-
1
-
-
8944225498
-
Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology
-
George J.N., Woolf S.H., Raskob G.E., et al. Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology. Blood 88 (1996) 3-40
-
(1996)
Blood
, vol.88
, pp. 3-40
-
-
George, J.N.1
Woolf, S.H.2
Raskob, G.E.3
-
2
-
-
0037648477
-
British Committee for Standards in Haematology General Haematology Task Force Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy
-
British Committee for Standards in Haematology General Haematology Task Force Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy. Br J Haematol 120 (2003) 574-596
-
(2003)
Br J Haematol
, vol.120
, pp. 574-596
-
-
-
3
-
-
34648812790
-
Update on the management of immune thrombocytopenic purpura in children
-
Tarantino M.D., and Bolton-Maggs P.H. Update on the management of immune thrombocytopenic purpura in children. Curr Opin Hematol 14 (2007) 526-534
-
(2007)
Curr Opin Hematol
, vol.14
, pp. 526-534
-
-
Tarantino, M.D.1
Bolton-Maggs, P.H.2
-
4
-
-
34648826759
-
Pathogenesis of chronic immune thrombocytopenic purpura
-
Cines D.B., and McMillan R. Pathogenesis of chronic immune thrombocytopenic purpura. Curr Opin Hematol 14 (2007) 511-514
-
(2007)
Curr Opin Hematol
, vol.14
, pp. 511-514
-
-
Cines, D.B.1
McMillan, R.2
-
5
-
-
34648836081
-
Immune thrombocytopenic purpura in adults
-
Godeau B., Provan D., and Bussel J. Immune thrombocytopenic purpura in adults. Curr Opin Hematol 14 (2007) 535-556
-
(2007)
Curr Opin Hematol
, vol.14
, pp. 535-556
-
-
Godeau, B.1
Provan, D.2
Bussel, J.3
-
6
-
-
33746508365
-
Megakaryocyte development and platelet production
-
Deutsch V.R., and Tomer A. Megakaryocyte development and platelet production. Br J Haematol 134 (2006) 453-466
-
(2006)
Br J Haematol
, vol.134
, pp. 453-466
-
-
Deutsch, V.R.1
Tomer, A.2
-
7
-
-
34648826777
-
Dynamic visualization of thrombopoiesis within bone marrow
-
Junt T., Schulze H., Chen Z., et al. Dynamic visualization of thrombopoiesis within bone marrow. Science 317 (2007) 1767-1770
-
(2007)
Science
, vol.317
, pp. 1767-1770
-
-
Junt, T.1
Schulze, H.2
Chen, Z.3
-
8
-
-
0037071389
-
The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production
-
Kaushansky K., and Drachman J.G. The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production. Oncogene 21 (2002) 3359-3367
-
(2002)
Oncogene
, vol.21
, pp. 3359-3367
-
-
Kaushansky, K.1
Drachman, J.G.2
-
9
-
-
0031035555
-
Localization of thrombopoietin mRNA expression in human kidney, liver, bone marrow, and spleen using in situ hybridization
-
Sungaran R., Markovic B., and Chong B.H. Localization of thrombopoietin mRNA expression in human kidney, liver, bone marrow, and spleen using in situ hybridization. Blood 89 (1997) 101-107
-
(1997)
Blood
, vol.89
, pp. 101-107
-
-
Sungaran, R.1
Markovic, B.2
Chong, B.H.3
-
10
-
-
33947227522
-
Programmed anuclear cell death delimits platelet life span
-
Mason K.D., Carpinelli M.R., Fletcher J.I., et al. Programmed anuclear cell death delimits platelet life span. Cell 128 (2007) 1173-1186
-
(2007)
Cell
, vol.128
, pp. 1173-1186
-
-
Mason, K.D.1
Carpinelli, M.R.2
Fletcher, J.I.3
-
11
-
-
0023218341
-
Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance
-
Ballem P.J., Segel G.M., Stratton J.E., et al. Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance. J Clin Invest 80 (1987) 33-40
-
(1987)
J Clin Invest
, vol.80
, pp. 33-40
-
-
Ballem, P.J.1
Segel, G.M.2
Stratton, J.E.3
-
12
-
-
0025876206
-
Increased antiplatelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenia
-
Semple J.W., and Freedman J. Increased antiplatelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenia. Blood 78 (1991) 2619-2625
-
(1991)
Blood
, vol.78
