PI3Kγ controls oxidative bursts in neutrophils via interactions with PKCα and p47phox

Biochemical Journal

Volumn 419, Issue 3, 2009, Pages 603-610

  Lehmann, Katja ^a   Müller, Jörg P ^a   Schlott, Bernhard ^b   Skroblin, Philipp ^a,c   Barz, Dagmar ^a   Norgauer, Johannes ^a   Wetzker, Reinhard ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b FRITZ LIPMANN INSTITUTE   (Germany)

^c LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

Author keywords

Neutrophil; Phosphoinositide 3 kinase (PI3K ); Protein kinase; Protein kinase C (PKC ); Reactive oxygen species

Indexed keywords

COMPLEX SIGNALLING; DIRECT INTERACTIONS; INFLAMMATORY IMMUNE RESPONSE; INTRACELLULAR MEDIATORS; NADPH OXIDASE; NEUTROPHIL; OXIDATIVE BURSTS; PHOSPHOINOSITIDE 3-KINASE; PROTEIN KINASE; PROTEIN KINASE C; REACTIVE OXYGEN SPECIES;

AMINES; AMINO ACIDS; ENZYME ACTIVITY; OXYGEN;

LEAKAGE (FLUID);

FORMYLMETHIONYLLEUCYLPHENYLALANINE; GENE PRODUCT; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C ALPHA; PROTEIN P47PHOX; REACTIVE OXYGEN METABOLITE; RECOMBINANT PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG; ISOENZYME; N FORMYLMETHIONYL LEUCYL PHENYLALANINE; N-FORMYLMETHIONYL-LEUCYL-PHENYLALANINE; NEUTROPHIL CYTOSOLIC FACTOR 1; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHATIDYLINOSITOL 3-KINASE GAMMA;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; LEUKOCYTE ACTIVATION; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RESPIRATORY BURST; SIGNAL TRANSDUCTION; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; METABOLISM; PHOSPHORYLATION; PROTEIN BINDING;

BACTERIA (MICROORGANISMS);

1-PHOSPHATIDYLINOSITOL 3-KINASE; ENZYME ACTIVATION; HUMANS; ISOENZYMES; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NADPH OXIDASE; NEUTROPHILS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE C-ALPHA; REACTIVE OXYGEN SPECIES; RESPIRATORY BURST;

EID: 64849092514     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20081268     Document Type: Article

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