Novel ORL1-selective antagonists with oral bioavailability and brain penetrability

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 11, 2008, Pages 3282-3285

  Okamoto, Osamu ^a   Kobayashi, Kensuke ^a   Kawamoto, Hiroshi ^a   Ito, Satoru ^a   Yoshizumi, Takashi ^a   Yamamoto, Izumi ^a   Hashimoto, Masaya ^a   Shimizu, Atsushi ^a   Takahashi, Hiroyuki ^a   Ishii, Yasuyuki ^a   Ozaki, Satoshi ^a   Ohta, Hisashi ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Nociceptin receptor; Nociceptin orphanin FQ; Opioid receptor like 1(ORL1) antagonist

Indexed keywords

2 (TERT BUTYLTHIO) 5 CHLORO 6 [4 (2 HYDROXYETHYL) 2 METHYLPIPERAZIN 1 YL) 1H BENZIMIDA; METHYL GROUP; OPIATE ANTAGONIST; PIPERAZINE;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG PENETRATION; DRUG POTENCY; MOUSE; NONHUMAN; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ADMINISTRATION, ORAL; ANIMALS; BENZIMIDAZOLES; BRAIN; COMBINATORIAL CHEMISTRY TECHNIQUES; HAPLORHINI; HUMANS; MICE; MOLECULAR STRUCTURE; RATS; RECEPTORS, OPIOID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 44149086167     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.04.037     Document Type: Article

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