Role of H2O2-activated TRPM2 calcium channel in oxidant-induced endothelial injury

Thrombosis and Haemostasis

Volumn 101, Issue 4, 2009, Pages 619-625

  Hecquet, Claudie M ^a   Malik, Asrar B ^a,b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Endothelial cells; Oxidative stress; TRPM2

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; AMINO ACID; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; HYDROGEN PEROXIDE; PROTEIN KINASE C ALPHA; PROTEIN TYROSINE PHOSPHATASE; TRANSIENT RECEPTOR POTENTIAL CHANNEL 2;

APOPTOSIS; BLOOD VESSEL PERMEABILITY; CONFERENCE PAPER; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; ENZYME ACTIVATION; HUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

ADENOSINE DIPHOSPHATE RIBOSE; ANIMALS; APOPTOSIS; CALCIUM SIGNALING; CAPILLARY PERMEABILITY; CLUSTERIN; ENDOTHELIAL CELLS; HUMANS; HYDROGEN PEROXIDE; INFLAMMATION; ION CHANNEL GATING; OXIDANTS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTEIN CONFORMATION; PROTEIN KINASE C-ALPHA; PROTEIN TYROSINE PHOSPHATASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 64849110665     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH08-10-0641     Document Type: Conference Paper

References (67)

1. Chandra J, Samali A, Orrenius S. Triggering and modulation of apoptosis by oxidative stress. Free Radic Biol Med 2000; 29: 323-333.
2. Langley B, Ratan RR.Oxidative stress-induced death in the nervous system: cell cycle dependent or independent? J Neurosci Res 2004; 77: 621-629.
3. 2+ entry and endothelial hyperpermeability. Circ Res 2008; 102: 347-355.
4. 2. Am J Physiol Heart Circ Physiol 1989; 256: H1012-H1022.
5. Stevens T, Garcia JG, Shasby DM, et al. Mechanisms regulating endothelial cell barrier function. Am J Physiol Lung Cell Mol Physiol 2000; 279: L419-L422.
6. Barnard ML, Matalon S. Mechanisms of extracellular reactive oxygen species injury to the pulmonary microvasculature. J Appl Physiol 1992; 72: 1724-1729.
7. Lum H, Roebuck K. Oxidant stress and endothelial cell dysfunction. Am J Physiol Cell Physiol 2001; 280: C719-C741.
8. Siflinger-Birnboim, A, Goligorsky MS, Delvecchio PJ, et al. Activation of protein kinase C pathway contributes to hydrogen peroxide-induced increase in endothelial permeability. Lab Invest 1992; 67: 24-30.
9. Dreher D, and Junod A F. Differential effects of superoxide, hydrogen peroxide, and hydroxyl radical on intracellular calcium in human endothelial cells. J Cell Physiol 1995; 162: 147-153.
10. 2+2 changes in endothelial cells induced by low doses of reactive oxygen species: role of hydrogen peroxide. Mol Cell Biochem 1997; 171: 11-21.
11. Groschner K, Rosker C, Lukas M. Role of TRP channels in oxidative stress. Novartis Found Symp 2004; 258: 222-230.
12. Kwan HY, Huang Y,and Ya o X. "TRP channels in endothelial function and dysfunction." Biochimica et Biophysica Acta (BBA) - Mol Basis Dis 2007; 1772: 907-914.
13. Dietrich A, Gudermann T. Another TRP to endothelial dysfunction: TRPM2 and endothelial permeability. Circ Res 2008; 102: 275-277.
14. 2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell 2002; 9 : 163-173.
15. Zhang W, Chu X, Tong Q, et al. A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. J Biol Chem 2003; 278: 16222-16229.
16. 2+ channel protein (TRPC7) highly expressed in brain. Genomics 1998; 54: 124-131
17. Kraft R, Grimm C, Grosse K, et al. Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia. Am J Physiol 2004; 286: C129-C137.
18. Inamura K., Sano Y. , Mochizuki S., et al. Response to ADP-ribose by activation of TRPM2 in the CRI-G1 insulinoma cell line. J Membr Biol 2003; 191: 201-207.
