Activatable smart probes for molecular optical imaging and therapy

Journal of Innovative Optical Health Sciences

Volumn 1, Issue 1, 2008, Pages 45-61

  Lovell, Jonathan F ^a   Zheng, Gang ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

activatable imaging probes; Optical imaging; photodynamic therapy

Indexed keywords

DETECTION AGENTS; DISEASE TREATMENT; IMAGING PROBE; IN-VIVO; OPTICAL IMAGING; REACTIVE OXYGEN SPECIES; SINGLET OXYGEN; SMALL ANIMAL; SMART PROBES; TISSUE CULTURE CELLS;

ANIMALS; DISEASES; NUCLEIC ACIDS; OPTICAL IMAGE STORAGE; OPTICAL PROPERTIES; OXYGEN; PHOTODYNAMIC THERAPY; PHOTOSENSITIZERS; TISSUE; TISSUE CULTURE; VISUALIZATION;

PROBES;

EID: 65249174132     PISSN: 17935458     EISSN: 17937205     Source Type: Journal    
DOI: 10.1142/S1793545808000157     Document Type: Review

References (76)

1. Bai, Y., Zhang, B., Xu, J., Duan, C., Dang, D., Liu, D. and Meng, Q. "Conformational switching fluorescent chemosensor for chloride anion," New. J. Chem. 29, 777-779 (2005). (Pubitemid 40904139)
2. Belousov, V. V., Fradkov, A. F., Lukyanov, K. A., Staroverov, D. B., Shakhbazov, K. S., Terskikh, A. V. and Lukyanov, S. "Genetically encoded fluorescent indicator for intracellular hydrogen peroxide," Nat. Methods 3, 281-286 (2006).
3. Blum, G., von Degenfeld, G., Merchant, M. J., Blau, H. M. and Bogyo, M. "Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes," Nat. Chem. Biol. 3, 668-677 (2007). (Pubitemid 47417706)
4. Bratu, D. P., Cha, B., Mhlanga, M. M., Kramer, F. R. and Tyagi, S. "Visualizing the distribution and transport of mRNAs in living cells," Proc. Natl. Acad. Sci. USA 100, 13308-13313 (2003). (Pubitemid 37444738)
5. Chen, J., Stefflova, K., Niedre, M. J., Wilson, B. C., Chance, B., Glickson, J. D. and Zheng, G. "Protease-triggered photosensitizing beacon based on singlet oxygen quenching and activation, J. Am. Chem. Soc. 126, 11450-11451 (2004). (Pubitemid 39244956)
6. Chudakov, D. M., Lukyanov, S. and Lukyanov, K. A. "Fluorescent proteins as a toolkit for in vivo imaging," Trends Biotechnol. 23, 605-613 (2005). (Pubitemid 41682374)
7. Cui, Z., Zhang, Z., Zhang, X.,Wen, J., Zhou, Y. and Xie, W. "Visualizing the dynamic behavior of poliovirus plus-strand RNA in living host cells," Nucleic. Acids. Res. 33, 3245-3252 (2005). (Pubitemid 41194468)
8. Dong, M., Tepp, W. H., Johnson, E. A. and Chapman, E. R. "Using fluorescent sensors to detect botulinum neurotoxin activity in vitro and in living cells," Proc. Natl. Acad. Sci. USA 101, 14701-14706 (2004). (Pubitemid 39410738)
9. Dunphy, I., Vinogradov, S. A. and Wilson, D. F. "Oxyphor R2 and G2: phosphors for measuring oxygen by oxygen-dependent quenching of phosphorescence," Anal. Biochem. 310, 191-198 (2002). (Pubitemid 35388261)
10. Farber, S. A., Pack, M., Ho, S. Y., Johnson, I. D., Wagner, D. S., Dosch, R., Mullins, M. C., Hendrickson, H. S., Hendrickson, E. K. and Halpern, M. E. "Genetic analysis of digestive physiology using fluorescent phospholipid reporters," Science 292, 1385-1388 (2001). (Pubitemid 32476227)
11. Fehr, M., Frommer, W. B. and Lalonde, S. "Visualization of maltose uptake in living yeast cells by fluorescent nanosensors," Proc. Natl. Acad. Sci. USA 99, 9846-9851 (2002). (Pubitemid 34831135)