, pp. 2619-2625
-
-
Semple, J.W.1
Freedman, J.2
-
13
-
-
51649127854
-
Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura
-
Yu J., Heck S., Patel V., et al. Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura. Blood 112 (2008) 1325-1328
-
(2008)
Blood
, vol.112
, pp. 1325-1328
-
-
Yu, J.1
Heck, S.2
Patel, V.3
-
14
-
-
0141684568
-
T-cell mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura
-
Olsson B., Andersson P.O., Jernas M., et al. T-cell mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat Med 9 (2003) 1123-1124
-
(2003)
Nat Med
, vol.9
, pp. 1123-1124
-
-
Olsson, B.1
Andersson, P.O.2
Jernas, M.3
-
15
-
-
0043245959
-
Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro
-
Chang M., Nakagawa P.A., Williams S.A., et al. Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro. Blood 102 (2003) 887-895
-
(2003)
Blood
, vol.102
, pp. 887-895
-
-
Chang, M.1
Nakagawa, P.A.2
Williams, S.A.3
-
16
-
-
0942287736
-
Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura
-
Howerzijl E.J., Blom N.R., Van der Want J.J.L., et al. Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura. Blood 103 (2004) 500-506
-
(2004)
Blood
, vol.103
, pp. 500-506
-
-
Howerzijl, E.J.1
Blom, N.R.2
Van der Want, J.J.L.3
-
17
-
-
51649128648
-
Recruitment of T cells into bone marrow of ITP patients possibly due to elevated expression of VLA-4 and CX3CR1
-
Olsson B., Ridell B., Carlsson L., et al. Recruitment of T cells into bone marrow of ITP patients possibly due to elevated expression of VLA-4 and CX3CR1. Blood 112 (2008) 1078-1084
-
(2008)
Blood
, vol.112
, pp. 1078-1084
-
-
Olsson, B.1
Ridell, B.2
Carlsson, L.3
-
18
-
-
38949096839
-
Congenital disorders associated with platelet dysfunctions
-
Nurden P., and Nurden A.T. Congenital disorders associated with platelet dysfunctions. Thromb Haemost 99 (2008) 253-263
-
(2008)
Thromb Haemost
, vol.99
, pp. 253-263
-
-
Nurden, P.1
Nurden, A.T.2
-
19
-
-
34648819037
-
The epidemiology of immune thrombocytopenic purpura
-
Fogarty P.F., and Segal J.B. The epidemiology of immune thrombocytopenic purpura. Curr Opin Hematol 14 (2007) 515-519
-
(2007)
Curr Opin Hematol
, vol.14
, pp. 515-519
-
-
Fogarty, P.F.1
Segal, J.B.2
-
20
-
-
0036215976
-
Novel approaches to refractory immune thrombocytopenic purpura
-
Bussel J.B. Novel approaches to refractory immune thrombocytopenic purpura. Blood Rev 16 (2002) 31-36
-
(2002)
Blood Rev
, vol.16
, pp. 31-36
-
-
Bussel, J.B.1
-
21
-
-
1242270468
-
Intravenous (IV) anti-D and IV immunoglobulin achieve acute platelet increases by different mechanisms: modulation of cytokine and platelet responses to IV anti-D by FcγRIIa and FcγRIIIa polymorphisms
-
Cooper N., Heddle N.M., De Haas M., et al. Intravenous (IV) anti-D and IV immunoglobulin achieve acute platelet increases by different mechanisms: modulation of cytokine and platelet responses to IV anti-D by FcγRIIa and FcγRIIIa polymorphisms. Br J Haematol 124 (2004) 511-518
-
(2004)
Br J Haematol
, vol.124
, pp. 511-518
-
-
Cooper, N.1
Heddle, N.M.2
De Haas, M.3
-
22
-
-
33744989699
-
Intravenous immunoglobulin ameliorates ITP via activating Fcγ receptors on dendritic cells
-
Siragam V., Crow A.R., Brinc D., et al. Intravenous immunoglobulin ameliorates ITP via activating Fcγ receptors on dendritic cells. Nat Med 12 (2006) 688-692
-
(2006)
Nat Med
, vol.12
, pp. 688-692
-
-
Siragam, V.1
Crow, A.R.2
Brinc, D.3
-
23
-
-
42349085035
-
Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc
-
Anthony R.M., Nimmerjahn F., Ashline D.J., et al. Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc. Science 320 (2008) 373-376
-
(2008)
Science
, vol.320
, pp. 373-376
-
-
Anthony, R.M.1
Nimmerjahn, F.2
Ashline, D.J.3
