메뉴 건너뛰기




Volumn 29, Issue 1, 1998, Pages 68-77

Inhibition of biliary glutathione secretion by cyclosporine A in the rat: Possible mechanisms and role in the cholestasis induced by the drug

Author keywords

Bile acid dependent and independent bile flow; Bile flow; Cholestasis; Cyclosporine A; Glutathione; Glutathione dependent and independent bile flow

Indexed keywords

CYCLOSPORIN A; GLUTATHIONE;

EID: 0032125182     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(98)80180-3     Document Type: Article
Times cited : (47)

References (57)
  • 1
    • 0028905779 scopus 로고
    • Cyclosporine A hepatotoxicity: Effect of prolonged treatment with cyclosporine on biliary lipid secretion in the rat
    • Galán AI, Fernández E, Morán D, Muñoz ME, Jiménez R. Cyclosporine A hepatotoxicity: effect of prolonged treatment with cyclosporine on biliary lipid secretion in the rat. Clin Exp Pharmacol Physiol. 22:1995;260-265.
    • (1995) Clin Exp Pharmacol Physiol , vol.22 , pp. 260-265
    • Galán, A.I.1    Fernández, E.2    Morán, D.3    Muñoz, M.E.4    Jiménez, R.5
  • 2
    • 0025294874 scopus 로고
    • Inhibition of hepatocytary vesicular transport by cyclosporin A in the rat: Relationship with cholestasis and hyperbilirubinemia
    • Román ID, Monte MJ, González-Buitrago JM, Esteller A, Jiménez R. Inhibition of hepatocytary vesicular transport by cyclosporin A in the rat: relationship with cholestasis and hyperbilirubinemia. Hepatology. 12:1990;83-91.
    • (1990) Hepatology , vol.12 , pp. 83-91
    • Román, I.D.1    Monte, M.J.2    González-Buitrago, J.M.3    Esteller, A.4    Jiménez, R.5
  • 4
    • 0029824515 scopus 로고    scopus 로고
    • Bile and blood ratios of cyclosporin and its metabolites in patients on continuous infusion during the first three weeks after liver transplantation
    • Debruyne D, Samba D, Lacotte J, Tartiere J, Deshayes JP, Segol PH, et al. Bile and blood ratios of cyclosporin and its metabolites in patients on continuous infusion during the first three weeks after liver transplantation. Clin Drug Invest. 12:1996;67-79.
    • (1996) Clin Drug Invest , vol.12 , pp. 67-79
    • Debruyne, D.1    Samba, D.2    Lacotte, J.3    Tartiere, J.4    Deshayes, J.P.5    Segol, P.H.6
  • 5
    • 0026517169 scopus 로고
    • The bile acid independent flow is reduced in the transplanted liver
    • Friman S, Persson H, Karlberg I, Svanvik J. The bile acid independent flow is reduced in the transplanted liver. Transplant Proc. 24:1992;396-397.
    • (1992) Transplant Proc , vol.24 , pp. 396-397
    • Friman, S.1    Persson, H.2    Karlberg, I.3    Svanvik, J.4
  • 6
    • 0029161684 scopus 로고
    • Inhibition of ileal bile acid transport by cyclosporin A in rat
    • Sauer P, Klöters-Plachky P, Stiehl A. Inhibition of ileal bile acid transport by cyclosporin A in rat. Eur J Clin Invest. 25:1995;677-682.
    • (1995) Eur J Clin Invest , vol.25 , pp. 677-682
    • Sauer, P.1    Klöters-Plachky, P.2    Stiehl, A.3
  • 8
    • 0023766272 scopus 로고
    • Inhibition of taurocholate and ouabain transport in isolated rat hepatocytes by cyclosporin A
    • Stacey N, Kotecka B. Inhibition of taurocholate and ouabain transport in isolated rat hepatocytes by cyclosporin A. Gastroenterology. 95:1988;780-786.
    • (1988) Gastroenterology , vol.95 , pp. 780-786
    • Stacey, N.1    Kotecka, B.2
  • 10
    • 0028284238 scopus 로고
    • Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver
    • Böhme M, Müller M, Leier I, Jedlitschky G, Keppler D. Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver. Gastroenterology. 107:1994;255-265.
