Hepatobiliary transport of glutathione and its role in cholestasis

Yaoxue Xuebao

Volumn 44, Issue 4, 2009, Pages 327-332

  Zhang, Xue Ying ^a   Yang, Jin ^a   Yin, Xue Fen ^a   Liu, Xiao Dong ^a   Wang, Guang Ji ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Cholestasis; Glutathione; Hepatobiliary transport; Multidrug resistance associated protein

Indexed keywords

GLUTATHIONE;

CHOLESTASIS; ENDOPLASMIC RETICULUM; HEPATOBILIARY SYSTEM; PROPHYLAXIS; PROTEIN FUNCTION; REVIEW;

ANIMALS; BIOLOGICAL TRANSPORT; CHOLESTASIS; ESTROGENS; GLUTATHIONE; HUMANS; JAUNDICE, CHRONIC IDIOPATHIC; LIVER; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION; PHALLOIDINE; URSODEOXYCHOLIC ACID;

EID: 64949186047     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (37)

1. DeLeve LD, Kaplowitz N. Glutathione metabolism and its role in hepatotoxicity [J]. Pharmacol Ther, 1991, 52: 287- 305.
2. Ballatori N, Truong AT. Glutathione as a primary osmotic driving force in hepatic bile formation [J]. Am J Physiol, 1992, 263: G617-624.
3. Abbott WA, Meister A. Intrahepatic transport and utilization of biliary glutathione and its metabolites [J]. Biochemistry, 1986, 83: 1246-1250.
4. Balendiran GK, Dabur R, Fraser D. The role of glutathione in cancer [J]. Cell Biochem Funct, 2004, 22: 343-352.
5. Ballatori N, Dutczak WJ. Identification and characterization of high and low affinity transport systems for reduced glutathione in liver cell canalicular membranes [J]. J Biol Chem, 1994, 269: 19731-19737.
6. Ookhtens M, Maddatu T. Mechanism of changes in hepatic sinusoidal and biliary glutathione efflux with age in rats [J]. Am J Physiol, 1991, 261: G648-G656.
7. Mittur AV, Kaplowitz N, Kempner E, et al. Novel properties of hepatic canalicular reduced glutathione transport revealed by radiation inactivation [J]. Am J Physiol Gastrointest Liver Physiol, 1998, 274: 923-930.
8. Ito K, Suzuki H, Hirohashi T, et al. Molecular-cloning of canalicular multispecific organic anion transporter defective in EHBR [J]. Am J Physiol, 1997, 272: G16-G22.
9. Paulusma CC, van Geer MA, Evers R, et al. Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione [J]. Biochem J, 1999, 338: 393-401.
10. Rebbeor JF, Connolly GC, Henson JH, et al. ATP-dependent GSH and glutathione S-conjugate transport in skate liver: role of an Mrp functional homologue [J]. Am J Physiol Gastrointest Liver Physiol, 2000, 279: G417-G425.
11. Evers R, De Haas M, Sparidans R, et al. Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export [J]. Br J Cancer, 2000, 83: 375-383.
12. Oude Elferink RP, Meijer DK, Kuipers F, et al. Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport [J]. Biochim Biophys Acta, 1995, 1241: 215-268.
13. Marchan R, Hammond CL, Ballatori N. Multidrug resistance-associated protein 1 as a major mediator of basal and apoptotic glutathione release [J]. Biochim Biophys Acta, 2008, 1778: 2413-2420.
14. Lorico A, Rappa Q Finch RA, et al. Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione [J]. Cancer Res, 1997, 57: 5238-5242.
15. Loe DW, Almquist KC, Deeley RQ et al. Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport [J]. J Biol Chem, 1996,271: 9675-9682.
16. Lai L, Tan TM. Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues [J]. Biochem J, 2002, 361: 497-503.
17. Wijnholds J, Mol CA, van Deemter L, et al. Multidrug- resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs [J]. Proc Natl Acad Sci USA, 2000, 97: 7476-7481.
18. Kondo T, Kuchiba K, Ohtsuka Y, et al. Clinical and genetic studies on Dubin-Johnson syndrome in a cluster area in Japan [J]. Jpn J Hum Genet, 1974, 18: 378-392.