12. Flors, C., Fryer, M. J., Waring, J., Reeder, B., Bechtold, U., Mullineaux, P. M., Nonell, S., Wilson, M. T. and Baker, N. R. "Imaging the production of singlet oxygen in vivo using a new fluorescent sensor, Singlet Oxygen Sensor Green," J. Exp. Bot. 57, 1725-1734 (2006). (Pubitemid 43992222)
13. Funovics, M., Weissleder, R. and Tung, C. "Protease sensors for bioimaging," Anal. Bioanal. Chem. 377, 956-963 (2003). (Pubitemid 40877826)
14. Gee, K. R., Zhou, Z., Qian, W. and Kennedy, R. "Detection and imaging of zinc secretion from pancreatic beta-cells using a new fluorescent zinc indicator," J. Am. Chem. Soc. 124, 776-778 (2002). (Pubitemid 34112786)
15. Giepmans, B. N. G., Adams, S. R., Ellisman, M. H. and Tsien, R. Y. "The fluorescent toolbox for assessing protein location and function," Science 312, 217-224 (2006).
16. Godavarty, A., Sevick-Muraca, E. M. and Eppstein, M. J. "Three-dimensional fluorescence lifetime tomography," Med. Phys. 32, 992-1000 (2005). (Pubitemid 40586784)
17. Goel, G., Kumar, A., Puniya, A. K., Chen, W. and Singh, K. "Molecular beacon: a multitask probe," J. Appl. Microbiol. 99, 435-442 (2005). (Pubitemid 41215820)
18. Grynkiewicz, G., Poenie, M. and Tsien, R. Y. "A new generation of Ca2+ indicators with greatly improved fluorescence properties," J. Biol. Chem. 260, 3440-3450 (1985). (Pubitemid 15114340)
19. Gurskaya, N. G., Verkhusha, V. V., Shcheglov, A. S., Staroverov, D. B., Chepurnykh, T.V., Fradkov,A. F., Lukyanov, S. and Lukyanov,K. A. "Engineering of amonomeric green-to-red photoactivatable fluorescent protein induced by blue light," Nat. Biotechnol. 24, 461-465 (2006).
20. Hara, M., Bindokas, V., Lopez, J. P., Kaihara, K., Landa, L. R., Harbeck, M. and Roe, M. W. "Imaging endoplasmic reticulum calcium with a fluorescent biosensor in transgenic mice," Am. J. Physiol. Cell Physiol. 287, C932-C938 (2004). (Pubitemid 39238316)
21. Hideg, E., Barta, C., Ḱalai, T., Vass, I., Hideg, K. and Asada, K. "Detection of singlet oxygen and superoxide with fluorescent sensors in leaves under stress by photoinhibition or UV radiation," Plant Cell Physiol. 43, 1154-1164 (2002). (Pubitemid 35337211)
22. Hu, C., Chinenov, Y. and Kerppola, T. K. "Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation," Mol. Cell 9, 789-798 (2002). (Pubitemid 34454889)
23. Jaffer, F. A., Kim, D., Quinti, L., Tung, C., Aikawa, E., Pande, A. N., Kohler, R. H., Shi, G., Libby, P. and Weissleder, R. "Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor," Circulation 115, 2292-2298 (2007). (Pubitemid 46685897)
24. Jiang, T., Olson, E. S., Nguyen, Q. T., Roy, M., Jennings, P. A. and Tsien, R. Y. "Tumor imaging by means of proteolytic activation of cell-penetrating peptides," Proc. Natl. Acad. Sci. USA 101, 17867-17872 (2004). (Pubitemid 40051978)
25. Johnson, I. "Fluorescent probes for living cells," Histochem. J. 30, 123-140 (1998). (Pubitemid 28149813)
26. Kay, A. R. "Evidence for chelatable zinc in the extracellular space of the hippocampus, but little evidence for synaptic release of Zn," J. Neurosci. 23, 6847-6855 (2003). (Pubitemid 36951213)
27. Kim, Y., Choi, Y., Weissleder, R. and Tung, C. "Membrane permeable esteraseactivated fluorescent imaging probe," Bioorg. Med. Chem. Lett. 17, 5054-5057 (2007). (Pubitemid 47259672)
28. Kojima, H., Nakatsubo, N., Kikuchi, K., Kawahara, S., Kirino, Y., Nagoshi, H., Hirata, Y. and Nagano, T. "Detection and imaging of nitric oxide with novel fluorescent indicators: diaminofluoresceins," Anal. Chem. 70, 2446-2453 (1998).
