Clinical and prognostic significance of rhoA and rhoC gene expression in esophageal squamous cell carcinoma

Annals of Surgical Oncology

Volumn 14, Issue 12, 2007, Pages 3593-3601

  Faried, Ahmad ^a,b   Faried, Leri S ^a   Usman, Nurhayat ^b   Kato, Hiroyuki ^a   Kuwano, Hiroyuki ^a  

^a GUNMA UNIVERSITY   (Japan)

^b PADJADJARAN UNIVERSITY   (Indonesia)

Author keywords

Esophageal squamous cell carcinoma; Prognostic marker; RhoA; RhoC

Indexed keywords

RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; RHOC; UNCLASSIFIED DRUG;

ADULT; ADVANCED CANCER; ARTICLE; CANCER PATIENT; CANCER SURGERY; CANCER SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; ESOPHAGUS METASTASIS; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MALE; REAL TIME POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; TUMOR DIFFERENTIATION;

ADULT; AGED; CARCINOMA, SQUAMOUS CELL; CELL DIFFERENTIATION; ESOPHAGEAL NEOPLASMS; ESOPHAGUS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHO GTP-BINDING PROTEINS; RHOA GTP-BINDING PROTEIN; RNA, MESSENGER; RNA, NEOPLASM; SURVIVAL; TUMOR CELLS, CULTURED;

EID: 36348997060     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-007-9562-x     Document Type: Article

References (36)