19. Kitamura T, Jansen P, Hardenbrook C, et al. Defective ATP-dependent bile canalicular transport of organic anions in mutaicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome [J]. Hepatology, 1996, 23: 1061-1066.
20. Nies AT, Keppler D. The apical conjugate efflux pump ABCC2 (MRP2) [J]. Pflugers Arch, 2007, 453: 643-659.
21. Kipp H, Arias IM. Intracellular trafficking and regulation of canalicular ATP-binding cassette transporters [J]. Semin Liver Dis. 2000, 20:339-351.
22. Mottino AD, Veggi LM, Wood M, et al. Biliary secretion of glutathione in estradiol 17beta-D-glucuronide-induced cholestasis [J]. J Pharmacol Exp Ther, 2003, 307: 306-313.
23. Mottino AD, Cao J, Veggi LM, et al. Altered localization and activity of canalicular Mrp2 in estradiol-17beta-D-glucuronide- induced cholestasis [J]. Hepatology, 2002, 35: 1409-1419.
24. Bouchard G, Yousef IM, Barriault C, et al. Role of glutathione and oxidative stress in phalloidin-induced cholestasis [J]. J Hepatol, 2000, 32: 550-560.
25. Moran D, De Buitrago JM, Fernandez E, et al. Inhibition of biliary glutathione secretion by cyclosporine A in the rat: possible mechanisms and role in the cholestasis induced by the drug [J]. J Hepatol, 1998, 29: 68-77.
26. Deters M, Nolte K, Kirchner G, et al. Comparative study analyzing effects of sirolimus-cyclosporin and sirolimus- tacrolimus combinations on bile flow in the rat [J], Dig Dis Sci, 2001, 46:2120-2126.
27. Beuers U, Denk GU, Soroka CJ, et al. Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase- dependent mechanisms in perfused rat livers and rat hepatocyte couplets [J]. J Biol Chem, 2003, 278: 17810-17818.
28. Elferink MG, Olinga P, Draaisma AL, et al. LPS-induced down regulation of MRP2 and BSEP in human liver is due to a posttranscriptional process [J]. Am J Physiol Gastrointest Liver Physiol, 2004, 287: G1008-G1016.
29. Milkiewicz P, Chilton AP, Hubscher SG, et al. Antidepressant induced cholestasis: hepatocellular redistribution of multidrug resistant protein (MRP2) [J]. Gut, 2003, 52: 300-303.
30. Lorchv, Murphy D, Hoersten L, et al. Unusual syndrome among premature infants: associated with a new intravenous vitamin E product [J]. Pediatrics, 1985, 75: 598-601.
31. Cao J, Huang L, Liu Y, et al. Differential regulation of hepatic bile salt and organic anion transporters in pregnant and postpartum rats and the role of prolactin [J]. Hepatology, 2001, 33: 140-147.
32. Cao J, Stieger B, Meier PJ, et al. Expression of rat hepatic multidrug resistance-associated proteins and organic anion transporters in pregnancy [J], Am J Physiol Gastrointest Liver Physiol, 2002, 283: G757-G766.
33. Shoda J, Miura T, Utsunomiya H, et al. Genipin enhances Mrp2 (Abcc2)-mediated bile formation and organic anion transport in rat liver [J]. Hepatology, 2004, 39: 167-178.
34. Ruiz ML, Villanueva SS, Luquita MG et al. Mechanisms involved in spironolactone-induced choleresis in the rat. Role of multidrug resistance-associated protein 2 [J]. Biochem Pharmacol, 2005, 69: 531-539.
35. Crocenzi FA, D'Andrea V, Catania VA, et al. Prevention of Mrp2 activity impairment in ethinylestradiol-induced cholestasis by ursodeoxycholate in the rat [J]. Drug Metab Dispos, 2005, 33: 888-891.
36. Tradtrantip L, Piyachaturawat P, Soroka CJ, et al. Phlorace- tophenone-induced choleresis in rats is mediated through Mrp2 [J]. Am J Physiol Gastrointest Liver Physiol, 2007, 293: G66-G74.
37. Pauli-Magnus C, Meier PJ. Hepatobiliary transporters and drug-induced cholestasis [J], Hepatology, 2006, 44: 778-787.