    • (1994) Gastroenterology , vol.107 , pp. 255-265
    • Böhme, M.1    Müller, M.2    Leier, I.3    Jedlitschky, G.4    Keppler, D.5
  • 11
    • 0027320960 scopus 로고
    • Inhibition by cyclosporin A of adenosine triphosphate-dependent transport from the hepatocyte into bile
    • Kadmon M, Klünemann C, Böhme M, Ishikawa T, Gorgas K, Otto G, et al. Inhibition by cyclosporin A of adenosine triphosphate-dependent transport from the hepatocyte into bile. Gastroenterology. 104:1993;1507-1514.
    • (1993) Gastroenterology , vol.104 , pp. 1507-1514
    • Kadmon, M.1    Klünemann, C.2    Böhme, M.3    Ishikawa, T.4    Gorgas, K.5    Otto, G.6
  • 12
    • 0027429147 scopus 로고
    • Differential inhibition by cyclosporins of primary-active ATP-dependent transporters in the hepatocyte canalicular membrane
    • Böhme M, Büchler M, Müller M, Keppler D. Differential inhibition by cyclosporins of primary-active ATP-dependent transporters in the hepatocyte canalicular membrane. FEBS Lett. 333:1993;193-196.
    • (1993) FEBS Lett , vol.333 , pp. 193-196
    • Böhme, M.1    Büchler, M.2    Müller, M.3    Keppler, D.4
  • 13
    • 0029982371 scopus 로고    scopus 로고
    • Bile secretion-models, mechanisms, and malfunctions. A perspective on the development of modern cellular and molecular concepts of bile secretion and cholestasis
    • Boyer JL. Bile secretion-models, mechanisms, and malfunctions. A perspective on the development of modern cellular and molecular concepts of bile secretion and cholestasis. J Gastroenterol. 31:1996;475-481.
    • (1996) J Gastroenterol , vol.31 , pp. 475-481
    • Boyer, J.L.1
  • 14
    • 0024499938 scopus 로고
    • Relation between biliary glutathione excretion and bile acid-independent bile flow
    • Ballatori N, Truong AT. Relation between biliary glutathione excretion and bile acid-independent bile flow. Am J Physiol. 256:1989;G22-G30.
    • (1989) Am J Physiol , vol.256
    • Ballatori, N.1    Truong, A.T.2
  • 15
    • 0026329755 scopus 로고
    • Biliary excretion of glutathione and glutathione adducts
    • Lauterburg BH. Biliary excretion of glutathione and glutathione adducts. Prog Pharmacol Clin Pharmacol. 8:1991;201-213.
    • (1991) Prog Pharmacol Clin Pharmacol , vol.8 , pp. 201-213
    • Lauterburg, B.H.1
  • 16
    • 0028020838 scopus 로고
    • Decreased biliary glutathione content is responsible for the decline in bile salt-independent flow induced by ethinyl estradiol in rats
    • Bouchard G, Yousef IM, Tuchweber B. Decreased biliary glutathione content is responsible for the decline in bile salt-independent flow induced by ethinyl estradiol in rats. Toxicol Lett. 74:1994;221-233.
    • (1994) Toxicol Lett , vol.74 , pp. 221-233
    • Bouchard, G.1    Yousef, I.M.2    Tuchweber, B.3
  • 17
    • 0025604921 scopus 로고
    • Importance and regulation of hepatic glutathione
    • Deleve LD, Kaplowitz N. Importance and regulation of hepatic glutathione. Semin Liver Dis. 10:1990;251-266.
    • (1990) Semin Liver Dis , vol.10 , pp. 251-266
    • Deleve, L.D.1    Kaplowitz, N.2
  • 18
    • 0028148189 scopus 로고
    • Identification and characterization of high and low affinity transport systems for reduced glutathione in liver cell canalicular membranes
    • Ballatori N, Dutczak WJ. Identification and characterization of high and low affinity transport systems for reduced glutathione in liver cell canalicular membranes. J Biol Chem. 269:1994;19731-19737.
