Regulation of inducible nitric oxide synthase in hepatic sinusoidal endothelial cells

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 271, Issue 2 34-2, 1996, Pages

  Rockey, Don C ^a,b   Chung, John J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO GENERAL HOSPITAL   (United States)

Author keywords

interferon ; lipopolysaccharide; liver; transcription; tumor necrosis factor

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INDUCTION; GENE EXPRESSION; KUPFFER CELL; LIVER CELL; LIVER SINUSOID; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STELLATE CELL; TRANSCRIPTION REGULATION;

EID: 0029836410     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1996.271.2.g260     Document Type: Article

References (31)

1. Billiar, T. R., R. D. Curran, D. J. Stuehr, M. A. West, B. G. Bentz, and R. L. Simmons. An L-arginine-dependent mechanism mediates Kupffer cell inhibition of hepatocyte protein synthesis in vitro. J. Exp. Med. 169: 1467-1472, 1989.
2. Bissell, D. M., L. E. Hammaker, and U. A. Meyer. Parenchymal cells from adult rat liver in nonproliferating monolayer culture. I. Functional studies. J. Cell Biol. 59: 722-734, 1973.
3. Bredt, D. S., P. M. Hwang, C. E. Glatt, C. Lowenstein, R. R. Reed, and S. H. Snyder. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature Lond. 351: 714-718, 1991.
4. Curran, R. D., T. R. Billiar, D. J. Stuehr, K. Hofmann, and R. L. Simmons. Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells. J. Exp. Med. 170: 1769-1774, 1989.
5. De Leeuw, A. M., S. P. McCarthy, A. Geerts, and D. L. Knook. Purified rat liver fat-storing cells in culture divide and contain collagen. Hepatology 4: 392-403, 1984.
6. Feder, L. S., and D. L. Laskin. Regulation of hepatic endothelial cell and macrophage proliferation and nitric oxide production by GM-CSF, M-CSF, and IL-1β following acute endotoxemia. J. Leukocyte Biol. 55: 507-513, 1994.
7. Geller, D. A., M. Di Silvio, A. K. Nussler, S. C. Wang, R. A. Shapiro, R. L. Simmons, and T. R. Billiar. Nitric oxide synthase expression is induced in hopatocytes in vivo during hepatic inflammation. J. Surg. Res. 55: 427-432, 1993.
8. 15N]nitrate in biological fluids. Anal. Biochem. 126: 131-138, 1982.
9. Guarner, C., G. Soriano, A. Tomas, O. Bulbena, M. T. Novella, J. Balanzo, F. Vilardell, M. Mourelle, and S. Moncada. Increased serum nitrite and nitrate levels in patients with cirrhosis: relationship to endotoxemia. Hepatology 18: 1139-1143, 1993.
10. Harbrecht, B. G., T. R. Billiar, J. Stadler, A. J. Demetris, J. Ochoa, R. D. Curran, and R. L. Simmons. Inhibition of nitric oxide synthesis during endotoxemia promotes intrahepatic thrombosis and an oxygen radical-mediated hepatic injury. J. Leukocyte Biol. 52: 390-394, 1992.
11. Irving, M. G., F. J. Roll, S. Huang, and D. M. Bissell. Characterization and culture of sinusoidal endothelium from normal rat liver: lipoprotein uptake and collagen phenotype. Gastroenterology 87: 1233-1247, 1984.
12. Kavanaugh, W. M., G. R. Harsh, N. F. Starksen, C. M. Rocco, and L. T. Williams. Transcriptional regulation of the A and B chain genes of platelet-derived growth factor in microvascular endothelial cells. J. Biol. Chem. 263: 8470-8472, 1988.
13. Labarca, C., and K. Paigen. A simple, rapid, and sensitive DNA assay procedure. Anal. Biochem. 102: 344-352, 1980.
14. Lamas, S., P. A. Marsden, G. K. Li, P. Tempst, and T. Michel. Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc. Natl. Acad. Sci. USA 89: 6348-6352, 1992.
