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Bessa J., Gebelein B., Pichaud F., Casares F., Mann R.S. Combinatorial control of Drosophila eye development by Eyeless, Homothorax, and Teashirt. Genes Dev. 16:2002;2415-2427 This paper shows interaction and cross-regulation among the three TFs: eyeless (ey), homothorax (hth) and teashirt (tsh). These interactions account for cell proliferation of the Drosophila eye imaginal disc and prevent the expression of later-acting TFs that are responsible for photoreceptor differentiation. The authors also provide evidence that the BMP-4 homologue Decapentaplegic controls transition from a proliferative to a committed state by repression of hth. The complex ey/hth/tsh is a good example of a combination of TFs that is used transiently during development to regulate cell proliferation within a specific structure.
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The authors altered the relative timing of cell cycle exit in the developing Xenopus retina by overexpressing cyclin E1 and the cdki p27Xic1. Early cell cycle exit potentiates the ability of Xath5 to promote retinal ganglion cell (RGC) fate, whereas inhibition of cell cycle exit biases Xath5-expressing cells toward later neuronal fates. This interesting paper suggests that the activity of factors that promote early cell cycle exit enhances the activity of factors that promote early cellular fates, thus giving further insights into the mechanisms underlying the timing of cell type differentiation during retinogenesis. In addition, the authors described an intriguing role of Notch pathway activation in promoting premature exit from the cell cycle, which also enhances Xath5 activity.
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Ohnuma S., Hopper S., Wang K.C., Philpott A., Harris W.A. Co-ordinating retinal histogenesis: early cell cycle exit enhances early cell fate determination in the Xenopus retina. Development. 129:2002;2435-2446 The authors altered the relative timing of cell cycle exit in the developing Xenopus retina by overexpressing cyclin E1 and the cdki p27Xic1. Early cell cycle exit potentiates the ability of Xath5 to promote retinal ganglion cell (RGC) fate, whereas inhibition of cell cycle exit biases Xath5-expressing cells toward later neuronal fates. This interesting paper suggests that the activity of factors that promote early cell cycle exit enhances the activity of factors that promote early cellular fates, thus giving further insights into the mechanisms underlying the timing of cell type differentiation during retinogenesis. In addition, the authors described an intriguing role of Notch pathway activation in promoting premature exit from the cell cycle, which also enhances Xath5 activity.
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Wu C.F., Nakamura H., Chan A.P., Zhou Y.H., Cao T., Kuang J., Gong S.G., He G., Etkin L.D. Tumorhead, a Xenopus gene product that inhibits neural differentiation through regulation of proliferation. Development. 128:2001;3381-3393 This paper highlights the effects of tumorhead in promoting cell proliferation and inhibiting neural differentiation of neural plate cells without affecting neural inducers, pan-neural or mesodermal markers.
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