    • (1994) J Biol Chem , vol.269 , pp. 19731-19737
    • Ballatori, N.1    Dutczak, W.J.2
  • 19
    • 0026511550 scopus 로고
    • Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats
    • Fernández-Checa JC, Takikawa H, Horie T, Ookhtens M, Kaplowitz N. Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats. J Biol Chem. 267:1992;1667-1673.
    • (1992) J Biol Chem , vol.267 , pp. 1667-1673
    • Fernández-Checa, J.C.1    Takikawa, H.2    Horie, T.3    Ookhtens, M.4    Kaplowitz, N.5
  • 21
    • 0030638506 scopus 로고    scopus 로고
    • Hepatic canalicular membrane. Introduction: Transport across the hepatocyte canalicular membrane
    • Keppler D, Arias IM. Hepatic canalicular membrane. Introduction: transport across the hepatocyte canalicular membrane. FASEB J. 11:1997;15-18.
    • (1997) FASEB J , vol.11 , pp. 15-18
    • Keppler, D.1    Arias, I.M.2
  • 22
    • 0029872253 scopus 로고    scopus 로고
    • Role of two recently cloned rat liver GSH transporters in the ubiquitous transport of GSH in mammalian cells
    • Lu SC, Sun WM, Yi J, Ookhtens M, Sze G, Kaplowitz N. Role of two recently cloned rat liver GSH transporters in the ubiquitous transport of GSH in mammalian cells. J Clin Invest. 97:1996;1488-1496.
    • (1996) J Clin Invest , vol.97 , pp. 1488-1496
    • Lu, S.C.1    Sun, W.M.2    Yi, J.3    Ookhtens, M.4    Sze, G.5    Kaplowitz, N.6
  • 23
    • 0029937429 scopus 로고    scopus 로고
    • Secretion of organic anions by hepatocytes: Involvement of homologues of the multidrug resistence protein
    • Müller M, Roelofsen H, Jansen PLM. Secretion of organic anions by hepatocytes: involvement of homologues of the multidrug resistence protein. Semin Liver Dis. 16:1996;211-220.
    • (1996) Semin Liver Dis , vol.16 , pp. 211-220
    • Müller, M.1    Roelofsen, H.2    Jansen, P.L.M.3
  • 25
    • 0000327340 scopus 로고    scopus 로고
    • The canalicular multispecific organic anions transporter mediates transport of reduced glutathione
    • [abstract]
    • Paulusma CC, Van Geer M, Heijn M, Evers R, Ottenhoff R, Oude Elferink RPJ. The canalicular multispecific organic anions transporter mediates transport of reduced glutathione. [abstract] Hepatology. 26:1997;292.
    • (1997) Hepatology , vol.26 , pp. 292
    • Paulusma, C.C.1    Van Geer, M.2    Heijn, M.3    Evers, R.4    Ottenhoff, R.5    Oude Elferink, R.P.J.6
  • 26
    • 0025103799 scopus 로고
    • Competitive interaction of cyclosporins with the vinca alkaloid-binding site of P-glycoprotein in multidrug-resistant cells
    • Tamai I, Safa AR. Competitive interaction of cyclosporins with the vinca alkaloid-binding site of P-glycoprotein in multidrug-resistant cells. J Biol Chem. 265:1990;16509-16513.
    • (1990) J Biol Chem , vol.265 , pp. 16509-16513
    • Tamai, I.1    Safa, A.R.2
  • 27
    • 0026603791 scopus 로고
    • Effect of cyclosporine on colchicine secretion by a liver canalicular transporter studied in vivo
    • Speeg KW, Maldonado AL, Liaci J, Muirhead D. Effect of cyclosporine on colchicine secretion by a liver canalicular transporter studied in vivo. Hepatology. 15:1992;899-903.
    • (1992) Hepatology , vol.15 , pp. 899-903
    • Speeg, K.W.1    Maldonado, A.L.2    Liaci, J.3    Muirhead, D.4
  • 28
    • 0024313160 scopus 로고
    • Uptake, production and metabolism of cysteinyl leukotrienes in the isolated perfused rat liver. Inhibition of leukotriene uptake by cyclosporine
    • Hagmann W, Parthé S, Kaiser I. Uptake, production and metabolism of cysteinyl leukotrienes in the isolated perfused rat liver. Inhibition of leukotriene uptake by cyclosporine. Biochem J. 261:1989;611-616.