15. Laskin, D. L., D. E. Heck, C. R. Gardner, L. S. Feder, and J. D. Laskin. Distinct patterns of nitric oxide production in hepatic macrophages and endothelial cells following acute exposure of rats to endotoxin. J. Leukocyte Biol. 56: 751-758, 1994.
16. Lowenstein, C. J., C. S. Glatt, D. S. Bredt, and S. H. Snyder. Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. Proc. Natl. Acad. Sci. USA 89: 6711-6715, 1992.
17. Ma, T. T., H. Ischiropoulos, and C. A. Brass. Endotoxin-stimulated nitric oxide production increases injury and reduces rat liver chemiluminescenee during reperfusion. Gastroenterology 108: 463-469, 1995.
18. Melton, D. A., P. A, Krieg, M. R. Rebagliati, T. Maniatis, K. Zinn, and M. R. Green. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res. 12: 7035-7056, 1984.
19. Moncada, S., and A. Higgs. The L-arginine-nitric oxide pathway. N. Engl. J. Med. 329: 2002-2012, 1993.
20. Nanji, A. A., S. S. Greenberg, S. R. Tahan, F. Fogt, J. Loscalzo, S. M. Hossein Sadrzadeh, and J. Xie. Nitric oxide production in experimental alcoholic liver disease in the rat: role in protection from injury. Gastroenterology 109: 499-907, 1995.
21. Nishida, J., R. S. MeCuskey, D. Mcdonnell, and E. S. Fox. Protective role of NO in hepatic microcirculatory dysfunction during endotoxemia. Am. J. Physiol. 267 (Gastrointest. Liver Physiol. 30): G1135-G1141, 1994.
22. Nussler, A. K., M. Di Silvio, Z. Z. Liu, D. A. Geller, P. Freeswick, K. Dorko, F. Bartoli, and T. R. Billiar. Further characterization and comparison of inducible nitric oxide synthase in mouse, rat, and human hepatocytes. Hepatology 21: 1552-1560, 1995.
23. Peng, H. B., P. Libby, and J. K. Liao. Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B. J. Biol. Chem. 270: 14214-14219, 1995.
24. Pitas, R. E., J. Boyles, R. W. Mahley, and D. M. Bissell. Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells. J. Cell Biol. 100: 103-117, 1985.
25. Rockey, D. C., and J. J. Chung. Inducible nitric oxide synthase in rat hepatic lipocytes and the effect of nitric oxide on lipocyte contractility. J. Clin. Invest. 95: 1199-1206, 1995.
26. Spitzer, J. A. Cytokine stimulation of nitric oxide formation and differential regulation in hepatocytes and nonparenchymal cells of endotoxemic rats. Hepatology 19: 217-228, 1994.
27. Vodovotz, Y., N. S. Kwon, M. Pospischil, J. Manning, J. Paik, and C. Nathan. Inactivation of nitric oxide synthase after prolonged incubation of mouse macrophages with IFN-gamma and bacterial lipopolysaccharide. J. Immunol. 152: 4110-4118, 1994.
28. Vodovotz, Y., D. Russell, Q. W. Xie, C. Bogdan, and C. Nathan. Vesicle membrane association of nitric oxide synthase in primary mouse macrophages. J. Immunol. 154: 2914-2925, 1995.
29. Weisz, A., S. Oguchi, L. Cicatiello, and H. Esumi. Dual mechanism for the control of inducible-type NO synthase gene expression in macrophages during activation by interferon-γ and bacterial lipopolysaccharide. Transcriptional and post-transcriptional regulation. J. Biol. Chem. 269: 8324-8333, 1994.
30. Whittle, B. J., and S. Moncada. Nitric oxide: the elusive mediator of the hyperdynamic circulation of cirrhosis? Hepatology 16: 1089-1092, 1992.
31. Xie, Q. W., Y. Kashiwabara, and C. Nathan. Role of transcription factor NF-kappa B/rel in induction of nitric oxide synthase. J. Biol. Chem. 269: 4705-4708, 1994.