKE, B.-J., MOORE, K.R. & BLAKELY, R.D. (1995). Sodium-dependent norepinephrine-induced currents in norepinephrine-transporter-transfected HED-293 cells blocked by cocaine and antideppressants. J. Exp. Biol., 198, 2197-2212.
7. GIROS, B., EL MESTIKAWY, S., GODINOT, N., ZHENG, K., HAN, H., YANG-FENG, T. & CARON, M.G. (1992). Cloning, pharmacological characterization, and chromosome assignement of the human dopamine transporter. Mol. Pharmacol., 42, 383-390.
8. GIROS, B., WANG, Y.-M., SUTER, S., MCLESKEY, S.B., PIFL, CH. & CARON, M.G. (1994). Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters. J. Biol. Chem., 269, 15985-15988.
9. GU, H., WALL, S.C. & RUDNICK, G. (1994). Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence. J. Biol. Chem., 269, 7124-7130.
10. 3H]-mazindol binding associated with neuronal dopamine and norepinephrine uptake sites. Mol. Pharmacol., 26, 35-44.
11. LEVI, G. & RAITERI, M. (1993). Carrier-mediated release of neurotransmitters. Trends Neurol. Sci., 16, 415-419.
12. 3H-desipramine binding associated with neuronal norepinephrine uptake sites in rat brain membranes. J. Neurosci., 2, 1515-1525.
13. PACHOLCZYK, T., BLAKELY, R. D. & AMARA, S.G. (1991). Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature, 350, 350-354.
14. PIFL, C., DROBNY, H., REITHER, H., HORNYKIEWICZ, O., & SINGER, E.A. (1995). Mechanism of the dopamine-releasing actions of amphetamine and cocaine: plasmalemmal dopamine transporter versus vesicular monoamine transporter. Mol. Pharmacol., 47, 368-373.
15. PIFL, C., GIROS, B. & CARON, M.G. (1993). Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenyl-pyridinium. J. Neurosci., 13, 4246-4253.
16. PIFL, C., HORNYKIEWICZ, O., GIROS, B. & CARON, M.G. (1996). Catecholamine transporters and 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine neurotoxicity, studies comparing the cloned human noradrenaline and human dopamine transporter. J. Pharmacol. Exp. Ther., 277, 1437-1443.
17. PIFL, C., PICHLER, L., KOBINGER, W. & HORNYKIEWICZ, O. (1988). The dopamine autoreceptor agonist B-HT 920 preferentially reduces brain dopamine release in vivo: biochemical indices of brain dopamine, noradrenaline and serotonin in ventricular perfusates in the cat. Eur. J. Pharmacol., 153, 33-44.
18. 3H] cocaine binding nassociated with dopamine uptake sites in the rat striatum and human putamen decrease after dopaminergic denervation and in Parkinson disease. Naunyn-Schmiedeberg's Arch. Pharmacol., 329, 227-235.
19. SINGER, E.A. (1988). Transmitter release from brain slices elicited by single pulses: a powerful method to study presynaptic mechanisms. Trends Pharmacol. Sci., 9, 274-276.
20. WORRAL, D.M. & WILLIAMS, D.C. (1994). Sodium ion-dependent transporters for neurotransmitters: a review of recent developments. Biochem. J., 297, 425-436.
21. ZEITNER, C.-J. & GRAEFE, K.-H. (1986). Sodium-dependence of the potency of inhibitors of the neuronal noradrenaline carrier in the rat vas deferens. Naunyn-Schmiedeberg's Arch. Pharmacol., 334, 397-402.