Dissociating anxiolytic and sedative effects of GABAAergic drugs using temperature and locomotor responses to acute stress

Psychopharmacology

Volumn 204, Issue 2, 2009, Pages 299-311

  Vinkers, Christiaan H ^a   Klanker, Marianne ^a   Groenink, Lucianne ^a   Korte, S Mechiel ^a   Cook, James M ^b   Van Linn, Michael L ^b   Hopkins, Seth C ^c   Olivier, Berend ^a,d  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^c SUNOVION PHARMACEUTICALS INC   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CCt; Body temperature; GABAA receptor subunit; Stress induced hyperthermia; TP003; Zolpidem

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; ALCOHOL; CLOTIAZEPAM; DIAZEPAM; GABOXADOL; LIGAND; ZOLPIDEM;

ACUTE STRESS; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; CONTROLLED STUDY; DRUG BINDING; HYPERTHERMIA; HYPOTHERMIA; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEDATION; TELEMETRY; TEMPERATURE; TEMPERATURE MEASUREMENT; THERMOREGULATION; TRANQUILIZING ACTIVITY;

ACUTE DISEASE; ANESTHETICS; ANIMALS; ANTI-ANXIETY AGENTS; BODY TEMPERATURE; CARBOLINES; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ETHANOL; GABA AGENTS; GABA AGONISTS; HYPNOTICS AND SEDATIVES; ISOXAZOLES; MALE; MOTOR ACTIVITY; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, GABA-A; STRESS, PSYCHOLOGICAL; TELEMETRY;

EID: 65449184473     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-009-1460-4     Document Type: Article

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