Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation

British Journal of Pharmacology

Volumn 156, Issue 4, 2009, Pages 575-586

  Hussain, R I ^a,b   Qvigstad, E ^a,b   Birkeland, J A K ^b,c   Eikemo, H ^a,b   Glende, A ^a,b   Sjaastad, I ^b,c   Skomedal, T ^a,b   Osnes, J B ^a,b   Levy, F O ^a,b   Krobert, K A ^a,b  

^a UNIVERSITY OF OSLO   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

Author keywords

Congestive heart failure; Contractility; Pertussis toxin; Rho kinase; Signal transduction; Ventricular function

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ALPHA 1 ADRENERGIC RECEPTOR; CALCIUM; CARBACHOL; ISOPRENALINE; MUSCARINIC M2 RECEPTOR; MYOSIN LIGHT CHAIN 2; MYOSIN LIGHT CHAIN KINASE; PERTUSSIS TOXIN; CARDIAC MYOSIN; CARDIOTONIC AGENT; MUSCARINIC RECEPTOR; MYOSIN LIGHT CHAIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DISEASE SEVERITY; DRUG EFFECT; DRUG MECHANISM; ECHOCARDIOGRAPHY; ENZYME INHIBITION; HEART FAILURE; HEART INFARCTION SIZE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE CONTRACTILITY; HEART PAPILLARY MUSCLE; HEART VENTRICLE ENDDIASTOLIC PRESSURE; HEART VENTRICLE WALL; HEART WEIGHT; INOTROPISM; LUNG WEIGHT; MALE; MUSCLE FORCE; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; ANIMAL; BLOOD PRESSURE; DISEASE MODEL; HEART CONTRACTION; HEART INFARCTION; HEART VENTRICLE; IN VITRO STUDY; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN BINDING; WISTAR RAT;

ANIMALS; BLOOD PRESSURE; CALCIUM; CARBACHOL; CARDIAC MYOSINS; CARDIOTONIC AGENTS; DISEASE MODELS, ANIMAL; HEART FAILURE; HEART VENTRICLES; ISOPROTERENOL; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; MYOSIN LIGHT CHAINS; PAPILLARY MUSCLES; PHOSPHORYLATION; PROTEIN BINDING; RATS; RATS, WISTAR; RECEPTORS, MUSCARINIC;

EID: 65349106516     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00016.x     Document Type: Article

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