-
24
-
-
7244232710
-
Splenectomy for adult patients with idiopathic thrombocytopenic purpura: a systematic review to assess long-term platelet count responses, prediction of response, and surgical complications
-
Kojouri K., Vesely S.K., Terrell D.R., and George J.N. Splenectomy for adult patients with idiopathic thrombocytopenic purpura: a systematic review to assess long-term platelet count responses, prediction of response, and surgical complications. Blood 104 (2004) 2623-2634
-
(2004)
Blood
, vol.104
, pp. 2623-2634
-
-
Kojouri, K.1
Vesely, S.K.2
Terrell, D.R.3
George, J.N.4
-
25
-
-
0036533583
-
Spleen is a primary site for activation of platelet-reactive T and B cells in patients with immune thrombocytopenic purpura
-
Kuwana M., Okazaki Y., Kaburaki J., et al. Spleen is a primary site for activation of platelet-reactive T and B cells in patients with immune thrombocytopenic purpura. J Immunol 168 (2002) 3675-3682
-
(2002)
J Immunol
, vol.168
, pp. 3675-3682
-
-
Kuwana, M.1
Okazaki, Y.2
Kaburaki, J.3
-
26
-
-
38349190476
-
Idiopathic thrombocytopenic purpura: Current concepts in pathophysiology and management
-
Stasi R., Evangelista M.L., Stipa E., et al. Idiopathic thrombocytopenic purpura: Current concepts in pathophysiology and management. Thromb Haemost 99 (2008) 4-13
-
(2008)
Thromb Haemost
, vol.99
, pp. 4-13
-
-
Stasi, R.1
Evangelista, M.L.2
Stipa, E.3
-
27
-
-
36348946412
-
Multiagent induction and maintenance therapy for patients with refractory immune thrombocytopenic purpura (ITP)
-
Boruchov D.M., Gururangan S., Driscoll M.C., and Bussell J.B. Multiagent induction and maintenance therapy for patients with refractory immune thrombocytopenic purpura (ITP). Blood 110 (2007) 3526-3531
-
(2007)
Blood
, vol.110
, pp. 3526-3531
-
-
Boruchov, D.M.1
Gururangan, S.2
Driscoll, M.C.3
Bussell, J.B.4
-
28
-
-
0037082457
-
Long-term salvage therapy with cyclosporin A in refractory immune thrombocytopenic purpura
-
Emilia G., Morselli M., Luppi M., et al. Long-term salvage therapy with cyclosporin A in refractory immune thrombocytopenic purpura. Blood 99 (2002) 1482-1485
-
(2002)
Blood
, vol.99
, pp. 1482-1485
-
-
Emilia, G.1
Morselli, M.2
Luppi, M.3
-
29
-
-
2042544763
-
The efficacy and safety of B-cell depletion with anti-CD20 monoclonal antibody in adults with chronic immune thrombocytopenic purpura
-
Cooper N., Stasi R., Cunningham-Rundles S., et al. The efficacy and safety of B-cell depletion with anti-CD20 monoclonal antibody in adults with chronic immune thrombocytopenic purpura. Br J Haematol 125 (2004) 232-239
-
(2004)
Br J Haematol
, vol.125
, pp. 232-239
-
-
Cooper, N.1
Stasi, R.2
Cunningham-Rundles, S.3
-
30
-
-
59449095901
-
One year follow-up of children and adolescents with chronic immune thrombocytopenic purpura (ITP) treated with rituximab
-
Mueller B.U., Bennett C.M., Feldman H.A., et al. One year follow-up of children and adolescents with chronic immune thrombocytopenic purpura (ITP) treated with rituximab. Pediatr Blood Cancer 52 (2009) 259-262
-
(2009)
Pediatr Blood Cancer
, vol.52
, pp. 259-262
-
-
Mueller, B.U.1
Bennett, C.M.2
Feldman, H.A.3
-
31
-
-
35548960551
-
Response to B-cell depleting therapy with rituximab reverts the abnormalities of T-cell subsets in patients with idiopathic thrombocytopenic purpura
-
Stasi R., Del Poeta G., Stipa E., et al. Response to B-cell depleting therapy with rituximab reverts the abnormalities of T-cell subsets in patients with idiopathic thrombocytopenic purpura. Blood 110 (2007) 2924-2930
-
(2007)
Blood
, vol.110
, pp. 2924-2930
-
-
Stasi, R.1
Del Poeta, G.2
Stipa, E.3
-
32
-
-
51649091745
-
Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell-depleting therapy with rituximab