    • (1989) Biochem J , vol.261 , pp. 611-616
    • Hagmann, W.1    Parthé, S.2    Kaiser, I.3
  • 29
    • 0025362577 scopus 로고
    • Inhibition of bile acid transport by cyclosporine A in rat liver plasma membrane vesicles
    • Moseley RH, Johnson TR, Morrissette JM. Inhibition of bile acid transport by cyclosporine A in rat liver plasma membrane vesicles. J Pharmacol Exp Ther. 253:1990;974-980.
    • (1990) J Pharmacol Exp Ther , vol.253 , pp. 974-980
    • Moseley, R.H.1    Johnson, T.R.2    Morrissette, J.M.3
  • 30
    • 0023811891 scopus 로고
    • Inhibition of taurocholate transport by cyclosporin A in cultured rat hepatocytes
    • Kukongviriyapan U, Stacey NH. Inhibition of taurocholate transport by cyclosporin A in cultured rat hepatocytes. J Pharmacol Exp Ther. 247:1988;685-689.
    • (1988) J Pharmacol Exp Ther , vol.247 , pp. 685-689
    • Kukongviriyapan, U.1    Stacey, N.H.2
  • 31
    • 0010340553 scopus 로고
    • Effect of cholestatic compounds on bile canalicular ATP-dependent and membrane potential-dependent transport system
    • [abstract]
    • Romanelli R, Che M, Leveille C, Gatmaitan Z, Arias IM. Effect of cholestatic compounds on bile canalicular ATP-dependent and membrane potential-dependent transport system. [abstract] Hepatology. 18:1993;139.
    • (1993) Hepatology , vol.18 , pp. 139
    • Romanelli, R.1    Che, M.2    Leveille, C.3    Gatmaitan, Z.4    Arias, I.M.5
  • 32
    • 0024432823 scopus 로고
    • Identification of the multidrug resistance-related P-glycoprotein as a cyclosporine binding protein
    • Foxwell BMJ, Mazkie A, Ling V, Ryffel B. Identification of the multidrug resistance-related P-glycoprotein as a cyclosporine binding protein. Mol Pharmacol. 36:1989;543-546.
    • (1989) Mol Pharmacol , vol.36 , pp. 543-546
    • Foxwell, B.M.J.1    Mazkie, A.2    Ling, V.3    Ryffel, B.4
  • 33
    • 0027418815 scopus 로고
    • Human P-glycoprotein transports cyclosporin A and FK 506
    • Saeki T, Ueda K, Tanigawa Y, Hori R, Komano T. Human P-glycoprotein transports cyclosporin A and FK 506. J Biol Chem. 268:1993;6077-6080.
    • (1993) J Biol Chem , vol.268 , pp. 6077-6080
    • Saeki, T.1    Ueda, K.2    Tanigawa, Y.3    Hori, R.4    Komano, T.5
  • 34
    • 0023038417 scopus 로고
    • Intrabiliary glutathione hydrolysis. A source of glutamate in bile
    • Ballatori N, Jacob R, Boyer JL. Intrabiliary glutathione hydrolysis. A source of glutamate in bile. J Biol Chem. 261:1986;7860-7865.
    • (1986) J Biol Chem , vol.261 , pp. 7860-7865
    • Ballatori, N.1    Jacob, R.2    Boyer, J.L.3
  • 35
    • 0026583206 scopus 로고
    • Comparison of cyclosporine and FK506 effects on glutathione levels in rat cochlea, brain, liver and kidney
    • Edkins RD, Rybak LP, Hoffman DW. Comparison of cyclosporine and FK506 effects on glutathione levels in rat cochlea, brain, liver and kidney. Biochem Pharmacol. 43:1992;911-913.
    • (1992) Biochem Pharmacol , vol.43 , pp. 911-913
    • Edkins, R.D.1    Rybak, L.P.2    Hoffman, D.W.3
  • 36
    • 0026952468 scopus 로고
    • Adaptational increase of liver glutathione content during long-term application of cyclosporine A may attenuate toxic side effects
    • Mueller K, Siems WG, Grune T, David H, Henke W, Jung K. Adaptational increase of liver glutathione content during long-term application of cyclosporine A may attenuate toxic side effects. Cell Mol Biol. 38:1992;729-738.
