Optimization of benzimidazole series as opioid receptor-like 1 (ORL1) antagonists: SAR study directed toward improvement of selectivity over hERG activity

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 11, 2009, Pages 3100-3103

  Kobayashi, Kensuke ^a   Kato, Tetsuya ^a   Yamamoto, Izumi ^a   Shimizu, Atsushi ^a   Mizutani, Sayaka ^a   Asai, Masanori ^a   Kawamoto, Hiroshi ^a   Ito, Satoru ^a   Yoshizumi, Takashi ^a   Hirayama, Mioko ^a   Ozaki, Satoshi ^a   Ohta, Hisashi ^a   Okamoto, Osamu ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Benzimidazole; hERG channel; Nociceptin orphanin FQ; ORL1 antagonist

Indexed keywords

BENZIMIDAZOLE; OPIATE ANTAGONIST; POTASSIUM CHANNEL HERG; SULFIDE;

ARTICLE; BINDING AFFINITY; DRUG SELECTIVITY; STRUCTURE ACTIVITY RELATION;

BENZIMIDAZOLES; CYCLOHEXANES; ETHER-A-GO-GO POTASSIUM CHANNELS; RECEPTORS, OPIOID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 65149088300     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.04.022     Document Type: Article

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36. +.