The pulmonary physician in critical care·6: The pathogenesis of ALI/ARDS

Thorax

Volumn 57, Issue 6, 2002, Pages 540-546

  Bellingan, G J ^a  

^a UNIVERSITY COLLEGE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; PLATELET DERIVED GROWTH FACTOR; SURFACTANT ASSOCIATED PROTEIN; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ADULT RESPIRATORY DISTRESS SYNDROME; ARTIFICIAL VENTILATION; HISTOPATHOLOGY; HUMAN; INFLAMMATION; LUNG FIBROSIS; NEUTROPHIL; PATHOGENESIS; PRIORITY JOURNAL; RESPIRATORY DISTRESS SYNDROME; REVIEW;

CYTOKINES; HUMANS; HYPERTENSION, PULMONARY; INFLAMMATION; NEUTROPHILS; PULMONARY FIBROSIS; RESPIRATION; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, ADULT;

EID: 0036282589     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thorax.57.6.540     Document Type: Review

References (92)

1. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial co-ordination
2. Adult respiratory distress syndrome
3. Acute lung injury and the acute respiratory distress syndrome
4. Pathophysiology of acute respiratory distress syndrome and acute lung injury
5. Pulmonary pathology of the adult respiratory distress syndrome
6. Clinical risks for development of the acute respiratory distress syndrome
7. The acute respiratory distress syndrome: Fibrosis in the fast lane
8. Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: A randomised controlled trial
9. Improved survival of patients with acute respiratory distress syndrome (ARDS): 1983-1993
10. Reduced mortality in association with the acute respiratory distress syndrome (ARDS)
11. Pathophysiology of acute respiratory distress syndrome and acute lung injury
12. The pulmonary physician in critical care·5: Acute lung injury and the acute respiratory distress syndrome: Definitions and epidemiology
13. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
14. Sir Isaac Newton, sepsis, SIRS, and CARS
15. Monocyte deactivation in septic patients: Restoration by IFN-gamma treatment
16. Acute respiratory distress syndrome caused by pulmonary and extrapulmonary injury: A comparative CT study
17. Morphometric differences of pulmonary lesions in primary and secondary ARDS: A preliminary study in autopsies
18. ARDS due to direct and indirect pulmonary injuries: ICU survival, broncho-alveolar lavage neutrophil counts and oxygenation
19. Bioluminescent measurement of multiorgan Cox-2 gene expression in transgenic mice treated with LPS
20. Structural alteration of lung parenchyma in the adult respiratory distress syndrome
21. Lung neutrophils in the adult respiratory distress syndrome. Clinical and pathophysiologic significance
22. Alveolar basement membrane breaks down in diffuse alveolar damage: An immunohistochemical study
23. Correlative study of adult respiratory distress syndrome by light, scanning and transmission electron microscopy
24. Acute lung injury. Pathogenesis of intraalveolar fibrosis
25. The fibroproliferative response to acute lung injury
26. Pulmonary fibrosis in severe acute respiratory failure
27. Extracellular matrix in normal and fibrotic human lungs
28. Recovery of function in survivors of the acute respiratory distress syndrome
29. Open lung biopsy does not correlate with pulmonary function after the adult respiratory distress syndrome
30. Pulmonary fibrosis correlates with outcome in adult respiratory distress syndrome. A study in mechanically ventilated patients
31. Early detection of type III procollagen peptide in acute lung injury. Pathogenic and prognostic significance
32. Fibroproliferation occurs early in the acute respiratory distress syndrome and impacts on outcome
33. Causes of mortality in patients with the adult respiratory distress syndrome
34. Multiple organ system failure and infection in adult respiratory distress syndrome
35. Fibrosis in ARDS: How close is the link between inflammation and fibroproliferation?
36. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome
37. Histologic aspects of pulmonary barotrauma in critically ill patients with acute respiratory failure
38. Carbon monoxide provides protection against hyperoxic lung injury
39. Pathogenesis and reversibility of the pulmonary lesions of oxygen toxicity in monkeys. 2. Ultrastructural and morphometric studies
40. Inflammatory cell activation in Sepsis
41. Leukacyte: Friend or foe?
42. Interactions between neutrophils and cytokines in blood and alveolar spaces during ARDS
43. Pulmonary fibrosis: Cytokines in the balance
44. The molecular genetics of sepsis
