-
1
-
-
0041465022
-
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
-
Berra E, Benizri E, Ginouve's A, Volmat V, Roux D, Pouysségur J. 2003. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J 22:4082-4090.
-
(2003)
EMBO J
, vol.22
, pp. 4082-4090
-
-
Berra, E.1
Benizri, E.2
Ginouve's, A.3
Volmat, V.4
Roux, D.5
Pouysségur, J.6
-
2
-
-
0025194853
-
2+ channels and is not mediated by acetylcholine, glutamate or aspartate release
-
2+ channels and is not mediated by acetylcholine, glutamate or aspartate release. J Pharmacol Exp Ther 254:664-670.
-
(1990)
J Pharmacol Exp Ther
, vol.254
, pp. 664-670
-
-
Bowyer, J.F.1
Weiner, N.2
-
3
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick RK, McKnight SL. 2001. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294:1337-1340.
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
4
-
-
0033763820
-
Expression of hypoxia-inducible factor-1α in the brain of rats during chronic hypoxia
-
Chávez JC, Agani F, Pichiule P, LaManna JC. 2000. Expression of hypoxia-inducible factor-1α in the brain of rats during chronic hypoxia. J Appl Physiol 89:1937-1942.
-
(2000)
J Appl Physiol
, vol.89
, pp. 1937-1942
-
-
Chávez, J.C.1
Agani, F.2
Pichiule, P.3
LaManna, J.C.4
-
5
-
-
0027979247
-
Hypoxia increases rate of transcription and stability of tyrosine hydroxylase mRNA in pheochromocytoma (PC12) Cells
-
Cryzyk-Krzeska MF, Furnari BA, Lawson EE, Millhorn DE. 1994. Hypoxia increases rate of transcription and stability of tyrosine hydroxylase mRNA in pheochromocytoma (PC12) Cells. J Biol Chem 269:760-764.
-
(1994)
J Biol Chem
, vol.269
, pp. 760-764
-
-
Cryzyk-Krzeska, M.F.1
Furnari, B.A.2
Lawson, E.E.3
Millhorn, D.E.4
-
6
-
-
1642455146
-
Plasticity of tyrosine hydroxylase gene expression in the rat nucleus tractus solitarius after ventilatory acclimatization to hypoxia
-
Dumas S, Pequignot JM, Ghilini G, Mallet J, Denavit-Saubie M. 1996. Plasticity of tyrosine hydroxylase gene expression in the rat nucleus tractus solitarius after ventilatory acclimatization to hypoxia. Brain Res Mol Brain Res 40:188-194.
-
(1996)
Brain Res Mol Brain Res
, vol.40
, pp. 188-194
-
-
Dumas, S.1
Pequignot, J.M.2
Ghilini, G.3
Mallet, J.4
Denavit-Saubie, M.5
-
7
-
-
9744239461
-
Tyrosine hydroxylase phosphorylation: Regulation and consequences
-
Dunkley PR, Bobrovskaya L, Graham ME, von Nygy-Felsobuki EI, Dickson PW, 2004. Tyrosine hydroxylase phosphorylation: regulation and consequences. J Neurochem 91:1025-1043.
-
(2004)
J Neurochem
, vol.91
, pp. 1025-1043
-
-
Dunkley, P.R.1
Bobrovskaya, L.2
Graham, M.E.3
von Nygy-Felsobuki, E.I.4
Dickson, P.W.5
-
8
-
-
17944375360
-
Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor gene product
-
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ. 2001. Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor gene product. Cell 107:43-54.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
O'Rourke, J.5
Mole, D.R.6
Mukherji, M.7
Metzen, E.8
Wilson, M.I.9
Dhanda, A.10
Tian, Y.M.11
Masson, N.12
Hamilton, D.L.13
Jaakkola, P.14
Barstead, R.15
Hodgkin, J.16
Maxwell, P.H.17
Pugh, C.W.18
Schofield, C.J.19
Ratcliffe, P.J.20
more..