    • (1992) Cell Mol Biol , vol.38 , pp. 729-738
    • Mueller, K.1    Siems, W.G.2    Grune, T.3    David, H.4    Henke, W.5    Jung, K.6
  • 37
    • 0024389669 scopus 로고
    • Effect of cyclosporine A on rat liver and kidney glutathione content
    • Duruibe VA, Okonmah A, Blyden GT. Effect of cyclosporine A on rat liver and kidney glutathione content. Pharmacology. 39:1989;205-212.
    • (1989) Pharmacology , vol.39 , pp. 205-212
    • Duruibe, V.A.1    Okonmah, A.2    Blyden, G.T.3
  • 38
    • 85030338221 scopus 로고
    • Changes in glutathione hepatic content and γ-glutamyl-cycle enzymes during CyA long term treatment in the rat
    • [abstract]. (Suppl. 1)
    • Morán D, Galán AI, Fernández E, Moreno C, Jiménez R, Muñoz ME. Changes in glutathione hepatic content and γ-glutamyl-cycle enzymes during CyA long term treatment in the rat. [abstract] J Hepatol. 23:1995;160. (Suppl. 1).
    • (1995) J Hepatol , vol.23 , pp. 160
    • Morán, D.1    Galán, A.I.2    Fernández, E.3    Moreno, C.4    Jiménez, R.5    Muñoz, M.E.6
  • 39
    • 0019167355 scopus 로고
    • Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
    • Griffith Ow. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem. 106:1980;207-212.
    • (1980) Anal Biochem , vol.106 , pp. 207-212
    • Griffith, O.W.1
  • 40
    • 0014481378 scopus 로고
    • Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues
    • Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal. Biochem. 27:1969;502-522.
    • (1969) Anal. Biochem , vol.27 , pp. 502-522
    • Tietze, F.1
  • 41
    • 0021080230 scopus 로고
    • Plasma glutathione and glutathione disulfide in the rat: Regulation and response to oxidative stress
    • Adams JD, Lauterburg BH, Mitchell JR. Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress. J Pharmacol Exp Ther. 227:1983;749-754.
    • (1983) J Pharmacol Exp Ther , vol.227 , pp. 749-754
    • Adams, J.D.1    Lauterburg, B.H.2    Mitchell, J.R.3
  • 45
    • 0010388978 scopus 로고
    • Interactions of cyclosporin A and its derivative IMM-125 with rat hepatocytes
    • [abstract]
    • Wolf A, Trendelenburg C, Aicher L, Schramm U, Fahr A, Fricker G. Interactions of cyclosporin A and its derivative IMM-125 with rat hepatocytes. [abstract] Hepatology. 22:1995;382.
    • (1995) Hepatology , vol.22 , pp. 382
    • Wolf, A.1    Trendelenburg, C.2    Aicher, L.3    Schramm, U.4    Fahr, A.5    Fricker, G.6
  • 46
    • 0023734122 scopus 로고
    • Influence of cyclosporine A on protein synthesis in rat liver
    • Bäckman L, Appelkvist EL, Dallner G. Influence of cyclosporine A on protein synthesis in rat liver. Exp Mol Pathol. 49:1988;38-49.
    • (1988) Exp Mol Pathol , vol.49 , pp. 38-49
    • Bäckman, L.1    Appelkvist, E.L.2    Dallner, G.3
  • 47
    • 0023873066 scopus 로고
    • Hepatocellular uptake of cyclosporin A by simple diffusion
    • Ziegler K, Polzin G, Frimmer M. Hepatocellular uptake of cyclosporin A by simple diffusion. Biochim Biophys Acta. 938:1988;44-50.
    • (1988) Biochim Biophys Acta , vol.938 , pp. 44-50
    • Ziegler, K.1    Polzin, G.2    Frimmer, M.3
  • 48
    • 0001203098 scopus 로고
    • Lipid alterations in the hepatocyte basolateral sinusoidal membrane (BLM) domain may explain cyclosporine (CsA) induced cholestasis in the rat
    • [abstract]
    • Whitington PF, Dudeja P, Hecht JR, Whitington SH, Brasitus TA. Lipid alterations in the hepatocyte basolateral sinusoidal membrane (BLM) domain may explain cyclosporine (CsA) induced cholestasis in the rat. [abstract] Hepatology. 8:1988;1363.