-
Stasi R., Cooper N., Del Poeta G., et al. Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell-depleting therapy with rituximab. Blood 112 (2008) 1147-1150
-
(2008)
Blood
, vol.112
, pp. 1147-1150
-
-
Stasi, R.1
Cooper, N.2
Del Poeta, G.3
-
33
-
-
0037438507
-
Suppression of autoreactive T-cell response to glycoprotein IIb-IIIa by blockade of CD40/CD154 interaction: implications for treatment of immune thrombocytopenic purpura
-
Kuwana M., Kawakami Y., and Ikeda Y. Suppression of autoreactive T-cell response to glycoprotein IIb-IIIa by blockade of CD40/CD154 interaction: implications for treatment of immune thrombocytopenic purpura. Blood 101 (2003) 621-623
-
(2003)
Blood
, vol.101
, pp. 621-623
-
-
Kuwana, M.1
Kawakami, Y.2
Ikeda, Y.3
-
34
-
-
19944426859
-
Platelet-associated CD154 in immune thrombocytopenic purpura
-
Solanilla A., Pasquet J.M., Viallard J.F., et al. Platelet-associated CD154 in immune thrombocytopenic purpura. Blood 105 (2005) 215-218
-
(2005)
Blood
, vol.105
, pp. 215-218
-
-
Solanilla, A.1
Pasquet, J.M.2
Viallard, J.F.3
-
35
-
-
42249083237
-
The effect of anti-CD40 ligand in immune thrombocytopenic purpura
-
Patel V.L., Schwartz J., and Bussel J.B. The effect of anti-CD40 ligand in immune thrombocytopenic purpura. Br J Haematol 141 (2008) 545-548
-
(2008)
Br J Haematol
, vol.141
, pp. 545-548
-
-
Patel, V.L.1
Schwartz, J.2
Bussel, J.B.3
-
36
-
-
34249733156
-
New thrombopoietic growth factors
-
Kuter D.J. New thrombopoietic growth factors. Blood 109 (2007) 4607-4616
-
(2007)
Blood
, vol.109
, pp. 4607-4616
-
-
Kuter, D.J.1
-
37
-
-
36549001698
-
Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura
-
Bussel J.B., Cheng G., Saleh M.N., et al. Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. N Engl J Med 357 (2007) 2237-2247
-
(2007)
N Engl J Med
, vol.357
, pp. 2237-2247
-
-
Bussel, J.B.1
Cheng, G.2
Saleh, M.N.3
-
38
-
-
38649120593
-
Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial
-
Kuter D.J., Bussel J.B., Lyons R.M., et al. Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial. Lancet 371 (2008) 395-403
-
(2008)
Lancet
, vol.371
, pp. 395-403
-
-
Kuter, D.J.1
Bussel, J.B.2
Lyons, R.M.3
-
39
-
-
63849111465
-
Safety and efficacy of long-term treatment with rombiplostim in thrombocytopenic patients with chronic ITP
-
Bussel J.B., Kuter D.J., Pullarkat V., et al. Safety and efficacy of long-term treatment with rombiplostim in thrombocytopenic patients with chronic ITP. Blood 113 (2009) 2161-2171
-
(2009)
Blood
, vol.113
, pp. 2161-2171
-
-
Bussel, J.B.1
Kuter, D.J.2
Pullarkat, V.3
-
40
-
-
50949104584
-
Rituximab efficacy and safety in adult splenectomy candidates with chronic immune thrombocytopenic purpura: results of a prospective multicenter phase 2 study
-
Godeau B., Porcher R., Fain O., et al. Rituximab efficacy and safety in adult splenectomy candidates with chronic immune thrombocytopenic purpura: results of a prospective multicenter phase 2 study. Blood 112 (2008) 999-1004
-
(2008)
Blood
, vol.112
, pp. 999-1004
-
-
Godeau, B.1
Porcher, R.2
Fain, O.3
-
41
-
-
0037111558
-
Recombinant human thrombopoietin: basic biology and evaluation of clinical studies
-
Kuter D.J., and Begley C.G. Recombinant human thrombopoietin: basic biology and evaluation of clinical studies. Blood 100 (2002) 3457-3469
-
(2002)
Blood
, vol.100
, pp. 3457-3469
-
-
Kuter, D.J.1
Begley, C.G.2
-
42
-
-
17844383458
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
James C., Ugo V., Le Couédic J.-P., et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 434 (2005) 1144-1148
-
(2005)
Nature
, vol.434
, pp. 1144-1148
-
-
James, C.1
Ugo, V.2
Le Couédic, J.-P.3
-
43
-
-
0031805239