19. Heiner I, Eisfeld J, Luckhoff A. Role and regulation of TRP channels in neutrophil granulocytes. Cell Calcium 2003; 33: 533-540.
20. Eisfeld J, Lückhoff A. TRPM2. Handb Exp Pharmacol 2007; 179: 237-252.
21. Yao X, Garland CJ. Recent developments in vascular endothelial cell transient receptor potential channels. Circ Res 2005; 97: 853-863.
22. Zhang W, Chu X, Tong Q, et al. A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. J Biol Chem 2003; 278: 16222-16229.
23. 2+ sensor calmodulin. J Biol Chem 2006; 281: 9076-9085.
24. Kühn FJ, Kühn C, Naziroglu M, et al. Role of an N-terminal splice segment in the activation of the cation channel TRPM2 by ADP-ribose and hydrogen peroxide. Neurochem Res 2008; 34: 227-233.
25. Schmitz C, Perraud AL. The TRPM cation channels in the immune context. Curr Pharm Des 2005; 11: 2765-2778.
26. Fonfria E, Marshall IC, Benham CD, et al. TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase. Br J Pharmacol 2004; 143:186-192.
27. Perraud AL, Fleig A, Dunn CA, et al. ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature 2001; 411:595-599
28. Perraud AL, Takanishi, CL, Shen B, et al. Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels. J Biol Chem 2005; 280: 6138-6148.
29. 2+ influx system mediated by LTRPC2. Science 2001; 293: 1327-1330.
30. Perraud AL, Shen B, Dunn CA, et al. NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase. J Biol Chem 2003; 278: 1794-1801.
31. Kuhn FJ, Luckhoff A. Sites of the NUDT9-H domain critical for ADP-ribose activation of the cation channel TRPM2. J Biol Chem 2004; 279: 46431-46437.
32. Wehage E, Eisfeld J, Heiner I, et al. Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose. J Biol Chem 2002; 277: 23150-23156.
33. 2+ permeable cation channels: from gene to biological function. Cell Calcium 2003; 33: 519-553.
34. Heiner I, Eisfeld J, Halaszovich CR, et al. Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes: evidence for currents through long TRP channel 2 induced by ADP- ribose and NAD. Biochem J 2003; 371: 1045-1053.
35. Uemura T, Kudoh J, Noda S, et al. Characterization of human and mouse TRPM2 genes: identification of a novel N-terminal truncated protein specifically expressed in human striatum. Biochem Biophys Res Commun 2005; 328: 1232-1243.
36. Zhang W, Hirschler-Laszkiewicz I, Tong Q, et al. TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage. Am J Physiol Cell Physiol 2006; 290: C1146-C1159.
37. Mei ZZ, Mao HJ, Jiang LH. Conserved cysteine residues in the pore region are obligatory for human TRPM2 channel function. Am J Physiol Cell Physiol 2006; 291: C1022-C1028.
38. Xia R, Mei ZZ, Mao HJ, et al. Identification of pore residues engaged in determining divalent cationic permeation in transient receptor potential melastatin subtype channel 2. J Biol Chem 2008; 283: 27426-27432.
39. Mederos y Schnitzler M, Wäring J, et al. Evolutionary determinants of divergent calcium selectivity of TRPM channels. FASEB J 2008; 22: 1540-1551.
40. Kühn FJ, Heiner I, Luckhoff A. TRPM2: a calcium influx pathway regulated by oxidative stress and the novel second messenger ADP-ribose. Pflugers Arch 2005; 451: 212-219.
41. Kolisek M, Beck A, Fleig A, et al. Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels. Mol Cell 2005; 18: 61-69.
42. Miller BA. The role of TRP channels in oxidative stress-induced cell death. J Membrane Biol 2006; 209: 1432-1424.
43. Nishikawa T, Edelstein D, Du XL, et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 2000; 404: 787-790.