29. Kwon, J. Y., Jang, Y. J., Lee, Y. J., Kim, K. M., Seo, M. S., Nam, W. and Yoon, J. "A highly selective fluorescent chemosensor for Pb2+," J. Am. Chem. Soc. 127, 10107-10111 (2005). (Pubitemid 41001443)
30. Lee, D., Khaja, S., Velasquez-Castano, J. C., Dasari, M., Sun, C., Petros, J., Taylor, W. R. and Murthy, N. "In vivo imaging of hydrogen peroxide with chemiluminescent nanoparticles," Nat. Mater. 6, 765-769 (2007). (Pubitemid 47515311)
31. Lin, J., Zhang, Z., Yang, J., Zeng, S., Liu, B. and Luo, Q. "Real-time detection of caspase-2 activation in a single living HeLa cell during cisplatin-induced apoptosis," J. Biomed. Opt. 11, 024011 (2006).
32. Lin, Z., Xie, L., Zhao, Y., Duan, C. and Qu, J. "Thiourea-based molecular clips for fluorescent discrimination of isomeric dicarboxylates," Org. Biomol. Chem. 5, 3535-3538 (2007). (Pubitemid 47587708)
33. Liu, L., Yermolaieva, O., Johnson, W. A., Abboud, F. M. and Welsh, M. J. "Identification and function of thermosensory neurons in Drosophila larvae," Nat. Neurosci. 6, 267-273 (2003). (Pubitemid 36278285)
34. Lu, J., Zhang, Z., Yang, J., Chu, J., Li, P., Zeng, S. and Luo, Q. "Visualization of beta-secretase cleavage in living cells using a genetically encoded surface-displayed FRET probe," Biochem. Biophys. Res. Commun. 362, 25-30 (2007). (Pubitemid 47296288)
35. Mahmood, U., Tung, C. H., Bogdanov, A. and Weissleder, R. "Near-infrared optical imaging of protease activity for tumor detection," Radiology 213, 866-870 (1999).
36. Massoud, T. F. and Gambhir, S. S. "Molecular imaging in living subjects: seeing fundamental biological processes in a new light," Genes. Dev. 17, 545-580 (2003). (Pubitemid 36307540)
37. McIntyre, J. O., Fingleton, B., Wells, K. S., Piston, D. W., Lynch, C. C., Gautam, S. and Matrisian, L. M. "Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity," Biochem. J. 377, 617-628 (2004). (Pubitemid 38228373)
38. Meade, T. J., Taylor, A. K. and Bull, S. R. "New magnetic resonance contrast agents as biochemical reporters," Curr. Opin. Neurobiol. 13, 597-602 (2003). (Pubitemid 37431189)
39. Miesenb̈ock, G., Angelis, D. A. D. and Rothman, J. E. "Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins," Nature 394, 192-195 (1998). (Pubitemid 28325974)
40. Miller, E. W., Tulyathan, O., Tulyanthan, O., Isacoff, E. Y. and Chang, C. J. "Molecular imaging of hydrogen peroxide produced for cell signaling," Nat. Chem. Biol. 3, 263-267 (2007). (Pubitemid 46625830)
41. Mitra, R. D., Silva, C. M. and Youvan, D. C. "Fluorescence resonance energy transfer between blue-emitting and red-shifted excitation derivatives of the green fluorescent protein," Gene 173, 13-17 (1996). (Pubitemid 26239674)
42. Miyawaki, A., Llopis, J., Heim, R., McCaffery, J. M., Adams, J. A., Ikura, M. and Tsien, R. Y. "Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin," Nature 388, 882-887 (1997). (Pubitemid 27377061)
43. Moerner, W. E. "New directions in single-molecule imaging and analysis," Proc. Natl. Acad. Sci. USA 104, 12596-12602 (2007). (Pubitemid 47255200)
44. Molenaar, C., Marras, S. A., Slats, J. C., Truffert, J. C., Lemâtre, M., Raap, A. K., Dirks, R. W. and Tanke, H. J. "Linear 2' O-Methyl RNA probes for the visualization of RNA in living cells," Nucleic. Acids Res. 29, E89-E89 (2001).
