The role of RhoC in growth and metastatic capacity of melanoma

Journal of Cutaneous Pathology

Volumn 36, Issue 6, 2009, Pages 629-636

  Boone, Barbara ^a,b   Van Gele, Mireille ^a   Lambert, Jo ^a,b   Haspeslagh, Marc ^b   Brochez, Lieve ^a,b  

^a Dermatology Research Unit   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN RHOC; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANCER GROWTH; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; MELANOCYTE; MELANOMA; METASTASIS; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; SKIN TUMOR; SKIN ULCER; UPREGULATION; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MELANOMA; MIDDLE AGED; NEOPLASM INVASIVENESS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHO GTP-BINDING PROTEINS; RNA, MESSENGER; SKIN NEOPLASMS;

EID: 65949124660     PISSN: 03036987     EISSN: 16000560     Source Type: Journal    
DOI: 10.1111/j.1600-0560.2008.01117.x     Document Type: Article

References (48)

1. Brochez L, Myny K, Bleyen L, De Backer G, Naeyaert JM. The melanoma burden in Belgium; premature morbidity and mortality make melanoma a considerable health problem. Melanoma Res 1999 9 : 614.
2. Karim-Kos HE, de Vries E, Soerjomataram I, Lemmens V, Siesling S, Coebergh JW. Recent trends of cancer in Europe: a combined approach of incidence, survival and mortality for 17 cancer sites since the 1990s. Eur J Cancer 2008 44 (10 1345 89.
3. Geller AC, Swetter SM, Brooks K, Demierre MF, Yaroch AL. Screening, early detection, and trends for melanoma: current status (2000-2006) and future directions. J Am Acad Dermatol 2007 57 : 555 quiz 73 76.
4. Jaffe AB, Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 2005 21 : 247.
5. Van Aelst L, D'Souza-Schorey C. Rho GTPases and signaling networks. Genes Dev 1997 11 : 2295.
6. van Golen KL, Wu ZF, Qiao XT, Bao LW, Merajver SD. RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype. Cancer Res 2000 60 : 5832.
7. Ikoma T, Takahashi T, Nagano S, et al. A definitive role of RhoC in metastasis of orthotopic lung cancer in mice. Clin Cancer Res 2004 10 : 1192.
8. Faried A, Faried LS, Kimura H, et al. RhoA and RhoC proteins promote both cell proliferation and cell invasion of human oesophageal squamous cell carcinoma cell lines in vitro and in vivo. Eur J Cancer 2006 42 : 1455.
9. Kleer CG, van Golen KL, Zhang Y, Wu ZF, Rubin MA, Merajver SD. Characterization of RhoC expression in benign and malignant breast disease: a potential new marker for small breast carcinomas with metastatic ability. Am J Pathol 2002 160 : 579.
10. Kleer CG, Griffith KA, Sabel MS, et al. RhoC-GTPase is a novel tissue biomarker associated with biologically aggressive carcinomas of the breast. Breast Cancer Res Treat 2005 93 : 101.
11. Horiuchi A, Imai T, Wang C, et al. Up-regulation of small GTPases, RhoA and RhoC is associated with tumor progression in ovarian carcinoma. Lab Invest 2003 83 : 861.
12. Kamai T, Tsujii T, Arai K, et al. Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer. Clin Cancer Res 2003 9 : 2632.
13. Wang W, Yang LY, Yang ZL, Huang GW, Lu WQ. Expression and significance of RhoC gene in hepatocellular carcinoma. World J Gastroenterol 2003 9 : 1950.
14. Wang W, Yang LY, Huang GW, et al. Genomic analysis reveals RhoC as a potential marker in hepatocellular carcinoma with poor prognosis. Br J Cancer 2004 90 : 2349.
15. Cai XJ, Xu GG, Shen B. [Expression of RhoC protein in human primary hepatocellular carcinoma and its clinical significance]. Zhejiang Da Xue Xue Bao Yi Xue Ban 2006 35 : 394.
16. Bellovin DI, Simpson KJ, Danilov T, et al. Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma. Oncogene 2006 25 : 6959.
17. Zhang HZ, Liu JG, Wei YP, Wu C, Cao YK, Wang M. [Expressions of RhoC and osteopontin in esophageal squamous carcinoma and association with the patients' prognosis]. Nan Fang Yi Ke Da Xue Xue Bao 2006 26 : 1612.
18. Zhang HZ, Liu JG, Wei YP, Wu C, Cao YK, Wang M. Expression of G3BP and RhoC in esophageal squamous carcinoma and their effect on prognosis. World J Gastroenterol 2007 13 : 4126.
19. Faried A, Faried LS, Usman N, Kato H, Kuwano H. Clinical and prognostic significance of RhoA and RhoC gene expression in esophageal squamous cell carcinoma. Ann Surg Oncol 2007 14 : 3593.
20. Suwa H, Ohshio G, Imamura T, et al. Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas. Br J Cancer 1998 77 : 147.
21. Liu N, Zhang G, Bi F, et al. RhoC is essential for the metastasis of gastric cancer. J Mol Med 2007 85 : 1149.
