Role of endothelin-1 in acute lung injury

Translational Research

Volumn 153, Issue 6, 2009, Pages 263-271

  Comellas, Alejandro P ^a   Briva, Arturo ^b  

^a UNIVERSITY OF IOWA   (United States)

^b DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYTOKINE; ENDOTHELIN 1; ENDOTHELIN B RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; INTERLEUKIN 1; INTERLEUKIN 6; INTERLEUKIN 8; ISOPRENALINE;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CAPILLARY PERMEABILITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; LUNG ALVEOLUS CELL; LUNG CIRCULATION; LUNG CLEARANCE; LUNG EDEMA; LUNG GAS EXCHANGE; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PNEUMONIA; PRIORITY JOURNAL; PROGNOSIS; RAT; REVIEW; SODIUM TRANSPORT; VASOCONSTRICTION;

EID: 65549151661     PISSN: 19315244     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trsl.2009.02.007     Document Type: Review

References (126)

1. Bernard G.R., Artigas A., Brigham K.L., et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 149 (1994) 818-824
2. Phua J., Stewart T.E., and Ferguson N.D. Acute respiratory distress syndrome 40 years later: time to revisit its definition. Crit Care Med 36 (2008) 2912-2921
3. Rubenfeld G.D., Caldwell E., Peabody E., et al. Incidence and outcomes of acute lung injury. N Engl J Med 353 (2005) 1685-1693
4. Angus D.C., Clermont G., Linde-Zwirble W.T., et al. Healthcare costs and long-term outcomes after acute respiratory distress syndrome: a phase III trial of inhaled nitric oxide. Crit Care Med 34 (2006) 2883-2890
5. Bellingan G.J. The pulmonary physician in critical care * 6: the pathogenesis of ALI/ARDS. Thorax 57 (2002) 540-546
6. Matthay M.A., Zimmerman G.A., Esmon C., et al. Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med 167 (2003) 1027-1035
7. Piantadosi C.A., and Schwartz D.A. The acute respiratory distress syndrome. Ann Intern Med 141 (2004) 460-470
8. Puneet P., Moochhala S., and Bhatia M. Chemokines in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol 288 (2005) L3-L15
9. Jacobs R.F., Tabor D.R., Burks A.W., and Campbell G.D. Elevated interleukin-1 release by human alveolar macrophages during the adult respiratory distress syndrome. Am Rev Respir Dis 140 (1989) S1686-S1692
10. Miller E.J., Cohen A.B., Nagao S., et al. Elevated levels of NAP-1/interleukin-8 are present in the airspaces of patients with the adult respiratory distress syndrome and are associated with increased mortality. Am Rev Respir Dis 146 (1992) 427-432
11. Suter P.M., Suter S., Girardin E., et al. High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis. Am Rev Respir Dis 145 (1992) 1016-1022
12. Aird W.C. Endothelial cell heterogeneity. Crit Care Med 31 (2003) S221-S230
13. Berthiaume Y., and Matthay M.A. Alveolar edema fluid clearance and acute lung injury. Respir Physiol Neurobiol 159 (2007) 350-359
14. Komarova Y.A., Mehta D., and Malik A.B. Dual regulation of endothelial junctional permeability. Sci STKE (2007) 2007 re8
15. Jacobson J.R., and Garcia J.G. Novel therapies for microvascular permeability in sepsis. Curr Drug Targets 8 (2007) 509-514
16. Vadasz I., Raviv S., and Sznajder J.I. Alveolar epithelium and Na,K-ATPase in acute lung injury. Intensive Care Med 33 (2007) 1243-1251
17. Ishizaka A., Matsuda T., Albertine K.H., et al. Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol 286 (2004) L1088-L1094
18. Uchida T., Shirasawa M., Ware L.B., et al. Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. Am J Respir Crit Care Med 173 (2006) 1008-1015
19. Langleben D., DeMarchie M., Laporta D., et al. Endothelin-1 in acute lung injury and the adult respiratory distress syndrome. Am Rev Respir Dis 148 (1993) 1646-1650
20. Mitaka C., Hirata Y., Nagura T., Tsunoda Y., and Amaha K. Circulating endothelin-1 concentrations in acute respiratory failure. Chest 104 (1993) 476-480