45. Moschou, E. A., Sharma, B. V., Deo, S. K. and Daunert, S. "Fluorescence glucose detection: advances toward the ideal in vivo biosensor," J. Fluoresc. 14, 535-547 (2004).
46. Nesterov, E. E., Skoch, J., Hyman, B. T., Klunk, W. E., Bacskai, B. J. and Swager, T. M. "In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers," Angew. Chem. Int. Ed. Engl. 44, 5452-5456 (2005). (Pubitemid 41273293)
47. Ntziachristos, V., Tung, C., Bremer, C. and Weissleder, R. "Fluorescence molecular tomography resolves protease activity in vivo," Nat. Med. 8, 757-760 (2002). (Pubitemid 34778731)
48. Ntziachristos, V., Yodh, A. G., Schnall, M. and Chance, B. "Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement," Proc. Natl. Acad. Sci. USA 97, 2767-2772 (2000). (Pubitemid 30159246)
49. O'Riordan, T. C., Fitzgerald, K., Ponomarev, G. V., Mackrill, J., Hynes, J., Taylor, C. and Papkovsky, D. B. "Sensing intracellular oxygen using near-infrared phosphorescent probes and live-cell fluorescence imaging," Am. J. Physiol. Regul. Integr. Comp. Physiol. 292, R1613-R1620 (2007). (Pubitemid 46557826)
50. Oleinick, N. L. and Evans, H. H. "The photobiology of photodynamic therapy: cellular targets and mechanisms," Radiat. Res. 150, S146-S156 (1998). (Pubitemid 28519059)
51. Patterson, G. H. and Lippincott-Schwartz, J. "A photoactivatable GFP for selective photolabeling of proteins and cells," Science 297, 1873-1877 (2002). (Pubitemid 35024347)
52. Peter, M. and Ameer-Beg, S. M. "Imaging molecular interactions by multiphoton FLIM," Biol. Cell 96, 231-236 (2004). (Pubitemid 38461447)
53. Petrat, F., Weisheit, D., Lensen, M., de Groot, H., Sustmann, R. and Rauen, U. "Selective determination of mitochondrial chelatable iron in viable cells with a new fluorescent sensor," Biochem. J. 362, 137-147 (2002). (Pubitemid 34174471)
54. Post, J. N., Lidke, K. A., Rieger, B. and Arndt-Jovin, D. J. "One-and two-photon photoactivation of a paGFP-fusion protein in live Drosophila embryos," FEBS Lett. 579, 325-330 (2005). (Pubitemid 40092407)
55. Ramanujan, V. K., Zhang, J., Biener, E. and Herman, B. "Multiphoton fluorescence lifetime contrast in deep tissue imaging: prospects in redox imaging and disease diagnosis," J. Biomed. Opt. 10, 051407 (2005).
56. Richards-Kortum, R. and Sevick-Muraca, E. "Quantitative optical spectroscopy for tissue diagnosis," Annu. Rev. Phys. Chem. 47, 555-606 (1996). (Pubitemid 126416975)
57. Russell, J., Diamond, K., Collins, T., Weston M., Lovell J., Hayward, J., Farrell, T., Patterson, M. and Fang, Q. "Characterization of time-domain fluorescence properties of typical photosensitizers for photodynamic therapy," Proc. SPIE 6437, 64270G1-9 (2007).
58. Sando, S., Abe, H. and Kool, E. T. "Quenched auto-ligating DNAs: multicolor identification of nucleic acids at single nucleotide resolution," J. Am. Chem. Soc. 126, 1081-1087 (2004). (Pubitemid 38140738)
59. Santangelo, P. J., Nix, B., Tsourkas, A. and Bao, G. "Dual FRET molecular beacons for mRNA detection in living cells," Nucleic. Acids. Res. 32, e57 (2004).
60. Skala, M. C., Riching, K. M., Bird, D. K., Gendron-Fitzpatrick, A., Eickhoff, J., Eliceiri, K. W., Keely, P. J. and Ramanujam, N. "In vivo multiphoton fluorescence lifetime imaging of protein-bound and free nicotinamide adenine dinucleotide in normal and precancerous epithelia," J. Biomed. Opt. 12, 024014 (2007).