22. Kleer CG, Teknos TN, Islam M, et al. RhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neck. Clin Cancer Res 2006 12 : 4485.
23. Marionnet C, Lalou C, Mollier K, et al. Differential molecular profiling between skin carcinomas reveals four newly reported genes potentially implicated in squamous cell carcinoma development. Oncogene 2003 22 : 3500.
24. Clark EA, Golub TR, Lander ES, Hynes RO. Genomic analysis of metastasis reveals an essential role for RhoC. Nature 2000 406 : 532.
25. Ruth MC, Xu Y, Maxwell IH, Ahn NG, Norris DA, Shellman YG. RhoC promotes human melanoma invasion in a PI3K/Akt-dependent pathway. J Invest Dermatol 2006 126 : 862.
26. Wang L, Yang L, Luo Y, Zheng Y. A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells. J Biol Chem 2003 278 : 44617.
27. Collisson EA, Kleer C, Wu M, et al. Atorvastatin prevents RhoC isoprenylation, invasion, and metastasis in human melanoma cells. Mol Cancer Ther 2003 2 : 941.
28. Westbroek W, Lambert J, De Schepper S, et al. Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts. Pigment Cell Res 2004 17 : 498.
29. Vandesompele J, De Paepe A, Speleman F. Elimination of primer-dimer artifacts and genomic coamplification using a two-step SYBR green I real-time RT-PCR. Anal Biochem 2002 303 : 95.
30. Vandesompele J, De Preter K, Pattyn F, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002 3 : RESEARCH0034.
31. Riebeling C, Muller C, Geilen CC. Expression and regulation of phospholipase D isoenzymes in human melanoma cells and primary melanocytes. Melanoma Res 2003 13 : 555.
32. Ormerod EJ, Everett CA, Hart IR. Enhanced experimental metastatic capacity of a human tumor line following treatment with 5-azacytidine. Cancer Res 1986 46 : 884.
33. Thies A, Mauer S, Fodstad O, Schumacher U. Clinically proven markers of metastasis predict metastatic spread of human melanoma cells engrafted in scid mice. Br J Cancer 2007 96 : 609.
34. Balch CM, Soong SJ, Atkins MB, et al. An evidence-based staging system for cutaneous melanoma. CA Cancer J Clin 2004 54 : 131 quiz 82 84.
35. Simpson KJ, Dugan AS, Mercurio AM. Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma. Cancer Res 2004 64 : 8694.
36. Pille JY, Denoyelle C, Varet J, et al. Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo. Mol Ther 2005 11 : 267.
37. van Golen KL, Bao L, DiVito MM, Wu Z, Prendergast GC, Merajver SD. Reversion of RhoC GTPase-induced inflammatory breast cancer phenotype by treatment with a farnesyl transferase inhibitor. Mol Cancer Ther 2002 1 : 575.
38. Sun HW, Tong SL, He J, et al. RhoA and RhoC -siRNA inhibit the proliferation and invasiveness activity of human gastric carcinoma by Rho/PI3K/Akt pathway. World J Gastroenterol 2007 13 : 3517.
39. Yao H, Dashner EJ, van Golen CM, van Golen KL. RhoC GTPase is required for PC-3 prostate cancer cell invasion but not motility. Oncogene 2006 25 : 2285.
40. Hakem A, Sanchez-Sweatman O, You-Ten A, et al. RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev 2005 19 : 1974.
41. Zhao ZQ, Yu PW, Zhao YL, Shi Y. [Expressions of RhoC CD44v6 and ICAM-1 in human gastric cancer and its clinicopathological significance]. Zhonghua Wei Chang Wai Ke Za Zhi 2005 8 : 352.
42. Sauvaigo S, Fretts RE, Riopelle RJ, Lagarde AE. Autonomous proliferation of MeWo human melanoma cell lines in serum-free medium: secretion of growth-stimulating activities. Int J Cancer 1986 37 : 123.
43. Shi Z, Chen ML, He QL, Zeng JH. Antisense RhoC gene suppresses proliferation and invasion capacity of human QBC939 cholangiocarcinoma cells. Hepatobiliary Pancreat Dis Int 2007 6 : 516.
44. van Golen KL, Bao LW, Pan Q, Miller FR, Wu ZF, Merajver SD. Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer. Clin Exp Metastasis 2002 19 : 301.
45. Koomen ER, Joosse A, Herings RM, et al. Is statin use associated with a reduced incidence, a reduced Breslow thickness or delayed metastasis of melanoma of the skin? Eur J Cancer 2007 43 : 2580.
46. Papadakis JA, Mikhailidis DP. Coronary events with lipid-lowering therapy: the AFCAPS/TexCAPS trial. Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA 1999 281 : 416 author reply 7 9.
47. Demierre MF. Consideration of statins for chemoprevention of cutaneous melanoma. J Drugs Dermatol 2005 4 : 125.
48. Negre-Aminou P, van Vliet AK, van Erck M, van Thiel GC, van Leeuwen RE, Cohen LH. Inhibition of proliferation of human smooth muscle cells by various HMG-CoA reductase inhibitors; comparison with other human cell types. Biochim Biophys Acta 1997 1345 : 259.