44. Martin E, Rosenthal RE, Fiskum G..Pyruvate dehydrogenase complex: metabolic link to ischemic brain injury and target of oxidative stress. J Neurosci Res 2005; 79: 240-247.
45. Ferrari R, Guardigli G, Mele D, et al. Oxidative stress during myocardial ischaemia and heart failure. Curr Pharm Des 2004; 10: 1699-1711.
46. Schuber F, Lund FE. Structure and enzymology of ADP-ribosyl cyclases: conserved enzymes that produce multiple calcium mobilizing metabolites.Curr Mol Med 2004; 4: 249-261.
47. Partidá-Sánchez S, Rivero-Nava L, Shi G, et al. CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses.Adv Exp Med Biol 2007; 590: 171-183.
48. Han MK, Cho YS, Kim YS, et al. Interaction of two classes of ADP-ribose transfer reactions in immune signaling. J Biol Chem 2000; 275: 20799-20805.
49. Grubisha O, Rafty LA, Takanishi CL, et al. Metabolite of SIR2 reaction modulates TRPM2 ion channel. J Biol Chem 2006; 281: 14057-14065.
50. Beck A, Kolisek M, Bagley LA, et al. Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes. FASEB J 2006; 20: 962-964.
51. Heiner I, Eisfeld J, Warnstedt M, et al. Endogenous ADP-ribose enables calcium-regulated cation currents through TRPM2 channels in neutrophil granulocytes. Biochem J 2006; 398: 225-232.
52. Fliegert R, Gasser A, and Guse AH. Regulation of calcium signalling by adenine-based second messengers. Biochem Soc Trans 2007; 35: 109-114.
53. Naziroglu M. (2007 ) New molecular mechanisms on the activation of TRPM2 channels by oxidative stress and ADP-ribose. Neurochem Res 2007; 32: 1990-2001.
54. 2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation. J Biol Chem 2003; 278: 11002-11006.
55. Lange I, Penner R, Fleig A, et al. Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils. Cell Calcium 2008; 44: 604-615.
56. Togashi K, Hara Y, Tominaga T, et al. TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J 2006; 25: 1804-1815.
57. 2+ influx via TRPM2 is not the sole determinant of subsequent cell death. Pflugers Arch 2008; 455: 1141-1151.
58. Siflinger-Birnboim A., Goligorsky MS, Delvecchio PJ, et al. Activation of protein kinase C pathway contributes to hydrogen peroxide-induced increase in endothelial permeability. Lab Invest 1992; 67: 24-30.
59. Gopalakrishna R and Jaken S. Protein kinase C signaling and oxidative stress. Free Radic Biol Med 2000; 28: 1349-1361.
60. Zhang W, Tong Q, Conrad K, et al. Regulation of TRP channel TRPM2 by the tyrosine phosphatase PTPL1. Am J Physiol Cell Physiol 2007; 292: C1746-C1758.
61. Poteser M, Graziani A, Rosker C, et al. TRPC3 and TRPC4 associate to form a redox-sensitive cation channel. Evidence for expression of native TRPC3-TRPC4 heterometric channels in endothelial cells. J Biol Chem 2006; 281: 13588-13595.
62. Kaslovsky RA, Parker K, Siflinger-Birnboim A, et al. Increased endothelial permeability after neutrophil activation occurs by a diffusion-dependent mechanism. Microvasc Res 1995; 49: 227.
63. Wang Q, Doerschuk CM. Neutrophil-induced changes in the biomechanical properties of endothelial cells: roles of ICAM-1 and reactive oxygen species. J Immunol 2000; 164: 6487.
64. Siflinger-Birnboim A, Malik AB. Regulation of endothelial permeability by second messengers. New Horiz 1996; 4: 87.
65. Han XB, Liu X, Hsueh W, et al. I.G. Macrophage inflammatory protein-2 mediates the bowel injury induced by platelet-activating factor. Am J Physiol Gastrointest Liver Physiol 2004; 287: G1220-G1226.
66. Buanne P, Di Carlo E, Caputi L, et al. Crucial pathophysiological role of CXCR2 in experimental ulcerative colitis in mice. J Leukoc Biol 2007; 82: 1239-1246.
67. 2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nature Med 2008; 14: 738-747.