Different binding modes of tropeines mediating inhibition and potentiation of α1 glycine receptors

Journal of Neurochemistry

Volumn 109, Issue 6, 2009, Pages 1725-1732

  Maksay, Gábor ^a,b,c   Laube, Bodo ^c,d   Schemm, Rudolf ^e   Grudzinska, Joanna ^c   Drwal, Malgorzata ^c   Betz, Heinrich ^c  

^a CHEMICAL RESEARCH CENTER   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

^d DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

^e MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

1 glycine receptors; Inhibition; Ligand docking; Molecular dynamics simulation; Potentiation; Tropeine binding

Indexed keywords

3ALPHA (3' METHOXY BENZOYLOXY)NORTROPANE; GLYCINE RECEPTOR; GLYCINE RECEPTOR ALPHA1; TROPANE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ELECTROPHYSIOLOGY; MOLECULAR DYNAMICS; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; VOLTAGE CLAMP; XENOPUS LAEVIS;

ANIMALS; BINDING SITES; BIOPHYSICS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; HUMANS; INDOLES; MEMBRANE POTENTIALS; MICROINJECTIONS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; NORTROPANES; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GLYCINE; XENOPUS LAEVIS;

XENOPUS LAEVIS;

EID: 65949108593     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.06083.x     Document Type: Article

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