45. Angiotensin converting enzyme I/D polymorphism in the acute respiratory distress syndrome
46. Interleukin-6 (-174G>C) polymorphism predicts outcome in acute respiratory failure
47. Transgenic and knockout mouse models of pulmonary inflammatory diseases
48. Acute effects of Eschericia coli endotoxin on the pulmonary microcirculation of anaesthetised sheep structure: Function relationships
49. Cellular alterations in the alveolar wall in bleomycin-induced pulmonary fibrasis in rats. An ultrastructural morphometric study
50. Differential responses of the endothelial and epithelial barriers of the lung in sheep to Esherichia coli endotoxin
51. Prevention by granulocyte depletion of increased lung vascular permeability of sheep following endotoxaemia
52. Neutrophil depletion does not prevent lung edema after endotoxin infusion in goats
53. Adult respiratory distress syndrome after allogenic bone-marrow transplantation; evidence for a neutrophil-independent mechanism
54. Elastolytic activity in pulmonary lavage fluid from patients with adult respiratory-distress syndrome
55. Evidence for the role of hydraxyl radical in complement and neutrophil dependent tissue injury
56. Oxygen free radicals in ARDS, septic shock and organ dysfunction
57. Relative production of tumour necrosis factor alpha and interleukin 10 in adult respiratory distress syndrome
58. Characterisation of the response to mice deficient in neutrophil elastase or cathepsin G to bleomycin
59. Role of selectins in development of adult respiratory distress syndrome
60. CD18 dependent and independent mechanisms of neutrophil emigration in pulmonary and systemic microcirculation in rabbits
61. Inhibition of CD18 or CD11b attenuates acute lung injury after acid instillation in rabbits
62. Mechanics of stimulated neutrophils: Cell stiffening induces retention in capillaries
63. Pro-inflammatory activity in bronchoalveolar lavage fluids from patients with ARDS, a prominent role for interleukin-1
64. Interleukin-8 and development of adult respiratory distress syndrome in at-risk patient groups
65. Results of the "MONARCS" phase III clinical trial of an anti-TNF-α antibody (afelimomab) in sepsis
66. Histopathology of pulmonary oedema and the acute respiratory distress syndrome
67. A role for acute hypoxia/hyperoxia in the pathogenesis of the acute respiratory distress syndrome - On in vivo model
68. Antioxidant status in patients with acute respiratory distress syndrome
69. Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury
70. Fas (CD95) induces alveolar epithelial cell apoptosis in vivo: Implications for acute pulmonary inflammation
71. Neutrophil apoptosis in the acute respiratory distress syndrome
72. Increased-permeability pulmonary edema from sepsis/endotoxemia
73. In vivo treatment with endatoxin increases rat pulmonary vascular contractility despite NOS induction
74. Pulmonary hypertension in sepsis: Measurement by the pulmonary artery diastolic wedge pressure gradient and the influence of passive and active factors
75. Endothelin-1 in adult respiratory distress syndrome
76. Surfactant medication for acute respiratory distress syndrome
77. Molecular and cellular processing of lung surfactant
78. SP-A SP-D inhibit spontaneous neutrophil apoptosis via activation of the Pl-3 kinase/AKT
79. Damage to surfactant-specific protein in acute respiratory distress syndrome
80. Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis
81. IL-13 is an important cytokine in the pathogenesis of pulmonary fibrosis
82. Elevated transforming growth factor-alpha levels in bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome
83. Macrophage production of basic fibroblast growth factor in the fibroproliferative disorder of alveolar fibrosis after lung injury
84. Transforming growth factor-beta (TGF-beta)
85. The role of TGF-beta in pulmonary fibrosis
86. Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung
87. The integrin alpha v beta 6 binds and activates latent TGF beta 1: A mechanism for regulating pulmonary inflammation and fibrosis
88. Transcellular water transport in lung alveolar epithelium through mercury sensitive water channels
89. Intact epithelial barrier function is critical for the resolution of alveolar oedema in humans
90. Granulocyte apoptosis and its role in the resolution and control of lung inflammation
91. Matrix metalloproteinases and TIMP in acute respiratory distress syndrome
92. Effect of elevated left atrial pressure and decreased plasma protein concentration on the development of pulmonary oedema