Novel anellated pyrazoloquinolin-3-ones: Synthesis and in vitro BZR activity

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 10, 2005, Pages 3531-3541

  Ferlin, Maria Grazia ^a   Chiarelotto, Gianfranco ^a   Dall'Acqua, Stefano ^a   MacIocco, Elisabetta ^b,c   Mascia, Maria Paola ^b,c   Pisu, Maria Giuseppina ^b,c   Biggio, Giovanni ^b,c  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

^c CNR   (Italy)

Author keywords

BZR pharmacophore receptor model; GABAA 1 2 2L receptor antagonists; Pyrazolopyrroloquinolinones

Indexed keywords

2 (3 NITROPHENYL) 5,8 DIHYDRO 2H PYRAZOLO[4,3 C]PYRROLO[3,2 F]QUINOLIN 3 ONE; 2 (4 CHLOROPHENYL) 5,8 DIHYDRO 2H PYRAZOLO[4,3 C]PYRROLO[3,2 F]QUINOLIN 3 ONE; 2 (4 CHLOROPHENYL) 8 METHYL 5 HYDRO 2H PYRAZOLO[4,3 C]PYRROLO[3,2 F]QUINOLIN 3 ONE; 2 (4 CYANOPHENYL) 5,8 DIHYDRO 2H PYRAZOLO[4,3 C]PYRROLO[3,2 F]QUINOLIN 3 ONE; 2 (4 METHOXYPHENYL) 5,8 DIHYDRO 2H PYRAZOLO[4,3 C]PYRROLO[3,2 F]QUINOLIN 3 ONE; 2 (4 METHOXYPHENYL) 8 METHYL 5 HYDRO 2H PYRAZOLO[4,3 C]PYRROLO[3,2 F]QUINOLIN 3 ONE; 2 (4 NITROPHENYL) 5,8 DIHYDRO 2H PYRAZOLO[4,3 C]PYRROLO[3,2 F]QUINOLIN 3 ONE; 2 PHENYL 5,8 DIHYDRO 2H PYRAZOLO[4,3 C]PYRROLO[3,2 F]QUINOLIN 3 ONE; 2 PHENYL 8 ETHYL 5 HYDRO 2H PYRAZOLO[4,3 C]PYRROLO[3,2 F]QUINOLIN 3 ONE; 2 PHENYL 8 METHYL 5 HYDRO 2H PYRAZOLO[4,3 C]PYRROLO[3,2 F]QUINOLIN 3 ONE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG SYNTHESIS; EVALUATION; GENE EXPRESSION; MALE; NONHUMAN; OOCYTE; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; XENOPUS LAEVIS;

XENOPUS LAEVIS;

EID: 17444365771     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.02.042     Document Type: Article

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