AMP-activated protein kinase is involved in neural stem cell growth suppression and cell cycle arrest by 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside and glucose deprivation by down-regulating phospho-retinoblastoma protein and cyclin D

Journal of Biological Chemistry

Volumn 284, Issue 10, 2009, Pages 6175-6184

  Zang, Yi ^a   Yu, Li Fang ^a   Nan, Fa Jun ^a   Feng, Lin Yin ^b   Li, Jia ^a,c  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c NONE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOELECTRIC POTENTIALS; CELL DEATH; CELL PROLIFERATION; CHEMICAL ACTIVATION; ENZYMES; GLUCOSE; RUBIDIUM COMPOUNDS;

AMP-ACTIVATED PROTEIN KINASE; ANTIPROLIFERATIVE EFFECT; CELL-CYCLE ARREST; DOMINANT NEGATIVE; DOMINANT-NEGATIVE MUTANTS; GLUCOSE DEPRIVATION; GROWTH SUPPRESSIONS; RETINOBLASTOMA PROTEIN;

STEM CELLS;

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENOSINE KINASE INHIBITOR; CASPASE; COMPOUND C; CYCLIN D; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IODOTUBERCIDIN; JANUS KINASE; JANUS KINASE INHIBITOR; POLY(ADENOSINE DIPHOSPHATE RIBOSE); RETINOBLASTOMA PROTEIN; STAT3 PROTEIN; UNCLASSIFIED DRUG; (6 (4 (2 PIPERIDIN 1 YLETHOXY)PHENYL)) 3 PYRIDIN 4 YLPYRAZOLO(1,5 A)PYRIMIDINE; (6-(4-(2-PIPERIDIN-1-YLETHOXY)PHENYL))-3-PYRIDIN-4-YLPYRAZOLO(1,5-A)PYRIMIDINE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE; AICA RIBONUCLEOTIDE; AMP ACTIVATED PROTEIN KINASE KINASE; AMP-ACTIVATED PROTEIN KINASE KINASE; ANTIDIABETIC AGENT; CYCLINE; DRUG DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN KINASE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; RIBONUCLEOTIDE; STAT3 PROTEIN, HUMAN; STAT3 PROTEIN, MOUSE; SWEETENING AGENT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL ENERGY; CELL LEVEL; CELL STRESS; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE OVEREXPRESSION; GLUCOSE DEPRIVATION; GLUCOSE METABOLISM; GROWTH INHIBITION; METABOLIC STRESS; MOUSE; NERVE CELL GROWTH; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; ANIMAL; ASTROCYTE; CELL DIFFERENTIATION; CELL LINE; DRUG EFFECT; HUMAN; METABOLISM; NERVE CELL; STEM CELL;

AMINOIMIDAZOLE CARBOXAMIDE; ANIMALS; APOPTOSIS; ASTROCYTES; CELL DIFFERENTIATION; CELL LINE, TRANSFORMED; CYCLINS; ENZYME ACTIVATION; G0 PHASE; G1 PHASE; GLUCOSE; HUMANS; HYPOGLYCEMIC AGENTS; JANUS KINASES; MICE; NEURONS; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN KINASES; PYRAZOLES; PYRIMIDINES; RETINOBLASTOMA PROTEIN; RIBONUCLEOTIDES; STAT3 TRANSCRIPTION FACTOR; STEM CELLS; SWEETENING AGENTS;

EID: 65249133087     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806887200     Document Type: Article

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