    • (1988) Hepatology , vol.8 , pp. 1363
    • Whitington, P.F.1    Dudeja, P.2    Hecht, J.R.3    Whitington, S.H.4    Brasitus, T.A.5
  • 50
    • 0031160517 scopus 로고    scopus 로고
    • Hepatic canalicular membrane 5: Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver
    • Keppler D, König J. Hepatic canalicular membrane 5: expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver. FASEB J. 11:1997;509-516.
    • (1997) FASEB J , vol.11 , pp. 509-516
    • Keppler, D.1    König, J.2
  • 51
    • 0040761368 scopus 로고    scopus 로고
    • CDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
    • Büchler M, König J, Brom M, Kartenbeck J, Spring H, Horie T, et al. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J Biol Chem. 271:1996;15091-15098.
    • (1996) J Biol Chem , vol.271 , pp. 15091-15098
    • Büchler, M.1    König, J.2    Brom, M.3    Kartenbeck, J.4    Spring, H.5    Horie, T.6
  • 53
    • 85030332979 scopus 로고
    • Reversal of cyclosporine-induced impairments on hepatic handling of BSP and DBSP in the rat by S-adenosyl-L-methionine
    • [abstract]. (Suppl. 1)
    • Ruiz J, Galán AI, Muñoz ME, Moreno C, González-Buitrago JM, Morán D, et al. Reversal of cyclosporine-induced impairments on hepatic handling of BSP and DBSP in the rat by S-adenosyl-L-methionine. [abstract] J Hepatol. 23:1995;159. (Suppl. 1).
    • (1995) J Hepatol , vol.23 , pp. 159
    • Ruiz, J.1    Galán, A.I.2    Muñoz, M.E.3    Moreno, C.4    González-Buitrago, J.M.5    Morán, D.6
  • 54
    • 0030960862 scopus 로고    scopus 로고
    • Progressive defect in biliary GSH secretion in streptozotocin-induced diabetic rats
    • Lu SC, Kuhlenkamp J, Wu H, Sun WM, Stone L, Kaplowitz N. Progressive defect in biliary GSH secretion in streptozotocin-induced diabetic rats. Am J Physiol. 272:1997;G374-G382.
    • (1997) Am J Physiol , vol.272
    • Lu, S.C.1    Kuhlenkamp, J.2    Wu, H.3    Sun, W.M.4    Stone, L.5    Kaplowitz, N.6
  • 55
    • 0027247438 scopus 로고
    • Selective induction by phenobarbital of electrogenic transport of glutathione and organic anions in rat liver canalicular membrane vesicles
    • Fernández-Checa JC, Ookhtens M, Kaplowitz N. Selective induction by phenobarbital of electrogenic transport of glutathione and organic anions in rat liver canalicular membrane vesicles. J Biol Chem. 268:1993;10836-10841.
    • (1993) J Biol Chem , vol.268 , pp. 10836-10841
    • Fernández-Checa, J.C.1    Ookhtens, M.2    Kaplowitz, N.3
  • 56
    • 0029095763 scopus 로고
    • Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein
    • Zaman GR, Lankelma J, Van Tellingen O, Beijnen J, Dekker H, Paulusma C, et al. Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein. Proc Natl Acad Sci USA. 92:1995;7690-7694.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7690-7694
    • Zaman, G.R.1    Lankelma, J.2    Van Tellingen, O.3    Beijnen, J.4    Dekker, H.5    Paulusma, C.6
  • 57
    • 0026503191 scopus 로고
    • Over-expression of the multidrug-resistance gene product in adult rat hepatocytes during primary culture
    • Fardel O, Ratanasavanh D, Loyer P, Ketterer B, Guillouzo A. Over-expression of the multidrug-resistance gene product in adult rat hepatocytes during primary culture. Eur J Biochem. 205:1992;847-852.
    • (1992) Eur J Biochem , vol.205 , pp. 847-852
    • Fardel, O.1    Ratanasavanh, D.2    Loyer, P.3    Ketterer, B.4    Guillouzo, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.