61. Stefflova, K., Chen, J. and Zheng, G. "Killer beacons for combined cancer imaging and therapy," Curr. Med. Chem. 14, 2110-2125 (2007). (Pubitemid 47578152)
62. Stefflova, K., Chen, J. and Zheng, G. "Using molecular beacons for cancer imaging and treatment," Frontiers in Bioscience 12, 4709-4721 (2007).
63. Tan, W., Wang, K. and Drake, T. J. "Molecular beacons," Curr. Opin. Chem. Biol. 8, 547-553 (2004). (Pubitemid 39278353)
64. Truong, K., Sawano, A., Mizuno, H., Hama, H., Tong, K., Mal, T., Miyawaki, A. and Ikura, M. "FRET-based in vivo Ca2+ imaging by a new calmodulin-GFP fusion molecule," Nat. Struct. Biol. 8, 1069-1073 (2001). (Pubitemid 33101629)
65. Tung, C., Zeng, Q., Shah, K., Kim, D., Schellingerhout, D. and Weissleder, R. "In vivo imaging of beta-galactosidase activity using far red fluorescent switch," Cancer Res. 64, 1579-1583 (2004). (Pubitemid 38428674)
66. Tyagi, S. and Kramer, F. R. "Molecular beacons: probes that fluoresce upon hybridization," Nat. Biotechnol. 14, 303-308 (1996).
67. Vargas, D. Y., Raj, A., Marras, S. A. E., Kramer, F. R. and Tyagi, S. "Mechanism of mRNA transport in the nucleus," Proc. Natl. Acad. Sci. USA 102, 17008-17013 (2005). (Pubitemid 41692674)
68. Wehrman, T. S., von Degenfeld, G., Krutzik, P. O., Nolan, G. P. and Blau, H. M. "Luminescent imaging of beta-galactosidase activity in living subjects using sequential reporter-enzyme luminescence," Nat. Methods 3, 295-301 (2006).
69. Weissleder, R., Tung, C. H., Mahmood, U. and Bogdanov, A. "In vivo imaging of tumors with protease-activated near-infrared fluorescent probes," Nat. Biotechnol. 17, 375-378 (1999). (Pubitemid 29166041)
70. Xi, C., Balberg, M., Boppart, S. A. and Raskin, L. "Use of DNA and peptide nucleic acid molecular beacons for detection and quantification of rRNA in solution and in whole cells," Appl. Environ. Microbiol. 69, 5673-5678 (2003). (Pubitemid 37150796)
71. Yang, L., McRae, R., Henary, M. M., Patel, R., Lai, B., Vogt, S. and Fahrni, C. J. "Imaging of the intracellular topography of copper with a fluorescent sensor and by synchrotron X-ray fluorescence microscopy," Proc. Natl. Acad. Sci. USA 102, 11179-11184 (2005). (Pubitemid 41153794)
72. Yasui, H. and Sakurai, H. "Chemiluminescent detection and imaging of reactive oxygen species in live mouse skin exposed to UVA," Biochem. Biophys. Res. Commun. 269, 131-136 (2000). (Pubitemid 30440266)
73. Zhang, J., Ma, Y., Taylor, S. S. and Tsien, R. Y. "Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering," Proc. Natl. Acad. Sci. USA 98, 14997-15002 (2001). (Pubitemid 34013958)
74. Zhang, Z., Yang, J., Lu, J., Lin, J., Zeng, S. and Luo, Q. "Fluorescence imaging to assess the matrix metalloproteinase activity and its inhibitor in vivo," J. Biomed. Opt. 13, 011006 (2008).
75. Zheng, G., Chen, J., Stefflova, K., Jarvi, M., Li, H. and Wilson, B. C. "Photodynamic molecular beacon as an activatable photosensitizer based on protease-controlled singlet oxygen quenching and activation," Proc. Natl. Acad. Sci. USA 104, 8989-8994 (2007). (Pubitemid 47175424)
76. Zipfel, W. R., Williams, R. M. and Webb, W. W. "Nonlinear magic: multiphoton microscopy in the biosciences," Nat. Biotechnol. 21, 1369-1377 (2003). (Pubitemid 37356624)