21. Sartori C., Vollenweider L., Loffler B.M., et al. Exaggerated endothelin release in high-altitude pulmonary edema. Circulation 99 (1999) 2665-2668
22. Yanagisawa M., Kurihara H., Kimura S., et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332 (1988) 411-415
23. Fagan K.A., McMurtry I.F., and Rodman D.M. Role of endothelin-1 in lung disease. Respir Res 2 (2001) 90-101
24. Haynes W.G., and Webb D.J. Contribution of endogenous generation of endothelin-1 to basal vascular tone. Lancet 344 (1994) 852-854
25. Hahn A.W., Resink T.J., Scott-Burden T., et al. Stimulation of endothelin mRNA and secretion in rat vascular smooth muscle cells: a novel autocrine function. Cell Regul 1 (1990) 649-659
26. Ito H., Hirata Y., Adachi S., et al. Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. J Clin Invest 92 (1993) 398-403
27. Ehrenreich H., Anderson R.W., Fox C.H., et al. Endothelins, peptides with potent vasoactive properties, are produced by human macrophages. J Exp Med 172 (1990) 1741-1748
28. Fukunaga M., Fujiwara Y., Ochi S., et al. Stimulatory effect of thrombin on endothelin-1 production in isolated glomeruli and cultured mesangial cells of rats. J Cardiovasc Pharmacol 17 (1991) S411-S413
29. Nakamura T., Ebihara I., Fukui M., et al. Renal expression of mRNAs for endothelin-1, endothelin-3 and endothelin receptors in NZB/W F1 mice. Ren Physiol Biochem 16 (1993) 233-243
30. Blouquit S., Sari A., Lombet A., et al. Effects of endothelin-1 on epithelial ion transport in human airways. Am J Respir Cell Mol Biol 29 (2003) 245-251
31. Henry P.J. Endothelin receptor distribution and function in the airways. Clin Exp Pharmacol Physiol 26 (1999) 162-167
32. Marciniak S.J., Plumpton C., Barker P.J., Huskisson N.S., and Davenport A.P. Localization of immunoreactive endothelin and proendothelin in the human lung. Pulm Pharmacol 5 (1992) 175-182
33. Jain R., Shaul P.W., Borok Z., and Willis B.C. Endothelin-1 induces alveolar epithelial-mesenchymal transition through endothelin type A receptor-mediated production of TGF-beta1. Am J Respir Cell Mol Biol 37 (2007) 38-47
34. Comellas A.P., Briva A., Dada L.A., et al. Endothelin-1 impairs alveolar epithelial function via endothelial ETB receptor. Am J Respir Crit Care Med 179 (2009) 113-122
35. Frank J.A., Briot R., Lee J.W., et al. Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs. Am J Physiol Lung Cell Mol Physiol 293 (2007) L52-L59
36. Marasciulo F.L., Montagnani M., and Potenza M.A. Endothelin-1: the yin and yang on vascular function. Curr Med Chem 13 (2006) 1655-1665
37. Luscher T.F., and Barton M. Endothelins and endothelin receptor antagonists: therapeutic considerations for a novel class of cardiovascular drugs. Circulation 102 (2000) 2434-2440
38. Muldoon L.L., Rodland K.D., Forsythe M.L., and Magun B.E. Stimulation of phosphatidylinositol hydrolysis, diacylglycerol release, and gene expression in response to endothelin, a potent new agonist for fibroblasts and smooth muscle cells. J Biol Chem 264 (1989) 8529-8536
39. Schiffrin E.L., and Touyz R.M. Vascular biology of endothelin. J Cardiovasc Pharmacol 32 (1998) S2-S13
40. Clavell A.L., Stingo A.J., Margulies K.B., Brandt R.R., and Burnett Jr. J.C. Role of endothelin receptor subtypes in the in vivo regulation of renal function. Am J Physiol 268 (1995) F455-F460
41. Lysko P.G., Elshourbagy N.A., Pullen M., and Nambi P. Developmental expression of endothelin receptors in cerebellar neurons differentiating in culture. Brain Res Dev Brain Res 88 (1995) 96-101
42. Rockey D.C., and Chung J.J. Regulation of inducible nitric oxide synthase in hepatic sinusoidal endothelial cells. Am J Physiol 271 (1996) G260-G267
