Gi-coupled receptors mediate phosphorylation of CPI-17 and MLC20 via preferential activation of the PI3K/ILK pathway

Biochemical Journal

Volumn 396, Issue 1, 2006, Pages 193-200

  Huang, Jiean ^a   Mahavadi, Sunila ^a   Sriwai, Wimolpak ^b   Hu, Wenhui ^b   Murthy, Karnam S ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Gi coupled receptor; Integrin linked kinase; Myosin light chain phosphatase; p21 activated kinase; Protein kinase C potentiated inhibitor 17 kDa protein (CPI 17); Smooth muscle

Indexed keywords

CALCIUM; CELLS; CHEMICAL ACTIVATION; ENZYME INHIBITION; MUSCLE; RNA;

INTEGRIN-LINKED KINASE; MYOSIN LIGHT CHAIN PHOSPHATASE; P21-ACTIVATED KINASE; PROTEIN KINASE C POTENTIATED INHIBITOR 17 KDA PROTEIN (CPI-17); SMOOTH MUSCLE;

ENZYME KINETICS;

2 MORPHOLINO 8 PHENYLCHROMONE; ACETYLCHOLINE; ADENOSINE DERIVATIVE; CALCIUM; CYCLOPENTYL ADENOSINE; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; INTEGRIN LINKED KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN CDC42; PROTEIN KINASE C INHIBITOR; PROTEIN P21; SERINE; SMALL INTERFERING RNA; SOMATOSTATIN; SOMATOSTATIN RECEPTOR; UNCLASSIFIED DRUG; 1 (5 CHLORO 1 NAPHTHALENESULFONYL)HEXAHYDRO 1H 1,4 DIAZEPINE; 1 (6 ((3 METHOXYESTRA 1,3,5(10) TRIEN 17 YL)AMINO)HEXYL) 1H PYRROLE 2,5 DIONE; 1-(6-((3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL)-1H-PYRROLE-2,5-DIONE; 2 PYRROLIDONE DERIVATIVE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ADENOSINE; ADENOSINE A1 RECEPTOR; AZEPINE DERIVATIVE; CHROMONE DERIVATIVE; CPI 17 PROTEIN, ORYCTOLAGUS CUNICULUS; CPI-17 PROTEIN, ORYCTOLAGUS CUNICULUS; DELTA OPIATE RECEPTOR; DRUG DERIVATIVE; ESTRANE DERIVATIVE; G PROTEIN COUPLED RECEPTOR; HYBRID PROTEIN; IMIDAZOLE DERIVATIVE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; INTEGRIN-LINKED KINASE; MORPHOLINE DERIVATIVE; MUSCARINIC M2 RECEPTOR; MUSCLE PROTEIN; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN PHOSPHATASE; N(6) CYCLOPENTYLADENOSINE; N(6)-CYCLOPENTYLADENOSINE; P21 ACTIVATED KINASE 1; PHOSPHOPROTEIN; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; PYRIDINE DERIVATIVE; SOMATOSTATIN RECEPTOR 3;

ANIMAL CELL; ARTICLE; DRUG ACTIVITY; DRUG INHIBITION; GENETIC TRANSFECTION; MUSCLE CELL; MUSCLE CONTRACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ANIMAL; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; RABBIT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOSINE; ANIMALS; AZEPINES; CALCIUM; CELLS, CULTURED; CHROMONES; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ESTRENES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; IMIDAZOLES; MORPHOLINES; MUSCLE CONTRACTION; MUSCLE PROTEINS; MYOCYTES, SMOOTH MUSCLE; MYOSIN LIGHT CHAINS; MYOSIN-LIGHT-CHAIN PHOSPHATASE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDINES; PYRROLIDINONES; RABBITS; RECEPTOR, ADENOSINE A1; RECEPTOR, MUSCARINIC M2; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, OPIOID, DELTA; RECEPTORS, SOMATOSTATIN; RECOMBINANT FUSION PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SOMATOSTATIN; TRANSFECTION;

EID: 33646848052     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20051772     Document Type: Article

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