Identification of novel benzimidazole series of potent and selective ORL1 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 11, 2008, Pages 3278-3281

  Okamoto, Osamu ^a   Kobayashi, Kensuke ^a   Kawamoto, Hiroshi ^a   Ito, Satoru ^a   Satoh, Atsushi ^a   Kato, Tetsuya ^a   Yamamoto, Izumi ^a   Mizutani, Sayaka ^a   Hashimoto, Masaya ^a   Shimizu, Atsushi ^a   Sakoh, Hiroki ^a   Nagatomi, Yasushi ^a   Iwasawa, Yoshikazu ^a   Takahashi, Hiroyuki ^a   Ishii, Yasuyuki ^a   Ozaki, Satoshi ^a   Ohta, Hisashi ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Nociceptin receptor (NOP); Nociceptin orphanin FQ; Opioid receptor like 1 (ORL1) antagonist

Indexed keywords

5 CHLORO 2 [(1 ETHYL 1 METHYLPROPYL)THIO] 6 [4 (2 HYDROXYETHYL)PIPERAZIN 1 YL] 1H BENZIMIDAZOLE; BENZIMIDAZOLE DERIVATIVE; OPIATE RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG BINDING; DRUG EFFECT; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; HUMAN; NONHUMAN; STRUCTURE ACTIVITY RELATION;

BENZIMIDAZOLES; COMBINATORIAL CHEMISTRY TECHNIQUES; HUMANS; MOLECULAR STRUCTURE; RECEPTORS, OPIOID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 44149086889     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.04.054     Document Type: Article

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