-
9
-
-
0025315644
-
In vivo mechanisms underlying dopamine release from rat nigrostriatal terminals: II. Studies using potassium and tyramine
-
Fairbrother IS, Arbuthnott GW, Kelly JS, Butcher SP. 1990. In vivo mechanisms underlying dopamine release from rat nigrostriatal terminals: II. Studies using potassium and tyramine. J Neurochem 54:1844-1851.
-
(1990)
J Neurochem
, vol.54
, pp. 1844-1851
-
-
Fairbrother, I.S.1
Arbuthnott, G.W.2
Kelly, J.S.3
Butcher, S.P.4
-
10
-
-
28844485065
-
Effects of triadimefon on extracellular dopamine, DOPAC, HVA and 5-HIAA in adult rat striatum
-
Gagnaire F, Micillino JC. 2005. Effects of triadimefon on extracellular dopamine, DOPAC, HVA and 5-HIAA in adult rat striatum. Toxicology 217:91-104.
-
(2005)
Toxicology
, vol.217
, pp. 91-104
-
-
Gagnaire, F.1
Micillino, J.C.2
-
11
-
-
1642286962
-
Modulating the hypoxia-inducible factor signaling pathway: Applications from cardiovascular disease to cancer
-
Hewitson KS, McNeill LA, Schofield CJ. 2004. Modulating the hypoxia-inducible factor signaling pathway: applications from cardiovascular disease to cancer. Curr Pharm Des 10:821-833.
-
(2004)
Curr Pharm Des
, vol.10
, pp. 821-833
-
-
Hewitson, K.S.1
McNeill, L.A.2
Schofield, C.J.3
-
13
-
-
0035917313
-
2 sensing
-
2 sensing. Science 292:464-468.
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin Jr., W.G.10
-
14
-
-
0037108807
-
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
-
Ivan M, Haberberger T, Gervasi DC, Michelson KS, Günzler V, Kondo K, Yang H, Sorokina I, Conaway RC, Conaway JW, Kaelin WG Jr. 2002. Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. PNAS 21:13459-13464.
-
(2002)
PNAS
, vol.21
, pp. 13459-13464
-
-
Ivan, M.1
Haberberger, T.2
Gervasi, D.C.3
Michelson, K.S.4
Günzler, V.5
Kondo, K.6
Yang, H.7
Sorokina, I.8
Conaway, R.C.9
Conaway, J.W.10
Kaelin Jr., W.G.11
-
15
-
-
0035917808
-
Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ. 2001. Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292:468-472.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
Maxwell, P.H.11
Pugh, C.W.12
Ratcliffe, P.J.13
-
16
-
-
0032521354
-
Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter
-
Jones SR, Gainetdinov RR, Wightman MR, Caron G. 1998. Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter. Neuroscience 18:1979-1986.
-
(1998)
Neuroscience
, vol.18
, pp. 1979-1986
-
-
Jones, S.R.1
Gainetdinov, R.R.2
Wightman, M.R.3
Caron, G.4
-
17
-
-
0030017489
-
Intricate regulation of tyrosine hydroxylase activity and gene expression
-
Kumer SC, Vrana KE. 1996. Intricate regulation of tyrosine hydroxylase activity and gene expression. J Neurochem 67:443-462.
-
(1996)
J Neurochem
, vol.67
, pp. 443-462
-
-
Kumer, S.C.1
Vrana, K.E.2
-
18
-
-
0036469038
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML. 2002. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Science 295:858-861.
-
(2002)
Science
, vol.295
, pp. 858-861
-
-
Lando, D.1
Peet, D.J.2
Whelan, D.A.3
Gorman, J.J.4
Whitelaw, M.L.5
-
19
-
-
0035887011
-
FIH-1 a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon PC, Hirota K, Semenza GL. 2001. FIH-1 a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15:2675-2686.
-
(2001)
Genes Dev
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
20
-
-
33745614894
-
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)
-
McDonough MA, Li V, Flashman E, Chowdhury R, Mohr C, Liénard BMR, Zondlo J, Oldman NJ, Clifton IJ, Lewis J, McNeill LA, Kurzeja RJM, Hewitson KS, Yang E, Jordan S, Syed RS, Schofield CJ. 2006. Cellular oxygen sensing: crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2). PNAS 103:9814-9819.
