Elevation of sphingoid base 1-phosphate as a potential contributor to hepatotoxicity in fumonisin B1-exposed mice

Archives of Pharmacal Research

Volumn 30, Issue 8, 2007, Pages 962-969

  Kim, Dong Hyun ^a   Lee, Youn Sun ^a   Lee, Yong Moon ^a   Oh, Seikwan ^b   Yun, Yeo Pyo ^a   Yoo, Hwan Soo ^a  

^a Chungbuk National University   (South Korea)

^b Ewha Womans University School of Medicine   (South Korea)

Author keywords

Fumonisin B1; Liver; Mice; Sphingosine 1 phosphate

Indexed keywords

CASPASE 3; DIHYDROSPHINGOSINE 1 PHOSPHATE; DIHYDROSPHINGOSINE 1-PHOSPHATE; DRUG DERIVATIVE; FUMONISIN; FUMONISIN B1; LYASE; LYSOPHOSPHOLIPID; MITOGEN ACTIVATED PROTEIN KINASE; MYCOTOXIN; PHOSPHOTRANSFERASE; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE LYASE (ALDOLASE); SPHINGOSINE 1-PHOSPHATE; SPHINGOSINE 1-PHOSPHATE LYASE (ALDOLASE); SPHINGOSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BIOSYNTHESIS; BLOOD; DRUG EFFECT; ENZYMOLOGY; INSTITUTE FOR CANCER RESEARCH MOUSE; LIVER; METABOLISM; MOUSE; TOXIC HEPATITIS;

ALDEHYDE-LYASES; ANIMALS; CASPASE 3; FUMONISINS; HEPATITIS, TOXIC; LIVER; LYSOPHOSPHOLIPIDS; MICE; MICE, INBRED ICR; MITOGEN-ACTIVATED PROTEIN KINASES; MYCOTOXINS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); SPHINGOSINE;

EID: 34548761482     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02993964     Document Type: Article

References (21)

1. Bu, S., Yamanaka, M., Pei, H., Bielawska, A., Bielawski, J., Hannun, Y. A., Obeid, L., and Trojanowska, M., Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. FASEB J., 20, 184-186 (2006).
2. de Nijs, M., van Egmond, H. P., Nauta, M., Rombouts, F. M., and Notermans, S. H., Assessment of human exposure to fumonisin B1. J. Food. Prot., 61, 879-884 (1998).
3. Enongene, E. N., Sharma, R. P., Bhandari, N., Voss, K. A., and Riley, R. T., Disruption of sphingolipid metabolism in small intestines, liver and kidney of mice dosed subcutaneously with fumonisin B(1). Food Chem. Toxicol., 38, 793-799 (2000).
4. Gennero, I., Fauvel, J., Nieto, M., Cariven, C., Gaits, F., Briand-Mesange, F., Chap, H., and Salles, J. P., Apoptotic effect of sphingosine 1-phosphate and increased sphingosine 1-phosphate hydrolysis on mesangial cells cultured at low cell density. J. Biol. Chem., 277, 12724-12734 (2002).
5. Gopee, N. V. and Sharma, R. P., Sphingoid bases and their phosphates: transient activation and delayed repression of protein kinase C isoforms and their possible involvement in fumonisin B1 cytotoxicity. Toxicology, 187, 239-250 (2003).
6. Haschek, W. M., Gumprecht, L. A., Smith, G., Tumbleson, M. E., and Constable, P. D., Fumonisin toxicosis in swine: an overview of porcine pulmonary edema and current perspectives. Environ. Health Perspect., 109 Suppl 2, 251-257 (2001).
7. He, Q., Bhandari, N., and Sharma, R. P., Fumonisin B(1) alters sphingolipid metabolism and tumor necrosis factor alpha expression in heart and lung of mice. Life Sci., 71, 2015-2023 (2002).
8. Johnson, V. J., He, Q., Kim, S. H., Kanti, A., and Sharma, R. P., Increased susceptibility of renal epithelial cells to TNFalpha-induced apoptosis following treatment with fumonisin B1. Chem. Biol. Interact., 145, 297-309 (2003).
9. Kim, D. H., Yoo, H. S., Lee, Y. M., Kie, J. H., Jang, S., and Oh, S., Elevation of sphinganine 1-phosphate as a predictive biomarker for fumonisin exposure and toxicity in mice. J. Toxicol. Environ. Health A, 69, 2071-2082 (2006).
10. Maceyka, M., Payne, S. G., Milstien, S., and Spiegel, S., Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. Biochim. Biophys. Acta, 1585, 193-201 (2002).
11. Marasas, W. F., Fumonisins: their implications for human and animal health. Nat. Toxins, 3, 193-198; discussion 221 (1995).
12. Marasas, W. F., Kellerman, T. S., Gelderblom, W. C., Coetzer, J. A., Thiel, P. G., and van der Lugt, J. J., Leukoencephalomalacia in a horse induced by fumonisin B1 isolated from Fusarium moniliforme. Onderstepoort J. Vet. Res., 55, 197-203 (1988).
13. Qiu, M. and Liu, X., Determination of sphinganine, sphingosine and Sa/So ratio in urine of humans exposed to dietary fumonisin B1. Food Addit. Contam., 18, 263-269 (2001).
14. Riley, R. T., An, N. H., Showker, J. L., Yoo, H. S., Norred, W. P., Chamberlain, W. J., Wang, E., Merrill, A. H., Jr., Motelin, G., Beasley, V. R., and Haschek, W. M., Alteration of tissue and serum sphinganine to sphingosine ratio: an early biomarker of exposure to fumonisin-containing feeds in pigs. Toxicol. Appl. Pharmacol., 118, 105-112 (1993).
15. Solfrizzo, M., Avantaggiato, G., and Visconti, A., Rapid method to determine sphinganine/sphingosine in human and animal urine as a biomarker for fumonisin exposure. J. Chromatogr. B Biomed Sci. Appl., 692, 87-93 (1997).
16. Steyn, P. S., Mycotoxins, general view, chemistry and structure. Toxicol. Lett., 82-83, 843-851 (1995).
17. Van Veldhoven, P. P. and Mannaerts, G. P., Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver. J. Biol. Chem., 266, 12502-12507 (1991).
18. Voss, K. A., Riley, R. T., Norred, W. P., Bacon, C. W., Meredith, F. I., Howard, P. C., Plattner, R. D., Collins, T. F., Hansen, D. K., and Porter, J. K., An overview of rodent toxicities: liver and kidney effects of fumonisins and Fusarium moniliforme. Environ. Health Perspect., 109 Suppl 2, 259-266 (2001).
19. Wang, E., Norred, W. P., Bacon, C. W., Riley, R. T., and Merrill, A. H., Jr., Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J. Biol. Chem., 266, 14486-14490 (1991).
20. Yoo, H. S., Norred, W. P., Wang, E., Merrill, A. H., Jr., and Riley, R. T., Fumonisin inhibition of de novo sphingolipid biosynthesis and cytotoxicity are correlated in LLC-PK1 cells. Toxicol. Appl. Pharmacol., 114, 9-15 (1992).
21. Yoshizumi, M., Abe, J., Tsuchiya, K., Berk, B. C., and Tamaki, T., Stress and vascular responses: atheroprotective effect of laminar fluid shear stress in endothelial cells: possible role of mitogen-activated protein kinases. J. Pharmacol. Sci., 91, 172-176 (2003).