Modulation of myosin phosphatase targeting subunit and protein phosphatase 1 in the heart

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 289, Issue 4 58-4, 2005, Pages

  Rajashree, Ravi ^a   Blunt, Bradford C ^a   Hofmann, Polly A ^a  

^a UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

Author keywords

adrenergic receptor; Isometric tension; Light chain 2; Rho kinase; Ventricular myocytes

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; CALCIUM ION; MYOSIN; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN 2; PHOSPHOPROTEIN PHOSPHATASE 1; RHO KINASE; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME SUBUNIT; HEART FUNCTION; HEART MUSCLE CELL; MUSCLE ISOMETRIC CONTRACTION; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; CALCIUM; CARDIAC MYOSINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOMETRIC CONTRACTION; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; MYOSIN LIGHT CHAINS; MYOSIN-LIGHT-CHAIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RATS; RECEPTORS, ADRENERGIC, ALPHA;

EID: 25444533278     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00318.2004     Document Type: Article

References (28)

1. 1-AR-induced positive inotropic response in heart is dependent on myosin light chain phosphorylation. Am J Physiol Heart Circ Physiol 283: H471-H480, 2002.
2. Bollen M. Combinatorial control of protein phosphatase-I. Trends Biochem Sci 26: 6-31, 2001.
3. Chisholm AA and Cohen P. Identification of a third form of protein phosphatase 1 in rabbit skeletal muscle that is associated with myosin. Biochim Biophys Acta 968: 392-400, 1988.
4. Davis JS, Hassanzadeh S, Winitsky S, Lin H, Satorius C, Vemuri R, Aletras AH, Wen H, and Epstein ND. The overall pattern of cardiac contraction depends on a spatial gradient of myosin regulatory light chain phosphorylation. Cell 107: 631-641, 2001.
5. duBell WH, Gigena MS, Guatimosim S, Long X, Lederer WJ, and Rogers TB. Effects of PP1/PP2A inhibitor calyculin A on the E-C coupling cascade in murine ventricular myocytes. Am J Physiol Heart Circ Physiol 282: H38-H48, 2002.
6. El-Armouche A, Rau T, Zolk O, Ditz D, Pamminger T, Zimmermann WH, Jackel E, Harding SE, Boknik P, Neumann J, and Eschenhagen T. Evidence for protein phosphatase inhibitor-1 playing an amplifier role in beta-adrenergic signaling in cardiac myocytes. FASEB J 17: 437-439, 2003.
7. Fabiato A. Myoplasmic free calcium concentration reached during the twitch of an intact isolated cardiac cell and during calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned cardiac cell from the adult rat or rabbit ventricle. J Gen Physiol 78: 457-497, 1981.
8. Fujioka M, Takahashi N, Odai H, Araki S, Ichikawa K, Feng J, Nakamura M, Kaibuchi K, Hartshorne DJ, Nakano T, and Ito M. A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping. Genomics 49: 59-68, 1998.
9. Grimm M, Haas P, Willipinski-Stapelfeldt B, Zimmermann WH, Rau T, Pantel K, Weyand M, and Eschenhagen T. Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha 1-adrenergic positive inotropic effect in human atrium. Cardiovasc Res 65: 211-220, 2005.
10. Gupta RC, Neumann J, Watanabe AM, and Sabbah HN. Inhibition of type 1 protein phosphatase activity by activation of beta-adrenoceptors in ventricular myocardium. Biochem Pharmacol 63: 1069-1076, 2002.
11. Kobayashi N, Nakano S, Mita S, Kobayashi T, Honda T, Tsubokou Y, and Matsuoka H. Involvement of Rho-kinase pathway for angiotensin II-induced plasminogen activator inhibitor-1 gene expression and cardiovascular remodeling in hypertensive rats. J Pharmacol Exp Ther 301: 459-466, 2002.
12. Lester JW, Gannaway KF, Reardon RA, Koon LD, and Hofmann PA. Effects of adenosine and protein kinase C stimulation on mechanical properties of rat cardiac myocytes. Am J Physiol Heart Circ Physiol 271: H1778-H1785, 1996.
13. Liu Q and Hofmann PA. Antiadrenergic effects of adenosine Ai receptor-mediated protein phosphatase 2a activation in the heart. Am J Physiol Heart Circ Physiol 283: H1314-H1321, 2002.
14. Morano I, Arndt H, Bachle-Stolz C, and Ruegg JC. Further studies on the effects of myosin P-light chain phosphorylation on contractile properties of skinned cardiac fibres. Basic Res Cardiol 81: 611-619, 1986.
15. 2+ movement. Basic Res Cardiol 97 Suppl 1: 191-195, 2002.
16. Nishio H, Ichikawa K, and Hartshorne DJ. Evidence for myosinbinding phosphatase in heart myofibrils. Biochem Biophys Res Commun 236: 570-575, 1997.
17. Ogut O and Brozovich FV. Regulation of force in vascular smooth muscle. J Mol Cell Cardiol 35: 347-355, 2003.
18. Putzer G. Invited review: regulation of myosin phosphorylation in smooth muscle. J Appl Physiol 91: 497-503, 2001.
19. Puceat M, Clement O, Lechene P, Pelosin JM, Ventura-Clapier R, and Vassort G. Neurohormonal control of calcium sensitivity of myofilaments in rat single heart cells. Circ Res 67: 517-524, 1990.
20. Sah VP, Hoshijima M, Chien KR, and Brown JH. Rho is required for Galphaq and alpha1-adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways. J Biol Chem 271: 31185-31190, 1996.
21. Sanbe A, Fewell JG, Gulick J, Osinska H, Lorenz J, Hall DG, Murray LA, Kimball TR, Witt SA, and Robbins J. Abnormal cardiac structure and function in mice expressing nonphosphorylatable cardiac regulatory myosin light chain 2. J Biol Chem 274: 21085-21094, 1999.
22. Seko T, Ito M, Kureishi Y, Okamoto R, Moriki N, Onishi K, Isaka N, Hartshorne DJ, and Nakano T. Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle. Circ Res 92: 411-418, 2003.
23. 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 83: 1325-1358, 2003.
24. 2+ sensitivity in failing hearts. Am J Physiol Heart Circ Physiol 281: H637-H646, 2001.
25. Sward K, Mita M, Wilson DP, Deng JT, Susnjar M, and Walsh MP. The role of RhoA and Rho-associated kinase in vascular smooth muscle contraction. Curr Hypertens Rep 5: 66-72, 2003.
26. Sweeney HL and Stull JT. Phosphorylation of myosin in permeabilized mammalian cardiac and skeletal muscle cells. Am J Physiol Cell Physiol 250: C657-C660, 1986.
27. Wera S and Hemmings BA. Serine/threonine protein phosphatases. Biochem J 311: 17-29, 1995.
28. Wolkowicz PE, Ku DD, Grenett HE, and Urthaler F. Occupation of the prostaglandin E2-type 1 receptor increases rat atrial contractility via a Y-27632-sensitive pathway. Prostaglandins Other Lipid Mediat 70: 91-105, 2002.