-
The diagnostic value of thrombopoietin level measurements in thrombocytopenia
-
Porcelijn L., Folman C.C., Bossers B., et al. The diagnostic value of thrombopoietin level measurements in thrombocytopenia. Thromb Haemost 79 (1998) 1101-1105
-
(1998)
Thromb Haemost
, vol.79
, pp. 1101-1105
-
-
Porcelijn, L.1
Folman, C.C.2
Bossers, B.3
-
44
-
-
52449135494
-
Transcriptional regulation of bone marrow thrombopoietin by platelet proteins
-
McIntosh B., and Kaushansky K. Transcriptional regulation of bone marrow thrombopoietin by platelet proteins. Exp Hematol 36 (2008) 799-806
-
(2008)
Exp Hematol
, vol.36
, pp. 799-806
-
-
McIntosh, B.1
Kaushansky, K.2
-
45
-
-
0030773876
-
Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine
-
Cwirla S.E., Balasubramanian P., Duffin D.J., et al. Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine. Science 276 (1997) 1696-1699
-
(1997)
Science
, vol.276
, pp. 1696-1699
-
-
Cwirla, S.E.1
Balasubramanian, P.2
Duffin, D.J.3
-
46
-
-
3543123430
-
An agonist murine monoclonal antibody to the human c-MPL receptor stimulates megakaryocytopoiesis
-
Deng B., Banu N., Malloy B., et al. An agonist murine monoclonal antibody to the human c-MPL receptor stimulates megakaryocytopoiesis. Blood 92 (1998) 1981-1988
-
(1998)
Blood
, vol.92
, pp. 1981-1988
-
-
Deng, B.1
Banu, N.2
Malloy, B.3
-
47
-
-
0034656323
-
Effects of megakaryocyte growth and development factor on platelet production, platelet life span and platelet function in healthy human volunteers
-
Harker L.A., Roskos L.K., Marzec U.M., et al. Effects of megakaryocyte growth and development factor on platelet production, platelet life span and platelet function in healthy human volunteers. Blood 95 (2000) 2514-2522
-
(2000)
Blood
, vol.95
, pp. 2514-2522
-
-
Harker, L.A.1
Roskos, L.K.2
Marzec, U.M.3
-
48
-
-
0034050651
-
Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynaecologic cancer
-
Vadhan-Raj S., Verschraegen C.F., Bueso-Ramos C., et al. Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynaecologic cancer. Ann Intern Med 132 (2000) 364-368
-
(2000)
Ann Intern Med
, vol.132
, pp. 364-368
-
-
Vadhan-Raj, S.1
Verschraegen, C.F.2
Bueso-Ramos, C.3
-
49
-
-
0035760892
-
Thrombocytopenia caused by the development of antibodies to thrombopoietin
-
Li J., Yang C., Xia Y., et al. Thrombocytopenia caused by the development of antibodies to thrombopoietin. Blood 98 (2001) 3241-3248
-
(2001)
Blood
, vol.98
, pp. 3241-3248
-
-
Li, J.1
Yang, C.2
Xia, Y.3
-
50
-
-
0032577533
-
A non-peptide compound which can mimic the effect of thrombopoietin via c-Mpl
-
Kimura T., Kaburaki H., Tsujino T., et al. A non-peptide compound which can mimic the effect of thrombopoietin via c-Mpl. FEBS Lett 428 (1998) 250-254
-
(1998)
FEBS Lett
, vol.428
, pp. 250-254
-
-
Kimura, T.1
Kaburaki, H.2
Tsujino, T.3
-
51
-
-
0346881171
-
AMG531 stimulates megakaryocytopoiesis in vitro by binding to Mpl
-
Broudy V.C., and Lin N.L. AMG531 stimulates megakaryocytopoiesis in vitro by binding to Mpl. Cytokine 25 (2004) 52-60
-
(2004)
Cytokine
, vol.25
, pp. 52-60
-
-
Broudy, V.C.1
Lin, N.L.2
-
52
-
-
10044296968
-
Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand
-
Wang B., Nichol J.L., and Sullivan J.T. Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand. Clin Pharmacol Ther 76 (2004) 628-638
-
(2004)
Clin Pharmacol Ther
, vol.76
, pp. 628-638
-
-
Wang, B.1
Nichol, J.L.2
Sullivan, J.T.3
-
53
-
-
19944432021
-
Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist
-
Erickson-Miller C.L., DeLorme E., Tian S.S., et al. Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist. Exp Hematol 33 (2005) 85-93
-
(2005)
Exp Hematol
, vol.33
, pp. 85-93
-
-
Erickson-Miller, C.L.1
