Modification of Nociception and Morphine Tolerance by the Selective Opiate Receptor-Like Orphan Receptor Antagonist (-)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8, 9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111)

Journal of Pharmacology and Experimental Therapeutics

Volumn 308, Issue 2, 2004, Pages 454-461

  Zaratin, Paola F ^a   Petrone, Giuseppe ^a   Sbacchi, Massimo ^a   Garnier, Martine ^a   Fossati, Claudia ^a   Petrillo, Paola ^a   Ronzoni, Silvio ^a   Giardina, Giuseppe A M ^a   Scheideler, Mark A ^a,b  

^a GSK   (Italy)

^b Department of Medicinal Chemistry ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 [4 (2,6 DICHLOROPHENYL) 1 PIPERIDINYLMETHYL] 6,7,8,9 TETRAHYDRO 1 METHYL 5H BENZOCYCLOHEPTEN 5 OL; CARRAGEENAN; CIS 1 METHYL 7 ((4 (2,6 DICHLOROPHENYL)PIPERIDIN 1 YL)METHYL) 6,7,8,9 TETRAHYDRO 5H BENZOCYCLOHEPTEN 5 OL; CIS-1-METHYL-7-((4-(2,6-DICHLOROPHENYL)PIPERIDIN-1-YL)METHYL)-6,7,8,9-TETRAHYDRO-5H-BENZOCYCLOHEPTEN-5-OL; CYCLOHEPTANE DERIVATIVE; MORPHINE; NOCICEPTIN; OPIATE ANTAGONIST; OPIATE DERIVATIVE; OPIATE RECEPTOR; OPIATE RECEPTOR LIKE ORPHAN RECEPTOR 1; ORL1 RECEPTOR; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; BINDING SITE; CHO CELL; CHRONIC PAIN; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG POTENTIATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG TOLERANCE; HAMSTER; HOT PLATE TEST; HUMAN; HUMAN CELL; HYPERALGESIA; INFLAMMATION; MALE; MORPHINE TOLERANCE; MOUSE; NOCICEPTION; NONHUMAN; PAIN; PHYSIOLOGY; PRIORITY JOURNAL; RECEPTOR AFFINITY; REPORTER GENE; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; CYCLOHEPTANES; DRUG TOLERANCE; HUMANS; MORPHINE; PAIN; PIPERIDINES; RECEPTORS, OPIOID;

EID: 1642498186     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.055848     Document Type: Article

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