43. Rockey D.C., and Chung J.J. Endothelin antagonism in experimental hepatic fibrosis. Implications for endothelin in the pathogenesis of wound healing. J Clin Invest 98 (1996) 1381-1388
44. Strachan F.E., Spratt J.C., Wilkinson I.B., et al. Systemic blockade of the endothelin-B receptor increases peripheral vascular resistance in healthy men. Hypertension 33 (1999) 581-585
45. de Nucci G., Thomas R., D'Orleans-Juste P., et al. Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor. Proc Natl Acad Sci U S A 85 (1988) 9797-9800
46. Hirata Y., Emori T., Eguchi S., et al. Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells. J Clin Invest 91 (1993) 1367-1373
47. D'Orleans-Juste P., Labonte J., Bkaily G., et al. Function of the endothelin(B) receptor in cardiovascular physiology and pathophysiology. Pharmacol Ther 95 (2002) 221-238
48. Liu S., Premont R.T., Kontos C.D., Huang J., and Rockey D.C. Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt. J Biol Chem 278 (2003) 49929-49935
49. Scotland R., Vallance P., and Ahluwalia A. Endothelin alters the reactivity of vasa vasorum: mechanisms and implications for conduit vessel physiology and pathophysiology. Br J Pharmacol 128 (1999) 1229-1234
50. Dupuis J., Stewart D.J., Cernacek P., and Gosselin G. Human pulmonary circulation is an important site for both clearance and production of endothelin-1. Circulation 94 (1996) 1578-1584
51. Nakano Y., Tasaka S., Saito F., et al. Endothelin-1 level in epithelial lining fluid of patients with acute respiratory distress syndrome. Respirology 12 (2007) 740-743
52. Helset E., Kjaeve J., and Hauge A. Endothelin-1-induced increases in microvascular permeability in isolated, perfused rat lungs requires leukocytes and plasma. Circ Shock 39 (1993) 15-20
53. Lehoux S., Plante G.E., Sirois M.G., Sirois P., and D'Orleans-Juste P. Phosphoramidon blocks big-endothelin-1 but not endothelin-1 enhancement of vascular permeability in the rat. Br J Pharmacol 107 (1992) 996-1000
54. Rodman D.M., Stelzner T.J., Zamora M.R., et al. Endothelin-1 increases the pulmonary microvascular pressure and causes pulmonary edema in salt solution but not blood-perfused rat lungs. J Cardiovasc Pharmacol 20 (1992) 658-663
55. Kuzkov V.V., Kirov M.Y., Sovershaev M.A., et al. Extravascular lung water determined with single transpulmonary thermodilution correlates with the severity of sepsis-induced acute lung injury. Crit Care Med 34 (2006) 1647-1653
56. Kosmidou I., Karmpaliotis D., Kirtane A.J., Barron H.V., and Gibson C.M. Vascular endothelial growth factors in pulmonary edema: an update. J Thromb Thrombolysis 25 (2008) 259-264
57. Horgan M.J., Pinheiro J.M., and Malik A.B. Mechanism of endothelin-1-induced pulmonary vasoconstriction. Circ Res 69 (1991) 157-164
58. Kuklin V., Kirov M., Sovershaev M., et al. Tezosentan-induced attenuation of lung injury in endotoxemic sheep is associated with reduced activation of protein kinase C. Crit Care 9 (2005) R211-R217
59. Matsuura A., Yamochi W., Hirata K., Kawashima S., and Yokoyama M. Stimulatory interaction between vascular endothelial growth factor and endothelin-1 on each gene expression. Hypertension 32 (1998) 89-95
60. Carpenter T.C., Schomberg S., and Stenmark K.R. Endothelin-mediated increases in lung VEGF content promote vascular leak in young rats exposed to viral infection and hypoxia. Am J Physiol Lung Cell Mol Physiol 289 (2005) L1075-L1082
61. Spinella F., Rosano L., Di Castro V., Natali P.G., and Bagnato A. Endothelin-1 induces vascular endothelial growth factor by increasing hypoxia-inducible factor-1alpha in ovarian carcinoma cells. J Biol Chem 277 (2002) 27850-27855
62. Kaner R.J., Ladetto J.V., Singh R., et al. Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema. Am J Respir Cell Mol Biol 22 (2000) 657-664