DeLorme, E.2
Tian, S.S.3
-
54
-
-
3042830471
-
Induction of megakaryocytopoiesis and thrombocytopoiesis by JTZ-132, a novel small molecule with thrombopoietin mimetic activities
-
Inagaki K., Oda T., Naka Y., et al. Induction of megakaryocytopoiesis and thrombocytopoiesis by JTZ-132, a novel small molecule with thrombopoietin mimetic activities. Blood 104 (2004) 58-64
-
(2004)
Blood
, vol.104
, pp. 58-64
-
-
Inagaki, K.1
Oda, T.2
Naka, Y.3
-
55
-
-
19944429567
-
A novel therapeutic approach for thrombocytopenia by minibody agonist of the thrombopoietin receptor
-
Orita T., Tsunoda H., Yabuta N., et al. A novel therapeutic approach for thrombocytopenia by minibody agonist of the thrombopoietin receptor. Blood 105 (2005) 562-566
-
(2005)
Blood
, vol.105
, pp. 562-566
-
-
Orita, T.1
Tsunoda, H.2
Yabuta, N.3
-
56
-
-
33749249751
-
A rationally designed agonist antibody fragment that functionally mimics thrombopoietin
-
Frederickson S., Renshaw M.W., Lin B., et al. A rationally designed agonist antibody fragment that functionally mimics thrombopoietin. Proc Natl Acad Sci USA 103 (2006) 14307-14312
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 14307-14312
-
-
Frederickson, S.1
Renshaw, M.W.2
Lin, B.3
-
57
-
-
34249719511
-
Phase I clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist
-
Jenkins J.M., Williams D., Deng Y., et al. Phase I clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist. Blood 109 (2007) 4739-4741
-
(2007)
Blood
, vol.109
, pp. 4739-4741
-
-
Jenkins, J.M.1
Williams, D.2
Deng, Y.3
-
58
-
-
67649111192
-
Long-term safety and efficacy of oral eltrombopag for the treatment of idiopathic thrombocytopenic purpura (ITP)
-
(abstr).
-
Bussel J.B., Cheng G., Saleh M.N., et al. Long-term safety and efficacy of oral eltrombopag for the treatment of idiopathic thrombocytopenic purpura (ITP). Haematologica 93 suppl (2008) 379 (abstr).
-
(2008)
Haematologica
, vol.93
, Issue.SUPPL
, pp. 379
-
-
Bussel, J.B.1
Cheng, G.2
Saleh, M.N.3
-
59
-
-
65349097189
-
Oral elthrombopag spares corticosteroids and reduces bleeding in patients with idiopathic thrombocytopenic purpura (ITP). 13th congress of the European Haematology Association, June 12-15, 2008, Copenhagen, Denmark. Abstract 0306
-
(abstr).
-
Bussel J.B., Cheng G., Saleh M.N., et al. Oral elthrombopag spares corticosteroids and reduces bleeding in patients with idiopathic thrombocytopenic purpura (ITP). 13th congress of the European Haematology Association, June 12-15, 2008, Copenhagen, Denmark. Abstract 0306. Haematologica 93 suppl (2008) 125 (abstr).
-
(2008)
Haematologica
, vol.93
, Issue.SUPPL
, pp. 125
-
-
Bussel, J.B.1
Cheng, G.2
Saleh, M.N.3
-
60
-
-
36148972012
-
Pharmacodynamics and pharmacokinetics of AMG 531, a thrombopoiesis-stimulating peptibody in healthy Japanese subjects: a randomized, placebo-controlled study
-
Kumagai Y., Fujita T., Ozaki M., et al. Pharmacodynamics and pharmacokinetics of AMG 531, a thrombopoiesis-stimulating peptibody in healthy Japanese subjects: a randomized, placebo-controlled study. J Clin Pharmacol 47 (2007) 1489-1497
-
(2007)
J Clin Pharmacol
, vol.47
, pp. 1489-1497
-
-
Kumagai, Y.1
Fujita, T.2
Ozaki, M.3
-
61
-
-
33750051618
-
An open-label, unit dose-finding study of AMG 531, a novel thrombopoiesis-stimulating peptibody, in patients with immune thrombocytopenic purpura
-
Newland A., Caulier M.T., Lappers-Klunne M., et al. An open-label, unit dose-finding study of AMG 531, a novel thrombopoiesis-stimulating peptibody, in patients with immune thrombocytopenic purpura. Br J Haematol 135 (2006) 547-553
-
(2006)
Br J Haematol
, vol.135
, pp. 547-553
-
-
Newland, A.1
Caulier, M.T.2
Lappers-Klunne, M.3
-
62
-
-
