Novel hexahydrospiro[piperidine-4,1′-pyrrolo[3,4-c]pyrroles: Highly selective small-molecule nociceptin/orphanin FQ receptor agonists

Journal of Medicinal Chemistry

Volumn 46, Issue 2, 2003, Pages 255-264

  Kolczewski, Sabine ^a   Adam, Geo ^a   Cesura, Andrea M ^a   Jenck, François ^a,b   Hennig, Michael ^a   Oberhauser, Thomas ^a   Poli, Sonia M ^a   Rössler, Felix ^a   Röver, Stephan ^a   Wichmann, Jürgen ^a   Dautzenberg, Frank M ^a,c  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b ACTELION PHARMACEUTICALS LTD   (Switzerland)

^c Axovan Ltd   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; DELTA OPIATE RECEPTOR; FORSKOLIN; HEXAHYDROSPIRO(PIPERIDINE 4,1' PYRROLO[3,4 C]PYRROLE; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; NOCICEPTIN RECEPTOR AGONIST; OPIATE RECEPTOR; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; PROTEIN EXPRESSION; RECEPTOR BINDING; SYNTHESIS;

BINDING, COMPETITIVE; CELL LINE; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; PYRIDINES; PYRROLES; RADIOLIGAND ASSAY; RECEPTORS, OPIOID; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; SPIRO COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037448426     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0209174     Document Type: Article

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