63. Fujii Y., Magder S., Cernacek P., et al. Endothelin receptor blockade attenuates lipopolysaccharide-induced pulmonary nitric oxide production. Am J Respir Crit Care Med 161 (2000) 982-989
64. Michael J.R., and Markewitz B.A. Endothelins and the lung. Am J Respir Crit Care Med 154 (1996) 555-581
65. Wang J., Oldner A., Winskog C., Edston E., and Walther S.M. Effects of endothelin receptor antagonism on acute lung injury induced by chlorine gas. Crit Care Med 34 (2006) 1731-1737
66. Carpenter T.C., and Stenmark K.R. Endothelin receptor blockade decreases lung water in young rats exposed to viral infection and hypoxia. Am J Physiol Lung Cell Mol Physiol 279 (2000) L547-L554
67. Ishizaki T., Shigemori K., Nakai T., et al. Endothelin-1 potentiates leukotoxin-induced edematous lung injury. J Appl Physiol 79 (1995) 1106-1111
68. Albertini M., Clement M.G., and Hussain S.N. Role of endothelin ETA receptors in sepsis-induced mortality, vascular leakage, and tissue injury in rats. Eur J Pharmacol 474 (2003) 129-135
69. Guimaraes C.L., Trentin P.G., and Rae G.A. Endothelin ET(B) receptor-mediated mechanisms involved in oleic acid-induced acute lung injury in mice. Clin Sci 103 (2002) 340S-344S
70. Carpenter T., Schomberg S., Steudel W., et al. Endothelin B receptor deficiency predisposes to pulmonary edema formation via increased lung vascular endothelial cell growth factor expression. Circ Res 93 (2003) 456-463
71. Gariepy C.E., Cass D.T., and Yanagisawa M. Null mutation of endothelin receptor type B gene in spotting lethal rats causes aganglionic megacolon and white coat color. Proc Natl Acad Sci U S A 93 (1996) 867-872
72. Ivy D., McMurtry I.F., Yanagisawa M., et al. Endothelin B receptor deficiency potentiates ET-1 and hypoxic pulmonary vasoconstriction. Am J Physiol Lung Cell Mol Physiol 280 (2001) L1040-L1048
73. Staub N.C. Pulmonary edema. Physiol Rev 54 (1974) 678-811
74. Dada L.A., and Sznajder J.I. Mechanisms of pulmonary edema clearance during acute hypoxemic respiratory failure: role of the Na,K-ATPase. Crit Care Med 31 (2003) S248-S252
75. Matthay M.A., Landolt C.C., and Staub N.C. Differential liquid and protein clearance from the alveoli of anesthetized sheep. J Appl Physiol 53 (1982) 96-104
76. Goodman B.E., Brown S.E., and Crandall E.D. Regulation of transport across pulmonary alveolar epithelial cell monolayers. J Appl Physiol 57 (1984) 703-710
77. Matthay M.A., Folkesson H.G., and Verkman A.S. Salt and water transport across alveolar and distal airway epithelia in the adult lung. Am J Physiol 270 (1996) L487-L503
78. Effros R.M., Mason G.R., Sietsema K., Silverman P., and Hukkanen J. Fluid reabsorption and glucose consumption in edematous rat lungs. Circ Res 60 (1987) 708-719
79. Effros R.M., Mason G.R., Hukkanen J., and Silverman P. New evidence for active sodium transport from fluid-filled rat lungs. J Appl Physiol 66 (1989) 906-919
80. Ware L.B., and Matthay M.A. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med 163 (2001) 1376-1383
81. Sznajder J.I. Alveolar edema must be cleared for the acute respiratory distress syndrome patient to survive. Am J Respir Crit Care Med 163 (2001) 1293-1294
82. Matthay M.A., Robriquet L., and Fang X. Alveolar epithelium: role in lung fluid balance and acute lung injury. Proc Am Thorac Soc 2 (2005) 206-213
83. Kaplan J.H. Biochemistry of Na,K-ATPase. Annu Rev Biochem 71 (2002) 511-535
84. Skou J.C. Nobel Lecture. The identification of the sodium pump. Biosci Rep 18 (1998) 155-169
85. Briva A., Vadasz I., Lecuona E., et al. High CO(2) levels impair alveolar epithelial function independently of pH. PLoS ONE 2 (2007) e1238
86. Comellas A.P., Dada L.A., Lecuona E., et al. Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial reactive oxygen species and the ubiquitin-conjugating system. Circ Res 98 (2006) 1314-1322