-
(2006)
PNAS
, vol.103
, pp. 9814-9819
-
-
McDonough, M.A.1
Li, V.2
Flashman, E.3
Chowdhury, R.4
Mohr, C.5
Liénard, B.M.R.6
Zondlo, J.7
Oldman, N.J.8
Clifton, I.J.9
Lewis, J.10
McNeill, L.A.11
Kurzeja, R.J.M.12
Hewitson, K.S.13
Yang, E.14
Jordan, S.15
Syed, R.S.16
Schofield, C.J.17
-
21
-
-
34147202137
-
Desferrioxamine enhances hypoxic ventilatory response and induces tyrosine hydroxylase gene expression in the rat brainstem in vivo
-
Nguyen MVC, Pouvreau S, El Hajjaji FZ, Denavit-Saubie M, Pequignot JM. 2007. Desferrioxamine enhances hypoxic ventilatory response and induces tyrosine hydroxylase gene expression in the rat brainstem in vivo. J Neurosci Res 85:1119-1125.
-
(2007)
J Neurosci Res
, vol.85
, pp. 1119-1125
-
-
Nguyen, M.V.C.1
Pouvreau, S.2
El Hajjaji, F.Z.3
Denavit-Saubie, M.4
Pequignot, J.M.5
-
22
-
-
0028859483
-
2-responsive sequences on the tyrosine hydroxylase gene
-
2-responsive sequences on the tyrosine hydroxylase gene. J Biol Chem 270:23774-23779.
-
(1995)
J Biol Chem
, vol.270
, pp. 23774-23779
-
-
Norris, M.L.1
Millhorn, D.E.2
-
23
-
-
0035783413
-
Selective cardiorespiratory and catecholaminergic areas express the hypoxia-inducible factor-1alpha (HIF-1alpha) under in vivo hypoxia in rat brainstem
-
Pascual O, Denavit-Saubie M, Dumas S, Kietzmann T, Ghilini G, Mallet J, Pequignot JM. 2001. Selective cardiorespiratory and catecholaminergic areas express the hypoxia-inducible factor-1alpha (HIF-1alpha) under in vivo hypoxia in rat brainstem. Eur J Neurosci 14:1981-1991.
-
(2001)
Eur J Neurosci
, vol.14
, pp. 1981-1991
-
-
Pascual, O.1
Denavit-Saubie, M.2
Dumas, S.3
Kietzmann, T.4
Ghilini, G.5
Mallet, J.6
Pequignot, J.M.7
-
24
-
-
0034141542
-
Effects of phosphorylation on binding of catecholamines to tyrosine hydroxylase: Specificity and thermodynamics
-
Ramsey AJ, Fitzpatrick PF. 2000. Effects of phosphorylation on binding of catecholamines to tyrosine hydroxylase: specificity and thermodynamics. Biochemistry 39:773-778.
-
(2000)
Biochemistry
, vol.39
, pp. 773-778
-
-
Ramsey, A.J.1
Fitzpatrick, P.F.2
-
25
-
-
12944252971
-
Amphetamine-induced loss of human dopamine transporter activity: An internalization-dependent and cocaine-sensitive mechanism
-
Saunders C, Ferrer JV, Shi L, Chen J, Merrill G, Lamb ME, Leeb-Lundberg F, Carvelli L, Javitch JA, Galli A. 2000. Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism. PNAS 97:6859-6855.
-
(2000)
PNAS
, vol.97
, pp. 6859-6855
-
-
Saunders, C.1
Ferrer, J.V.2
Shi, L.3
Chen, J.4
Merrill, G.5
Lamb, M.E.6
Leeb-Lundberg, F.7
Carvelli, L.8
Javitch, J.A.9
Galli, A.10
-
26
-
-
0027273214
-
Regional specificity of the long-term regulation of tyrosine hydroxylase in some catecholaminergic rat brainstem areas. I. Influence of long-term hypoxia
-
Schmitt P, Pequignot J, Garcia C, Pujol JF, Pequignot JM. 1993. Regional specificity of the long-term regulation of tyrosine hydroxylase in some catecholaminergic rat brainstem areas. I. Influence of long-term hypoxia. Brain Res 611:53-60.