1. Berrino F, Sant M, Verdecchia A, et al., eds. Survival of Cancer Patients in Europe: The EUROCARE Study. IARC Scientific Publication No. 132. Lyon, France: IARC 1995
2. Walsh TN, Noonan N, Hollywood D, Kelly A, Keeling N, Hennessy TP. A comparison of multimodal therapy and surgery for esophageal adenocarcinoma. N Engl J Med 1996;335:462-7
3. Urba SG, Orringer MB, Turrisi A, et al. Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma. J Clin Oncol 2001;19:305-13
4. Hall A. Rho GTPases and the actin cytoskeleton. Science 1998;279:509-14
5. del Peso L, Hernandez-Alcoceba R, Embade N, et al. Rho proteins induce metastatic property in vivo. Oncogene 1997;15:3047-57
6. Fritz G, Just I, Kaina B. Rho GTPases are over-expressed in human tumors. Int J Cancer 1999;81:682-7
7. Horiuchi A, Imai T, Wang C, et al. Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma. Lab Invest 2003;83:861-70
8. Kamai T, Tsujii T, Arai K, et al. Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer. Clin Cancer Res 2003;9:2632-41
9. Faried A, Nakajima M, Sohda M, Miyazaki T, Kato H, Kuwano H. Correlation between RhoA overexpression and tumor progression in esophageal squamous cell carcinoma. Eur J Surg Oncol 2005;31:410-4
10. Li XR, Ji F, Ouyang J, Wu W, Qian LY, Yang KY. Overexpression of RhoA is associated with poor prognosis in hepatocellular carcinoma. Eur J Surg Oncol 2006;32:1130-4
11. Kamai T, Arai K, Tsujii M, Honda M, Yoshida K. Overexpression of RhoA mRNA is associated with advanced stage in testicular germ cell tumour. BJU Int 2001;87:227-31
12. Kleer CG, van Golen KL, Zhang Y, et al. Characterization of RhoC expression in benign and malignant breast disease: a potential new marker for small breast carcinomas with metastatic ability. Am J Pathol 2002;160:579-84
13. Kleer CG, Griffith KA, Sabel MS, et al. RhoC-GTPase is a novel tissue biomarker associated with biologically aggressive carcinoma of the breast. Breast Cancer Res Treat 2005;93:101-10
14. Kleer CG, Teknos TN, Islam M, et al. RhoC GTPase as a potential marker of lymph node metastasis in squamous cell carcinoma of the head and neck. Clin Cancer Res 2006;12:4485-90
15. Suwa H, Ohshio G, Imamura T, et al. Overexpression of the rhoC gene correlates with the progression of ductal adenocarcinoma of the pancreas. Br J Cancer 1998;77:147-52
16. Wang W, Yang LY, Huang, et al. Genomic analysis revels RhoC as a potential marker in hepatocellular carcinoma with poor prognosis. Br J Cancer 2004;90:2349-55
17. Clark EA, Golub TR, Lander ES, Hynes RO. Genomic analysis of metastasis reveals an essential role for RhoC. Nature 2000;406:532-5
18. van Golen KL, Wu ZF, Qiao XT, Bao LW, Merajver SD. RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype. Cancer Res 2000;60:5832-8
19. Faried A, Faried LS, Kimura H, et al. RhoA and RhoC proteins promote both cell proliferation and cell invasion of human oesophageal squamous cell carcinoma cell lines in vitro and in vivo. Eur J Cancer 2006;42:1455-65
20. Sobin LH, Wittekind C, eds. TNM: Classification of Malignant Tumours. 6th ed. New York: Wiley, 2002
21. Nishihira T, Hashimoto Y, Katayama M, Mori S, Kuroki T. Molecular and cellular features of esophageal cancer cells. J Cancer Res Clin Oncol 1993;119:441-9
22. Takahashi K, Kanazawa H, Chan H, Hosono T, Takahara M, Saito K. A case of esophageal carcinoma metastatic to the mandible and characterization of two cell lines (TT and TTn) established from the oral tumor. Jpn J Oral Maxillofac Surg 1990;36:307-16
23. Sashiyama H, Shino Y, Sakao S, et al. Alteration of integrin expression rates to malignant progression of human papillomavirus-immortalized esophageal keratinocytes. Cancer Lett 2002;177:21-8
24. Xu M, Miller MS. Determination of murine fetal reverse transcriptase-polymerase chain reaction. Toxicol Appl Pharmacol 2004;201:295-302
25. R statistical software. Available at: ftp://ftp.u-aizu.ac.jp/pub/lang/R/ CRAN/
26. Zhou J, Zhao LQ, Xiong MM, et al. Gene expression profiles at different stages of human esophageal squamous cell carcinoma. World J Gastroenterol 2003;9:9-15
27. Lawler K, Foran E, O'Sullivan G, Long A, Kenny D. Mobility and invasiveness of metastatic esophageal cancer are potentiated by shear stress in a ROCK- and Ras-dependent manner. Am J Physiol Cell Physiol 2006;291:C668-77
28. Zhang FL, Casey PJ. Protein prenylation: molecular mechanisms and functional consequences. Annu Rev Biochem 1996;65:241-69
29. Adamson P, Marshall CJ, Hall A, Tilbrook PA. Post-translational modifications of p21rho proteins. J Biol Chem 1992;267:20033-8
30. van Golen KL, Bao L, DiVito MM, Wu Z, Prendergast GC, Merajver SD. Reversion of RhoC GTPase-induced inflammatory breast cancer phenotype by treatment with a farnesyltransferase inhibitor. Mol Cancer Ther 2002;1:575-83
31. Collisson EA, Kleer C, Wu M, et al. Atorvastatin prevents RhoC isoprenylation, invasion, and metastasis in human melanoma cells. Mol Cancer Ther 2003;2:941-8
32. Tang D, Park HJ, Georgescu SP, Sebti SM, Hamilton AD, Galper JB. Simvastatin potentiates tumor necrosis factor alpha-mediated apoptosis of human vascular endothelial cells via the inhibition of the geranylgeranylation of RhoA. Life Sci 2006;79:1484-92
33. Kawata S, Yamasaki E, Nagase T, et al. Effect of pravastatin on survival in patients with advanced hepatocellular carcinoma: a randomized controlled trial. Br J Cancer 2001;84:886-91
34. Itoh K, Yoshioka K, Akedo H, Uehata M, Ishizaki T, Narumiya S. An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nat Med 1999;5:221-5
35. Imamura F, Mukai M, Ayaki M, Akedo H. Y-27632, an inhibitor of Rho-associated protein kinase, suppresses tumor cell invasion via regulation of focal adhesion and focal adhesion kinase. Jpn J Cancer Res 2000;91:811-6
36. Somlyo AV, Bradshaw D, Ramos S, Murphy C, Myers CE, Somlyo AP. Rho-kinase inhibitor retards migration and in vivo dissemination of human prostate cancer cells. Biochem Biophys Res Commun 2000;269:652-9