Design, synthesis, and quantitative structure-activity relationship of cytotoxic γ-carboline derivatives

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 9, 2009, Pages 3324-3331

  Chen, Jing ^a   Dong, Xiaowu ^a   Liu, Tao ^a   Lou, Jianshu ^a   Jiang, Chaoyi ^a   Huang, Wenhai ^a   He, Qiaojun ^a   Yang, Bo ^a   Hu, Yongzhou ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Carboline derivatives; 3D QSAR; CoMFA; Cytotoxicity

Indexed keywords

2 METHOXYPHENYL GAMMA CARBOLINE 6 SULFONATE; 3 CHLOROPHENYL C CARBOLINE 6 SULFONATE; 3,4,5 TRIMETHOXYPHENYL C CARBOLINE 6 SULFONATE; 3,9 DIETHYL 6 (N ETHYL N (3,4,5 TRIMETHOXYPHENYL)SULFAMOYL) C CARBOLINE 3 IUM BROMIDE; 4 CHLOROPHENYL C CARBOLINE 6 SULFONATE; 4 METHOXYPHENYL GAMMA CARBOLINE 6 SULFONATE; 4 NITROPHENYL C CARBOLINE 6 SULFONATE; 9 ETHYL 6 (2 CHLOROBENZAMIDO) GAMMA CARBOLINE; 9 ETHYL 6 (2 HYDROXYBENZAMIDO) GAMMA CARBOLINE; 9 ETHYL 6 (3, 4, 5 TRIMETHOXYBENZAMIDO) GAMMA CARBOLINE; 9 ETHYL 6 (4 BROMOBENZAMIDO) GAMMA CARBOLINE; 9 ETHYL 6 (4 METHOXYBENZAMIDO) GAMMA CARBOLINE; 9 ETHYL 6 (4 METHYLSULFONYL) GAMMA CARBOLINE; 9 ETHYL 6 BENZAMIDO C CARBOLINE; 9 ETHYL 6 NICOTINAMIDO GAMMA CARBOLINE; 9 ETHYL N (1 METHYL INDOL 5 YL) C CARBOLINE 6 SULFONAMIDE; 9 ETHYL N (3,4,5 TRIMETHOXYPHENYL) C CARBOLINE 6 SULFONAMIDE; 9 ETHYL N (PYRIDINE 4 YL) C CARBOLINE 6 SULFONAMIDE; 9 ETHYL N PHENYL C CARBOLINE 6 SULFONAMIDE; ANTINEOPLASTIC AGENT; CARBOLINE DERIVATIVE; N (3,4,5 TRIMETHOXYPHENYL) C CARBOLINE 6 SULFONAMIDE; N (4 BROMOPHENYL) C CARBOLINE 6 SULFONAMIDE; N (4 METHOXYPHENYL) C CARBOLINE 6 SULFONAMIDE; N (QUINOLIN 5 YL) C CARBOLINE 6 SULFONAMIDE; N PHENYL C CARBOLINE 6 SULFONAMIDE; N,9 DIETHYL N (3,4,5 TRIMETHOXYPHENYL) C CARBOLINE 6 SULFONAMIDE; NAPHTHALEN 1 YL GAMMA CARBOLINE 6 SULFONATE; PACLITAXEL; PHENYL C CARBOLINE 6 SULFONATE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL STRAIN HCT116; CELL STRAIN K 562; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CARBOLINES; CELL LINE, TUMOR; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HUMANS; K562 CELLS; MODELS, MOLECULAR; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STATIC ELECTRICITY;

EID: 65249104037     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.03.037     Document Type: Article

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