33750035507
-
AMG531, a thrombopoietin-stimulating protein, for chronic ITP
-
Bussel J.B., Kuter D.J., George J.N., et al. AMG531, a thrombopoietin-stimulating protein, for chronic ITP. New Engl J Med 355 (2006) 1672-1681
-
(2006)
New Engl J Med
, vol.355
, pp. 1672-1681
-
-
Bussel, J.B.1
Kuter, D.J.2
George, J.N.3
-
63
-
-
47649107369
-
Antiphospholipid antibodies in adults with immune thrombocytopenic purpura
-
Despujol C.-D., Michel M., Khellaf M., et al. Antiphospholipid antibodies in adults with immune thrombocytopenic purpura. Br J Haematol 142 (2008) 638-643
-
(2008)
Br J Haematol
, vol.142
, pp. 638-643
-
-
Despujol, C.-D.1
Michel, M.2
Khellaf, M.3
-
64
-
-
33744456732
-
A novel nonpeptidyl human c-MPL activator stimulates human megakaryopoiesis and thrombopoiesis
-
Nakamura T., Miyakawa Y., Miyamura A., et al. A novel nonpeptidyl human c-MPL activator stimulates human megakaryopoiesis and thrombopoiesis. Blood 107 (2006) 4300-4307
-
(2006)
Blood
, vol.107
, pp. 4300-4307
-
-
Nakamura, T.1
Miyakawa, Y.2
Miyamura, A.3
-
65
-
-
50949114155
-
Interferon alpha 2b-induced thrombocytopenia is caused by inhibition of platelet production but not proliferation and endomitosis in human megakaryocytes
-
Yamane A., Nakamura T., Suzuki H., et al. Interferon alpha 2b-induced thrombocytopenia is caused by inhibition of platelet production but not proliferation and endomitosis in human megakaryocytes. Blood 112 (2008) 542-550
-
(2008)
Blood
, vol.112
, pp. 542-550
-
-
Yamane, A.1
Nakamura, T.2
Suzuki, H.3
-
66
-
-
52249095318
-
AKR-501 (YM477) in combination with thrombopoietin enhances human megakaryocytopoiesis
-
Fukushima-Shintani M., Suzuki K.I., Iwatsuki Y., et al. AKR-501 (YM477) in combination with thrombopoietin enhances human megakaryocytopoiesis. Exp Hematol 36 (2008) 1337-1342
-
(2008)
Exp Hematol
, vol.36
, pp. 1337-1342
-
-
Fukushima-Shintani, M.1
Suzuki, K.I.2
Iwatsuki, Y.3
-
67
-
-
34250618306
-
Single and multiple oral doses of AKR-501 (YM477) increases the platelet count in healthy volunteers
-
Desjardins R.E., Tempel D.L., Lucek R., and Kuter D.J. Single and multiple oral doses of AKR-501 (YM477) increases the platelet count in healthy volunteers. J Support Oncol 5 suppl 2 (2007) 68-69
-
(2007)
J Support Oncol
, vol.5
, Issue.SUPPL. 2
, pp. 68-69
-
-
Desjardins, R.E.1
Tempel, D.L.2
Lucek, R.3
Kuter, D.J.4
-
68
-
-
54349089372
-
The effect of a novel, small nonpeptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis
-
Nogami W., Yoshida H., Koizumi K., et al. The effect of a novel, small nonpeptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis. Haematologica 93 (2008) 1495-1504
-
(2008)
Haematologica
, vol.93
, pp. 1495-1504
-
-
Nogami, W.1
Yoshida, H.2
Koizumi, K.3
-
69
-
-
33751197936
-
R406, an orally available spleen tyrosine kinase inhibitor blocks Fc receptor signaling and reduces immune complex-mediated inflammation
-
Braselmann S., Taylor V., Zhao H., et al. R406, an orally available spleen tyrosine kinase inhibitor blocks Fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther 319 (2006) 998-1008
-
(2006)
J Pharmacol Exp Ther
, vol.319
, pp. 998-1008
-
-
Braselmann, S.1
Taylor, V.2
Zhao, H.3
-
70
-
-
43949092440
-
An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus
-
Bahjat F.R., Pine P.R., Reitsma A., et al. An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus. Arthritis Rheum 58 (2008) 1433-1444
-
(2008)
Arthritis Rheum
, vol.58
, pp. 1433-1444
-
-
Bahjat, F.R.1
Pine, P.R.2
Reitsma, A.3
-
71
-
-
65349104905
-
Of mice and men: an open-label pilot study for treatment of immune thrombocytopenic purpura (ITP) by an inhibitor of Syk
-
10.1182/blood-2008-07-166439 published online Dec 18.