-
(1993)
Brain Res
, vol.611
, pp. 53-60
-
-
Schmitt, P.1
Pequignot, J.2
Garcia, C.3
Pujol, J.F.4
Pequignot, J.M.5
-
27
-
-
0037389490
-
Regulation of tyrosine hydroxylase promoter activity by the von Hippel-Lindau tumor suppressor protein and hypoxia-inducible transcription factors
-
Schnell PO, Ignacak ML, Bauer AL, Striet JB, Paulding WR, Czyzyk-Krzeska MF. 2003. Regulation of tyrosine hydroxylase promoter activity by the von Hippel-Lindau tumor suppressor protein and hypoxia-inducible transcription factors. J Neurochem 85:483-491.
-
(2003)
J Neurochem
, vol.85
, pp. 483-491
-
-
Schnell, P.O.1
Ignacak, M.L.2
Bauer, A.L.3
Striet, J.B.4
Paulding, W.R.5
Czyzyk-Krzeska, M.F.6
-
28
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
-
Semenza GL, Wang GL. 1992. A nuclear factor induced by hypoxia via de novo synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Moll Cell Biol 12:5447-5454.
-
(1992)
Moll Cell Biol
, vol.12
, pp. 5447-5454
-
-
Semenza, G.L.1
Wang, G.L.2
-
29
-
-
29244485561
-
Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system
-
Siddiq A, Ayoub IA, Chavez JC, Aminova L, Shah S, Lamanna JC, Patton SM, Connor JR, Cherny RA, Volitakis I, Bush AI, Lansetmo I, Seeley T, Gunzler V, Ratan RR. 2005. Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system. J Biol Chem 280:41732-41743.
-
(2005)
J Biol Chem
, vol.280
, pp. 41732-41743
-
-
Siddiq, A.1
Ayoub, I.A.2
Chavez, J.C.3
Aminova, L.4
Shah, S.5
Lamanna, J.C.6
Patton, S.M.7
Connor, J.R.8
Cherny, R.A.9
Volitakis, I.10
Bush, A.I.11
Lansetmo, I.12
Seeley, T.13
Gunzler, V.14
Ratan, R.R.15
-
30
-
-
0035159670
-
Hif-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia
-
Stroka DM, Buckhardt T, Desbaillets I, Wenger RH, Neil DAH, Bauer C, Gassmann M, Candinas D. 2001. Hif-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia. FASEB J 15:2445-2453.
-
(2001)
FASEB J
, vol.15
, pp. 2445-2453
-
-
Stroka, D.M.1
Buckhardt, T.2
Desbaillets, I.3
Wenger, R.H.4
Neil, D.A.H.5
Bauer, C.6
Gassmann, M.7
Candinas, D.8
-
31
-
-
0032213236
-
The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
-
Tian H, Hammer RE, Matsumoto AM, Russell DW, McKnight SL. 1998. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev 12:3320-3324.
-
(1998)
Genes Dev
, vol.12
, pp. 3320-3324
-
-
Tian, H.1
Hammer, R.E.2
Matsumoto, A.M.3
Russell, D.W.4
McKnight, S.L.5
-
32
-
-
49949091073
-
Dopamine transporter inhibition is required for cocaine-induced stereotypy
-
Tilley MR, Gu HH. 2008. Dopamine transporter inhibition is required for cocaine-induced stereotypy. Neuroreport 19:1137-1140.
-
(2008)
Neuroreport
, vol.19
, pp. 1137-1140
-
-
Tilley, M.R.1
Gu, H.H.2
-
33
-
-
0027136260
-
Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: Implications for models of hypoxia signal transduction
-
Wang GL, Semenza GL. 1993. Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood 82:3610-3615.
-
(1993)
Blood
, vol.82
, pp. 3610-3615
-
-
Wang, G.L.1
Semenza, G.L.2
|