87. Dada L.A., Chandel N.S., Ridge K.M., et al. Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta. J Clin Invest 111 (2003) 1057-1064
88. Vadasz I., Morty R.E., Olschewski A., et al. Thrombin impairs alveolar fluid clearance by promoting endocytosis of Na+,K+-ATPase. Am J Respir Cell Mol Biol 33 (2005) 343-354
89. Factor P., Dumasius V., Saldias F., Brown L.A., and Sznajder J.I. Adenovirus-mediated transfer of an Na+/K+-ATPase beta1 subunit gene improves alveolar fluid clearance and survival in hyperoxic rats. Hum Gene Ther 11 (2000) 2231-2242
90. Factor P., Dumasius V., Saldias F., and Sznajder J.I. Adenoviral-mediated overexpression of the NA,K-ATPase beta1 subunit gene increases lung edema clearance and improves survival during acute hyperoxic lung injury in rats. Chest 116 (1999) 24S-25S
91. Myrianthefs P.M., Briva A., Lecuona E., et al. Hypocapnic but not metabolic alkalosis impairs alveolar fluid reabsorption. Am J Respir Crit Care Med 171 (2005) 1267-1271
92. Sugita M., Ferraro P., Dagenais A., et al. Alveolar liquid clearance and sodium channel expression are decreased in transplanted canine lungs. Am J Respir Crit Care Med 167 (2003) 1440-1450
93. Cher C.D., Armugam A., Lachumanan R., Coghlan M.W., and Jeyaseelan K. Pulmonary inflammation and edema induced by phospholipase A2: global gene analysis and effects on aquaporins and Na+/K+-ATPase. J Biol Chem 278 (2003) 31352-31360
94. Litvan J., Briva A., Wilson M.S., et al. Beta-adrenergic receptor stimulation and adenoviral overexpression of superoxide dismutase prevent the hypoxia-mediated decrease in Na,K-ATPase and alveolar fluid reabsorption. J Biol Chem 281 (2006) 19892-19898
95. Dempsey E.C., Cool C.D., and Littler C.M. Lung disease and PKCs. Pharmacol Res 55 (2007) 545-559
96. Fink M.P. Role of reactive oxygen and nitrogen species in acute respiratory distress syndrome. Curr Opin Crit Care 8 (2002) 6-11
97. Modesti P.A., Vanni S., Morabito M., et al. Role of endothelin-1 in exposure to high altitude: Acute mountain sickness and endothelin-1 (ACME-1) study. Circulation 114 (2006) 1410-1416
98. Kourembanas S., Marsden P.A., McQuillan L.P., and Faller D.V. Hypoxia induces endothelin gene expression and secretion in cultured human endothelium. J Clin Invest 88 (1991) 1054-1057
99. Clerici C., and Matthay M.A. Hypoxia regulates gene expression of alveolar epithelial transport proteins. J Appl Physiol 88 (2000) 1890-1896
100. Mairbaurl H., Wodopia R., Eckes S., Schulz S., and Bartsch P. Impairment of cation transport in A549 cells and rat alveolar epithelial cells by hypoxia. Am J Physiol 273 (1997) L797-L806
101. Vivona M.L., Matthay M., Chabaud M.B., Friedlander G., and Clerici C. Hypoxia reduces alveolar epithelial sodium and fluid transport in rats: reversal by beta-adrenergic agonist treatment. Am J Respir Cell Mol Biol 25 (2001) 554-561
102. Knowles M.R., Carson J.L., Collier A.M., Gatzy J.T., and Boucher R.C. Measurements of nasal transepithelial electric potential differences in normal human subjects in vivo. Am Rev Respir Dis 124 (1981) 484-490
103. Mairbaurl H., Weymann J., Mohrlein A., et al. Nasal epithelium potential difference at high altitude (4,559 m): evidence for secretion. Am J Respir Crit Care Med 167 (2003) 862-867
104. Sartori C., Duplain H., Lepori M., et al. High altitude impairs nasal transepithelial sodium transport in HAPE-prone subjects. Eur Respir J 23 (2004) 916-920
105. Scherrer U., Vollenweider L., Delabays A., et al. Inhaled nitric oxide for high-altitude pulmonary edema. N Engl J Med 334 (1996) 624-629
106. Ghofrani H.A., Reichenberger F., Kohstall M.G., et al. Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: a randomized, double-blind, placebo-controlled crossover trial. Ann Intern Med 141 (2004) 169-177