-
Podolanczuk A., Lazarus A.H., Crow A.R., et al. Of mice and men: an open-label pilot study for treatment of immune thrombocytopenic purpura (ITP) by an inhibitor of Syk. Blood (2008) 10.1182/blood-2008-07-166439 published online Dec 18.
-
(2008)
Blood
-
-
Podolanczuk, A.1
Lazarus, A.H.2
Crow, A.R.3
-
72
-
-
36549047972
-
Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C
-
McHutchison J.G., Dusheiko G., Shiffman M.L., et al. Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. N Engl J Med 357 (2007) 2227-2236
-
(2007)
N Engl J Med
, vol.357
, pp. 2227-2236
-
-
McHutchison, J.G.1
Dusheiko, G.2
Shiffman, M.L.3
-
73
-
-
47549100894
-
The role of AMG-531 in the treatment of thrombocytopenia in idiopathic thrombocytopenic purpura and myelodysplastic syndromes
-
Tiu R.V., and Sekeres M.A. The role of AMG-531 in the treatment of thrombocytopenia in idiopathic thrombocytopenic purpura and myelodysplastic syndromes. Expert Opin Biol Ther 8 (2008) 1021-1030
-
(2008)
Expert Opin Biol Ther
, vol.8
, pp. 1021-1030
-
-
Tiu, R.V.1
Sekeres, M.A.2
-
74
-
-
41349111682
-
Overview of thrombopoietic agents in the treatment of thrombocytopenia
-
Kobos R., and Bussel J.B. Overview of thrombopoietic agents in the treatment of thrombocytopenia. Clin Lymphoma Myeloma 8 (2008) 33-40
-
(2008)
Clin Lymphoma Myeloma
, vol.8
, pp. 33-40
-
-
Kobos, R.1
Bussel, J.B.2
-
75
-
-
36248977130
-
Thrombopoietin inhibits nerve growth factor-induced neuronal differentiation and ERK signalling
-
Samoylenko A., Byts N., Rajalingam K., et al. Thrombopoietin inhibits nerve growth factor-induced neuronal differentiation and ERK signalling. Cell Signal 20 (2008) 154-162
-
(2008)
Cell Signal
, vol.20
, pp. 154-162
-
-
Samoylenko, A.1
Byts, N.2
Rajalingam, K.3
-
76
-
-
38849176235
-
Human thrombopoietin reduces myocardial infarct size, apoptosis, and stunning following ischaemia/reperfusion in rats
-
Baker J.E., Su J., Hsu A., et al. Human thrombopoietin reduces myocardial infarct size, apoptosis, and stunning following ischaemia/reperfusion in rats. Cardiovasc Res 77 (2008) 44-53
-
(2008)
Cardiovasc Res
, vol.77
, pp. 44-53
-
-
Baker, J.E.1
Su, J.2
Hsu, A.3
-
77
-
-
33746642069
-
Management of patients with refractory immune thrombocytopenic purpura
-
George J.N. Management of patients with refractory immune thrombocytopenic purpura. J Thromb Haemost 4 (2006) 1664-1672
-
(2006)
J Thromb Haemost
, vol.4
, pp. 1664-1672
-
-
George, J.N.1
-
78
-
-
58449105994
-
Improved quality of life for romiplostim-treated patients with chronic immune thrombocytopenic purpura: results from two randomized, placebo-controlled trials
-
George J.N., Mathias S.D., Go R.S., et al. Improved quality of life for romiplostim-treated patients with chronic immune thrombocytopenic purpura: results from two randomized, placebo-controlled trials. Br J Haematol 144 (2009) 409-415
-
(2009)
Br J Haematol
, vol.144
, pp. 409-415
-
-
George, J.N.1
Mathias, S.D.2
Go, R.S.3
-
79
-
-
60849086771
-
Effects of eradication of Helicobacter pylori infection in patients with immune thrombocytopenic purpura: a systematic review
-
Stasi R., Sarpatwari A., Segal J.B., et al. Effects of eradication of Helicobacter pylori infection in patients with immune thrombocytopenic purpura: a systematic review. Blood 113 (2009) 1231-1240
-
(2009)
Blood
, vol.113
, pp. 1231-1240
-
-
Stasi, R.1
Sarpatwari, A.2
Segal, J.B.3
-
80
-
-
20444438369
-
Paths to understanding the genetic basis of autoimmune disease
-
Rioux J.D., and Abbas A.K. Paths to understanding the genetic basis of autoimmune disease. Nature 435 (2005) 584-589
-
(2005)
Nature
, vol.435
, pp. 584-589
-
-
Rioux, J.D.1
Abbas, A.K.2
|