107. Berger M.M., Rozendal C.S., Schieber C., et al. The effect of endothelin-1 on alveolar fluid clearance and pulmonary edema formation in the rat. Anesth Analg 108 (2009) 225-231
108. Guo Y., DuVall M.D., Crow J.P., and Matalon S. Nitric oxide inhibits Na+ absorption across cultured alveolar type II monolayers. Am J Physiol 274 (1998) L369-L377
109. Hardiman K.M., McNicholas-Bevensee C.M., Fortenberry J., et al. Regulation of amiloride-sensitive Na(+) transport by basal nitric oxide. Am J Respir Cell Mol Biol 30 (2004) 720-728
110. Hickman-Davis J.M., McNicholas-Bevensee C., Davis I.C., et al. Reactive species mediate inhibition of alveolar type II sodium transport during mycoplasma infection. Am J Respir Crit Care Med 173 (2006) 334-344
111. Jain L., Chen X.J., Brown L.A., and Eaton D.C. Nitric oxide inhibits lung sodium transport through a cGMP-mediated inhibition of epithelial cation channels. Am J Physiol 274 (1998) L475-L484
112. Kaestle S.M., Reich C.A., Yin N., et al. Nitric oxide-dependent inhibition of alveolar fluid clearance in hydrostatic lung edema. Am J Physiol Lung Cell Mol Physiol 293 (2007) L859-L869
113. Nielsen V.G., Baird M.S., Chen L., and Matalon S. DETANONOate, a nitric oxide donor, decreases amiloride-sensitive alveolar fluid clearance in rabbits. Am J Respir Crit Care Med 161 (2000) 1154-1160
114. Berthiaume Y., Staub N.C., and Matthay M.A. Beta-adrenergic agonists increase lung liquid clearance in anesthetized sheep. J Clin Invest 79 (1987) 335-343
115. Ewart H.S., and Klip A. Hormonal regulation of the Na(+)-K(+)-ATPase: mechanisms underlying rapid and sustained changes in pump activity. Am J Physiol 269 (1995) C295-C311
116. Ghofrani H.A., Kohstall M.G., Weissmann N., et al. Alveolar epithelial barrier functions in ventilated perfused rabbit lungs. Am J Physiol Lung Cell Mol Physiol 280 (2001) L896-L904
117. Pittet J.F., Wiener-Kronish J.P., McElroy M.C., Folkesson H.G., and Matthay M.A. Stimulation of lung epithelial liquid clearance by endogenous release of catecholamines in septic shock in anesthetized rats. J Clin Invest 94 (1994) 663-671
118. Saldias F.J., Lecuona E., Comellas A.P., et al. beta-adrenergic stimulation restores rat lung ability to clear edema in ventilator-associated lung injury. [In Process Citation]. Am J Respir Crit Care Med 162 (2000) 282-287
119. Bertorello A.M., Ridge K.M., Chibalin A.V., Katz A.I., and Sznajder J.I. Isoproterenol increases Na+-K+-ATPase activity by membrane insertion of alpha-subunits in lung alveolar cells. Am J Physiol 276 (1999) L20-L27
120. Chibalin A.V., Katz A.I., Berggren P.O., and Bertorello A.M. Receptor-mediated inhibition of renal Na(+)-K(+)-ATPase is associated with endocytosis of its alpha- and beta-subunits. Am J Physiol 273 (1997) C1458-C1465
121. Lecuona E., Dada L.A., Sun H., et al. Na,K-ATPase alpha1-subunit dephosphorylation by protein phosphatase 2A is necessary for its recruitment to the plasma membrane. FASEB J 20 (2006) 2618-2620
122. Lecuona E., Ridge K., Pesce L., Batlle D., and Sznajder J.I. The GTP-binding protein RhoA mediates Na,K-ATPase exocytosis in alveolar epithelial cells. Mol Biol Cell 14 (2003) 3888-3897
123. Perkins G.D., McAuley D.F., Thickett D.R., and Gao F. The beta-agonist lung injury trial (BALTI): a randomized placebo-controlled clinical trial. Am J Respir Crit Care Med 173 (2006) 281-287
124. Sartori C., Allemann Y., Duplain H., et al. Salmeterol for the prevention of high-altitude pulmonary edema. N Engl J Med 346 (2002) 1631-1636
125. Matthay M.A., and Calfee C.S. Aerosolized beta-adrenergic agonist therapy reduces pulmonary edema following lung surgery. Chest 133 (2008) 833-835
126. Rutschman D.H., Olivera W., and Sznajder J.I. Active transport and passive liquid movement in isolated perfused rat lungs. J Appl Physiol 75 (1993) 1574-1580